HUE041456T2 - JAK1 inhibitorok myelodysplasiás szindrómák kezelésére - Google Patents

JAK1 inhibitorok myelodysplasiás szindrómák kezelésére

Info

Publication number
HUE041456T2
HUE041456T2 HUE15710994A HUE15710994A HUE041456T2 HU E041456 T2 HUE041456 T2 HU E041456T2 HU E15710994 A HUE15710994 A HU E15710994A HU E15710994 A HUE15710994 A HU E15710994A HU E041456 T2 HUE041456 T2 HU E041456T2
Authority
HU
Hungary
Prior art keywords
treatment
myelodysplastic syndromes
jak1 inhibitors
jak1
inhibitors
Prior art date
Application number
HUE15710994A
Other languages
English (en)
Hungarian (hu)
Inventor
Krishna Vaddi
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of HUE041456T2 publication Critical patent/HUE041456T2/hu

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HUE15710994A 2014-02-28 2015-02-27 JAK1 inhibitorok myelodysplasiás szindrómák kezelésére HUE041456T2 (hu)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461946124P 2014-02-28 2014-02-28

Publications (1)

Publication Number Publication Date
HUE041456T2 true HUE041456T2 (hu) 2019-05-28

Family

ID=52693052

Family Applications (1)

Application Number Title Priority Date Filing Date
HUE15710994A HUE041456T2 (hu) 2014-02-28 2015-02-27 JAK1 inhibitorok myelodysplasiás szindrómák kezelésére

Country Status (29)

Country Link
US (4) US20150246046A1 (enExample)
EP (1) EP3110409B1 (enExample)
JP (1) JP6576941B2 (enExample)
KR (1) KR20160136323A (enExample)
CN (2) CN106456773A (enExample)
AU (1) AU2015222913B2 (enExample)
CA (1) CA2940659C (enExample)
CL (1) CL2016002144A1 (enExample)
CR (1) CR20160449A (enExample)
CY (1) CY1120857T1 (enExample)
DK (1) DK3110409T3 (enExample)
EA (1) EA201691745A1 (enExample)
ES (1) ES2688553T3 (enExample)
HR (1) HRP20181661T1 (enExample)
HU (1) HUE041456T2 (enExample)
IL (1) IL247475B (enExample)
LT (1) LT3110409T (enExample)
MX (1) MX372939B (enExample)
MY (1) MY185392A (enExample)
PE (1) PE20161388A1 (enExample)
PL (1) PL3110409T3 (enExample)
PT (1) PT3110409T (enExample)
RS (1) RS57723B1 (enExample)
SG (2) SG11201607083VA (enExample)
SI (1) SI3110409T1 (enExample)
SM (1) SMT201800551T1 (enExample)
UA (1) UA121857C2 (enExample)
WO (1) WO2015131031A1 (enExample)
ZA (1) ZA201606610B (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2474545B1 (en) 2005-12-13 2016-11-09 Incyte Holdings Corporation Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
DK2173752T4 (en) 2007-06-13 2022-08-01 Incyte Holdings Corp Salte af janus-kinase-inhibitor (r)-3-(4-(7h-pyrrolo(2,3-d)pyrimidin-4-yl)-1h-pyrazol-1-yl)-3-cyclopentylpropannitril
TWI484962B (zh) 2009-05-22 2015-05-21 Incyte Corp 作為jak抑制劑之3-〔4-(7h-吡咯并〔2,3-d〕嘧啶-4-基)-1h-吡唑-1-基〕辛烷或庚腈
ME02386B (me) 2010-03-10 2016-09-20 Incyte Holdings Corp Derivati piperidin-4-il azetidina kao inhibitori jak1
SG185567A1 (en) 2010-05-21 2012-12-28 Incyte Corp Topical formulation for a jak inhibitor
US8933085B2 (en) 2010-11-19 2015-01-13 Incyte Corporation Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
BR112013032720A2 (pt) 2011-06-20 2016-09-13 Incyte Corp "derivados de azetidinil fenil, piridil ou pirazinil carboxamida como inibidores de jak, composição e uso dos referidos derivados"
UA111854C2 (uk) 2011-09-07 2016-06-24 Інсайт Холдінгс Корпорейшн Способи і проміжні сполуки для отримання інгібіторів jak
PE20151141A1 (es) 2012-11-01 2015-08-06 Incyte Corp Derivados triciclicos fusionados de tiofeno como inhibidores de jak
TW202228704A (zh) 2012-11-15 2022-08-01 美商英塞特控股公司 盧梭利替尼之緩釋性劑型
EP2943485B1 (en) 2013-01-14 2017-09-20 Incyte Holdings Corporation Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors
AU2014207691B2 (en) 2013-01-15 2018-08-30 Incyte Holdings Corporation Thiazolecarboxamides and pyridinecarboxamide compounds useful as Pim kinase inhibitors
PT3489239T (pt) 2013-03-06 2021-12-17 Incyte Holdings Corp Processos e intermediários para a preparação de um inibidor de jak
KR102729910B1 (ko) 2013-05-17 2024-11-15 인사이트 홀딩스 코포레이션 Jak 저해제로서 비피라졸 유도체
MY203694A (en) 2013-08-07 2024-07-14 Incyte Holdings Corp Sustained release dosage forms for a jak1 inhibitor
EP3036238A1 (en) 2013-08-23 2016-06-29 Incyte Corporation Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
DK3129021T3 (da) 2014-04-08 2020-11-09 Incyte Corp Behandling af b-celle-maligniteter ved en kombination af jak- og pi3k-inhibitorer
SG11201609016VA (en) 2014-04-30 2016-11-29 Incyte Corp Processes of preparing a jak1 inhibitor and new forms thereto
US9498467B2 (en) 2014-05-30 2016-11-22 Incyte Corporation Treatment of chronic neutrophilic leukemia (CNL) and atypical chronic myeloid leukemia (aCML) by inhibitors of JAK1
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US9540347B2 (en) 2015-05-29 2017-01-10 Incyte Corporation Pyridineamine compounds useful as Pim kinase inhibitors
TWI734699B (zh) 2015-09-09 2021-08-01 美商英塞特公司 Pim激酶抑制劑之鹽
WO2017059251A1 (en) 2015-10-02 2017-04-06 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
WO2017155325A1 (ko) * 2016-03-09 2017-09-14 울산대학교 산학협력단 Jak1 억제제를 유효성분으로 포함하는 줄기세포의 증식, 분화 촉진 또는 노화 억제용 조성물
KR101934107B1 (ko) * 2016-12-15 2018-12-31 가톨릭대학교산학협력단 골수형성이상 증후군 환자의 저메틸화 제제 치료 반응성 및 생존 예후 예측용 조성물
CA3055233C (en) 2017-01-23 2022-08-09 Shanghai Longwood Biopharmaceuticals Co., Ltd. Jak kinase inhibitor and preparation method and use thereof
CN109867676B (zh) * 2017-12-01 2020-10-30 北京普祺医药科技有限公司 一种吡咯并嘧啶衍生的化合物、药物组合物以及其用途
TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法
PL3746429T3 (pl) 2018-01-30 2022-06-20 Incyte Corporation Procesy do otrzymywania (1-(3-fluoro-2-(trifluorometylo)izonikotynoilo)piperydyn-4-onu)
CN117959583A (zh) 2018-02-01 2024-05-03 施菲姆德控股有限责任公司 血管内血泵以及使用和制造方法
KR102830476B1 (ko) 2018-02-16 2025-07-08 인사이트 코포레이션 사이토카인-관련 장애의 치료를 위한 jak1 경로 억제제
RS65624B1 (sr) 2018-03-30 2024-07-31 Incyte Corp Lečenje supurativnog hidradenitisa upotrebom jak inhbitora
US11584961B2 (en) 2018-03-30 2023-02-21 Incyte Corporation Biomarkers for inflammatory skin disease
EP3775923A1 (en) 2018-04-13 2021-02-17 Incyte Corporation Biomarkers for graft-versus-host disease
SG11202011680YA (en) 2018-06-01 2020-12-30 Incyte Corp Dosing regimen for the treatment of pi3k related disorders
IL282643B2 (en) 2018-10-31 2025-08-01 Incyte Corp A selective jak1 inhibitor for use in a method of treating hematological disease
CN111320633B (zh) * 2018-12-14 2022-09-27 中国医药研究开发中心有限公司 吡咯/咪唑并六元杂芳环类化合物及其制备方法和医药用途
EA202192426A1 (ru) 2019-03-05 2021-11-15 Инсайт Корпорейшн Ингибиторы путей jak1 для лечения хронической дисфункции аллотрансплантата легких
CA3156007A1 (en) 2019-09-27 2021-04-01 Disc Medicine, Inc. METHODS OF TREATING MYELOFIBROSE AND ASSOCIATED CONDITIONS
EP4041204A1 (en) 2019-10-10 2022-08-17 Incyte Corporation Biomarkers for graft-versus-host disease
WO2021072098A1 (en) 2019-10-10 2021-04-15 Incyte Corporation Biomarkers for graft-versus-host disease
US11992490B2 (en) 2019-10-16 2024-05-28 Incyte Corporation Use of JAK1 inhibitors for the treatment of cutaneous lupus erythematosus and Lichen planus (LP)
CN111358791A (zh) * 2020-03-13 2020-07-03 深圳百奥捷生物科技有限公司 Jak/stat信号通路磷酸盐抑制剂在制备治疗dba疾病的药物中的应用
HRP20241560T1 (hr) 2020-06-02 2025-01-17 Incyte Corporation Postupci za proizvodnju inhibitora jak1
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
KR20230118118A (ko) 2020-12-08 2023-08-10 인사이트 코포레이션 백반증의 치료를 위한 jak1 경로 저해제
JP2024503372A (ja) * 2021-01-18 2024-01-25 アクティブ バイオテック エイビー 骨髄異形成症候群の処置における使用のためのタスキニモドまたはその薬学的に許容される塩
US12268667B2 (en) 2021-05-03 2025-04-08 Incyte Corporation JAK1 pathway inhibitors for the treatment of prurigo nodularis
WO2024222835A1 (en) * 2023-04-27 2024-10-31 Sironax Ltd. Sarm1 modulators, preparations, and uses thereof

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5521184A (en) 1992-04-03 1996-05-28 Ciba-Geigy Corporation Pyrimidine derivatives and processes for the preparation thereof
WO2000009495A1 (en) 1998-08-11 2000-02-24 Novartis Ag Isoquinoline derivatives with angiogenesis inhibiting activity
US6133031A (en) 1999-08-19 2000-10-17 Isis Pharmaceuticals Inc. Antisense inhibition of focal adhesion kinase expression
GB9905075D0 (en) 1999-03-06 1999-04-28 Zeneca Ltd Chemical compounds
GB0004890D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
PL202623B1 (pl) 2000-06-28 2009-07-31 Smithkline Beecham Plc Sposób wytwarzania drobno zmielonego preparatu substancji leczniczej, drobno zmielona substancja lecznicza wytworzona tym sposobem i zawierająca ją kompozycja farmaceutyczna
DE60230890D1 (de) 2001-09-19 2009-03-05 Aventis Pharma Sa Indolizine als kinaseproteinhemmer
MXPA04004137A (es) 2001-10-30 2005-01-25 Novartis Ag Derivados de estauroesporina como inhibidores de la actividad de cinasa de tirosina del receptor flt3.
TW200406374A (en) 2002-05-29 2004-05-01 Novartis Ag Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
GB0215676D0 (en) 2002-07-05 2002-08-14 Novartis Ag Organic compounds
AR042052A1 (es) 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas
UA80767C2 (en) 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
GB0305929D0 (en) 2003-03-14 2003-04-23 Novartis Ag Organic compounds
PE20050952A1 (es) 2003-09-24 2005-12-19 Novartis Ag Derivados de isoquinolina como inhibidores de b-raf
BRPI0517887A (pt) 2004-11-24 2008-10-21 Novartis Ag combinações de inibidores de jaks
TW200635899A (en) 2004-12-22 2006-10-16 Astrazeneca Ab Chemical compounds
EP2474545B1 (en) * 2005-12-13 2016-11-09 Incyte Holdings Corporation Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors
US8158616B2 (en) 2008-03-11 2012-04-17 Incyte Corporation Azetidine and cyclobutane derivatives as JAK inhibitors
CA2762174C (en) * 2009-05-22 2018-02-20 Incyte Corporation N-(hetero)aryl-pyrrolidine derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines and pyrrol-3-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
TW201113285A (en) 2009-09-01 2011-04-16 Incyte Corp Heterocyclic derivatives of pyrazol-4-yl-pyrrolo[2,3-d]pyrimidines as janus kinase inhibitors
ME02386B (me) * 2010-03-10 2016-09-20 Incyte Holdings Corp Derivati piperidin-4-il azetidina kao inhibitori jak1
US9034884B2 (en) 2010-11-19 2015-05-19 Incyte Corporation Heterocyclic-substituted pyrrolopyridines and pyrrolopyrimidines as JAK inhibitors
US8933085B2 (en) * 2010-11-19 2015-01-13 Incyte Corporation Cyclobutyl substituted pyrrolopyridine and pyrrolopyrimidine derivatives as JAK inhibitors
WO2012071612A1 (en) * 2010-12-03 2012-06-07 Ym Biosciences Australia Pty Ltd Treatment of jak2-mediated conditions
BR112013032720A2 (pt) * 2011-06-20 2016-09-13 Incyte Corp "derivados de azetidinil fenil, piridil ou pirazinil carboxamida como inibidores de jak, composição e uso dos referidos derivados"
TW201313721A (zh) 2011-08-18 2013-04-01 Incyte Corp 作為jak抑制劑之環己基氮雜環丁烷衍生物
AR091079A1 (es) * 2012-05-18 2014-12-30 Incyte Corp Derivados de pirrolopirimidina y pirrolopiridina sustituida con piperidinilciclobutilo como inhibidores de jak
US10155987B2 (en) * 2012-06-12 2018-12-18 Dana-Farber Cancer Institute, Inc. Methods of predicting resistance to JAK inhibitor therapy
PE20151141A1 (es) * 2012-11-01 2015-08-06 Incyte Corp Derivados triciclicos fusionados de tiofeno como inhibidores de jak
KR102729910B1 (ko) * 2013-05-17 2024-11-15 인사이트 홀딩스 코포레이션 Jak 저해제로서 비피라졸 유도체

Also Published As

Publication number Publication date
EP3110409A1 (en) 2017-01-04
BR112016019511A8 (pt) 2023-01-24
US20190111058A1 (en) 2019-04-18
ES2688553T3 (es) 2018-11-05
DK3110409T3 (en) 2018-10-22
CL2016002144A1 (es) 2016-12-16
EP3110409B1 (en) 2018-08-15
SMT201800551T1 (it) 2019-01-11
SG10201807952PA (en) 2018-10-30
CN106456773A (zh) 2017-02-22
PE20161388A1 (es) 2016-12-28
US20210069193A1 (en) 2021-03-11
AU2015222913B2 (en) 2019-12-12
IL247475A0 (en) 2016-11-30
MX2016011103A (es) 2017-02-28
LT3110409T (lt) 2019-01-25
BR112016019511A2 (enExample) 2017-08-15
KR20160136323A (ko) 2016-11-29
CR20160449A (es) 2016-12-20
EA201691745A1 (ru) 2016-12-30
CA2940659A1 (en) 2015-09-03
PT3110409T (pt) 2018-11-07
HRP20181661T1 (hr) 2018-12-14
WO2015131031A1 (en) 2015-09-03
UA121857C2 (uk) 2020-08-10
MX372939B (es) 2020-04-03
AU2015222913A1 (en) 2016-09-29
US20150246046A1 (en) 2015-09-03
JP6576941B2 (ja) 2019-09-18
CA2940659C (en) 2023-01-03
NZ724464A (en) 2021-01-29
SG11201607083VA (en) 2016-09-29
US20220378791A1 (en) 2022-12-01
SI3110409T1 (sl) 2018-11-30
CN112494652A (zh) 2021-03-16
RS57723B1 (sr) 2018-12-31
MY185392A (en) 2021-05-17
ZA201606610B (en) 2020-08-26
IL247475B (en) 2020-05-31
JP2017506659A (ja) 2017-03-09
PL3110409T3 (pl) 2018-12-31
CY1120857T1 (el) 2019-12-11

Similar Documents

Publication Publication Date Title
IL321844A (en) Menin–MLL interaction inhibitors
ZA201606610B (en) Jak1 inhibitors for the treatment of myelodysplastic syndromes
IL287113A (en) smyd inhibitors
IL259560A (en) Inhibitors of the menin-mll interaction
PL3512850T3 (pl) Inhibitory interakcji menina-mll
IL258154A (en) Pyrazolopyrimidine history as btk inhibitors for cancer treatment
IL253945A0 (en) kdm1a inhibitors to treat the disease
IL248895A0 (en) Phosphatidylinositol 3-kinase inhibitors
IL254266A0 (en) Glucosylceramide synthase inhibitors for the treatment of diseases
ZA201700916B (en) Heterobicyclic compounds and their use for the treatment of tuberculosis
IL265139B (en) Dopamine-b-hydroxylase inhibitors
GB201612860D0 (en) Inhibitors
PT3122349T (pt) Composições para o tratamento da autodigestão
SG11201702700UA (en) Methods for the treatment of peri-implantitis
IL247366A0 (en) Inhibitors of wnt signaling pathways
PL3151899T3 (pl) Urządzenie do leczenia zwężeń przełyku
ZA201704589B (en) Compounds for the treatment of cancer
GB201418154D0 (en) Inhibitors