KR20080007357A - 압축성이 열등한 치료학적 화합물을 갖는 조성물을제조하는 압출방법 - Google Patents

압축성이 열등한 치료학적 화합물을 갖는 조성물을제조하는 압출방법 Download PDF

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Publication number
KR20080007357A
KR20080007357A KR1020077026095A KR20077026095A KR20080007357A KR 20080007357 A KR20080007357 A KR 20080007357A KR 1020077026095 A KR1020077026095 A KR 1020077026095A KR 20077026095 A KR20077026095 A KR 20077026095A KR 20080007357 A KR20080007357 A KR 20080007357A
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KR
South Korea
Prior art keywords
therapeutic compound
mixture
granules
pharmaceutical composition
extruder
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020077026095A
Other languages
English (en)
Korean (ko)
Inventor
마다브 바산타바다
제이 라크쉬만
웨이-친 통
아부 티. 엠. 세라주딘
야틴드라 조시
제임스 코왈스키
Original Assignee
노파르티스 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20080007357A publication Critical patent/KR20080007357A/ko
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020077026095A 2005-05-10 2006-05-08 압축성이 열등한 치료학적 화합물을 갖는 조성물을제조하는 압출방법 Ceased KR20080007357A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US67958705P 2005-05-10 2005-05-10
US60/679,587 2005-05-10
US69315505P 2005-06-23 2005-06-23
US60/693,155 2005-06-23

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020137031633A Division KR20130135403A (ko) 2005-05-10 2006-05-08 압축성이 열등한 치료학적 화합물을 갖는 조성물을 제조하는 압출방법

Publications (1)

Publication Number Publication Date
KR20080007357A true KR20080007357A (ko) 2008-01-18

Family

ID=37022916

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020077026095A Ceased KR20080007357A (ko) 2005-05-10 2006-05-08 압축성이 열등한 치료학적 화합물을 갖는 조성물을제조하는 압출방법
KR1020137031633A Ceased KR20130135403A (ko) 2005-05-10 2006-05-08 압축성이 열등한 치료학적 화합물을 갖는 조성물을 제조하는 압출방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020137031633A Ceased KR20130135403A (ko) 2005-05-10 2006-05-08 압축성이 열등한 치료학적 화합물을 갖는 조성물을 제조하는 압출방법

Country Status (16)

Country Link
US (2) US20100152299A1 (https=)
EP (1) EP1881819A1 (https=)
JP (1) JP5400377B2 (https=)
KR (2) KR20080007357A (https=)
CN (1) CN102552162A (https=)
AU (2) AU2006244213B2 (https=)
BR (1) BRPI0608609A2 (https=)
CA (1) CA2607624A1 (https=)
IL (1) IL186456A0 (https=)
MA (1) MA29465B1 (https=)
MX (1) MX2007014041A (https=)
NO (1) NO20076298L (https=)
NZ (2) NZ562304A (https=)
RU (1) RU2405539C2 (https=)
TN (1) TNSN07415A1 (https=)
WO (1) WO2006122021A1 (https=)

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JP6449871B2 (ja) 2013-07-12 2019-01-09 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング エチレン−酢酸ビニルポリマーを含有する改変防止剤形
CA3042642A1 (en) 2013-08-12 2015-02-19 Pharmaceutical Manufacturing Research Services, Inc. Extruded immediate release abuse deterrent pill
EP3073994A1 (en) 2013-11-26 2016-10-05 Grünenthal GmbH Preparation of a powdery pharmaceutical composition by means of cryo-milling
US10172797B2 (en) 2013-12-17 2019-01-08 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
EP3142646A1 (en) 2014-05-12 2017-03-22 Grünenthal GmbH Tamper resistant immediate release capsule formulation comprising tapentadol
EA201692388A1 (ru) 2014-05-26 2017-05-31 Грюненталь Гмбх Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы
CA2955229C (en) 2014-07-17 2020-03-10 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
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CA2983640A1 (en) 2015-04-24 2016-10-27 Grunenthal Gmbh Tamper-resistant fixed dose combination providing fast release of two drugs from different particles
US20160310437A1 (en) 2015-04-24 2016-10-27 Grünenthal GmbH Tamper-resistant fixed dose combination providing fast release of two drugs from particles
BR112017021475A2 (pt) 2015-04-24 2018-07-10 Gruenenthal Gmbh forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente
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Also Published As

Publication number Publication date
EP1881819A1 (en) 2008-01-30
MA29465B1 (fr) 2008-05-02
AU2006244213A1 (en) 2006-11-16
RU2405539C2 (ru) 2010-12-10
JP2008540540A (ja) 2008-11-20
WO2006122021A1 (en) 2006-11-16
TNSN07415A1 (en) 2009-03-17
IL186456A0 (en) 2008-01-20
CN102552162A (zh) 2012-07-11
KR20130135403A (ko) 2013-12-10
US20120077879A1 (en) 2012-03-29
US20100152299A1 (en) 2010-06-17
AU2010212296B2 (en) 2011-06-16
AU2006244213B2 (en) 2010-05-13
CA2607624A1 (en) 2006-11-16
MX2007014041A (es) 2008-02-11
NO20076298L (no) 2007-12-06
NZ585116A (en) 2011-12-22
BRPI0608609A2 (pt) 2010-01-19
NZ562304A (en) 2010-06-25
RU2007145522A (ru) 2009-06-20
JP5400377B2 (ja) 2014-01-29
AU2010212296A1 (en) 2010-09-02

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