KR20140107691A - 의약 조성물 - Google Patents

의약 조성물 Download PDF

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Publication number
KR20140107691A
KR20140107691A KR1020147022986A KR20147022986A KR20140107691A KR 20140107691 A KR20140107691 A KR 20140107691A KR 1020147022986 A KR1020147022986 A KR 1020147022986A KR 20147022986 A KR20147022986 A KR 20147022986A KR 20140107691 A KR20140107691 A KR 20140107691A
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KR
South Korea
Prior art keywords
solvent
polymer
agent
mixture
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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KR1020147022986A
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English (en)
Korean (ko)
Inventor
케빈 존 비트토프
제프리 피. 캣스트라
필립 가스파
Original Assignee
버텍스 파마슈티칼스 인코포레이티드
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Publication of KR20140107691A publication Critical patent/KR20140107691A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020147022986A 2006-03-20 2007-03-19 의약 조성물 Ceased KR20140107691A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US78427506P 2006-03-20 2006-03-20
US60/784,275 2006-03-20
US87169206P 2006-12-22 2006-12-22
US60/871,692 2006-12-22
PCT/US2007/064294 WO2007109605A2 (en) 2006-03-20 2007-03-19 Pharmaceutical compositions

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020087025510A Division KR20090025187A (ko) 2006-03-20 2007-03-19 의약 조성물

Publications (1)

Publication Number Publication Date
KR20140107691A true KR20140107691A (ko) 2014-09-04

Family

ID=38523222

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020147022986A Ceased KR20140107691A (ko) 2006-03-20 2007-03-19 의약 조성물
KR1020087025510A Abandoned KR20090025187A (ko) 2006-03-20 2007-03-19 의약 조성물

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020087025510A Abandoned KR20090025187A (ko) 2006-03-20 2007-03-19 의약 조성물

Country Status (22)

Country Link
US (3) US20070218012A1 (enExample)
EP (1) EP2001497A4 (enExample)
JP (2) JP2009530416A (enExample)
KR (2) KR20140107691A (enExample)
CN (1) CN103272234A (enExample)
AR (1) AR063468A1 (enExample)
AU (2) AU2007226984B2 (enExample)
BR (1) BRPI0708957A2 (enExample)
CA (1) CA2646335A1 (enExample)
EA (1) EA018811B1 (enExample)
EC (1) ECSP088759A (enExample)
GE (1) GEP20125378B (enExample)
IL (1) IL194176A (enExample)
MX (1) MX2008011976A (enExample)
NO (1) NO20084334L (enExample)
NZ (1) NZ571934A (enExample)
PE (1) PE20080170A1 (enExample)
RS (1) RS20090406A (enExample)
SG (1) SG170087A1 (enExample)
TW (2) TW201414469A (enExample)
UY (1) UY30225A1 (enExample)
WO (1) WO2007109605A2 (enExample)

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Also Published As

Publication number Publication date
IL194176A (en) 2013-10-31
ECSP088759A (es) 2008-10-31
GEP20125378B (en) 2012-01-10
WO2007109605A3 (en) 2008-01-03
AR063468A1 (es) 2009-01-28
KR20090025187A (ko) 2009-03-10
EP2001497A2 (en) 2008-12-17
US20090247468A1 (en) 2009-10-01
WO2007109605A2 (en) 2007-09-27
UY30225A1 (es) 2007-10-31
US8853152B2 (en) 2014-10-07
TW201414469A (zh) 2014-04-16
EP2001497A4 (en) 2012-11-07
MX2008011976A (es) 2009-04-07
SG170087A1 (en) 2011-04-29
CA2646335A1 (en) 2007-09-27
US20140183768A1 (en) 2014-07-03
JP2014037435A (ja) 2014-02-27
AU2007226984B2 (en) 2013-02-21
CN103272234A (zh) 2013-09-04
TWI428125B (zh) 2014-03-01
IL194176A0 (en) 2011-08-01
AU2013205948A1 (en) 2013-06-06
TW200806280A (en) 2008-02-01
JP2009530416A (ja) 2009-08-27
NZ571934A (en) 2012-05-25
US20070218012A1 (en) 2007-09-20
BRPI0708957A2 (pt) 2011-06-28
NO20084334L (no) 2008-11-27
RS20090406A (sr) 2010-12-31
EA200802008A1 (ru) 2009-04-28
EA018811B1 (ru) 2013-10-30
PE20080170A1 (es) 2008-03-10
AU2007226984A1 (en) 2007-09-27

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