CN101583605B - 作为hsp90抑制剂的三唑衍生物 - Google Patents

作为hsp90抑制剂的三唑衍生物 Download PDF

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Publication number
CN101583605B
CN101583605B CN2007800499639A CN200780049963A CN101583605B CN 101583605 B CN101583605 B CN 101583605B CN 2007800499639 A CN2007800499639 A CN 2007800499639A CN 200780049963 A CN200780049963 A CN 200780049963A CN 101583605 B CN101583605 B CN 101583605B
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virus
disease
cancer
hsp90
methyl
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CN101583605A (zh
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H-M·埃根韦莱
M·沃尔夫
H-P·布赫施塔勒
C·西伦贝格
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Merck Patent GmbH
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Merck Patent GmbH
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    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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CN2007800499639A 2007-01-18 2007-12-11 作为hsp90抑制剂的三唑衍生物 Expired - Fee Related CN101583605B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102007002715.1 2007-01-18
DE102007002715A DE102007002715A1 (de) 2007-01-18 2007-01-18 Triazolderivat
PCT/EP2007/010775 WO2008086857A1 (de) 2007-01-18 2007-12-11 Triazolderivat als hsp 90 inhibitor

Publications (2)

Publication Number Publication Date
CN101583605A CN101583605A (zh) 2009-11-18
CN101583605B true CN101583605B (zh) 2013-06-19

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Country Status (22)

Country Link
US (1) US8816070B2 (https=)
EP (1) EP2102175B1 (https=)
JP (1) JP5266253B2 (https=)
KR (1) KR20090101381A (https=)
CN (1) CN101583605B (https=)
AR (1) AR064951A1 (https=)
AU (1) AU2007344512B2 (https=)
BR (1) BRPI0720956A2 (https=)
CA (1) CA2675737C (https=)
CL (1) CL2008000134A1 (https=)
DE (1) DE102007002715A1 (https=)
EA (1) EA015366B1 (https=)
EC (1) ECSP099586A (https=)
ES (1) ES2455504T3 (https=)
MX (1) MX2009007479A (https=)
MY (1) MY151452A (https=)
NZ (1) NZ579069A (https=)
PE (1) PE20090051A1 (https=)
TW (1) TW200838502A (https=)
UA (1) UA98320C2 (https=)
WO (1) WO2008086857A1 (https=)
ZA (1) ZA200905700B (https=)

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CN101801983B (zh) * 2007-08-13 2014-01-29 辛塔制药公司 调控hsp90活性的三唑化合物
AR077405A1 (es) 2009-07-10 2011-08-24 Sanofi Aventis Derivados del indol inhibidores de hsp90, composiciones que los contienen y utilizacion de los mismos para el tratamiento del cancer
FR2949467B1 (fr) 2009-09-03 2011-11-25 Sanofi Aventis Nouveaux derives de 5,6,7,8-tetrahydroindolizine inhibiteurs d'hsp90, compositions les contenant et utilisation
BR112012009215A2 (pt) * 2009-10-19 2019-09-24 Synta Pharmaceuticals Corp "terapia combinada contra o cancer com compostos inibidores de hsp90"
US9205086B2 (en) 2010-04-19 2015-12-08 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a Hsp90 inhibitory compounds and a EGFR inhibitor
DE102010024338A1 (de) 2010-06-18 2011-12-22 Merck Patent Gmbh Verfahren zur Herstellung von 5-[4-(2-Methyl-phenyl)-3-hydroxy-4H-[1,2,4]triazol-5-yl]-2,4-dihydroxy-methyl-butyl-benzamid
MX2013003633A (es) * 2010-10-01 2013-04-24 Taisho Pharmaceutical Co Ltd Derivado de 1, 2, 4-triazolona.
DK2670404T3 (en) * 2011-02-02 2018-11-19 Univ Princeton CIRCUIT MODULATORS AS VIRUS PRODUCTION MODULATORS
EP2773345A1 (en) 2011-11-02 2014-09-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
AU2012332424A1 (en) 2011-11-02 2014-06-05 Synta Pharmaceuticals Corp. Combination therapy of Hsp90 inhibitors with platinum-containing agents
WO2013074594A1 (en) 2011-11-14 2013-05-23 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with braf inhibitors
CN106478531B (zh) * 2015-08-25 2019-06-28 南京华威医药科技集团有限公司 2-(5-溴-4-(4-环丙基萘-1-基)-4h-1，2，4-三唑-3-基硫基)乙酸中间体
JP7508375B2 (ja) * 2018-05-14 2024-07-01 リアタ ファーマシューティカルズ インコーポレイテッド 熱ショックタンパク質経路に関連する疾患の治療のための、修飾された糖基を有するビアリールアミド
CN115006395B (zh) * 2022-04-29 2023-03-14 佛山病原微生物研究院 一种xl888在制备用于抗腺病毒感染的药物中的用途

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WO2006087077A2 (de) * 2005-02-17 2006-08-24 Merck Patent Gmbh Hsp90 hemmende triazolderivate
WO2006055760A9 (en) * 2004-11-18 2006-09-21 Synta Pharmaceuticals Corp Triazole compounds that modulate hsp90 activity

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Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
WO2006055760A9 (en) * 2004-11-18 2006-09-21 Synta Pharmaceuticals Corp Triazole compounds that modulate hsp90 activity
WO2006087077A2 (de) * 2005-02-17 2006-08-24 Merck Patent Gmbh Hsp90 hemmende triazolderivate

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US20100113542A1 (en) 2010-05-06
ES2455504T3 (es) 2014-04-15
ECSP099586A (es) 2009-09-29
DE102007002715A1 (de) 2008-07-24
JP2010516639A (ja) 2010-05-20
BRPI0720956A2 (pt) 2014-03-18
EP2102175A1 (de) 2009-09-23
TW200838502A (en) 2008-10-01
UA98320C2 (en) 2012-05-10
MY151452A (en) 2014-05-30
PE20090051A1 (es) 2009-01-26
CN101583605A (zh) 2009-11-18
WO2008086857A1 (de) 2008-07-24
AU2007344512B2 (en) 2012-11-01
CA2675737A1 (en) 2008-07-24
US8816070B2 (en) 2014-08-26
JP5266253B2 (ja) 2013-08-21
MX2009007479A (es) 2009-08-13
KR20090101381A (ko) 2009-09-25
AU2007344512A1 (en) 2008-07-24
CL2008000134A1 (es) 2008-05-16
EA015366B1 (ru) 2011-06-30
AR064951A1 (es) 2009-05-06
NZ579069A (en) 2011-09-30
EP2102175B1 (de) 2014-01-22
CA2675737C (en) 2015-03-24
EA200900913A1 (ru) 2009-12-30
ZA200905700B (en) 2010-05-26

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