CR20140380A - Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina - Google Patents
Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitinaInfo
- Publication number
- CR20140380A CR20140380A CR20140380A CR20140380A CR20140380A CR 20140380 A CR20140380 A CR 20140380A CR 20140380 A CR20140380 A CR 20140380A CR 20140380 A CR20140380 A CR 20140380A CR 20140380 A CR20140380 A CR 20140380A
- Authority
- CR
- Costa Rica
- Prior art keywords
- pirazolopirimidinyl
- ubiquitine
- inhibitors
- activating enzyme
- formula
- Prior art date
Links
- 102000004190 Enzymes Human genes 0.000 title 1
- 108090000790 Enzymes Proteins 0.000 title 1
- 230000003213 activating effect Effects 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000018478 Ubiquitin-Activating Enzymes Human genes 0.000 abstract 2
- 108010091546 Ubiquitin-Activating Enzymes Proteins 0.000 abstract 2
- 150000005829 chemical entities Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261600070P | 2012-02-17 | 2012-02-17 | |
| PCT/US2013/026113 WO2013123169A1 (en) | 2012-02-17 | 2013-02-14 | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CR20140380A true CR20140380A (es) | 2014-10-28 |
Family
ID=48982730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CR20140380A CR20140380A (es) | 2012-02-17 | 2014-08-12 | Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina |
Country Status (30)
| Country | Link |
|---|---|
| US (4) | US9290500B2 (enExample) |
| EP (3) | EP3173413B1 (enExample) |
| JP (1) | JP6122877B2 (enExample) |
| KR (1) | KR20140123104A (enExample) |
| CN (1) | CN104136399B (enExample) |
| AR (1) | AR092797A1 (enExample) |
| BR (1) | BR112014020365B1 (enExample) |
| CA (1) | CA2864672C (enExample) |
| CL (1) | CL2014002181A1 (enExample) |
| CO (1) | CO7071135A2 (enExample) |
| CR (1) | CR20140380A (enExample) |
| DO (1) | DOP2014000187A (enExample) |
| EA (1) | EA035020B1 (enExample) |
| EC (1) | ECSP14019113A (enExample) |
| ES (1) | ES2739150T3 (enExample) |
| GE (1) | GEP201706687B (enExample) |
| HK (1) | HK1201817A1 (enExample) |
| IL (1) | IL234016A0 (enExample) |
| MA (1) | MA35932B1 (enExample) |
| MX (1) | MX352963B (enExample) |
| NZ (1) | NZ628969A (enExample) |
| PE (1) | PE20142244A1 (enExample) |
| PH (1) | PH12014501832A1 (enExample) |
| SG (2) | SG10201606581RA (enExample) |
| TN (1) | TN2014000351A1 (enExample) |
| TW (1) | TWI593688B (enExample) |
| UA (1) | UA116534C2 (enExample) |
| UY (1) | UY34629A (enExample) |
| WO (1) | WO2013123169A1 (enExample) |
| ZA (1) | ZA201406103B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| GEP201706687B (en) | 2012-02-17 | 2017-06-26 | Millennium Pharmaceuticals Inc (A Delaware Corporation) | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme |
| CN104684559A (zh) | 2012-08-03 | 2015-06-03 | 米伦纽姆医药公司 | 针对Uba6的吲哚取代的吡咯并嘧啶基抑制剂 |
| JP6378759B2 (ja) | 2013-07-02 | 2018-08-22 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｓｕｍｏ活性化酵素阻害剤として有用なヘテロアリール化合物 |
| EP3901159A1 (en) | 2014-07-01 | 2021-10-27 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of sumo activating enzyme |
| JP6698648B2 (ja) * | 2014-10-29 | 2020-05-27 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ユビキチン活性化酵素阻害物質及び化学療法剤の投与 |
| WO2016069393A1 (en) | 2014-10-29 | 2016-05-06 | Millennium Pharmaceuticals, Inc. | Administration of ubiquitin-activating enzyme inhibitor and radiation |
| CN112996790B (zh) | 2018-10-30 | 2023-11-03 | 克洛诺斯生物公司 | 用于调节cdk9活性的化合物、组合物和方法 |
| CN117412973A (zh) * | 2021-05-31 | 2024-01-16 | 上海瑛派药业有限公司 | 含氮稠合杂芳双环化合物作为usp1抑制剂及其应用 |
| WO2023021498A1 (en) * | 2021-08-16 | 2023-02-23 | Moya Bio Ltd. | Fused azole and furan based nucleoside analogs and uses thereof |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1485396A2 (en) | 2002-02-28 | 2004-12-15 | Biota, Inc. | Nucleoside 5'-monophosphate mimics and their prodrugs |
| JP4790265B2 (ja) | 2002-09-04 | 2011-10-12 | シェーリング コーポレイション | サイクリン依存性キナーゼインヒビターとしての新規ピラゾロピリミジン |
| TW200413377A (en) | 2002-09-04 | 2004-08-01 | Schering Corp | Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| US7563798B2 (en) | 2002-09-04 | 2009-07-21 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US7196092B2 (en) | 2002-09-04 | 2007-03-27 | Schering Corporation | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors |
| WO2004087707A1 (en) | 2003-03-31 | 2004-10-14 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
| JP2005008581A (ja) * | 2003-06-20 | 2005-01-13 | Kissei Pharmaceut Co Ltd | 新規なピラゾロ［１，５−ａ］ピリミジン誘導体、それを含有する医薬組成物およびそれらの用途 |
| EP1680431A1 (en) | 2003-10-17 | 2006-07-19 | Rigel Pharmaceuticals, Inc. | Benzothiazole and thiazole'5,5-b!pyridine compositions and their use as ubiquitin ligase inhibitors |
| EP1758873A1 (en) | 2004-06-22 | 2007-03-07 | Rigel Pharmaceuticals, Inc. | Ubiquitin ligase inhibitors |
| HRP20120847T1 (hr) | 2005-02-04 | 2012-11-30 | Millennium Pharmaceuticals, Inc. | Inhibitori e1 aktivirajuä†ih enzima |
| US7642266B2 (en) | 2005-10-06 | 2010-01-05 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| CA2639924C (en) | 2006-02-02 | 2017-01-10 | Millennium Pharmaceuticals, Inc. | Purinyl-and pyrrolo[2,3-d]pyrimidinyl cyclopentyl compounds and their use as inhibitors of e1 activating enzymes |
| WO2007099021A1 (en) * | 2006-02-28 | 2007-09-07 | Sez Ag | Device and method for liquid treating disc-like articles |
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| DE602007009998D1 (de) * | 2006-08-08 | 2010-12-02 | Millennium Pharm Inc | Heteroarylverbindungen als hemmer der e1-aktivierenden enzyme |
| CN101765585B (zh) | 2007-06-12 | 2017-03-15 | 尔察祯有限公司 | 抗菌剂 |
| EP2540727B1 (en) | 2007-08-02 | 2018-07-25 | Millennium Pharmaceuticals, Inc. | Sulfamoylating reagent |
| WO2009082691A1 (en) | 2007-12-21 | 2009-07-02 | Board Of Regents, University Of Texas System | Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity |
| WO2010086040A1 (en) | 2009-01-29 | 2010-08-05 | Biomarin Iga, Ltd. | Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy |
| WO2010088518A2 (en) | 2009-01-31 | 2010-08-05 | Kalypsys, Inc. | Heterocyclic modulators of gpr119 for treatment of disease |
| SG10201402148SA (en) | 2009-05-14 | 2014-07-30 | Millennium Pharm Inc | Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate |
| KR20120130777A (ko) | 2010-03-01 | 2012-12-03 | 유니버시티 오브 테네시 리서치 파운데이션 | 암 치료용 화합물 |
| US20120077814A1 (en) | 2010-09-10 | 2012-03-29 | Zhong Wang | Sulfonamide, sulfamate, and sulfamothioate derivatives |
| JP6038150B2 (ja) | 2011-08-24 | 2016-12-07 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｎｅｄｄ８活性化酵素阻害剤 |
| GEP201706687B (en) | 2012-02-17 | 2017-06-26 | Millennium Pharmaceuticals Inc (A Delaware Corporation) | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme |
| CN104684559A (zh) | 2012-08-03 | 2015-06-03 | 米伦纽姆医药公司 | 针对Uba6的吲哚取代的吡咯并嘧啶基抑制剂 |
| JP6378759B2 (ja) | 2013-07-02 | 2018-08-22 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | Ｓｕｍｏ活性化酵素阻害剤として有用なヘテロアリール化合物 |
| EP3901159A1 (en) | 2014-07-01 | 2021-10-27 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of sumo activating enzyme |
-
2013
- 2013-02-14 GE GEAP201313560A patent/GEP201706687B/en unknown
- 2013-02-14 CA CA2864672A patent/CA2864672C/en active Active
- 2013-02-14 US US13/767,314 patent/US9290500B2/en active Active
- 2013-02-14 MX MX2014009944A patent/MX352963B/es active IP Right Grant
- 2013-02-14 EP EP16205139.5A patent/EP3173413B1/en active Active
- 2013-02-14 BR BR112014020365-2A patent/BR112014020365B1/pt not_active IP Right Cessation
- 2013-02-14 JP JP2014557765A patent/JP6122877B2/ja not_active Expired - Fee Related
- 2013-02-14 NZ NZ628969A patent/NZ628969A/en not_active IP Right Cessation
- 2013-02-14 UA UAA201409297A patent/UA116534C2/uk unknown
- 2013-02-14 HK HK15102227.4A patent/HK1201817A1/xx unknown
- 2013-02-14 KR KR1020147025556A patent/KR20140123104A/ko not_active Ceased
- 2013-02-14 CN CN201380009784.8A patent/CN104136399B/zh active Active
- 2013-02-14 EP EP19170607.6A patent/EP3536692B1/en active Active
- 2013-02-14 EP EP13748707.0A patent/EP2814791A4/en not_active Withdrawn
- 2013-02-14 EA EA201400831A patent/EA035020B1/ru not_active IP Right Cessation
- 2013-02-14 PE PE2014001278A patent/PE20142244A1/es active IP Right Grant
- 2013-02-14 SG SG10201606581RA patent/SG10201606581RA/en unknown
- 2013-02-14 SG SG11201404757WA patent/SG11201404757WA/en unknown
- 2013-02-14 WO PCT/US2013/026113 patent/WO2013123169A1/en not_active Ceased
- 2013-02-14 ES ES16205139T patent/ES2739150T3/es active Active
- 2013-02-15 AR ARP130100480A patent/AR092797A1/es unknown
- 2013-02-15 UY UY0001034629A patent/UY34629A/es not_active Application Discontinuation
- 2013-02-18 TW TW102105676A patent/TWI593688B/zh not_active IP Right Cessation
-
2014
- 2014-08-07 IL IL234016A patent/IL234016A0/en unknown
- 2014-08-11 TN TNP2014000351A patent/TN2014000351A1/fr unknown
- 2014-08-12 CR CR20140380A patent/CR20140380A/es unknown
- 2014-08-13 PH PH12014501832A patent/PH12014501832A1/en unknown
- 2014-08-14 CL CL2014002181A patent/CL2014002181A1/es unknown
- 2014-08-15 DO DO2014000187A patent/DOP2014000187A/es unknown
- 2014-08-20 ZA ZA2014/06103A patent/ZA201406103B/en unknown
- 2014-09-10 MA MA37338A patent/MA35932B1/fr unknown
- 2014-09-16 CO CO14205517A patent/CO7071135A2/es unknown
- 2014-09-17 EC ECIEPI201419113A patent/ECSP14019113A/es unknown
-
2016
- 2016-02-19 US US15/048,007 patent/US9663525B2/en active Active
-
2017
- 2017-04-17 US US15/488,800 patent/US9796725B2/en active Active
- 2017-09-08 US US15/699,818 patent/US10202389B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CR20140380A (es) | Inhibidores de pirazolopirimidinilo de enzima activadora de ubiquitina | |
| AR110381A2 (es) | Inhibidores biarilo de tirosina cinasa de bruton | |
| EA201490567A1 (ru) | Новые бициклические производные дигидрохинолин-2-она | |
| EA201590224A1 (ru) | Имидазотриазинкарбонитрилы, используемые в качестве ингибиторов киназы | |
| EA201490596A1 (ru) | Новые производные дигидрохинолин-2-она | |
| UA110338C2 (xx) | Хімічні сполуки | |
| BR112013016595A2 (pt) | inibidores de neprilisina | |
| CR20140229A (es) | Nuevos derivados bicíclicos de dihidroisoquinolin-1-ona | |
| UA111382C2 (uk) | Інгібітори протеїнкінази | |
| EA201792021A1 (ru) | Ингибитор jak | |
| EA201290880A1 (ru) | Новые соединения - ингибиторы фермента | |
| UY34092A (es) | Nuevos compuestos como inhibidores de jak | |
| CR20140106A (es) | Compuestos y composiciones como inhibidores de la quinasa c-kit | |
| EA201490724A1 (ru) | Замещенные соединения тетрагидроизохинолина в качестве ингибиторов фактора xia | |
| UY34216A (es) | Nuevos compuestos que inhiben la actividad de la Lp-PLA2 | |
| UY34559A (es) | Inhibidores de bromodominios | |
| UY33958A (es) | Inhibidores de la glucosilceramida sintasa | |
| UY34851A (es) | Inhibidores macrocíclicos de virus flaviviridae | |
| CR20140024A (es) | Compuestos inhibidores de metaloenzimas | |
| UY33937A (es) | Composiciones farmacéuticas que contienen inhibidores de dpp-4 y/o sglt-2 y metformina | |
| UA113062C2 (xx) | Похідні 5-фтор-4-іміно-3-(заміщеного)-3,4-дигідропіримідин-2(1h)ону | |
| HUE054473T2 (hu) | Eljárás HIV-integráz inhibitor hatású vegyületek elõállítására | |
| IN2014CN04558A (enExample) | ||
| EA201492210A1 (ru) | Соединения, ингибирующие активность катехол-o-метилтрансферазы | |
| EA201490474A1 (ru) | Аминохиназолины в качестве ингибиторов киназ |