EA200802008A1 - Фармацевтические композиции - Google Patents
Фармацевтические композицииInfo
- Publication number
- EA200802008A1 EA200802008A1 EA200802008A EA200802008A EA200802008A1 EA 200802008 A1 EA200802008 A1 EA 200802008A1 EA 200802008 A EA200802008 A EA 200802008A EA 200802008 A EA200802008 A EA 200802008A EA 200802008 A1 EA200802008 A1 EA 200802008A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- pharmaceutical compositions
- spray drying
- drying methods
- pharmaceutical
- compositions
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
Описаны способы распылительной сушки.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US78427506P | 2006-03-20 | 2006-03-20 | |
US87169206P | 2006-12-22 | 2006-12-22 | |
PCT/US2007/064294 WO2007109605A2 (en) | 2006-03-20 | 2007-03-19 | Pharmaceutical compositions |
Publications (2)
Publication Number | Publication Date |
---|---|
EA200802008A1 true EA200802008A1 (ru) | 2009-04-28 |
EA018811B1 EA018811B1 (ru) | 2013-10-30 |
Family
ID=38523222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA200802008A EA018811B1 (ru) | 2006-03-20 | 2007-03-19 | Способы получения твердой дисперсии лекарственного средства и твердые дисперсии лекарственного средства, полученные этим способом |
Country Status (22)
Country | Link |
---|---|
US (3) | US20070218012A1 (ru) |
EP (1) | EP2001497A4 (ru) |
JP (2) | JP2009530416A (ru) |
KR (2) | KR20090025187A (ru) |
CN (1) | CN103272234A (ru) |
AR (1) | AR063468A1 (ru) |
AU (2) | AU2007226984B2 (ru) |
BR (1) | BRPI0708957A2 (ru) |
CA (1) | CA2646335A1 (ru) |
EA (1) | EA018811B1 (ru) |
EC (1) | ECSP088759A (ru) |
GE (1) | GEP20125378B (ru) |
IL (1) | IL194176A (ru) |
MX (1) | MX2008011976A (ru) |
NO (1) | NO20084334L (ru) |
NZ (1) | NZ571934A (ru) |
PE (1) | PE20080170A1 (ru) |
RS (1) | RS20090406A (ru) |
SG (1) | SG170087A1 (ru) |
TW (2) | TW201414469A (ru) |
UY (1) | UY30225A1 (ru) |
WO (1) | WO2007109605A2 (ru) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2661399C1 (ru) * | 2013-11-22 | 2018-07-16 | Мерк Шарп И Доум Корп. | Композиция ненуклеозидного ингибитора обратной транскриптазы |
Families Citing this family (63)
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HU227742B1 (en) | 1996-10-18 | 2012-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
AR045596A1 (es) | 2003-09-05 | 2005-11-02 | Vertex Pharma | Inhibidores de proteasas de serina en particular proteasa ns3-ns4a del vhc |
US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
AR055395A1 (es) | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
CA2643688A1 (en) | 2006-02-27 | 2007-08-30 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
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US7645789B2 (en) | 2006-04-07 | 2010-01-12 | Vertex Pharmaceuticals Incorporated | Indole derivatives as CFTR modulators |
US10022352B2 (en) | 2006-04-07 | 2018-07-17 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
CN101460489A (zh) | 2006-04-07 | 2009-06-17 | 弗特克斯药品有限公司 | Atp-结合盒转运蛋白调节剂 |
US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
MX2009006806A (es) * | 2006-12-22 | 2009-08-27 | Vertex Pharma | Secado por rocio fluidizado. |
GEP20125645B (en) | 2007-02-27 | 2012-09-25 | Vertex Pharma | Co-crystals and pharmaceutical compositions comprising the same |
MX2009009176A (es) | 2007-02-27 | 2009-09-28 | Vertex Pharma | Inhibidores de serina-proteasas. |
JP5443360B2 (ja) | 2007-08-30 | 2014-03-19 | バーテックス ファーマシューティカルズ インコーポレイテッド | 共結晶体およびそれを含む医薬組成物 |
CA2715018C (en) | 2008-03-20 | 2012-11-13 | Virun, Inc. | Vitamin e derivatives and their uses |
BRPI0909187A2 (pt) | 2008-03-20 | 2015-08-04 | Virun Inc | Emulsões incluindo tocoferol de derivados de peg |
EP2396028A2 (en) | 2009-02-12 | 2011-12-21 | Vertex Pharmceuticals Incorporated | Hcv combination therapies comprising pegylated interferon, ribavirin and telaprevir |
TW201043269A (en) * | 2009-04-14 | 2010-12-16 | Bristol Myers Squibb Co | Bioavailable compositions of amorphous alpha-(N-sulfonamido)acetamide compound |
NZ596610A (en) * | 2009-05-27 | 2014-04-30 | Samyang Biopharmaceuticals | A poorly soluble drug containing microsphere with improved bioavailability and method of preparing the same |
EP2470019A4 (en) * | 2009-08-25 | 2013-03-13 | Cardiokine Biopharma Llc | COMPOSITIONS FOR THE ADMINISTRATION OF NON-SOLUBLE AGENTS |
SG182589A1 (en) | 2010-01-29 | 2012-08-30 | Vertex Pharma | Therapies for treating hepatitis c virus infection |
CA2792330C (en) * | 2010-03-23 | 2017-01-03 | Virun, Inc | Nanoemulsion including a peg-derivative of vitamin e and a sucrose fatty acid ester |
US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
DK2826776T3 (da) * | 2010-03-25 | 2020-12-14 | Vertex Pharma | Fast dispersion af amorf form af (r)-1(2,2-difluorbenzo(d)(1,3)dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluor-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl)-cyclopropancarboxamid |
JP2013525371A (ja) | 2010-04-22 | 2013-06-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | シクロアルキルカルボキサミド−インドール化合物の製造方法 |
US8741373B2 (en) | 2010-06-21 | 2014-06-03 | Virun, Inc. | Compositions containing non-polar compounds |
CN102293734A (zh) * | 2010-06-25 | 2011-12-28 | 江苏恒瑞医药股份有限公司 | 托伐普坦固体分散体及其制备方法 |
TW201208704A (en) | 2010-07-14 | 2012-03-01 | Vertex Pharma | Palatable pharmaceutical composition |
WO2012054870A2 (en) | 2010-10-21 | 2012-04-26 | Vertex Pharmaceuticals Incorporated | Biomarkers for hcv infected patients |
WO2012063246A1 (en) * | 2010-11-11 | 2012-05-18 | Mapi Pharma Ltd. | Amorphous form of lurasidone hydrochloride |
WO2012109646A1 (en) | 2011-02-11 | 2012-08-16 | Vertex Pharmaceuticals Incorporated | Treatment of hcv in hiv infection patients |
WO2013014665A1 (en) | 2011-07-28 | 2013-01-31 | Mapi Pharma Ltd. | Intermediate compounds and process for the preparation of lurasidone and salts thereof |
TW201600087A (zh) | 2011-10-21 | 2016-01-01 | 艾伯維有限公司 | 治療c型肝炎病毒(hcv)的方法 |
DK2583677T1 (da) | 2011-10-21 | 2015-01-19 | Abbvie Inc | Fremgangsmåder til behandling af HCV omfattende mindst to direktevirkende antivirale midler, ribavirin, men ikke inteferon |
US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
WO2013089479A1 (ko) * | 2011-12-15 | 2013-06-20 | 주식회사 삼양바이오팜 | 세레콕시브 함유 고체분산체 및 그 제조방법 |
WO2013116339A1 (en) | 2012-01-31 | 2013-08-08 | Vertex Pharmaceuticals Incorporated | High potency formulations of vx-950 |
WO2013120025A1 (en) | 2012-02-10 | 2013-08-15 | Virun, Inc. | Beverage compositions containing non-polar compounds |
AU2013290444B2 (en) | 2012-07-16 | 2018-04-26 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions of (R)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl) cyclopropanecarboxamide and administration thereof |
WO2014015217A1 (en) | 2012-07-19 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Biomarkers for hcv infected patients |
WO2014042945A1 (en) * | 2012-09-11 | 2014-03-20 | Bend Research, Inc. | Methods for making pharmaceutical solid dosage forms of spray-dried dispersions |
EA028009B1 (ru) | 2013-01-22 | 2017-09-29 | Ф.Хоффманн-Ля Рош Аг | Фармацевтическая композиция с улучшенной биодоступностью |
US9351517B2 (en) | 2013-03-15 | 2016-05-31 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and compositions containing same |
KR20150112416A (ko) * | 2014-03-28 | 2015-10-07 | 주식회사 일화 | 세레콕시브 고체분산체 및 그 제조방법 |
PT107568B (pt) * | 2014-03-31 | 2018-11-05 | Hovione Farm S A | Processo de secagem por atomização para a produção de pós com propriedades melhoradas. |
EP4223294A1 (en) | 2014-04-15 | 2023-08-09 | Vertex Pharmaceuticals Incorporated | Pharmaceutical compositions for the treatment of cystic fibrosis transmembrane conductance regulator mediated diseases |
US9861611B2 (en) | 2014-09-18 | 2018-01-09 | Virun, Inc. | Formulations of water-soluble derivatives of vitamin E and soft gel compositions, concentrates and powders containing same |
WO2016090240A1 (en) * | 2014-12-04 | 2016-06-09 | Astex Pharmaceuticals, Inc. | Pharmaceutical compositions for increasing the bioavailability of poorly soluble drugs |
JP7129703B2 (ja) | 2016-04-28 | 2022-09-02 | エモリー ユニバーシティー | アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用 |
GB201609222D0 (en) | 2016-05-25 | 2016-07-06 | F2G Ltd | Pharmaceutical formulation |
WO2018159852A1 (ja) * | 2017-03-03 | 2018-09-07 | 三栄源エフ・エフ・アイ株式会社 | クルクミン含有製剤 |
CN110958880B (zh) * | 2017-05-30 | 2023-08-08 | 东莞东阳光太景医药研发有限责任公司 | 固体分散制剂 |
US10155234B1 (en) * | 2017-08-04 | 2018-12-18 | ZoomEssence, Inc. | Ultrahigh efficiency spray drying apparatus and process |
US10486173B2 (en) | 2017-08-04 | 2019-11-26 | ZoomEssence, Inc. | Ultrahigh efficiency spray drying apparatus and process |
CA3071115C (en) | 2017-08-04 | 2022-06-21 | ZoomEssence, Inc. | Ultrahigh efficiency spray drying apparatus and process |
US10569244B2 (en) | 2018-04-28 | 2020-02-25 | ZoomEssence, Inc. | Low temperature spray drying of carrier-free compositions |
US11819503B2 (en) | 2019-04-23 | 2023-11-21 | F2G Ltd | Method of treating coccidioides infection |
EP4185273A1 (en) | 2020-07-24 | 2023-05-31 | Lonza Bend Inc. | Spray drying of supersaturated solutions of api with acetic acid |
EP4221692B1 (en) | 2020-10-02 | 2023-12-20 | Lonza Bend Inc. | Acetic acid as processing aid in spray drying for basic drugs |
WO2023158616A1 (en) * | 2022-02-18 | 2023-08-24 | Viking Therapeutics, Inc. | ORAL DOSAGE FORMS OF TRβ AGONIST VK2809 FOR THE TREATMENT OF LIVER DISORDERS AND METHODS OF PREPARING THE SAME |
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US6800297B2 (en) * | 2000-06-15 | 2004-10-05 | Acusphere, Inc. | Porous COX-2 inhibitor matrices and methods of manufacture thereof |
SV2003000617A (es) * | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
DE10055857A1 (de) * | 2000-11-10 | 2002-08-22 | Creative Peptides Sweden Ab Dj | Neue pharmazeutische Depotformulierung |
RS61604A (en) | 2002-02-01 | 2006-10-27 | Pfizer Products Inc. | Method for making homogeneous spray-dried solid amorphous drug dispersions utilizing modified spray-drying apparatus |
JP4550824B2 (ja) * | 2003-03-05 | 2010-09-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | C型肝炎抑制化合物 |
SG153800A1 (en) * | 2004-06-08 | 2009-07-29 | Vertex Pharma | Pharmaceutical compositions |
PT1993360T (pt) * | 2005-12-28 | 2017-05-25 | Vertex Pharma | Formas sólidas de n-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-di-hidro-4-oxoquinolina-3-carboxamida |
-
2007
- 2007-03-19 EA EA200802008A patent/EA018811B1/ru not_active IP Right Cessation
- 2007-03-19 JP JP2009501679A patent/JP2009530416A/ja not_active Withdrawn
- 2007-03-19 EP EP07758806A patent/EP2001497A4/en not_active Withdrawn
- 2007-03-19 KR KR1020087025510A patent/KR20090025187A/ko active IP Right Grant
- 2007-03-19 TW TW102143937A patent/TW201414469A/zh unknown
- 2007-03-19 CA CA002646335A patent/CA2646335A1/en not_active Abandoned
- 2007-03-19 KR KR1020147022986A patent/KR20140107691A/ko not_active Application Discontinuation
- 2007-03-19 NZ NZ571934A patent/NZ571934A/en not_active IP Right Cessation
- 2007-03-19 SG SG201101683-9A patent/SG170087A1/en unknown
- 2007-03-19 AU AU2007226984A patent/AU2007226984B2/en not_active Ceased
- 2007-03-19 MX MX2008011976A patent/MX2008011976A/es active IP Right Grant
- 2007-03-19 GE GEAP200710941A patent/GEP20125378B/en unknown
- 2007-03-19 CN CN2013101589038A patent/CN103272234A/zh active Pending
- 2007-03-19 BR BRPI0708957-0A patent/BRPI0708957A2/pt not_active IP Right Cessation
- 2007-03-19 US US11/687,779 patent/US20070218012A1/en not_active Abandoned
- 2007-03-19 RS RSP-2009/0406A patent/RS20090406A/sr unknown
- 2007-03-19 WO PCT/US2007/064294 patent/WO2007109605A2/en active Application Filing
- 2007-03-19 TW TW096109377A patent/TWI428125B/zh not_active IP Right Cessation
- 2007-03-20 UY UY30225A patent/UY30225A1/es unknown
- 2007-03-20 PE PE2007000308A patent/PE20080170A1/es not_active Application Discontinuation
- 2007-03-20 AR ARP070101121A patent/AR063468A1/es unknown
-
2008
- 2008-09-17 IL IL194176A patent/IL194176A/en not_active IP Right Cessation
- 2008-09-22 EC EC2008008759A patent/ECSP088759A/es unknown
- 2008-10-16 NO NO20084334A patent/NO20084334L/no not_active Application Discontinuation
-
2009
- 2009-06-10 US US12/481,962 patent/US8853152B2/en not_active Expired - Fee Related
-
2013
- 2013-05-21 AU AU2013205948A patent/AU2013205948A1/en not_active Abandoned
- 2013-11-20 JP JP2013240174A patent/JP2014037435A/ja active Pending
-
2014
- 2014-03-04 US US14/196,509 patent/US20140183768A1/en not_active Abandoned
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2661399C1 (ru) * | 2013-11-22 | 2018-07-16 | Мерк Шарп И Доум Корп. | Композиция ненуклеозидного ингибитора обратной транскриптазы |
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