KR20150037950A - 4-메틸-2,3,5,9,9b-펜타아자-사이클로펜타[a]나프탈렌 - Google Patents

4-메틸-2,3,5,9,9b-펜타아자-사이클로펜타[a]나프탈렌 Download PDF

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KR20150037950A
KR20150037950A KR20157002607A KR20157002607A KR20150037950A KR 20150037950 A KR20150037950 A KR 20150037950A KR 20157002607 A KR20157002607 A KR 20157002607A KR 20157002607 A KR20157002607 A KR 20157002607A KR 20150037950 A KR20150037950 A KR 20150037950A
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alkyl
group
rti
cycloalkyl
substituted
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Korean (ko)
Inventor
리카르도 지오바니니
바르바라 베르타니
사라 프라티니
안토니오 주스티노 디
한스-요아힘 랑카우
한스 슈탕게
흐리슈티안 그룬발트
노르베르트 회프겐
바르바라 랑겐
우테 에거란트
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베링거 인겔하임 인터내셔날 게엠베하
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Application filed by 베링거 인겔하임 인터내셔날 게엠베하 filed Critical 베링거 인겔하임 인터내셔날 게엠베하
Publication of KR20150037950A publication Critical patent/KR20150037950A/ko
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/08Antiepileptics; Anticonvulsants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/20Hypnotics; Sedatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR20157002607A 2012-07-31 2013-07-29 4-메틸-2,3,5,9,9b-펜타아자-사이클로펜타[a]나프탈렌 Withdrawn KR20150037950A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12178713.9 2012-07-31
EP12178713 2012-07-31
PCT/EP2013/065894 WO2014019979A1 (en) 2012-07-31 2013-07-29 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes

Publications (1)

Publication Number Publication Date
KR20150037950A true KR20150037950A (ko) 2015-04-08

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ID=48906250

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KR20157002607A Withdrawn KR20150037950A (ko) 2012-07-31 2013-07-29 4-메틸-2,3,5,9,9b-펜타아자-사이클로펜타[a]나프탈렌

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US (2) US20140045856A1 (enExample)
EP (1) EP2882749B1 (enExample)
JP (1) JP6356671B2 (enExample)
KR (1) KR20150037950A (enExample)
CN (1) CN104428302B (enExample)
AP (1) AP2015008202A0 (enExample)
AR (1) AR091939A1 (enExample)
AU (1) AU2013298621B2 (enExample)
BR (1) BR112015002118A2 (enExample)
CA (1) CA2880447A1 (enExample)
CL (1) CL2015000096A1 (enExample)
CO (1) CO7310531A2 (enExample)
EA (1) EA028958B1 (enExample)
EC (1) ECSP15006871A (enExample)
GE (1) GEP201706707B (enExample)
IL (1) IL236494A0 (enExample)
MA (1) MA37798B1 (enExample)
MX (1) MX2015000965A (enExample)
NZ (1) NZ703797A (enExample)
PE (1) PE20150706A1 (enExample)
PH (1) PH12015500211B1 (enExample)
SG (1) SG11201500772VA (enExample)
TN (1) TN2015000022A1 (enExample)
TW (1) TW201418255A (enExample)
UA (1) UA115561C2 (enExample)
UY (1) UY34955A (enExample)
WO (1) WO2014019979A1 (enExample)

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ECSP15006871A (es) 2015-12-31
HK1208440A1 (en) 2016-03-04
JP6356671B2 (ja) 2018-07-11
PH12015500211B1 (en) 2018-01-17
EP2882749A1 (en) 2015-06-17
AR091939A1 (es) 2015-03-11
EA028958B1 (ru) 2018-01-31
EA201500182A1 (ru) 2015-07-30
UY34955A (es) 2014-01-31
CA2880447A1 (en) 2014-02-06
SG11201500772VA (en) 2015-02-27
MX2015000965A (es) 2015-04-10
TW201418255A (zh) 2014-05-16
US20140045856A1 (en) 2014-02-13
WO2014019979A1 (en) 2014-02-06
CN104428302A (zh) 2015-03-18
US9085584B2 (en) 2015-07-21
AU2013298621B2 (en) 2017-12-21
AU2013298621A1 (en) 2015-02-05
CN104428302B (zh) 2017-03-22
AP2015008202A0 (en) 2015-01-31
PE20150706A1 (es) 2015-06-03
BR112015002118A2 (pt) 2017-07-04
NZ703797A (en) 2017-09-29
EP2882749B1 (en) 2018-04-04
GEP201706707B (en) 2017-07-25
UA115561C2 (uk) 2017-11-27
PH12015500211A1 (en) 2015-03-16
CL2015000096A1 (es) 2015-06-19
CO7310531A2 (es) 2015-06-30
US20140045857A1 (en) 2014-02-13
IL236494A0 (en) 2015-02-26
JP2015523406A (ja) 2015-08-13
TN2015000022A1 (en) 2016-06-29
MA37798B1 (fr) 2018-11-30

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