KR20140123104A - 유비퀴틴 활성화 효소의 피라졸로피리미디닐 억제제 - Google Patents
유비퀴틴 활성화 효소의 피라졸로피리미디닐 억제제 Download PDFInfo
- Publication number
- KR20140123104A KR20140123104A KR1020147025556A KR20147025556A KR20140123104A KR 20140123104 A KR20140123104 A KR 20140123104A KR 1020147025556 A KR1020147025556 A KR 1020147025556A KR 20147025556 A KR20147025556 A KR 20147025556A KR 20140123104 A KR20140123104 A KR 20140123104A
- Authority
- KR
- South Korea
- Prior art keywords
- sulfamate
- pyrimidin
- pyrazolo
- methyl
- rac
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 0 CC1(C)O[C@]([C@@](C[C@@]2CO)Nc3ccnc4cc(*)n[n]34)[C@@]2O1 Chemical compound CC1(C)O[C@]([C@@](C[C@@]2CO)Nc3ccnc4cc(*)n[n]34)[C@@]2O1 0.000 description 4
- KHETXCDANRAZGQ-UHFFFAOYSA-N CC(Nc1cc(-c2ccccc2)n[n]11)=CC1=O Chemical compound CC(Nc1cc(-c2ccccc2)n[n]11)=CC1=O KHETXCDANRAZGQ-UHFFFAOYSA-N 0.000 description 1
- OMRRJDISSSCCIZ-RWJCITIMSA-N CC1(C)O[C@@H]([C@@H](C[C@@H]2CO)Nc3ccnc4cc(-c5cccc6c5cccc6)n[n]34)[C@@H]2O1 Chemical compound CC1(C)O[C@@H]([C@@H](C[C@@H]2CO)Nc3ccnc4cc(-c5cccc6c5cccc6)n[n]34)[C@@H]2O1 OMRRJDISSSCCIZ-RWJCITIMSA-N 0.000 description 1
- CAIHCCXOUUSNSY-FAZCCQOOSA-N COC(C(C=C1)=CC(CC=C2)C1=C2c1n[n]2c(N[C@H](C[C@H](COS(N)(=O)=O)[C@H]3O)[C@@H]3O)ccnc2c1)=O Chemical compound COC(C(C=C1)=CC(CC=C2)C1=C2c1n[n]2c(N[C@H](C[C@H](COS(N)(=O)=O)[C@H]3O)[C@@H]3O)ccnc2c1)=O CAIHCCXOUUSNSY-FAZCCQOOSA-N 0.000 description 1
- YBVOOESZDWCLFS-UHFFFAOYSA-N Cc1nc2cc(-c3ccccc3)n[n]2c(Cl)c1 Chemical compound Cc1nc2cc(-c3ccccc3)n[n]2c(Cl)c1 YBVOOESZDWCLFS-UHFFFAOYSA-N 0.000 description 1
- WSPHEEWLJHJNCK-WLKPROSASA-N Cc1nc2cc(-c3ccccc3)n[n]2c(N[C@H](C[C@H](CO)[C@H]2OC(c3ccccc3)=O)[C@@H]2OC(c2ccccc2)=O)c1 Chemical compound Cc1nc2cc(-c3ccccc3)n[n]2c(N[C@H](C[C@H](CO)[C@H]2OC(c3ccccc3)=O)[C@@H]2OC(c2ccccc2)=O)c1 WSPHEEWLJHJNCK-WLKPROSASA-N 0.000 description 1
- LFVBSFKFKWBKIB-LRHNDGHRSA-N Cc1nc2cc(-c3ccccc3)n[n]2c(N[C@H](C[C@H](COS(N)(=O)=O)[C@H]2O)[C@@H]2O)c1 Chemical compound Cc1nc2cc(-c3ccccc3)n[n]2c(N[C@H](C[C@H](COS(N)(=O)=O)[C@H]2O)[C@@H]2O)c1 LFVBSFKFKWBKIB-LRHNDGHRSA-N 0.000 description 1
- GUAHEWCHNSONQK-SRBBEKPSSA-N NS(OC[C@@H](C[C@H]([C@@H]1O)Nc2ccnc3cc(-c4c(ccc(C(O)=O)c5)c5ccc4)n[n]23)[C@H]1O)(=O)=O Chemical compound NS(OC[C@@H](C[C@H]([C@@H]1O)Nc2ccnc3cc(-c4c(ccc(C(O)=O)c5)c5ccc4)n[n]23)[C@H]1O)(=O)=O GUAHEWCHNSONQK-SRBBEKPSSA-N 0.000 description 1
- QCPOIDRINIAUKU-SRBBEKPSSA-N NS(OC[C@@H](C[C@H]([C@@H]1O)Nc2ccnc3cc(-c4c(cccc5)c5ccc4)n[n]23)[C@H]1O)(=O)=O Chemical compound NS(OC[C@@H](C[C@H]([C@@H]1O)Nc2ccnc3cc(-c4c(cccc5)c5ccc4)n[n]23)[C@H]1O)(=O)=O QCPOIDRINIAUKU-SRBBEKPSSA-N 0.000 description 1
- PWSZRRFDVPMZGM-UHFFFAOYSA-N Nc1cc(-c2ccccc2)n[nH]1 Chemical compound Nc1cc(-c2ccccc2)n[nH]1 PWSZRRFDVPMZGM-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261600070P | 2012-02-17 | 2012-02-17 | |
| US61/600,070 | 2012-02-17 | ||
| PCT/US2013/026113 WO2013123169A1 (en) | 2012-02-17 | 2013-02-14 | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20140123104A true KR20140123104A (ko) | 2014-10-21 |
Family
ID=48982730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147025556A Ceased KR20140123104A (ko) | 2012-02-17 | 2013-02-14 | 유비퀴틴 활성화 효소의 피라졸로피리미디닐 억제제 |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US9290500B2 (enExample) |
| EP (3) | EP3536692B1 (enExample) |
| JP (1) | JP6122877B2 (enExample) |
| KR (1) | KR20140123104A (enExample) |
| CN (1) | CN104136399B (enExample) |
| AR (1) | AR092797A1 (enExample) |
| BR (1) | BR112014020365B1 (enExample) |
| CA (1) | CA2864672C (enExample) |
| CL (1) | CL2014002181A1 (enExample) |
| CO (1) | CO7071135A2 (enExample) |
| CR (1) | CR20140380A (enExample) |
| DO (1) | DOP2014000187A (enExample) |
| EA (1) | EA035020B1 (enExample) |
| EC (1) | ECSP14019113A (enExample) |
| ES (1) | ES2739150T3 (enExample) |
| GE (1) | GEP201706687B (enExample) |
| HK (1) | HK1201817A1 (enExample) |
| IL (1) | IL234016A0 (enExample) |
| MA (1) | MA35932B1 (enExample) |
| MX (1) | MX352963B (enExample) |
| NZ (1) | NZ628969A (enExample) |
| PE (1) | PE20142244A1 (enExample) |
| PH (1) | PH12014501832A1 (enExample) |
| SG (2) | SG11201404757WA (enExample) |
| TN (1) | TN2014000351A1 (enExample) |
| TW (1) | TWI593688B (enExample) |
| UA (1) | UA116534C2 (enExample) |
| UY (1) | UY34629A (enExample) |
| WO (1) | WO2013123169A1 (enExample) |
| ZA (1) | ZA201406103B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| US9290500B2 (en) | 2012-02-17 | 2016-03-22 | Millennium Pharmaceuticals, Inc. | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme |
| WO2014022744A1 (en) | 2012-08-03 | 2014-02-06 | Millennium Pharmaceuticals, Inc. | INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF Uba6 |
| WO2015002994A2 (en) | 2013-07-02 | 2015-01-08 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of sumo activating enzyme |
| HUE045748T2 (hu) | 2014-07-01 | 2020-01-28 | Millennium Pharm Inc | Heteroaril vegyületek mint SUMO aktiváló enzimek inhibitorai |
| JP6698648B2 (ja) * | 2014-10-29 | 2020-05-27 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ユビキチン活性化酵素阻害物質及び化学療法剤の投与 |
| US10335411B2 (en) * | 2014-10-29 | 2019-07-02 | Millennium Pharmaceuticals, Inc. | Administration of ubiquitin-activating enzyme inhibitor and radiation |
| IL282254B2 (en) | 2018-10-30 | 2025-08-01 | Kronos Bio Inc | Compounds, compositions, and methods for modulating cdk9 activity |
| CN117412973A (zh) * | 2021-05-31 | 2024-01-16 | 上海瑛派药业有限公司 | 含氮稠合杂芳双环化合物作为usp1抑制剂及其应用 |
| WO2023021498A1 (en) * | 2021-08-16 | 2023-02-23 | Moya Bio Ltd. | Fused azole and furan based nucleoside analogs and uses thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003073989A2 (en) | 2002-02-28 | 2003-09-12 | Biota, Inc. | Nucleoside 5'-monophosphate mimics and their prodrugs |
| US7196092B2 (en) | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7563798B2 (en) | 2002-09-04 | 2009-07-21 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| CN1310918C (zh) | 2002-09-04 | 2007-04-18 | 先灵公司 | 作为细胞周期蛋白依赖激酶抑制剂的吡唑并嘧啶 |
| CA2497544C (en) | 2002-09-04 | 2010-11-02 | Schering Corporation | Pyrazolo[1,5-a]pyrimidines compounds as cyclin dependent kinase inhibitors |
| US20070179161A1 (en) | 2003-03-31 | 2007-08-02 | Vernalis (Cambridge) Limited. | Pyrazolopyrimidine compounds and their use in medicine |
| JP2005008581A (ja) | 2003-06-20 | 2005-01-13 | Kissei Pharmaceut Co Ltd | 新規なピラゾロ［１，５−ａ］ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途 |
| WO2005037845A1 (en) | 2003-10-17 | 2005-04-28 | Rigel Pharmaceuticals, Inc. | Benzothiazole and thiazole[5,5-b] pyridine compositions and their use as ubiquitin ligase inhibitors |
| WO2006002284A1 (en) | 2004-06-22 | 2006-01-05 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
| JP5048520B2 (ja) | 2005-02-04 | 2012-10-17 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | Ｅ１活性化酵素の阻害剤 |
| US7642266B2 (en) | 2005-10-06 | 2010-01-05 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| SG169369A1 (en) | 2006-02-02 | 2011-03-30 | Millennium Pharm Inc | Inhibitors of e1 activating enzymes |
| CN101395698B (zh) * | 2006-02-28 | 2010-06-09 | 兰姆研究股份公司 | 用于液体处理盘形物体的装置及方法 |
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| ATE485276T1 (de) * | 2006-08-08 | 2010-11-15 | Millennium Pharm Inc | Heteroarylverbindungen als hemmer der e1- aktivierenden enzyme |
| CA2934114A1 (en) | 2007-06-12 | 2008-12-18 | Achaogen, Inc. | Antibacterial agents |
| EP2540727B1 (en) | 2007-08-02 | 2018-07-25 | Millennium Pharmaceuticals, Inc. | Sulfamoylating reagent |
| WO2009082691A1 (en) | 2007-12-21 | 2009-07-02 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
| WO2010086040A1 (en) | 2009-01-29 | 2010-08-05 | Biomarin Iga, Ltd. | Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy |
| WO2010088518A2 (en) | 2009-01-31 | 2010-08-05 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
| UA108986C2 (uk) * | 2009-05-14 | 2015-07-10 | Мілленніум Фармасьютікалз, Інк. | Кристалічна форма гідрохлориду ((1s,2s,4r)-4-{4-[(1s)-2,3-дигідро-1h-інден-1-іламіно]-7h-піроло[2,3-d]піримідин-7іл}-2-гідроксициклопентил)метилсульфамату (варіанти) |
| KR101939704B1 (ko) | 2010-03-01 | 2019-01-17 | 지티엑스, 인코포레이티드 | 암 치료용 화합물 |
| US20120077814A1 (en) | 2010-09-10 | 2012-03-29 | Zhong Wang | Sulfonamide, sulfamate, and sulfamothioate derivatives |
| SG11201400102WA (en) | 2011-08-24 | 2014-03-28 | Millennium Pharm Inc | Inhibitors of nedd8-activating enzyme |
| US9290500B2 (en) | 2012-02-17 | 2016-03-22 | Millennium Pharmaceuticals, Inc. | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme |
| WO2014022744A1 (en) | 2012-08-03 | 2014-02-06 | Millennium Pharmaceuticals, Inc. | INDOLE-SUBSTITUTED PYRROLOPYRIMIDINYL INHIBITORS OF Uba6 |
| WO2015002994A2 (en) | 2013-07-02 | 2015-01-08 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of sumo activating enzyme |
| HUE045748T2 (hu) | 2014-07-01 | 2020-01-28 | Millennium Pharm Inc | Heteroaril vegyületek mint SUMO aktiváló enzimek inhibitorai |
-
2013
- 2013-02-14 US US13/767,314 patent/US9290500B2/en active Active
- 2013-02-14 MX MX2014009944A patent/MX352963B/es active IP Right Grant
- 2013-02-14 GE GEAP201313560A patent/GEP201706687B/en unknown
- 2013-02-14 EP EP19170607.6A patent/EP3536692B1/en active Active
- 2013-02-14 PE PE2014001278A patent/PE20142244A1/es active IP Right Grant
- 2013-02-14 BR BR112014020365-2A patent/BR112014020365B1/pt not_active IP Right Cessation
- 2013-02-14 SG SG11201404757WA patent/SG11201404757WA/en unknown
- 2013-02-14 EP EP13748707.0A patent/EP2814791A4/en not_active Withdrawn
- 2013-02-14 HK HK15102227.4A patent/HK1201817A1/xx unknown
- 2013-02-14 WO PCT/US2013/026113 patent/WO2013123169A1/en not_active Ceased
- 2013-02-14 CN CN201380009784.8A patent/CN104136399B/zh active Active
- 2013-02-14 ES ES16205139T patent/ES2739150T3/es active Active
- 2013-02-14 JP JP2014557765A patent/JP6122877B2/ja not_active Expired - Fee Related
- 2013-02-14 KR KR1020147025556A patent/KR20140123104A/ko not_active Ceased
- 2013-02-14 EA EA201400831A patent/EA035020B1/ru not_active IP Right Cessation
- 2013-02-14 NZ NZ628969A patent/NZ628969A/en not_active IP Right Cessation
- 2013-02-14 UA UAA201409297A patent/UA116534C2/uk unknown
- 2013-02-14 EP EP16205139.5A patent/EP3173413B1/en active Active
- 2013-02-14 CA CA2864672A patent/CA2864672C/en active Active
- 2013-02-14 SG SG10201606581RA patent/SG10201606581RA/en unknown
- 2013-02-15 AR ARP130100480A patent/AR092797A1/es unknown
- 2013-02-15 UY UY0001034629A patent/UY34629A/es not_active Application Discontinuation
- 2013-02-18 TW TW102105676A patent/TWI593688B/zh not_active IP Right Cessation
-
2014
- 2014-08-07 IL IL234016A patent/IL234016A0/en unknown
- 2014-08-11 TN TNP2014000351A patent/TN2014000351A1/fr unknown
- 2014-08-12 CR CR20140380A patent/CR20140380A/es unknown
- 2014-08-13 PH PH12014501832A patent/PH12014501832A1/en unknown
- 2014-08-14 CL CL2014002181A patent/CL2014002181A1/es unknown
- 2014-08-15 DO DO2014000187A patent/DOP2014000187A/es unknown
- 2014-08-20 ZA ZA2014/06103A patent/ZA201406103B/en unknown
- 2014-09-10 MA MA37338A patent/MA35932B1/fr unknown
- 2014-09-16 CO CO14205517A patent/CO7071135A2/es unknown
- 2014-09-17 EC ECIEPI201419113A patent/ECSP14019113A/es unknown
-
2016
- 2016-02-19 US US15/048,007 patent/US9663525B2/en active Active
-
2017
- 2017-04-17 US US15/488,800 patent/US9796725B2/en active Active
- 2017-09-08 US US15/699,818 patent/US10202389B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20140912 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
Patent event code: PA02012R01D Patent event date: 20180129 Comment text: Request for Examination of Application |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
Comment text: Notification of reason for refusal Patent event date: 20190727 Patent event code: PE09021S01D |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
Patent event date: 20191003 Comment text: Decision to Refuse Application Patent event code: PE06012S01D Patent event date: 20190727 Comment text: Notification of reason for refusal Patent event code: PE06011S01I |