EA015366B1 - Производное триазола в качестве ингибитора hsp90 - Google Patents

Производное триазола в качестве ингибитора hsp90 Download PDF

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Publication number
EA015366B1
EA015366B1 EA200900913A EA200900913A EA015366B1 EA 015366 B1 EA015366 B1 EA 015366B1 EA 200900913 A EA200900913 A EA 200900913A EA 200900913 A EA200900913 A EA 200900913A EA 015366 B1 EA015366 B1 EA 015366B1
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EA
Eurasian Patent Office
Prior art keywords
cancer
diseases
hydroxy
methyl
triazol
Prior art date
Application number
EA200900913A
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English (en)
Russian (ru)
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EA200900913A1 (ru
Inventor
Ханс-Михаэль Эггенвайлер
Михаэль Вольф
Ханс-Петер Бухшталлер
Кристиан Зирренберг
Original Assignee
Мерк Патент Гмбх
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Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of EA200900913A1 publication Critical patent/EA200900913A1/ru
Publication of EA015366B1 publication Critical patent/EA015366B1/ru

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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
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    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Diabetes (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Cardiology (AREA)
  • Biotechnology (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
EA200900913A 2007-01-18 2007-12-11 Производное триазола в качестве ингибитора hsp90 EA015366B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007002715A DE102007002715A1 (de) 2007-01-18 2007-01-18 Triazolderivat
PCT/EP2007/010775 WO2008086857A1 (de) 2007-01-18 2007-12-11 Triazolderivat als hsp 90 inhibitor

Publications (2)

Publication Number Publication Date
EA200900913A1 EA200900913A1 (ru) 2009-12-30
EA015366B1 true EA015366B1 (ru) 2011-06-30

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EA200900913A EA015366B1 (ru) 2007-01-18 2007-12-11 Производное триазола в качестве ингибитора hsp90

Country Status (22)

Country Link
US (1) US8816070B2 (https=)
EP (1) EP2102175B1 (https=)
JP (1) JP5266253B2 (https=)
KR (1) KR20090101381A (https=)
CN (1) CN101583605B (https=)
AR (1) AR064951A1 (https=)
AU (1) AU2007344512B2 (https=)
BR (1) BRPI0720956A2 (https=)
CA (1) CA2675737C (https=)
CL (1) CL2008000134A1 (https=)
DE (1) DE102007002715A1 (https=)
EA (1) EA015366B1 (https=)
EC (1) ECSP099586A (https=)
ES (1) ES2455504T3 (https=)
MX (1) MX2009007479A (https=)
MY (1) MY151452A (https=)
NZ (1) NZ579069A (https=)
PE (1) PE20090051A1 (https=)
TW (1) TW200838502A (https=)
UA (1) UA98320C2 (https=)
WO (1) WO2008086857A1 (https=)
ZA (1) ZA200905700B (https=)

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CN101801983B (zh) * 2007-08-13 2014-01-29 辛塔制药公司 调控hsp90活性的三唑化合物
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
BR112012009215A2 (pt) * 2009-10-19 2019-09-24 Synta Pharmaceuticals Corp "terapia combinada contra o cancer com compostos inibidores de hsp90"
US9205086B2 (en) 2010-04-19 2015-12-08 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor
DE102010024338A1 (de) 2010-06-18 2011-12-22 Merck Patent Gmbh Verfahren zur Herstellung von 5-[4-(2-Methyl-phenyl)-3-hydroxy-4H-[1,2,4]triazol-5-yl]-2,4-dihydroxy-methyl-butyl-benzamid
MX2013003633A (es) * 2010-10-01 2013-04-24 Taisho Pharmaceutical Co Ltd Derivado de 1, 2, 4-triazolona.
DK2670404T3 (en) * 2011-02-02 2018-11-19 Univ Princeton CIRCUIT MODULATORS AS VIRUS PRODUCTION MODULATORS
EP2773345A1 (en) 2011-11-02 2014-09-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
AU2012332424A1 (en) 2011-11-02 2014-06-05 Synta Pharmaceuticals Corp. Combination therapy of Hsp90 inhibitors with platinum-containing agents
WO2013074594A1 (en) 2011-11-14 2013-05-23 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with braf inhibitors
CN106478531B (zh) * 2015-08-25 2019-06-28 南京华威医药科技集团有限公司 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸中间体
JP7508375B2 (ja) * 2018-05-14 2024-07-01 リアタ ファーマシューティカルズ インコーポレイテッド 熱ショックタンパク質経路に関連する疾患の治療のための、修飾された糖基を有するビアリールアミド
CN115006395B (zh) * 2022-04-29 2023-03-14 佛山病原微生物研究院 一种xl888在制备用于抗腺病毒感染的药物中的用途

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JP2003523313A (ja) 1999-03-12 2003-08-05 アメリカ合衆国 シャペロン蛋白質の阻害方法
WO2001072779A1 (en) 2000-03-24 2001-10-04 Duke University Characterization of grp94-ligand interactions and purification, screening, and therapeutic methods relating thereto
AU2001271567A1 (en) 2000-06-29 2002-01-14 Trustees Of Boston University Use of geldanamycin and related compounds for prophylaxis or treatment of fibrogenic disorders
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US20100113542A1 (en) 2010-05-06
ES2455504T3 (es) 2014-04-15
ECSP099586A (es) 2009-09-29
DE102007002715A1 (de) 2008-07-24
JP2010516639A (ja) 2010-05-20
BRPI0720956A2 (pt) 2014-03-18
EP2102175A1 (de) 2009-09-23
TW200838502A (en) 2008-10-01
UA98320C2 (en) 2012-05-10
MY151452A (en) 2014-05-30
PE20090051A1 (es) 2009-01-26
CN101583605A (zh) 2009-11-18
WO2008086857A1 (de) 2008-07-24
AU2007344512B2 (en) 2012-11-01
CA2675737A1 (en) 2008-07-24
CN101583605B (zh) 2013-06-19
US8816070B2 (en) 2014-08-26
JP5266253B2 (ja) 2013-08-21
MX2009007479A (es) 2009-08-13
KR20090101381A (ko) 2009-09-25
AU2007344512A1 (en) 2008-07-24
CL2008000134A1 (es) 2008-05-16
AR064951A1 (es) 2009-05-06
NZ579069A (en) 2011-09-30
EP2102175B1 (de) 2014-01-22
CA2675737C (en) 2015-03-24
EA200900913A1 (ru) 2009-12-30
ZA200905700B (en) 2010-05-26

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