KR20040015206A - 코르티코트로핀 방출 인자 (crf)의 길항제로서의 접합피리미딘 - Google Patents
코르티코트로핀 방출 인자 (crf)의 길항제로서의 접합피리미딘 Download PDFInfo
- Publication number
- KR20040015206A KR20040015206A KR10-2003-7014160A KR20037014160A KR20040015206A KR 20040015206 A KR20040015206 A KR 20040015206A KR 20037014160 A KR20037014160 A KR 20037014160A KR 20040015206 A KR20040015206 A KR 20040015206A
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- South Korea
- Prior art keywords
- methyl
- dihydro
- formula
- compound
- pyrrolo
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- C07—ORGANIC CHEMISTRY
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
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- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0465—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (17)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0110567.5 | 2001-04-30 | ||
GB0110569A GB0110569D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0110569.1 | 2001-04-30 | ||
GB0110570.9 | 2001-04-30 | ||
GB0110567A GB0110567D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0110570A GB0110570D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0117399.6 | 2001-07-17 | ||
GB0117401.0 | 2001-07-17 | ||
GB0117399A GB0117399D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0117401A GB0117401D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0117420A GB0117420D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0117420.0 | 2001-07-17 | ||
GB0203201.9 | 2002-02-11 | ||
GB0203201A GB0203201D0 (en) | 2002-02-11 | 2002-02-11 | Chemical compounds |
GB0206834.4 | 2002-03-22 | ||
GB0206834A GB0206834D0 (en) | 2002-03-22 | 2002-03-22 | Chemical compounds |
PCT/GB2002/002029 WO2002088095A1 (en) | 2001-04-30 | 2002-04-30 | Fused pyrimidines as antagonists of the corticotropin releasing factor (crf) |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20040015206A true KR20040015206A (ko) | 2004-02-18 |
Family
ID=27571152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR10-2003-7014160A KR20040015206A (ko) | 2001-04-30 | 2002-04-30 | 코르티코트로핀 방출 인자 (crf)의 길항제로서의 접합피리미딘 |
Country Status (19)
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2004533465A (ja) * | 2001-06-12 | 2004-11-04 | グラクソ グループ リミテッド | コルチコトロピン放出因子アンタゴニスト |
GB0117396D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
EP1583531B1 (en) * | 2003-01-16 | 2007-04-18 | SB Pharmco Puerto Rico Inc | Heteroaryl-substituted pyrrolo[2, 3- b]pyridine derivatives as crf receptor antagonists |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
GB0308208D0 (en) * | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
AU2004235907B2 (en) * | 2003-05-05 | 2007-08-30 | F. Hoffmann La-Roche Ag | Fused pyrimidine derivatives with CRF activity |
WO2005013997A1 (en) | 2003-08-12 | 2005-02-17 | F. Hoffmann-La Roche Ag | Spiro-substituted tetrahydroquinazolines as corticotropin releasing factor (cfr) antagonists |
DE602004009200T2 (de) * | 2003-08-12 | 2008-07-10 | F. Hoffmann-La Roche Ag | Tetrahydrochinazolinderivate als cfr-antagonisten |
RU2394035C2 (ru) * | 2003-12-22 | 2010-07-10 | Эс Би ФАРМКО ПУЭРТО РИКО ИНК. | Антагонисты crf-рецепторов и способы, относящиеся к ним |
RU2006128580A (ru) * | 2004-01-06 | 2008-02-20 | Тайсо Фармасьютикал Ко., Лтд. (Jp) | Производные тиенопиримидина и тиенопиридина, замещенные циклической аминогруппой |
CA2556946A1 (en) * | 2004-03-05 | 2005-09-15 | Taisho Pharmaceutical Co., Ltd. | Pyrrolopyrimidine derivatives |
GEP20105024B (en) | 2004-06-02 | 2010-06-25 | Takeda Pharmaceuticals Co | Fused heterocyclic compound |
JP2008503443A (ja) * | 2004-06-25 | 2008-02-07 | 大正製薬株式会社 | テトラヒドロピリジンで置換されたピロロピリミジン及びピロロピリジンの誘導体 |
DE602005014375D1 (de) * | 2004-10-19 | 2009-06-18 | Neurocrine Biosciences Inc | Crf-rezeptor-antagonisten und zugehörige verfahren |
GB0519957D0 (en) * | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
US8088779B2 (en) * | 2005-09-30 | 2012-01-03 | Smithkline Beecham (Cork) Limited | Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (CRF) receptor antagonists |
JP5231410B2 (ja) | 2006-07-06 | 2013-07-10 | アレイ バイオファーマ、インコーポレイテッド | Aktプロテインキナーゼ阻害剤としてのジヒドロフロピリミジン |
BRPI0713555A2 (pt) | 2006-07-06 | 2012-03-20 | Array Biopharma, Inc. | ciclopenta [d] pirimidinas como inibidores de akt protéina cinase |
US9303040B2 (en) | 2006-07-06 | 2016-04-05 | Array Biopharma Inc. | Substituted piperazines as AKT inhibitors |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
WO2008008895A1 (en) * | 2006-07-13 | 2008-01-17 | Smithkline Beecham Corporation | Gpr119 agonists for the treatment of diabetes and related disorders |
DE102007004303A1 (de) | 2006-08-04 | 2008-02-07 | Osram Opto Semiconductors Gmbh | Dünnfilm-Halbleiterbauelement und Bauelement-Verbund |
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2002
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- 2002-04-30 CN CNA028107462A patent/CN1649848A/zh active Pending
- 2002-04-30 PL PL02366934A patent/PL366934A1/xx not_active Application Discontinuation
- 2002-04-30 HU HU0304054A patent/HUP0304054A2/hu unknown
- 2002-04-30 CA CA002446514A patent/CA2446514A1/en not_active Abandoned
- 2002-04-30 WO PCT/GB2002/002029 patent/WO2002088095A1/en active IP Right Grant
- 2002-04-30 JP JP2002585397A patent/JP2004528349A/ja active Pending
- 2002-04-30 IL IL15806202A patent/IL158062A0/xx unknown
- 2002-04-30 BR BR0209267-0A patent/BR0209267A/pt not_active IP Right Cessation
- 2002-04-30 US US10/476,368 patent/US7279474B2/en not_active Expired - Fee Related
- 2002-04-30 AU AU2002253357A patent/AU2002253357B2/en not_active Ceased
- 2002-04-30 CZ CZ20032946A patent/CZ20032946A3/cs unknown
- 2002-04-30 EP EP02722478A patent/EP1383747B1/en not_active Expired - Lifetime
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NO20034836L (no) | 2003-10-29 |
NO20034836D0 (no) | 2003-10-29 |
CZ20032946A3 (en) | 2004-05-12 |
BR0209267A (pt) | 2004-06-15 |
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US20040176400A1 (en) | 2004-09-09 |
ATE386727T1 (de) | 2008-03-15 |
ES2301633T3 (es) | 2008-07-01 |
AR033295A1 (es) | 2003-12-10 |
JP2004528349A (ja) | 2004-09-16 |
MXPA03009938A (es) | 2005-09-07 |
WO2002088095A1 (en) | 2002-11-07 |
PL366934A1 (en) | 2005-02-07 |
DE60225127T2 (de) | 2009-02-19 |
US7279474B2 (en) | 2007-10-09 |
EP1383747A1 (en) | 2004-01-28 |
DE60225127D1 (en) | 2008-04-03 |
CN1649848A (zh) | 2005-08-03 |
IL158062A0 (en) | 2004-03-28 |
EP1383747B1 (en) | 2008-02-20 |
HUP0304054A2 (hu) | 2004-04-28 |
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