JP2014524241A - コラーゲン７及び関連する方法 - Google Patents

コラーゲン７及び関連する方法 Download PDF

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Publication number
JP2014524241A
JP2014524241A JP2014524112A JP2014524112A JP2014524241A JP 2014524241 A JP2014524241 A JP 2014524241A JP 2014524112 A JP2014524112 A JP 2014524112A JP 2014524112 A JP2014524112 A JP 2014524112A JP 2014524241 A JP2014524241 A JP 2014524241A
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JP
Japan
Prior art keywords
collagen
cell
functional fragment
recombinant
express
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014524112A
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English (en)
Japanese (ja)
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JP2014524241A5 (enExample
Inventor
ソウザ，マーク デ
ヴィスワナータン，マリニ
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Lotus Tissue Repair Inc
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Lotus Tissue Repair Inc
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Publication of JP2014524241A publication Critical patent/JP2014524241A/ja
Publication of JP2014524241A5 publication Critical patent/JP2014524241A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/13—Dipeptidases (3.4.13)
    • C12Y304/13009—Xaa-Pro dipeptidase (3.4.13.9) i.e. prolidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/485—Exopeptidases (3.4.11-3.4.19)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
    • C12Y114/11002—Procollagen-proline dioxygenase (1.14.11.2), i.e. proline-hydroxylase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
JP2014524112A 2011-08-03 2012-08-03 コラーゲン７及び関連する方法 Pending JP2014524241A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161514796P 2011-08-03 2011-08-03
US61/514,796 2011-08-03
PCT/US2012/049553 WO2013020064A1 (en) 2011-08-03 2012-08-03 Collagen 7 and related methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2017171852A Division JP2017209117A (ja) 2011-08-03 2017-09-07 コラーゲン７及び関連する方法

Publications (2)

Publication Number Publication Date
JP2014524241A true JP2014524241A (ja) 2014-09-22
JP2014524241A5 JP2014524241A5 (enExample) 2015-07-23

Family

ID=47629706

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2014524112A Pending JP2014524241A (ja) 2011-08-03 2012-08-03 コラーゲン７及び関連する方法
JP2017171852A Abandoned JP2017209117A (ja) 2011-08-03 2017-09-07 コラーゲン７及び関連する方法

Family Applications After (1)

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JP2017171852A Abandoned JP2017209117A (ja) 2011-08-03 2017-09-07 コラーゲン７及び関連する方法

Country Status (10)

Country Link
US (1) US9676837B2 (enExample)
EP (1) EP2753704A4 (enExample)
JP (2) JP2014524241A (enExample)
KR (1) KR20140054160A (enExample)
CN (2) CN103842517A (enExample)
AU (2) AU2012289916B2 (enExample)
BR (1) BR112014002546A2 (enExample)
CA (1) CA2843896A1 (enExample)
MX (1) MX351565B (enExample)
WO (1) WO2013020064A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019058165A (ja) * 2017-09-22 2019-04-18 モダン メドウ，インコーポレイテッド 組換え酵母株
JP2019511498A (ja) * 2016-03-16 2019-04-25 フェニックス ティシュー リペア インコーポレイテッドＰｈｏｅｎｉｘ Ｔｉｓｓｕｅ Ｒｅｐａｉｒ，Ｉｎｃ． ７型コラーゲンの精製方法

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DE60138535D1 (de) 2000-02-04 2009-06-10 Children S Hospital Res Founda Verwendung von lysosomal acid lipase zur behandlung von atherosklerose und ähnlichen krankheiten
KR101742346B1 (ko) 2010-04-23 2017-06-15 시나게바 바이오파르마, 코포레이션 리소솜 축적병 효소
BR122019021757B1 (pt) 2010-09-09 2020-12-08 Alexion Pharmaceuticals, Inc composição farmacêutica para tratamento de um paciente humano sofrendo de uma deficiência de lipase ácida lisossomal (lal)
EP2675472A4 (en) 2011-02-15 2014-09-17 Synageva Biopharma Corp METHOD FOR THE TREATMENT OF LACK OF LYSOSOMAL SAURER LIPASE
WO2012149136A1 (en) 2011-04-26 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Production and delivery of a stable collagen
KR102415811B1 (ko) 2014-01-31 2022-07-04 팩터 바이오사이언스 인크. 핵산 제조 및 송달을 위한 방법 및 산물
US10227394B2 (en) 2014-04-08 2019-03-12 University Of Southern California Polypeptide compositions with type VII collagen fibronectin type III-like repeats and treatment methods for wound closure and healing
KR102204367B1 (ko) * 2014-07-16 2021-01-19 주식회사 엘지생활건강 피부 주름 개선용 화장료 조성물
US11241505B2 (en) 2015-02-13 2022-02-08 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
GB201601571D0 (en) * 2016-01-28 2016-03-16 Nordic Bioscience As Collagen type Vll alpha 1 assay
IL264439B2 (en) 2016-08-17 2024-08-01 Factor Bioscience Inc non-viral, cell-free composition comprising a synthetic messenger RNA (MRNA) encoding a gene-editing protein for use in treating cancer, and a synthetic RNA encoding a gene-editing protein for use in treatment
US11180541B2 (en) 2017-09-28 2021-11-23 Geltor, Inc. Recombinant collagen and elastin molecules and uses thereof
CN109022464A (zh) * 2018-07-02 2018-12-18 西安巨子生物基因技术股份有限公司 重组人源型胶原蛋白的羟基化方法
AU2020248453A1 (en) * 2019-03-27 2021-10-28 Phoenix Tissue Repair, Inc. Systems and methods for producing collagen 7 compositions
GB2597416A (en) 2019-04-12 2022-01-26 Geltor Inc Recombinant elastin and production thereof
CA3145425A1 (en) 2019-07-03 2021-01-07 Factor Bioscience Inc. Cationic lipids and uses thereof
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
EP4093761A4 (en) 2020-01-24 2024-04-17 Geltor, Inc. Animal-free dietary collagen
KR20240004264A (ko) * 2021-03-04 2024-01-11 젤라텍, 인크. 배양된 동물 세포로부터의 콜라겐을 사용한 재료의 제조 방법
US20240424065A1 (en) 2021-10-12 2024-12-26 Phoenix Tissue Repair, Inc. Collagen 7 protein replacement therapy
CN117143223B (zh) * 2022-08-23 2024-03-08 山西锦波生物医药股份有限公司 一种生物合成人体结构性材料的制备方法
CN116854807A (zh) * 2023-07-26 2023-10-10 浙江大学 一种重组人源ⅶ型胶原蛋白及其制备方法与应用
CN120137008B (zh) * 2025-03-18 2025-09-26 广东普言生物科技有限公司 一种重组Ⅶ型胶原蛋白Pro.C7及其制备方法和应用

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WO2012149136A1 (en) * 2011-04-26 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Production and delivery of a stable collagen

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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019511498A (ja) * 2016-03-16 2019-04-25 フェニックス ティシュー リペア インコーポレイテッドＰｈｏｅｎｉｘ Ｔｉｓｓｕｅ Ｒｅｐａｉｒ，Ｉｎｃ． ７型コラーゲンの精製方法
JP2022016605A (ja) * 2016-03-16 2022-01-21 フェニックス ティシュー リペア インコーポレイテッド ７型コラーゲンの精製方法
JP7340583B2 (ja) 2016-03-16 2023-09-07 フェニックス ティシュー リペア インコーポレイテッド ７型コラーゲンの精製方法
JP2019058165A (ja) * 2017-09-22 2019-04-18 モダン メドウ，インコーポレイテッド 組換え酵母株
JP2021036889A (ja) * 2017-09-22 2021-03-11 モダン メドウ，インコーポレイテッド 組換え酵母株

Also Published As

Publication number Publication date
JP2017209117A (ja) 2017-11-30
KR20140054160A (ko) 2014-05-08
BR112014002546A2 (pt) 2017-03-14
EP2753704A4 (en) 2015-07-08
EP2753704A1 (en) 2014-07-16
CA2843896A1 (en) 2013-02-07
US20150011733A1 (en) 2015-01-08
MX351565B (es) 2017-10-19
AU2017254910A1 (en) 2017-11-23
CN108165593A (zh) 2018-06-15
WO2013020064A1 (en) 2013-02-07
CN103842517A (zh) 2014-06-04
US9676837B2 (en) 2017-06-13
AU2012289916B2 (en) 2017-08-03
MX2014001383A (es) 2014-08-26
AU2012289916A1 (en) 2014-02-20

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