KR20140054160A - 콜라겐 ７ 및 관련 방법들 - Google Patents

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Publication number

KR20140054160A

KR20140054160A KR1020147005544A KR20147005544A KR20140054160A KR 20140054160 A KR20140054160 A KR 20140054160A KR 1020147005544 A KR1020147005544 A KR 1020147005544A KR 20147005544 A KR20147005544 A KR 20147005544A KR 20140054160 A KR20140054160 A KR 20140054160A

Authority

KR

South Korea

Prior art keywords

gly

pro

collagen

leu

val

Prior art date

2011-08-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

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• 108010035532 Collagen Proteins 0.000 title claims abstract description 125
• 102000008186 Collagen Human genes 0.000 title claims abstract description 125
• 229920001436 collagen Polymers 0.000 title claims abstract description 124
• 238000000034 method Methods 0.000 title claims description 63
• 239000012634 fragment Substances 0.000 claims abstract description 82
• 150000007523 nucleic acids Chemical class 0.000 claims abstract description 66
• 108020004707 nucleic acids Proteins 0.000 claims abstract description 29
• 102000039446 nucleic acids Human genes 0.000 claims abstract description 29
• 239000013598 vector Substances 0.000 claims abstract description 19
• 238000004519 manufacturing process Methods 0.000 claims abstract description 9
• 210000004027 cell Anatomy 0.000 claims description 151
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 44
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 37
• 108090000623 proteins and genes Proteins 0.000 claims description 36
• 102000051366 Glycosyltransferases Human genes 0.000 claims description 31
• 108700023372 Glycosyltransferases Proteins 0.000 claims description 31
• 239000013604 expression vector Substances 0.000 claims description 31
• 102000004169 proteins and genes Human genes 0.000 claims description 31
• 241000282414 Homo sapiens Species 0.000 claims description 28
• 108020004705 Codon Proteins 0.000 claims description 23
• 239000004471 Glycine Substances 0.000 claims description 22
• 229920001184 polypeptide Polymers 0.000 claims description 22
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 22
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 22
• 239000001963 growth medium Substances 0.000 claims description 15
• 230000014509 gene expression Effects 0.000 claims description 12
• 238000002360 preparation method Methods 0.000 claims description 10
• 238000000746 purification Methods 0.000 claims description 8
• 239000006228 supernatant Substances 0.000 claims description 8
• 102000003838 Sialyltransferases Human genes 0.000 claims description 7
• 108090000141 Sialyltransferases Proteins 0.000 claims description 7
• 238000004113 cell culture Methods 0.000 claims description 7
• 210000004962 mammalian cell Anatomy 0.000 claims description 6
• 238000003259 recombinant expression Methods 0.000 claims description 6
• 229920002684 Sepharose Polymers 0.000 claims description 5
• BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 claims description 5
• 229910052921 ammonium sulfate Inorganic materials 0.000 claims description 5
• 235000011130 ammonium sulphate Nutrition 0.000 claims description 5
• 210000004978 chinese hamster ovary cell Anatomy 0.000 claims description 5
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• KZNQNBZMBZJQJO-UHFFFAOYSA-N N-glycyl-L-proline Natural products NCC(=O)N1CCCC1C(O)=O KZNQNBZMBZJQJO-UHFFFAOYSA-N 0.000 description 28
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• UCBPDSYUVAAHCD-UWVGGRQHSA-N Leu-Pro-Gly Chemical compound CC(C)C[C@H](N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O UCBPDSYUVAAHCD-UWVGGRQHSA-N 0.000 description 13
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• 101000836383 Homo sapiens Serpin H1 Proteins 0.000 description 8
• UGTHTQWIQKEDEH-BQBZGAKWSA-N L-alanyl-L-prolylglycine zwitterion Chemical compound C[C@H](N)C(=O)N1CCC[C@H]1C(=O)NCC(O)=O UGTHTQWIQKEDEH-BQBZGAKWSA-N 0.000 description 8
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• AUFHLLPVPSMEOG-YUMQZZPRSA-N Arg-Gly-Glu Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(O)=O AUFHLLPVPSMEOG-YUMQZZPRSA-N 0.000 description 7
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• GAAHQHNCMIAYEX-UWVGGRQHSA-N Gly-Pro-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H]1CCCN1C(=O)CN GAAHQHNCMIAYEX-UWVGGRQHSA-N 0.000 description 7
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