NZ562304A - Extrusion process for making compositions with poorly compressible therapeutic compounds e.g. metformin hydrochloride - Google Patents
Extrusion process for making compositions with poorly compressible therapeutic compounds e.g. metformin hydrochlorideInfo
- Publication number
- NZ562304A NZ562304A NZ562304A NZ56230406A NZ562304A NZ 562304 A NZ562304 A NZ 562304A NZ 562304 A NZ562304 A NZ 562304A NZ 56230406 A NZ56230406 A NZ 56230406A NZ 562304 A NZ562304 A NZ 562304A
- Authority
- NZ
- New Zealand
- Prior art keywords
- therapeutic compound
- mixture
- metformin hydrochloride
- extruder
- poorly compressible
- Prior art date
Links
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- 229960004329 metformin hydrochloride Drugs 0.000 title claims abstract description 15
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ585116A NZ585116A (en) | 2005-05-10 | 2006-05-08 | Extrusion process for making compositions with poorly compressible therapeutic compounds e.g. metformin hydrochloride |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67958705P | 2005-05-10 | 2005-05-10 | |
| US69315505P | 2005-06-23 | 2005-06-23 | |
| PCT/US2006/017708 WO2006122021A1 (en) | 2005-05-10 | 2006-05-08 | Extrusion process for making compositions with poorly compressible therapeutic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ562304A true NZ562304A (en) | 2010-06-25 |
Family
ID=37022916
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ562304A NZ562304A (en) | 2005-05-10 | 2006-05-08 | Extrusion process for making compositions with poorly compressible therapeutic compounds e.g. metformin hydrochloride |
| NZ585116A NZ585116A (en) | 2005-05-10 | 2006-05-08 | Extrusion process for making compositions with poorly compressible therapeutic compounds e.g. metformin hydrochloride |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ585116A NZ585116A (en) | 2005-05-10 | 2006-05-08 | Extrusion process for making compositions with poorly compressible therapeutic compounds e.g. metformin hydrochloride |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20100152299A1 (https=) |
| EP (1) | EP1881819A1 (https=) |
| JP (1) | JP5400377B2 (https=) |
| KR (2) | KR20080007357A (https=) |
| CN (1) | CN102552162A (https=) |
| AU (2) | AU2006244213B2 (https=) |
| BR (1) | BRPI0608609A2 (https=) |
| CA (1) | CA2607624A1 (https=) |
| IL (1) | IL186456A0 (https=) |
| MA (1) | MA29465B1 (https=) |
| MX (1) | MX2007014041A (https=) |
| NO (1) | NO20076298L (https=) |
| NZ (2) | NZ562304A (https=) |
| RU (1) | RU2405539C2 (https=) |
| TN (1) | TNSN07415A1 (https=) |
| WO (1) | WO2006122021A1 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7776314B2 (en) | 2002-06-17 | 2010-08-17 | Grunenthal Gmbh | Abuse-proofed dosage system |
| DE10361596A1 (de) | 2003-12-24 | 2005-09-29 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| DE10336400A1 (de) | 2003-08-06 | 2005-03-24 | Grünenthal GmbH | Gegen Missbrauch gesicherte Darreichungsform |
| US20070048228A1 (en) | 2003-08-06 | 2007-03-01 | Elisabeth Arkenau-Maric | Abuse-proofed dosage form |
| DE102005005446A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| DE102004032049A1 (de) | 2004-07-01 | 2006-01-19 | Grünenthal GmbH | Gegen Missbrauch gesicherte, orale Darreichungsform |
| DE102005005449A1 (de) | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform |
| GB2447898B (en) * | 2007-03-24 | 2011-08-17 | Reckitt Benckiser Healthcare | A tablet having improved stability with at least two actives |
| KR101616246B1 (ko) | 2008-01-25 | 2016-05-02 | 그뤼넨탈 게엠베하 | 약제학적 투여형 |
| MX2010011962A (es) * | 2008-04-30 | 2010-11-30 | Novartis Ag | Proceso continuo para hacer composiciones farmaceuticas. |
| BRPI0913843A2 (pt) * | 2008-07-03 | 2015-10-20 | Novartis Ag | processo de granulação por fusão |
| WO2011009602A1 (en) | 2009-07-22 | 2011-01-27 | Grünenthal GmbH | Hot-melt extruded controlled release dosage form |
| TWI473628B (zh) | 2009-07-22 | 2015-02-21 | 用於對氧化敏感之類鴉片藥劑之抗破壞劑型 | |
| WO2012028318A1 (en) | 2010-09-02 | 2012-03-08 | Grünenthal GmbH | Tamper resistant dosage form comprising an anionic polymer |
| CA2808219C (en) | 2010-09-02 | 2019-05-14 | Gruenenthal Gmbh | Tamper resistant dosage form comprising inorganic salt |
| AU2012289764B2 (en) | 2011-07-29 | 2017-03-02 | Grünenthal GmbH | Tamper-resistant tablet providing immediate drug release |
| ES2648129T3 (es) | 2011-07-29 | 2017-12-28 | Grünenthal GmbH | Pastilla a prueba de manipulación que proporciona una liberación inmediata de un medicamento |
| US20130225697A1 (en) | 2012-02-28 | 2013-08-29 | Grunenthal Gmbh | Tamper-resistant dosage form comprising pharmacologically active compound and anionic polymer |
| PL2838512T3 (pl) | 2012-04-18 | 2018-12-31 | Grünenthal GmbH | Farmaceutyczna postać dawkowania odporna na niewłaściwe użycie i odporna na uderzeniowe uwalnianie dawki |
| US10064945B2 (en) | 2012-05-11 | 2018-09-04 | Gruenenthal Gmbh | Thermoformed, tamper-resistant pharmaceutical dosage form containing zinc |
| GB201218012D0 (en) * | 2012-10-08 | 2012-11-21 | Jagotec Ag | Dosage forms |
| AU2014273227B2 (en) | 2013-05-29 | 2019-08-15 | Grunenthal Gmbh | Tamper-resistant dosage form containing one or more particles |
| JP6466417B2 (ja) | 2013-05-29 | 2019-02-06 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 二峰性放出プロファイルを有する改変防止（ｔａｍｐｅｒ−ｒｅｓｉｓｔａｎｔ）剤形 |
| JP6449871B2 (ja) | 2013-07-12 | 2019-01-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | エチレン−酢酸ビニルポリマーを含有する改変防止剤形 |
| CA3042642A1 (en) | 2013-08-12 | 2015-02-19 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded immediate release abuse deterrent pill |
| EP3073994A1 (en) | 2013-11-26 | 2016-10-05 | Grünenthal GmbH | Preparation of a powdery pharmaceutical composition by means of cryo-milling |
| US10172797B2 (en) | 2013-12-17 | 2019-01-08 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| US9492444B2 (en) | 2013-12-17 | 2016-11-15 | Pharmaceutical Manufacturing Research Services, Inc. | Extruded extended release abuse deterrent pill |
| EP3142646A1 (en) | 2014-05-12 | 2017-03-22 | Grünenthal GmbH | Tamper resistant immediate release capsule formulation comprising tapentadol |
| EA201692388A1 (ru) | 2014-05-26 | 2017-05-31 | Грюненталь Гмбх | Лекарственная форма в виде множества частиц, защищенная от вызываемого этанолом сброса дозы |
| CA2955229C (en) | 2014-07-17 | 2020-03-10 | Pharmaceutical Manufacturing Research Services, Inc. | Immediate release abuse deterrent liquid fill dosage form |
| WO2016064873A1 (en) | 2014-10-20 | 2016-04-28 | Pharmaceutical Manufacturing Research Services, Inc. | Extended release abuse deterrent liquid fill dosage form |
| CA2983640A1 (en) | 2015-04-24 | 2016-10-27 | Grunenthal Gmbh | Tamper-resistant fixed dose combination providing fast release of two drugs from different particles |
| US20160310437A1 (en) | 2015-04-24 | 2016-10-27 | Grünenthal GmbH | Tamper-resistant fixed dose combination providing fast release of two drugs from particles |
| BR112017021475A2 (pt) | 2015-04-24 | 2018-07-10 | Gruenenthal Gmbh | forma de dosagem resistente à adulteração (tamper) com liberação imediata e resistência contra extração de solvente |
| MX2017013643A (es) | 2015-04-24 | 2018-03-08 | Gruenenthal Gmbh | Combinacion de dosis fija resistente a la manipulacion que proporciona una liberacion rapida de dos farmacos desde particulas y una matriz. |
| WO2017042325A1 (en) | 2015-09-10 | 2017-03-16 | Grünenthal GmbH | Protecting oral overdose with abuse deterrent immediate release formulations |
| DE102018010063A1 (de) | 2018-03-16 | 2019-09-19 | Ludwig-Maximilians-Universität München | Herstellung vesikulärer Phospholipid-Gele durch Schnecken-Extrusion |
| CN108888599B (zh) * | 2018-07-26 | 2021-06-08 | 国药集团致君（深圳）制药有限公司 | 双氯芬酸钠缓释组合物及其制备方法 |
| CN116887866A (zh) | 2020-12-03 | 2023-10-13 | 巴特尔纪念研究院 | 聚合物纳米颗粒和dna纳米结构组合物及用于非病毒递送的方法 |
| WO2022216977A1 (en) | 2021-04-07 | 2022-10-13 | Batelle Memorial Institute | Rapid design, build, test, and learn technologies for identifying and using non-viral carriers |
| WO2023088962A1 (en) * | 2021-11-16 | 2023-05-25 | Dsm Ip Assets B.V. | Granule comprising encapsulated active ingredients |
| US20250009005A1 (en) * | 2021-11-16 | 2025-01-09 | Dsm Ip Assets B.V. | High potency granules obtainable by continuous melt granulation |
| WO2023145871A1 (ja) * | 2022-01-31 | 2023-08-03 | 住友精化株式会社 | 製剤用組成物の製造方法及び製剤の製造方法 |
| WO2023145869A1 (ja) * | 2022-01-31 | 2023-08-03 | 住友精化株式会社 | 製剤用組成物の製造方法及び製剤の製造方法 |
| TW202412735A (zh) * | 2022-08-31 | 2024-04-01 | 義大利商沙克米機械合作伊莫拉公司 | 製造固體藥劑的方法及裝置 |
| WO2025072751A1 (en) | 2023-09-29 | 2025-04-03 | Battelle Memorial Institute | Polymer nanoparticle compositions for in vivo expression of polypeptides |
| US12441996B2 (en) | 2023-12-08 | 2025-10-14 | Battelle Memorial Institute | Use of DNA origami nanostructures for molecular information based data storage systems |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2571046B1 (fr) * | 1984-10-03 | 1987-10-16 | Roquette Freres | Procede de preparation de mannitol granulaire directement compressible |
| US5965161A (en) * | 1994-11-04 | 1999-10-12 | Euro-Celtique, S.A. | Extruded multi-particulates |
| DE19504831A1 (de) * | 1995-02-14 | 1996-09-05 | Basf Ag | Feste Wirkstoffzubereitungen enthaltend Hydroxypropylcellulose |
| DE19504832A1 (de) * | 1995-02-14 | 1996-08-22 | Basf Ag | Feste Wirkstoff-Zubereitungen |
| DE19509806A1 (de) * | 1995-03-21 | 1996-09-26 | Basf Ag | Lagerstabile Arzneiformen |
| DE19721467A1 (de) * | 1997-05-22 | 1998-11-26 | Basf Ag | Verfahren zur Herstellung kleinteiliger Zubereitungen biologisch aktiver Stoffe |
| HN1998000115A (es) * | 1997-08-21 | 1999-06-02 | Warner Lambert Co | Formas de dosificación farmacéuticas sólidas |
| DE19934610A1 (de) * | 1999-07-23 | 2001-01-25 | Bayer Ag | Schnellfreisetzende Extrudate und Verfahren zu ihrer Herstellung sowie daraus erhältliche Zubereitungen |
| AU2000273085A1 (en) * | 2000-10-02 | 2002-04-15 | Usv Limited | Sustained release pharmaceutical compositions containing metformin and method ofits production |
| WO2003004009A1 (en) * | 2001-07-02 | 2003-01-16 | Geneva Pharmaceuticals, Inc. | Pharmaceutical composition |
| US20040202718A1 (en) * | 2001-09-28 | 2004-10-14 | Tyebji Ziauddin Z. | Dosage form for treatment of diabetes mellitus |
| IN192180B (https=) * | 2001-09-28 | 2004-03-06 | Ranbaxy Lab | |
| DE102005005446A1 (de) * | 2005-02-04 | 2006-08-10 | Grünenthal GmbH | Bruchfeste Darreichungsformen mit retardierter Freisetzung |
| FR2858556B1 (fr) * | 2003-08-06 | 2006-03-10 | Galenix Innovations | Composition pharmaceutique solide dispersible et/ou orodispersible non pelliculee contenant au moins le principe actif metformine, et procede de preparation |
| EP1734953A4 (en) * | 2004-03-02 | 2008-08-20 | Abeille Pharmaceuticals Inc | CO-PR PARATIONS OF KITS OF BIOACTIVE AGENTS |
| BRPI0616694B8 (pt) * | 2005-09-29 | 2021-05-25 | Novartis Ag | processo para preparar comprimido farmacêutico com 80 e 96% em peso com base no peso seco de vildagliptina e metformina ou seus sais farmaceuticamente aceitáveis |
| WO2007106182A2 (en) * | 2005-11-09 | 2007-09-20 | Novartis Ag | Process for making pharmaceutical compositions with a transient plasticizer |
-
2006
- 2006-05-08 EP EP06759308A patent/EP1881819A1/en not_active Withdrawn
- 2006-05-08 CA CA002607624A patent/CA2607624A1/en not_active Abandoned
- 2006-05-08 KR KR1020077026095A patent/KR20080007357A/ko not_active Ceased
- 2006-05-08 KR KR1020137031633A patent/KR20130135403A/ko not_active Ceased
- 2006-05-08 NZ NZ562304A patent/NZ562304A/en not_active IP Right Cessation
- 2006-05-08 WO PCT/US2006/017708 patent/WO2006122021A1/en not_active Ceased
- 2006-05-08 CN CN2011103445944A patent/CN102552162A/zh active Pending
- 2006-05-08 RU RU2007145522/15A patent/RU2405539C2/ru not_active IP Right Cessation
- 2006-05-08 US US11/909,509 patent/US20100152299A1/en not_active Abandoned
- 2006-05-08 BR BRPI0608609-8A patent/BRPI0608609A2/pt not_active IP Right Cessation
- 2006-05-08 AU AU2006244213A patent/AU2006244213B2/en not_active Ceased
- 2006-05-08 MX MX2007014041A patent/MX2007014041A/es active IP Right Grant
- 2006-05-08 JP JP2008511233A patent/JP5400377B2/ja not_active Expired - Fee Related
- 2006-05-08 NZ NZ585116A patent/NZ585116A/en not_active IP Right Cessation
-
2007
- 2007-10-07 IL IL186456A patent/IL186456A0/en unknown
- 2007-11-09 TN TNP2007000415A patent/TNSN07415A1/en unknown
- 2007-11-20 MA MA30393A patent/MA29465B1/fr unknown
- 2007-12-06 NO NO20076298A patent/NO20076298L/no not_active Application Discontinuation
-
2010
- 2010-08-12 AU AU2010212296A patent/AU2010212296B2/en not_active Ceased
-
2011
- 2011-11-30 US US13/307,864 patent/US20120077879A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1881819A1 (en) | 2008-01-30 |
| MA29465B1 (fr) | 2008-05-02 |
| AU2006244213A1 (en) | 2006-11-16 |
| RU2405539C2 (ru) | 2010-12-10 |
| JP2008540540A (ja) | 2008-11-20 |
| WO2006122021A1 (en) | 2006-11-16 |
| TNSN07415A1 (en) | 2009-03-17 |
| IL186456A0 (en) | 2008-01-20 |
| KR20080007357A (ko) | 2008-01-18 |
| CN102552162A (zh) | 2012-07-11 |
| KR20130135403A (ko) | 2013-12-10 |
| US20120077879A1 (en) | 2012-03-29 |
| US20100152299A1 (en) | 2010-06-17 |
| AU2010212296B2 (en) | 2011-06-16 |
| AU2006244213B2 (en) | 2010-05-13 |
| CA2607624A1 (en) | 2006-11-16 |
| MX2007014041A (es) | 2008-02-11 |
| NO20076298L (no) | 2007-12-06 |
| NZ585116A (en) | 2011-12-22 |
| BRPI0608609A2 (pt) | 2010-01-19 |
| RU2007145522A (ru) | 2009-06-20 |
| JP5400377B2 (ja) | 2014-01-29 |
| AU2010212296A1 (en) | 2010-09-02 |
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