JP6122877B2 - ユビキチン活性化酵素のピラゾロピリミジニル阻害剤 - Google Patents

ユビキチン活性化酵素のピラゾロピリミジニル阻害剤 Download PDF

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Publication number
JP6122877B2
JP6122877B2 JP2014557765A JP2014557765A JP6122877B2 JP 6122877 B2 JP6122877 B2 JP 6122877B2 JP 2014557765 A JP2014557765 A JP 2014557765A JP 2014557765 A JP2014557765 A JP 2014557765A JP 6122877 B2 JP6122877 B2 JP 6122877B2
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halo
aliphatic
compound
pharmaceutically acceptable
acceptable salt
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JP2014557765A
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Japanese (ja)
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JP2015508775A5 (enExample
JP2015508775A (ja
Inventor
ローシャン アフローゼ，
ローシャン アフローゼ，
インドゥ ティー． バラサン，
インドゥ ティー． バラサン，
ジェフェリー ピー． チャバリ，
ジェフェリー ピー． チャバリ，
ポール イー． フレミング，
ポール イー． フレミング，
ジェフェリー エル． ゴーリン，
ジェフェリー エル． ゴーリン，
マリオ ジラード，
マリオ ジラード，
スティーブン ピー． ラングストン，
スティーブン ピー． ラングストン，
フランソワ アール． ソーシー，
フランソワ アール． ソーシー，
ツ−チン ウォン，
ツ−チン ウォン，
インチュン イエ，
インチュン イエ，
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Millennium Pharmaceuticals Inc
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Millennium Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2014557765A 2012-02-17 2013-02-14 ユビキチン活性化酵素のピラゾロピリミジニル阻害剤 Expired - Fee Related JP6122877B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261600070P 2012-02-17 2012-02-17
US61/600,070 2012-02-17
PCT/US2013/026113 WO2013123169A1 (en) 2012-02-17 2013-02-14 Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme

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JP2015508775A JP2015508775A (ja) 2015-03-23
JP2015508775A5 JP2015508775A5 (enExample) 2017-03-16
JP6122877B2 true JP6122877B2 (ja) 2017-04-26

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US (4) US9290500B2 (enExample)
EP (3) EP3536692B1 (enExample)
JP (1) JP6122877B2 (enExample)
KR (1) KR20140123104A (enExample)
CN (1) CN104136399B (enExample)
AR (1) AR092797A1 (enExample)
BR (1) BR112014020365B1 (enExample)
CA (1) CA2864672C (enExample)
CL (1) CL2014002181A1 (enExample)
CO (1) CO7071135A2 (enExample)
CR (1) CR20140380A (enExample)
DO (1) DOP2014000187A (enExample)
EA (1) EA035020B1 (enExample)
EC (1) ECSP14019113A (enExample)
ES (1) ES2739150T3 (enExample)
GE (1) GEP201706687B (enExample)
HK (1) HK1201817A1 (enExample)
IL (1) IL234016A0 (enExample)
MA (1) MA35932B1 (enExample)
MX (1) MX352963B (enExample)
NZ (1) NZ628969A (enExample)
PE (1) PE20142244A1 (enExample)
PH (1) PH12014501832A1 (enExample)
SG (2) SG10201606581RA (enExample)
TN (1) TN2014000351A1 (enExample)
TW (1) TWI593688B (enExample)
UA (1) UA116534C2 (enExample)
UY (1) UY34629A (enExample)
WO (1) WO2013123169A1 (enExample)
ZA (1) ZA201406103B (enExample)

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US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
CN104136399B (zh) 2012-02-17 2018-08-07 米伦纽姆医药公司 泛素活化酶的吡唑并嘧啶基抑制剂
JP2015524442A (ja) 2012-08-03 2015-08-24 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｕｂａ６のインドール置換ピロロピリミジニル阻害剤
CN105492429A (zh) 2013-07-02 2016-04-13 米伦纽姆医药公司 Sumo活化酶的杂芳基抑制剂
BR112016030787B1 (pt) 2014-07-01 2022-12-20 Takeda Pharmaceutical Company Limited Entidade química, composição farmacêutica e seu uso
TW201628621A (zh) 2014-10-29 2016-08-16 千禧製藥公司 泛素活化酶抑制劑及輻射之施用
US20180133221A1 (en) * 2014-10-29 2018-05-17 Millennium Pharmaceuticals, Inc. Administration of ubiquitin-activating enzyme inhibitor and chemotherapeutic agents
US11155560B2 (en) 2018-10-30 2021-10-26 Kronos Bio, Inc. Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity
CN117412973A (zh) * 2021-05-31 2024-01-16 上海瑛派药业有限公司 含氮稠合杂芳双环化合物作为usp1抑制剂及其应用
WO2023021498A1 (en) * 2021-08-16 2023-02-23 Moya Bio Ltd. Fused azole and furan based nucleoside analogs and uses thereof

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DE60313872T2 (de) 2002-09-04 2008-01-17 Schering Corp. Pyrazoloä1,5-aüpyrimidine als hemmstoffe cyclin-abhängiger kinasen
ES2285164T3 (es) 2002-09-04 2007-11-16 Schering Corporation Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina.
US7563798B2 (en) 2002-09-04 2009-07-21 Schering Corporation Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors
US7196092B2 (en) 2002-09-04 2007-03-27 Schering Corporation N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
US20070179161A1 (en) 2003-03-31 2007-08-02 Vernalis (Cambridge) Limited. Pyrazolopyrimidine compounds and their use in medicine
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US20050282818A1 (en) 2004-06-22 2005-12-22 Rigel Pharmaceuticals, Inc. Ubiquitin ligase inhibitors
PT1848718E (pt) 2005-02-04 2012-10-11 Millennium Pharm Inc Inibidores de enzimas de activação e1
CN101321759A (zh) 2005-10-06 2008-12-10 先灵公司 作为蛋白激酶抑制剂的吡唑并嘧啶化合物
KR101450535B1 (ko) 2006-02-02 2014-10-14 밀레니엄 파머슈티컬스 인코퍼레이티드 Ｅ１ 활성화 효소의 억제제
WO2007099021A1 (en) * 2006-02-28 2007-09-07 Sez Ag Device and method for liquid treating disc-like articles
US8008307B2 (en) 2006-08-08 2011-08-30 Millennium Pharmaceuticals, Inc. Heteroaryl compounds useful as inhibitors of E1 activating enzymes
EA201501088A1 (ru) * 2006-08-08 2017-01-30 Миллениум Фармасьютикалз, Инк. Гетероарильные соединения, применяемые в качестве ингибиторов e1 активирующих ферментов
TWI519508B (zh) 2007-06-12 2016-02-01 Achaogen Inc 抗菌劑
WO2009042013A1 (en) 2007-08-02 2009-04-02 Millennium Pharmaceuticals, Inc. Process for the synthesis of e1 activating enzyme inhibitors
US9216983B2 (en) 2007-12-21 2015-12-22 Board Of Regents, University Of Texas System Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity
WO2010086040A1 (en) 2009-01-29 2010-08-05 Biomarin Iga, Ltd. Pyrazolo-pyrimidines for treatment of duchenne muscular dystrophy
WO2010088518A2 (en) 2009-01-31 2010-08-05 Kalypsys, Inc. Heterocyclic modulators of gpr119 for treatment of disease
SG175929A1 (en) 2009-05-14 2011-12-29 Millennium Pharm Inc Hydrochloride salt of ((1s,2s,4r)-4-{4-[(1s)-2,3-dihydro-1h-inden-1-ylamino]-7h-pyrrolo [2,3-d]pyrimidin-7-yl}-2-hydroxycyclopentyl)methyl sulfamate
JP5879273B2 (ja) 2010-03-01 2016-03-08 ジーティーエックス・インコーポレイテッド 癌を処置するための化合物
US20120077814A1 (en) 2010-09-10 2012-03-29 Zhong Wang Sulfonamide, sulfamate, and sulfamothioate derivatives
SG11201400102WA (en) 2011-08-24 2014-03-28 Millennium Pharm Inc Inhibitors of nedd8-activating enzyme
CN104136399B (zh) 2012-02-17 2018-08-07 米伦纽姆医药公司 泛素活化酶的吡唑并嘧啶基抑制剂
JP2015524442A (ja) 2012-08-03 2015-08-24 ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． Ｕｂａ６のインドール置換ピロロピリミジニル阻害剤
CN105492429A (zh) 2013-07-02 2016-04-13 米伦纽姆医药公司 Sumo活化酶的杂芳基抑制剂
BR112016030787B1 (pt) 2014-07-01 2022-12-20 Takeda Pharmaceutical Company Limited Entidade química, composição farmacêutica e seu uso

Also Published As

Publication number Publication date
US9290500B2 (en) 2016-03-22
US20170217968A1 (en) 2017-08-03
SG10201606581RA (en) 2016-09-29
US20130217682A1 (en) 2013-08-22
KR20140123104A (ko) 2014-10-21
IL234016A0 (en) 2014-09-30
SG11201404757WA (en) 2014-09-26
GEP201706687B (en) 2017-06-26
HK1201817A1 (en) 2015-09-11
ECSP14019113A (es) 2015-09-30
WO2013123169A1 (en) 2013-08-22
US9796725B2 (en) 2017-10-24
PE20142244A1 (es) 2015-01-07
EP2814791A4 (en) 2015-08-19
US20160244455A1 (en) 2016-08-25
TW201345909A (zh) 2013-11-16
BR112014020365B1 (pt) 2023-02-23
EA201400831A1 (ru) 2014-12-30
AR092797A1 (es) 2015-05-06
ZA201406103B (en) 2017-11-29
CA2864672C (en) 2018-01-09
MX2014009944A (es) 2014-11-10
PH12014501832A1 (en) 2014-11-17
US20170369499A1 (en) 2017-12-28
US10202389B2 (en) 2019-02-12
CR20140380A (es) 2014-10-28
TWI593688B (zh) 2017-08-01
ES2739150T3 (es) 2020-01-29
EP2814791A1 (en) 2014-12-24
EP3173413A1 (en) 2017-05-31
MX352963B (es) 2017-12-15
UY34629A (es) 2013-09-02
EP3536692A1 (en) 2019-09-11
EP3173413B1 (en) 2019-05-01
CN104136399B (zh) 2018-08-07
DOP2014000187A (es) 2014-10-15
NZ628969A (en) 2017-03-31
CL2014002181A1 (es) 2014-12-12
TN2014000351A1 (en) 2015-12-21
CO7071135A2 (es) 2014-09-30
BR112014020365A2 (pt) 2020-12-22
CA2864672A1 (en) 2013-08-22
CN104136399A (zh) 2014-11-05
US20140088096A9 (en) 2014-03-27
EP3536692B1 (en) 2021-04-07
EA035020B1 (ru) 2020-04-17
MA35932B1 (fr) 2014-12-01
UA116534C2 (uk) 2018-04-10
JP2015508775A (ja) 2015-03-23
US9663525B2 (en) 2017-05-30

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