KR20080109085A - Ｇ-단백질 결합 수용체(ｇｐｒ119) 작용제로서의 아제티딘 유도체 - Google Patents
Ｇ-단백질 결합 수용체(ｇｐｒ119) 작용제로서의 아제티딘 유도체 Download PDFInfo
- Publication number
- KR20080109085A KR20080109085A KR1020087027643A KR20087027643A KR20080109085A KR 20080109085 A KR20080109085 A KR 20080109085A KR 1020087027643 A KR1020087027643 A KR 1020087027643A KR 20087027643 A KR20087027643 A KR 20087027643A KR 20080109085 A KR20080109085 A KR 20080109085A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- pharmaceutically acceptable
- alkyl
- acceptable salt
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- OKSRCHHNHPVNNZ-UHFFFAOYSA-O CC(CC1)C=CC1Oc1ccc(CN(C2)CC2Oc(cc2)ccc2-c(cc2)ccc2S(C)([OH2+])=O)cc1 Chemical compound CC(CC1)C=CC1Oc1ccc(CN(C2)CC2Oc(cc2)ccc2-c(cc2)ccc2S(C)([OH2+])=O)cc1 OKSRCHHNHPVNNZ-UHFFFAOYSA-O 0.000 description 1
- SYVPUGOJMOLVGP-UHFFFAOYSA-O CS(C1=CC=C(c(cc2)ccc2OC2CN(Cc(cc3)ccc3OC3C=CC=CC3)C2)NC1)([OH2+])=O Chemical compound CS(C1=CC=C(c(cc2)ccc2OC2CN(Cc(cc3)ccc3OC3C=CC=CC3)C2)NC1)([OH2+])=O SYVPUGOJMOLVGP-UHFFFAOYSA-O 0.000 description 1
- JKKQKXUAEIZMSX-UHFFFAOYSA-N CS(c(cc1)ncc1-c(cc1)ccc1OC1CN(Cc(cc2)ccc2OC(F)(F)F)C1)=O Chemical compound CS(c(cc1)ncc1-c(cc1)ccc1OC1CN(Cc(cc2)ccc2OC(F)(F)F)C1)=O JKKQKXUAEIZMSX-UHFFFAOYSA-N 0.000 description 1
- WXPRCKQCESNJFC-UHFFFAOYSA-N CS(c(cc1)ncc1-c(cc1)ccc1OC1CN(Cc2ccccc2)C1)=O Chemical compound CS(c(cc1)ncc1-c(cc1)ccc1OC1CN(Cc2ccccc2)C1)=O WXPRCKQCESNJFC-UHFFFAOYSA-N 0.000 description 1
- YNLVFSBJFIXWRG-UHFFFAOYSA-N Cc1cc(CN(C2)CC2Oc(cc2)ccc2-c(cc2)cnc2S(C)=O)ccc1 Chemical compound Cc1cc(CN(C2)CC2Oc(cc2)ccc2-c(cc2)cnc2S(C)=O)ccc1 YNLVFSBJFIXWRG-UHFFFAOYSA-N 0.000 description 1
- GZPSUGVXNAHNPR-UHFFFAOYSA-N N#Cc(cc1)ccc1-c(cc1)ccc1OC1CN(Cc(cc2)ccc2Oc2ccccc2)C1 Chemical compound N#Cc(cc1)ccc1-c(cc1)ccc1OC1CN(Cc(cc2)ccc2Oc2ccccc2)C1 GZPSUGVXNAHNPR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0607196.3A GB0607196D0 (en) | 2006-04-11 | 2006-04-11 | G-protein coupled receptor agonists |
| GB0607196.3 | 2006-04-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20080109085A true KR20080109085A (ko) | 2008-12-16 |
Family
ID=36539676
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087027643A Ceased KR20080109085A (ko) | 2006-04-11 | 2007-04-11 | Ｇ-단백질 결합 수용체(ｇｐｒ119) 작용제로서의 아제티딘 유도체 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20090281076A1 (enExample) |
| EP (1) | EP2010485B1 (enExample) |
| JP (1) | JP2009533410A (enExample) |
| KR (1) | KR20080109085A (enExample) |
| CN (1) | CN101466667A (enExample) |
| AU (1) | AU2007235674A1 (enExample) |
| BR (1) | BRPI0709953A2 (enExample) |
| CA (1) | CA2648687A1 (enExample) |
| GB (1) | GB0607196D0 (enExample) |
| MX (1) | MX2008012946A (enExample) |
| NO (1) | NO20084364L (enExample) |
| NZ (1) | NZ571962A (enExample) |
| WO (1) | WO2007116230A1 (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2025674A1 (de) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| US20100286112A1 (en) | 2007-09-10 | 2010-11-11 | Oscar Barba | Compounds for the treatment of metabolic disorders |
| JP5465177B2 (ja) | 2007-09-20 | 2014-04-09 | アイアールエム・リミテッド・ライアビリティ・カンパニー | Ｇｐｒ１１９活性のモジュレーターとしての化合物および組成物 |
| GB0720390D0 (en) | 2007-10-18 | 2007-11-28 | Prosidion Ltd | G-Protein coupled receptor agonists |
| GB0720389D0 (en) * | 2007-10-18 | 2008-11-12 | Prosidion Ltd | G-Protein Coupled Receptor Agonists |
| CA2714703A1 (en) * | 2008-02-22 | 2009-08-27 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
| CA2716332A1 (en) * | 2008-02-22 | 2009-08-27 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
| EP2146210A1 (en) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY |
| CA2720950A1 (en) * | 2008-04-07 | 2009-10-15 | Irm Llc | Compounds and compositions as modulators of gpr119 activity |
| MX2011000664A (es) * | 2008-07-16 | 2011-02-24 | Schering Corp | Derivados biciclicos heterociclicos y uso de los mismos como moduladores de gpr119. |
| US8575364B2 (en) | 2008-10-30 | 2013-11-05 | Janssen Pharmaceutica Nv | Modulators of serotonin receptor |
| WO2010059393A1 (en) | 2008-10-30 | 2010-05-27 | Janssen Pharmaceutica Nv | Serotonin receptor modulators |
| ES2403120T3 (es) | 2008-12-24 | 2013-05-14 | Cadila Healthcare Limited | Nuevos derivados de oxima |
| GB0904284D0 (en) | 2009-03-12 | 2009-04-22 | Prosidion Ltd | Compounds for the treatment of metabolic disorders |
| GB0904285D0 (en) | 2009-03-12 | 2009-04-22 | Prosidion Ltd | Compounds for the treatment of metabolic disorders |
| GB0904287D0 (en) | 2009-03-12 | 2009-04-22 | Prosidion Ltd | Compounds for the treatment of metabolic disorders |
| TW201111361A (en) | 2009-06-24 | 2011-04-01 | Boehringer Ingelheim Int | New compounds, pharmaceutical composition and methods relating thereto |
| TW201113269A (en) | 2009-06-24 | 2011-04-16 | Boehringer Ingelheim Int | New compounds, pharmaceutical composition and methods relating thereto |
| MX2012004078A (es) * | 2009-10-09 | 2012-07-25 | Irm Llc | Compuestos y composiciones como moduladores de la actividad de gpr119. |
| WO2011107494A1 (de) | 2010-03-03 | 2011-09-09 | Sanofi | Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung |
| EP2547339A1 (en) | 2010-03-18 | 2013-01-23 | Boehringer Ingelheim International GmbH | Combination of a gpr119 agonist and the dpp-iv inhibitor linagliptin for use in the treatment of diabetes and related conditions |
| GB201006167D0 (en) | 2010-04-14 | 2010-05-26 | Prosidion Ltd | Compounds for the treatment of metabolic disorders |
| GB201006166D0 (en) | 2010-04-14 | 2010-05-26 | Prosidion Ltd | Compounds for the treatment of metabolic disorders |
| TW201209054A (en) | 2010-05-28 | 2012-03-01 | Prosidion Ltd | Novel compounds |
| US8933024B2 (en) | 2010-06-18 | 2015-01-13 | Sanofi | Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases |
| US8530413B2 (en) | 2010-06-21 | 2013-09-10 | Sanofi | Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments |
| TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
| TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
| TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
| WO2012025811A1 (en) | 2010-08-23 | 2012-03-01 | Lupin Limited | Indolylpyrimidines as modulators of gpr119 |
| AU2011303597A1 (en) | 2010-09-17 | 2013-04-11 | Purdue Pharma L.P. | Pyridine compounds and the uses thereof |
| KR101563793B1 (ko) | 2010-10-08 | 2015-10-27 | 카딜라 핼쓰캐어 리미티드 | 신규한 ｇｐｒ 119 작용물질 |
| AR083904A1 (es) | 2010-11-18 | 2013-04-10 | Prosidion Ltd | Derivados de 1,4-pirrolidinas disustituidos y 3-il-aminas y sus usos en el tratamiento de desordenes metabolicos |
| GB201114389D0 (en) | 2011-08-22 | 2011-10-05 | Prosidion Ltd | Novel compounds |
| EP2643311A1 (en) | 2010-11-26 | 2013-10-02 | Lupin Limited | Bicyclic gpr119 modulators |
| EP2683699B1 (de) | 2011-03-08 | 2015-06-24 | Sanofi | Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung |
| US8828994B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
| US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
| US8828995B2 (en) | 2011-03-08 | 2014-09-09 | Sanofi | Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof |
| US9181214B2 (en) | 2011-06-09 | 2015-11-10 | Rhizen Pharmaceuticals Sa | Bicyclic compounds as modulators of GPR-119 |
| WO2013037390A1 (en) | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2872127A1 (en) | 2012-07-11 | 2015-05-20 | Elcelyx Therapeutics, Inc. | Compositions comprising statins, biguanides and further agents for reducing cardiometabolic risk |
| CN104725354A (zh) * | 2015-03-12 | 2015-06-24 | 佛山市赛维斯医药科技有限公司 | 一类含烟酸酰胺和哌啶结构化合物及其用途 |
| CN104788424A (zh) * | 2015-03-12 | 2015-07-22 | 佛山市赛维斯医药科技有限公司 | 含烟酸酰胺和哌啶结构的ptp1b抑制剂、制备方法及其用途 |
| CN106749179A (zh) * | 2015-03-12 | 2017-05-31 | 佛山市赛维斯医药科技有限公司 | 一种含烟酸酰胺和哌啶结构ptp1b抑制剂及其用途 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5130309A (en) * | 1991-04-12 | 1992-07-14 | A. H. Robins Company, Incorporated | Aryloxy and aryloxyalklazetidines as antiarrhythmic and anticonvulsant agents |
| NZ336623A (en) * | 1997-02-10 | 2000-11-24 | Pfizer Prod Inc | 2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines for use in the treatment and prevention of disorders of the central nervous system |
| AR041786A1 (es) * | 2002-03-15 | 2005-06-01 | Novartis Ag | Derivados de azetidina como antagonistas del receptor ccr-3, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la elaboracion de un medicamento |
| SE0301368D0 (sv) * | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Chemical compounds |
| JP4958560B2 (ja) * | 2003-12-24 | 2012-06-20 | プロシディオン・リミテッド | Ｇｐｃｒ受容体作動薬としてのヘテロ環誘導体 |
| AR051094A1 (es) * | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| AP2007004047A0 (en) * | 2005-01-20 | 2007-06-30 | Pfizer Ltd | Substituted triazole derivatives as oxtocin antagonists |
| WO2006113704A2 (en) * | 2005-04-18 | 2006-10-26 | Neurogen Corporation | Subtituted heteroaryl cb1 antagonists |
-
2006
- 2006-04-11 GB GBGB0607196.3A patent/GB0607196D0/en not_active Ceased
-
2007
- 2007-04-11 CA CA002648687A patent/CA2648687A1/en not_active Abandoned
- 2007-04-11 EP EP07733612A patent/EP2010485B1/en active Active
- 2007-04-11 AU AU2007235674A patent/AU2007235674A1/en not_active Abandoned
- 2007-04-11 CN CNA2007800217539A patent/CN101466667A/zh active Pending
- 2007-04-11 BR BRPI0709953-3A patent/BRPI0709953A2/pt not_active IP Right Cessation
- 2007-04-11 NZ NZ571962A patent/NZ571962A/en not_active IP Right Cessation
- 2007-04-11 WO PCT/GB2007/050190 patent/WO2007116230A1/en not_active Ceased
- 2007-04-11 JP JP2009504834A patent/JP2009533410A/ja active Pending
- 2007-04-11 US US12/296,717 patent/US20090281076A1/en not_active Abandoned
- 2007-04-11 MX MX2008012946A patent/MX2008012946A/es active IP Right Grant
- 2007-04-11 KR KR1020087027643A patent/KR20080109085A/ko not_active Ceased
-
2008
- 2008-10-17 NO NO20084364A patent/NO20084364L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20084364L (no) | 2008-10-31 |
| EP2010485B1 (en) | 2012-10-17 |
| NZ571962A (en) | 2011-07-29 |
| WO2007116230A1 (en) | 2007-10-18 |
| EP2010485A1 (en) | 2009-01-07 |
| BRPI0709953A2 (pt) | 2011-08-02 |
| AU2007235674A1 (en) | 2007-10-18 |
| JP2009533410A (ja) | 2009-09-17 |
| CA2648687A1 (en) | 2007-10-18 |
| CN101466667A (zh) | 2009-06-24 |
| US20090281076A1 (en) | 2009-11-12 |
| GB0607196D0 (en) | 2006-05-17 |
| MX2008012946A (es) | 2008-11-28 |
| WO2007116230A8 (en) | 2007-12-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20081111 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| A201 | Request for examination | ||
| PA0201 | Request for examination |
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