KR20090101381A - Ｈｓｐ90 억제제로서의 트리아졸 유도체 - Google Patents

Ｈｓｐ90 억제제로서의 트리아졸 유도체 Download PDF

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Publication number
KR20090101381A
KR20090101381A KR1020097016991A KR20097016991A KR20090101381A KR 20090101381 A KR20090101381 A KR 20090101381A KR 1020097016991 A KR1020097016991 A KR 1020097016991A KR 20097016991 A KR20097016991 A KR 20097016991A KR 20090101381 A KR20090101381 A KR 20090101381A
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disease
carcinoma
tumor
hydroxy
methyl
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Korean (ko)
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한스-미하엘 에겐바일러
미하엘 볼프
한스-페터 부흐슈탈러
크리슈티안 지렌베르크
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메르크 파텐트 게엠베하
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
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    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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    • C07D209/56—Ring systems containing three or more rings
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
KR1020097016991A 2007-01-18 2007-12-11 Ｈｓｐ90 억제제로서의 트리아졸 유도체 Withdrawn KR20090101381A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007002715.1 2007-01-18
DE102007002715A DE102007002715A1 (de) 2007-01-18 2007-01-18 Triazolderivat

Publications (1)

Publication Number Publication Date
KR20090101381A true KR20090101381A (ko) 2009-09-25

Family

ID=39345628

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KR1020097016991A Withdrawn KR20090101381A (ko) 2007-01-18 2007-12-11 Ｈｓｐ90 억제제로서의 트리아졸 유도체

Country Status (22)

Country Link
US (1) US8816070B2 (https=)
EP (1) EP2102175B1 (https=)
JP (1) JP5266253B2 (https=)
KR (1) KR20090101381A (https=)
CN (1) CN101583605B (https=)
AR (1) AR064951A1 (https=)
AU (1) AU2007344512B2 (https=)
BR (1) BRPI0720956A2 (https=)
CA (1) CA2675737C (https=)
CL (1) CL2008000134A1 (https=)
DE (1) DE102007002715A1 (https=)
EA (1) EA015366B1 (https=)
EC (1) ECSP099586A (https=)
ES (1) ES2455504T3 (https=)
MX (1) MX2009007479A (https=)
MY (1) MY151452A (https=)
NZ (1) NZ579069A (https=)
PE (1) PE20090051A1 (https=)
TW (1) TW200838502A (https=)
UA (1) UA98320C2 (https=)
WO (1) WO2008086857A1 (https=)
ZA (1) ZA200905700B (https=)

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Publication number Priority date Publication date Assignee Title
CN101801983B (zh) * 2007-08-13 2014-01-29 辛塔制药公司 调控hsp90活性的三唑化合物
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
BR112012009215A2 (pt) * 2009-10-19 2019-09-24 Synta Pharmaceuticals Corp "terapia combinada contra o cancer com compostos inibidores de hsp90"
US9205086B2 (en) 2010-04-19 2015-12-08 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor
DE102010024338A1 (de) 2010-06-18 2011-12-22 Merck Patent Gmbh Verfahren zur Herstellung von 5-[4-(2-Methyl-phenyl)-3-hydroxy-4H-[1,2,4]triazol-5-yl]-2,4-dihydroxy-methyl-butyl-benzamid
MX2013003633A (es) * 2010-10-01 2013-04-24 Taisho Pharmaceutical Co Ltd Derivado de 1, 2, 4-triazolona.
DK2670404T3 (en) * 2011-02-02 2018-11-19 Univ Princeton CIRCUIT MODULATORS AS VIRUS PRODUCTION MODULATORS
EP2773345A1 (en) 2011-11-02 2014-09-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
AU2012332424A1 (en) 2011-11-02 2014-06-05 Synta Pharmaceuticals Corp. Combination therapy of Hsp90 inhibitors with platinum-containing agents
WO2013074594A1 (en) 2011-11-14 2013-05-23 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with braf inhibitors
CN106478531B (zh) * 2015-08-25 2019-06-28 南京华威医药科技集团有限公司 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸中间体
JP7508375B2 (ja) * 2018-05-14 2024-07-01 リアタ ファーマシューティカルズ インコーポレイテッド 熱ショックタンパク質経路に関連する疾患の治療のための、修飾された糖基を有するビアリールアミド
CN115006395B (zh) * 2022-04-29 2023-03-14 佛山病原微生物研究院 一种xl888在制备用于抗腺病毒感染的药物中的用途

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JP2003523313A (ja) 1999-03-12 2003-08-05 アメリカ合衆国 シャペロン蛋白質の阻害方法
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AU2001271567A1 (en) 2000-06-29 2002-01-14 Trustees Of Boston University Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders
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JP2005519848A (ja) 2000-11-02 2005-07-07 スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ Ｈｓｐ９０に結合するための小分子組成物
WO2003041643A2 (en) 2001-11-09 2003-05-22 Conforma Therapeutics Corporation Hsp90-inhibiting zearalanol compounds and methods of producing and using same
EP1456180B1 (en) 2001-12-21 2007-10-03 Vernalis (Cambridge) Limited 3-(2,4)dihydroxyphenyl-4-phenylpyrazoles and their medical use
GB0228417D0 (en) 2002-12-05 2003-01-08 Cancer Rec Tech Ltd Pyrazole compounds
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US20050020534A1 (en) 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with antimetabolites
US7691838B2 (en) 2003-05-30 2010-04-06 Kosan Biosciences Incorporated Method for treating diseases using HSP90-inhibiting agents in combination with antimitotics
US20050026893A1 (en) 2003-05-30 2005-02-03 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with immunosuppressants
US20050020556A1 (en) 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with platinum coordination complexes
US20050054625A1 (en) 2003-05-30 2005-03-10 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with nuclear export inhibitors
US20050020557A1 (en) 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with enzyme inhibitors
US20050054589A1 (en) 2003-05-30 2005-03-10 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with antibiotics
WO2006055760A1 (en) * 2004-11-18 2006-05-26 Synta Pharmaceuticals Corp. Triazole compounds that modulate hsp90 activity
DE102005007304A1 (de) 2005-02-17 2006-08-24 Merck Patent Gmbh Triazolderivate

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US20100113542A1 (en) 2010-05-06
ES2455504T3 (es) 2014-04-15
ECSP099586A (es) 2009-09-29
DE102007002715A1 (de) 2008-07-24
JP2010516639A (ja) 2010-05-20
BRPI0720956A2 (pt) 2014-03-18
EP2102175A1 (de) 2009-09-23
TW200838502A (en) 2008-10-01
UA98320C2 (en) 2012-05-10
MY151452A (en) 2014-05-30
PE20090051A1 (es) 2009-01-26
CN101583605A (zh) 2009-11-18
WO2008086857A1 (de) 2008-07-24
AU2007344512B2 (en) 2012-11-01
CA2675737A1 (en) 2008-07-24
CN101583605B (zh) 2013-06-19
US8816070B2 (en) 2014-08-26
JP5266253B2 (ja) 2013-08-21
MX2009007479A (es) 2009-08-13
AU2007344512A1 (en) 2008-07-24
CL2008000134A1 (es) 2008-05-16
EA015366B1 (ru) 2011-06-30
AR064951A1 (es) 2009-05-06
NZ579069A (en) 2011-09-30
EP2102175B1 (de) 2014-01-22
CA2675737C (en) 2015-03-24
EA200900913A1 (ru) 2009-12-30
ZA200905700B (en) 2010-05-26

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