AU2013298621B2 - 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes - Google Patents

4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes Download PDF

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Publication number
AU2013298621B2
AU2013298621B2 AU2013298621A AU2013298621A AU2013298621B2 AU 2013298621 B2 AU2013298621 B2 AU 2013298621B2 AU 2013298621 A AU2013298621 A AU 2013298621A AU 2013298621 A AU2013298621 A AU 2013298621A AU 2013298621 B2 AU2013298621 B2 AU 2013298621B2
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alkyl
group
optionally
substituted
cycloalkyl
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AU2013298621A1 (en
Inventor
Barbara Bertani
Giustino DI ANTONIO
Ute Egerland
Sara Frattini
Riccardo Giovannini
Christian GRUNWALD
Norbert Hofgen
Barbara Langen
Hans-Joachim Lankau
Hans Stange
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Boehringer Ingelheim International GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2013298621A 2012-07-31 2013-07-29 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes Ceased AU2013298621B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12178713 2012-07-31
EP12178713.9 2012-07-31
PCT/EP2013/065894 WO2014019979A1 (en) 2012-07-31 2013-07-29 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes

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AU2013298621A1 AU2013298621A1 (en) 2015-02-05
AU2013298621B2 true AU2013298621B2 (en) 2017-12-21

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AU2013298621A Ceased AU2013298621B2 (en) 2012-07-31 2013-07-29 4-methyl-2,3,5,9,9b-pentaaza-cyclopenta[a]naphthalenes

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US (2) US20140045856A1 (enExample)
EP (1) EP2882749B1 (enExample)
JP (1) JP6356671B2 (enExample)
KR (1) KR20150037950A (enExample)
CN (1) CN104428302B (enExample)
AP (1) AP2015008202A0 (enExample)
AR (1) AR091939A1 (enExample)
AU (1) AU2013298621B2 (enExample)
BR (1) BR112015002118A2 (enExample)
CA (1) CA2880447A1 (enExample)
CL (1) CL2015000096A1 (enExample)
CO (1) CO7310531A2 (enExample)
EA (1) EA028958B1 (enExample)
EC (1) ECSP15006871A (enExample)
GE (1) GEP201706707B (enExample)
IL (1) IL236494A0 (enExample)
MA (1) MA37798B1 (enExample)
MX (1) MX2015000965A (enExample)
NZ (1) NZ703797A (enExample)
PE (1) PE20150706A1 (enExample)
PH (1) PH12015500211B1 (enExample)
SG (1) SG11201500772VA (enExample)
TN (1) TN2015000022A1 (enExample)
TW (1) TW201418255A (enExample)
UA (1) UA115561C2 (enExample)
UY (1) UY34955A (enExample)
WO (1) WO2014019979A1 (enExample)

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US10195201B2 (en) 2015-05-05 2019-02-05 Merck Sharp & Dohme Corp. Heteroaryl-pyrimidinone compounds as PDE2 inhibitors
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
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JP2015523406A (ja) 2015-08-13
CN104428302B (zh) 2017-03-22
CA2880447A1 (en) 2014-02-06
AR091939A1 (es) 2015-03-11
EP2882749A1 (en) 2015-06-17
ECSP15006871A (es) 2015-12-31
US20140045856A1 (en) 2014-02-13
TN2015000022A1 (en) 2016-06-29
EP2882749B1 (en) 2018-04-04
IL236494A0 (en) 2015-02-26
PH12015500211A1 (en) 2015-03-16
MA37798B1 (fr) 2018-11-30
EA028958B1 (ru) 2018-01-31
AU2013298621A1 (en) 2015-02-05
MX2015000965A (es) 2015-04-10
TW201418255A (zh) 2014-05-16
UY34955A (es) 2014-01-31
US9085584B2 (en) 2015-07-21
WO2014019979A1 (en) 2014-02-06
AP2015008202A0 (en) 2015-01-31
PE20150706A1 (es) 2015-06-03
KR20150037950A (ko) 2015-04-08
NZ703797A (en) 2017-09-29
BR112015002118A2 (pt) 2017-07-04
EA201500182A1 (ru) 2015-07-30
GEP201706707B (en) 2017-07-25
US20140045857A1 (en) 2014-02-13
PH12015500211B1 (en) 2018-01-17
CO7310531A2 (es) 2015-06-30
SG11201500772VA (en) 2015-02-27
UA115561C2 (uk) 2017-11-27
JP6356671B2 (ja) 2018-07-11
CN104428302A (zh) 2015-03-18
CL2015000096A1 (es) 2015-06-19
HK1208440A1 (en) 2016-03-04

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