AU2012289916B2 - Collagen 7 and related methods - Google Patents

Collagen 7 and related methods Download PDF

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Publication number
AU2012289916B2
AU2012289916B2 AU2012289916A AU2012289916A AU2012289916B2 AU 2012289916 B2 AU2012289916 B2 AU 2012289916B2 AU 2012289916 A AU2012289916 A AU 2012289916A AU 2012289916 A AU2012289916 A AU 2012289916A AU 2012289916 B2 AU2012289916 B2 AU 2012289916B2
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AU
Australia
Prior art keywords
collagen
functional fragment
mammalian cell
nucleic acid
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2012289916A
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English (en)
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AU2012289916A1 (en
Inventor
Mark De Souza
Malini VISWANATHAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Phoenix Tissue Repair Inc
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Phoenix Tissue Repair Inc
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Publication of AU2012289916A1 publication Critical patent/AU2012289916A1/en
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Priority to AU2017254910A priority Critical patent/AU2017254910A1/en
Assigned to PHOENIX TISSUE REPAIR, INC. reassignment PHOENIX TISSUE REPAIR, INC. Request for Assignment Assignors: LOTUS TISSUE REPAIR INC.
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/13—Dipeptidases (3.4.13)
    • C12Y304/13009—Xaa-Pro dipeptidase (3.4.13.9) i.e. prolidase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/485—Exopeptidases (3.4.11-3.4.19)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y114/00—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14)
    • C12Y114/11—Oxidoreductases acting on paired donors, with incorporation or reduction of molecular oxygen (1.14) with 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors (1.14.11)
    • C12Y114/11002—Procollagen-proline dioxygenase (1.14.11.2), i.e. proline-hydroxylase

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
AU2012289916A 2011-08-03 2012-08-03 Collagen 7 and related methods Ceased AU2012289916B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017254910A AU2017254910A1 (en) 2011-08-03 2017-11-02 Collagen 7 and related methods

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161514796P 2011-08-03 2011-08-03
US61/514,796 2011-08-03
PCT/US2012/049553 WO2013020064A1 (en) 2011-08-03 2012-08-03 Collagen 7 and related methods

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017254910A Division AU2017254910A1 (en) 2011-08-03 2017-11-02 Collagen 7 and related methods

Publications (2)

Publication Number Publication Date
AU2012289916A1 AU2012289916A1 (en) 2014-02-20
AU2012289916B2 true AU2012289916B2 (en) 2017-08-03

Family

ID=47629706

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2012289916A Ceased AU2012289916B2 (en) 2011-08-03 2012-08-03 Collagen 7 and related methods
AU2017254910A Abandoned AU2017254910A1 (en) 2011-08-03 2017-11-02 Collagen 7 and related methods

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017254910A Abandoned AU2017254910A1 (en) 2011-08-03 2017-11-02 Collagen 7 and related methods

Country Status (10)

Country Link
US (1) US9676837B2 (enExample)
EP (1) EP2753704A4 (enExample)
JP (2) JP2014524241A (enExample)
KR (1) KR20140054160A (enExample)
CN (2) CN103842517A (enExample)
AU (2) AU2012289916B2 (enExample)
BR (1) BR112014002546A2 (enExample)
CA (1) CA2843896A1 (enExample)
MX (1) MX351565B (enExample)
WO (1) WO2013020064A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60138535D1 (de) 2000-02-04 2009-06-10 Children S Hospital Res Founda Verwendung von lysosomal acid lipase zur behandlung von atherosklerose und ähnlichen krankheiten
KR101742346B1 (ko) 2010-04-23 2017-06-15 시나게바 바이오파르마, 코포레이션 리소솜 축적병 효소
BR122019021757B1 (pt) 2010-09-09 2020-12-08 Alexion Pharmaceuticals, Inc composição farmacêutica para tratamento de um paciente humano sofrendo de uma deficiência de lipase ácida lisossomal (lal)
EP2675472A4 (en) 2011-02-15 2014-09-17 Synageva Biopharma Corp METHOD FOR THE TREATMENT OF LACK OF LYSOSOMAL SAURER LIPASE
WO2012149136A1 (en) 2011-04-26 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Production and delivery of a stable collagen
KR102415811B1 (ko) 2014-01-31 2022-07-04 팩터 바이오사이언스 인크. 핵산 제조 및 송달을 위한 방법 및 산물
US10227394B2 (en) 2014-04-08 2019-03-12 University Of Southern California Polypeptide compositions with type VII collagen fibronectin type III-like repeats and treatment methods for wound closure and healing
KR102204367B1 (ko) * 2014-07-16 2021-01-19 주식회사 엘지생활건강 피부 주름 개선용 화장료 조성물
US11241505B2 (en) 2015-02-13 2022-02-08 Factor Bioscience Inc. Nucleic acid products and methods of administration thereof
GB201601571D0 (en) * 2016-01-28 2016-03-16 Nordic Bioscience As Collagen type Vll alpha 1 assay
CA3015685A1 (en) 2016-03-16 2017-09-21 Phoenix Tissue Repair, Inc. Methods of purifying collagen 7
IL264439B2 (en) 2016-08-17 2024-08-01 Factor Bioscience Inc non-viral, cell-free composition comprising a synthetic messenger RNA (MRNA) encoding a gene-editing protein for use in treating cancer, and a synthetic RNA encoding a gene-editing protein for use in treatment
US11028146B2 (en) * 2017-09-22 2021-06-08 Modern Meadow, Inc. Recombinant yeast strains
US11180541B2 (en) 2017-09-28 2021-11-23 Geltor, Inc. Recombinant collagen and elastin molecules and uses thereof
CN109022464A (zh) * 2018-07-02 2018-12-18 西安巨子生物基因技术股份有限公司 重组人源型胶原蛋白的羟基化方法
AU2020248453A1 (en) * 2019-03-27 2021-10-28 Phoenix Tissue Repair, Inc. Systems and methods for producing collagen 7 compositions
GB2597416A (en) 2019-04-12 2022-01-26 Geltor Inc Recombinant elastin and production thereof
CA3145425A1 (en) 2019-07-03 2021-01-07 Factor Bioscience Inc. Cationic lipids and uses thereof
US10501404B1 (en) 2019-07-30 2019-12-10 Factor Bioscience Inc. Cationic lipids and transfection methods
EP4093761A4 (en) 2020-01-24 2024-04-17 Geltor, Inc. Animal-free dietary collagen
KR20240004264A (ko) * 2021-03-04 2024-01-11 젤라텍, 인크. 배양된 동물 세포로부터의 콜라겐을 사용한 재료의 제조 방법
US20240424065A1 (en) 2021-10-12 2024-12-26 Phoenix Tissue Repair, Inc. Collagen 7 protein replacement therapy
CN117143223B (zh) * 2022-08-23 2024-03-08 山西锦波生物医药股份有限公司 一种生物合成人体结构性材料的制备方法
CN116854807A (zh) * 2023-07-26 2023-10-10 浙江大学 一种重组人源ⅶ型胶原蛋白及其制备方法与应用
CN120137008B (zh) * 2025-03-18 2025-09-26 广东普言生物科技有限公司 一种重组Ⅶ型胶原蛋白Pro.C7及其制备方法和应用

Citations (2)

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Publication number Priority date Publication date Assignee Title
US20020142391A1 (en) * 1991-06-12 2002-10-03 Kivirikko Kari I. Synthesis of human procollagens and collagens in recombinant DNA systems
US20050229264A1 (en) * 1999-11-12 2005-10-13 Chang Robert C Recombinant gelatins

Family Cites Families (5)

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AU6181300A (en) 1999-07-29 2001-02-19 Helix Research Institute Liver cancer-associated genes
US7026463B2 (en) 1999-08-13 2006-04-11 Matthew Glenn Polynucleotides and polypeptides, materials incorporating them and methods for using them
CN1552889A (zh) * 2003-12-18 2004-12-08 四川铭让生物科技有限公司 制备胶原蛋白和胶原多肽的方法及其用途
JP4490498B2 (ja) * 2008-09-30 2010-06-23 新田ゼラチン株式会社 疾病抑制剤
WO2012149136A1 (en) * 2011-04-26 2012-11-01 The Board Of Trustees Of The Leland Stanford Junior University Production and delivery of a stable collagen

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020142391A1 (en) * 1991-06-12 2002-10-03 Kivirikko Kari I. Synthesis of human procollagens and collagens in recombinant DNA systems
US20050229264A1 (en) * 1999-11-12 2005-10-13 Chang Robert C Recombinant gelatins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHEN, M. et al., "The recombinant expression of full-length type VII collagen and characterization of molecular mechanisms underlying dystrophic epidermolysis bullosa", Journal of Biological Chemistry. 2002, Vol. 277, pages 2118-2124 *

Also Published As

Publication number Publication date
JP2017209117A (ja) 2017-11-30
KR20140054160A (ko) 2014-05-08
BR112014002546A2 (pt) 2017-03-14
EP2753704A4 (en) 2015-07-08
EP2753704A1 (en) 2014-07-16
JP2014524241A (ja) 2014-09-22
CA2843896A1 (en) 2013-02-07
US20150011733A1 (en) 2015-01-08
MX351565B (es) 2017-10-19
AU2017254910A1 (en) 2017-11-23
CN108165593A (zh) 2018-06-15
WO2013020064A1 (en) 2013-02-07
CN103842517A (zh) 2014-06-04
US9676837B2 (en) 2017-06-13
MX2014001383A (es) 2014-08-26
AU2012289916A1 (en) 2014-02-20

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Owner name: PHOENIX TISSUE REPAIR, INC.

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