KR20080109085A - Ｇ-단백질 결합 수용체(ｇｐｒ119) 작용제로서의 아제티딘 유도체 - Google Patents
Ｇ-단백질 결합 수용체(ｇｐｒ119) 작용제로서의 아제티딘 유도체 Download PDFInfo
- Publication number
- KR20080109085A KR20080109085A KR1020087027643A KR20087027643A KR20080109085A KR 20080109085 A KR20080109085 A KR 20080109085A KR 1020087027643 A KR1020087027643 A KR 1020087027643A KR 20087027643 A KR20087027643 A KR 20087027643A KR 20080109085 A KR20080109085 A KR 20080109085A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- pharmaceutically acceptable
- alkyl
- acceptable salt
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- OKSRCHHNHPVNNZ-UHFFFAOYSA-O CC(CC1)C=CC1Oc1ccc(CN(C2)CC2Oc(cc2)ccc2-c(cc2)ccc2S(C)([OH2+])=O)cc1 Chemical compound CC(CC1)C=CC1Oc1ccc(CN(C2)CC2Oc(cc2)ccc2-c(cc2)ccc2S(C)([OH2+])=O)cc1 OKSRCHHNHPVNNZ-UHFFFAOYSA-O 0.000 description 1
- SYVPUGOJMOLVGP-UHFFFAOYSA-O CS(C1=CC=C(c(cc2)ccc2OC2CN(Cc(cc3)ccc3OC3C=CC=CC3)C2)NC1)([OH2+])=O Chemical compound CS(C1=CC=C(c(cc2)ccc2OC2CN(Cc(cc3)ccc3OC3C=CC=CC3)C2)NC1)([OH2+])=O SYVPUGOJMOLVGP-UHFFFAOYSA-O 0.000 description 1
- JKKQKXUAEIZMSX-UHFFFAOYSA-N CS(c(cc1)ncc1-c(cc1)ccc1OC1CN(Cc(cc2)ccc2OC(F)(F)F)C1)=O Chemical compound CS(c(cc1)ncc1-c(cc1)ccc1OC1CN(Cc(cc2)ccc2OC(F)(F)F)C1)=O JKKQKXUAEIZMSX-UHFFFAOYSA-N 0.000 description 1
- WXPRCKQCESNJFC-UHFFFAOYSA-N CS(c(cc1)ncc1-c(cc1)ccc1OC1CN(Cc2ccccc2)C1)=O Chemical compound CS(c(cc1)ncc1-c(cc1)ccc1OC1CN(Cc2ccccc2)C1)=O WXPRCKQCESNJFC-UHFFFAOYSA-N 0.000 description 1
- YNLVFSBJFIXWRG-UHFFFAOYSA-N Cc1cc(CN(C2)CC2Oc(cc2)ccc2-c(cc2)cnc2S(C)=O)ccc1 Chemical compound Cc1cc(CN(C2)CC2Oc(cc2)ccc2-c(cc2)cnc2S(C)=O)ccc1 YNLVFSBJFIXWRG-UHFFFAOYSA-N 0.000 description 1
- GZPSUGVXNAHNPR-UHFFFAOYSA-N N#Cc(cc1)ccc1-c(cc1)ccc1OC1CN(Cc(cc2)ccc2Oc2ccccc2)C1 Chemical compound N#Cc(cc1)ccc1-c(cc1)ccc1OC1CN(Cc(cc2)ccc2Oc2ccccc2)C1 GZPSUGVXNAHNPR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0607196.3A GB0607196D0 (en) | 2006-04-11 | 2006-04-11 | G-protein coupled receptor agonists |
| GB0607196.3 | 2006-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20080109085A true KR20080109085A (ko) | 2008-12-16 |
Family
ID=36539676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087027643A Ceased KR20080109085A (ko) | 2006-04-11 | 2007-04-11 | Ｇ-단백질 결합 수용체(ｇｐｒ119) 작용제로서의 아제티딘 유도체 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20090281076A1 (enExample) |
| EP (1) | EP2010485B1 (enExample) |
| JP (1) | JP2009533410A (enExample) |
| KR (1) | KR20080109085A (enExample) |
| CN (1) | CN101466667A (enExample) |
| AU (1) | AU2007235674A1 (enExample) |
| BR (1) | BRPI0709953A2 (enExample) |
| CA (1) | CA2648687A1 (enExample) |
| GB (1) | GB0607196D0 (enExample) |
| MX (1) | MX2008012946A (enExample) |
| NO (1) | NO20084364L (enExample) |
| NZ (1) | NZ571962A (enExample) |
| WO (1) | WO2007116230A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| EP2200609A1 (en) | 2007-09-10 | 2010-06-30 | Prosidion Limited | Compounds for the treatment of metabolic disorders |
| MX2010003117A (es) | 2007-09-20 | 2010-04-01 | Irm Llc | Compuestos y composiciones como moduladores de la actividad de gpr119. |
| GB0720390D0 (en) | 2007-10-18 | 2007-11-28 | Prosidion Ltd | G-Protein coupled receptor agonists |
| GB0720389D0 (en) * | 2007-10-18 | 2008-11-12 | Prosidion Ltd | G-Protein Coupled Receptor Agonists |
| KR20100120689A (ko) * | 2008-02-22 | 2010-11-16 | 아이알엠 엘엘씨 | Ｇｐｒ119 활성의 조절제로서의 화합물 및 조성물 |
| US20110172244A1 (en) * | 2008-02-22 | 2011-07-14 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
| EP2108960A1 (en) | 2008-04-07 | 2009-10-14 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY |
| EA018703B1 (ru) * | 2008-04-07 | 2013-10-30 | Айрм Ллк | Соединения и композиции в качестве модуляторов активности gpr119 |
| CA2730593A1 (en) * | 2008-07-16 | 2010-01-21 | Schering Corporation | Bicyclic heterocycle derivatives and use thereof as gpr119 modulators |
| US8642583B2 (en) | 2008-10-30 | 2014-02-04 | Janssen Pharmaceutica Nv | Serotonin receptor modulators |
| WO2010059390A1 (en) | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Modulators of serotonin receptor |
| WO2010084512A1 (en) | 2008-12-24 | 2010-07-29 | Cadila Healthcare Limited | Novel oxime derivatives |
| GB0904285D0 (en) | 2009-03-12 | 2009-04-22 | Prosidion Ltd | Compounds for the treatment of metabolic disorders |
| GB0904287D0 (en) | 2009-03-12 | 2009-04-22 | Prosidion Ltd | Compounds for the treatment of metabolic disorders |
| GB0904284D0 (en) | 2009-03-12 | 2009-04-22 | Prosidion Ltd | Compounds for the treatment of metabolic disorders |
| US8293729B2 (en) | 2009-06-24 | 2012-10-23 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical composition and methods relating thereto |
| US8481731B2 (en) | 2009-06-24 | 2013-07-09 | Boehringer Ingelheim International Gmbh | Compounds, pharmaceutical composition and methods relating thereto |
| JP2013507366A (ja) * | 2009-10-09 | 2013-03-04 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Ｇｐｒ１１９活性モジュレーターとしての化合物および組成物 |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| US20130109703A1 (en) | 2010-03-18 | 2013-05-02 | Boehringer Ingelheim International Gmbh | Combination of a GPR119 Agonist and the DPP-IV Inhibitor Linagliptin for Use in the Treatment of Diabetes and Related Conditions |
| GB201006167D0 (en) | 2010-04-14 | 2010-05-26 | Prosidion Ltd | Compounds for the treatment of metabolic disorders |
| GB201006166D0 (en) | 2010-04-14 | 2010-05-26 | Prosidion Ltd | Compounds for the treatment of metabolic disorders |
| TW201209054A (en) | 2010-05-28 | 2012-03-01 | Prosidion Ltd | Novel compounds |
| EP2582709B1 (de) | 2010-06-18 | 2018-01-24 | Sanofi | Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| WO2012025811A1 (en) | 2010-08-23 | 2012-03-01 | Lupin Limited | Indolylpyrimidines as modulators of gpr119 |
| EP2616441B1 (en) | 2010-09-17 | 2019-08-07 | Purdue Pharma L.P. | Pyridine compounds and the uses thereof |
| PH12013500671A1 (en) | 2010-10-08 | 2018-04-11 | Cadila Healthcare Ltd | Novel gpr 119 agonists |
| AR083904A1 (es) | 2010-11-18 | 2013-04-10 | Prosidion Ltd | Derivados de 1,4-pirrolidinas disustituidos y 3-il-aminas y sus usos en el tratamiento de desordenes metabolicos |
| GB201114389D0 (en) | 2011-08-22 | 2011-10-05 | Prosidion Ltd | Novel compounds |
| WO2012069917A1 (en) | 2010-11-26 | 2012-05-31 | Lupin Limited | Bicyclic gpr119 modulators |
| EP2683704B1 (de) | 2011-03-08 | 2014-12-17 | Sanofi | Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2766349B1 (de) | 2011-03-08 | 2016-06-01 | Sanofi | Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung |
| WO2012120054A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012120056A1 (de) | 2011-03-08 | 2012-09-13 | Sanofi | Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| WO2012170867A1 (en) | 2011-06-09 | 2012-12-13 | Rhizen Pharmaceuticals Sa | Novel compounds as modulators of gpr-119 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2872127A1 (en) | 2012-07-11 | 2015-05-20 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| CN104788424A (zh) * | 2015-03-12 | 2015-07-22 | 佛山市赛维斯医药科技有限公司 | 含烟酸酰胺和哌啶结构的ptp1b抑制剂、制备方法及其用途 |
| CN104725355A (zh) * | 2015-03-12 | 2015-06-24 | 佛山市赛维斯医药科技有限公司 | 一种含烟酸酰胺和哌啶结构ptp1b抑制剂及其用途 |
| CN104725354A (zh) * | 2015-03-12 | 2015-06-24 | 佛山市赛维斯医药科技有限公司 | 一类含烟酸酰胺和哌啶结构化合物及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5130309A (en) * | 1991-04-12 | 1992-07-14 | A. H. Robins Company, Incorporated | Aryloxy and aryloxyalklazetidines as antiarrhythmic and anticonvulsant agents |
| SK101199A3 (en) * | 1997-02-10 | 2000-10-09 | Pfizer Prod Inc | 2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines, their use and pharmaceutical compositions based thereupon |
| TW200305395A (en) * | 2002-03-15 | 2003-11-01 | Novartis Ag | Organic compounds |
| SE0301368D0 (sv) * | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Chemical compounds |
| WO2005061489A1 (en) * | 2003-12-24 | 2005-07-07 | Prosidion Limited | Heterocyclic derivatives as gpcr receptor agonists |
| EP2316458A1 (en) * | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| AP2007004047A0 (en) * | 2005-01-20 | 2007-06-30 | Pfizer Ltd | Substituted triazole derivatives as oxtocin antagonists |
| CA2606288A1 (en) * | 2005-04-18 | 2006-10-26 | Neurogen Corporation | Subtituted heteroaryl cb1 antagonists |
-
2006
- 2006-04-11 GB GBGB0607196.3A patent/GB0607196D0/en not_active Ceased
-
2007
- 2007-04-11 AU AU2007235674A patent/AU2007235674A1/en not_active Abandoned
- 2007-04-11 US US12/296,717 patent/US20090281076A1/en not_active Abandoned
- 2007-04-11 MX MX2008012946A patent/MX2008012946A/es active IP Right Grant
- 2007-04-11 BR BRPI0709953-3A patent/BRPI0709953A2/pt not_active IP Right Cessation
- 2007-04-11 EP EP07733612A patent/EP2010485B1/en active Active
- 2007-04-11 JP JP2009504834A patent/JP2009533410A/ja active Pending
- 2007-04-11 KR KR1020087027643A patent/KR20080109085A/ko not_active Ceased
- 2007-04-11 NZ NZ571962A patent/NZ571962A/en not_active IP Right Cessation
- 2007-04-11 WO PCT/GB2007/050190 patent/WO2007116230A1/en not_active Ceased
- 2007-04-11 CN CNA2007800217539A patent/CN101466667A/zh active Pending
- 2007-04-11 CA CA002648687A patent/CA2648687A1/en not_active Abandoned
-
2008
- 2008-10-17 NO NO20084364A patent/NO20084364L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007116230A1 (en) | 2007-10-18 |
| BRPI0709953A2 (pt) | 2011-08-02 |
| US20090281076A1 (en) | 2009-11-12 |
| MX2008012946A (es) | 2008-11-28 |
| AU2007235674A1 (en) | 2007-10-18 |
| CN101466667A (zh) | 2009-06-24 |
| EP2010485A1 (en) | 2009-01-07 |
| JP2009533410A (ja) | 2009-09-17 |
| CA2648687A1 (en) | 2007-10-18 |
| GB0607196D0 (en) | 2006-05-17 |
| NZ571962A (en) | 2011-07-29 |
| NO20084364L (no) | 2008-10-31 |
| WO2007116230A8 (en) | 2007-12-27 |
| EP2010485B1 (en) | 2012-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20081111 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
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