KR20020062340A - 신규 형태의 프라바스타틴 나트륨 - Google Patents
신규 형태의 프라바스타틴 나트륨 Download PDFInfo
- Publication number
- KR20020062340A KR20020062340A KR1020027007610A KR20027007610A KR20020062340A KR 20020062340 A KR20020062340 A KR 20020062340A KR 1020027007610 A KR1020027007610 A KR 1020027007610A KR 20027007610 A KR20027007610 A KR 20027007610A KR 20020062340 A KR20020062340 A KR 20020062340A
- Authority
- KR
- South Korea
- Prior art keywords
- pravastatin sodium
- pravastatin
- crystalline
- temperature
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 title claims abstract description 367
- 229960001495 pravastatin sodium Drugs 0.000 title claims abstract description 339
- 239000002904 solvent Substances 0.000 claims abstract description 34
- 238000000034 method Methods 0.000 claims description 167
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical group CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 135
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- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 63
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 50
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 48
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- 208000035150 Hypercholesterolemia Diseases 0.000 claims description 29
- 201000001320 Atherosclerosis Diseases 0.000 claims description 27
- TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims description 27
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 15
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/02—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen
- C07C69/22—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety
- C07C69/33—Esters of acyclic saturated monocarboxylic acids having the carboxyl group bound to an acyclic carbon atom or to hydrogen having three or more carbon atoms in the acid moiety esterified with hydroxy compounds having more than three hydroxy groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/26—All rings being cycloaliphatic the ring system containing ten carbon atoms
- C07C2602/28—Hydrogenated naphthalenes
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17068599P | 1999-12-14 | 1999-12-14 | |
| US60/170,685 | 1999-12-14 | ||
| US19064900P | 2000-03-20 | 2000-03-20 | |
| US60/190,649 | 2000-03-20 | ||
| PCT/US2000/033867 WO2001043723A1 (en) | 1999-12-14 | 2000-12-14 | Novel forms of pravastatin sodium |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20020062340A true KR20020062340A (ko) | 2002-07-25 |
Family
ID=26866349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020027007610A Abandoned KR20020062340A (ko) | 1999-12-14 | 2000-12-14 | 신규 형태의 프라바스타틴 나트륨 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US7001919B2 (https=) |
| EP (1) | EP1242051A4 (https=) |
| JP (2) | JP2003516959A (https=) |
| KR (1) | KR20020062340A (https=) |
| CN (1) | CN1434702A (https=) |
| AU (1) | AU779306B2 (https=) |
| CA (1) | CA2394200C (https=) |
| CZ (1) | CZ20021998A3 (https=) |
| HK (1) | HK1049441A1 (https=) |
| HU (1) | HUP0204005A3 (https=) |
| IL (1) | IL150187A0 (https=) |
| PL (1) | PL364929A1 (https=) |
| SK (1) | SK8312002A3 (https=) |
| WO (1) | WO2001043723A1 (https=) |
| YU (1) | YU45202A (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL150187A0 (en) * | 1999-12-14 | 2002-12-01 | Biogal Pharmaceutical Co Ltd | Novel forms of pravastatin sodium |
| WO2002092094A1 (en) * | 2001-03-27 | 2002-11-21 | Sumitomo Pharmaceuticals Co., Ltd. | Crystalline isoxazole derivative and medical preparation thereof |
| WO2005084669A1 (en) * | 2004-03-01 | 2005-09-15 | Lek Pharmaceuticals D.D. | Pharmaceutical composition |
| JP2008509154A (ja) | 2004-08-06 | 2008-03-27 | トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド | 新規なスタチン薬剤組成物および関連治療方法 |
| CN101115706A (zh) * | 2005-02-09 | 2008-01-30 | 特瓦药厂私人有限公司 | 制备普伐他汀钠的方法 |
| JP4813841B2 (ja) * | 2005-07-25 | 2011-11-09 | キユーピー株式会社 | プラバスタチンナトリウムの製造方法 |
| CN101648867B (zh) * | 2009-09-04 | 2012-07-11 | 天津大学 | 一种普伐他汀钠晶型及其制备方法和应用 |
| EP2343054A1 (en) | 2010-01-04 | 2011-07-13 | LEK Pharmaceuticals d.d. | Pellets and microparticles of pravastatin sodium and a process of making them |
| WO2012085191A1 (en) | 2010-12-23 | 2012-06-28 | Dsm Sinochem Pharmaceuticals Netherlands B.V. | Crystalline form of pravastatine and process for the preparation thereof |
| MY180626A (en) | 2013-11-15 | 2020-12-03 | Akebia Therapeutics Inc | Solid forms of {[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl]amino}acetic acid, compositions, and uses thereof |
| CN105949062B (zh) * | 2016-06-24 | 2017-06-13 | 广东蓝宝制药有限公司 | 一种规模化制备普伐他汀钠d型晶体的工艺 |
| CN111018714B (zh) * | 2019-12-27 | 2020-09-04 | 广东蓝宝制药有限公司 | 一种获得高纯a晶型普伐他汀钠的制备方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4319039A (en) * | 1979-06-15 | 1982-03-09 | Merck & Co., Inc. | Preparation of ammonium salt of hypocholesteremic fermentation product |
| DK149080C (da) | 1980-06-06 | 1986-07-28 | Sankyo Co | Fremgangsmaade til fremstilling af derivater af ml-236b-carboxylsyre |
| ATE69602T1 (de) | 1985-09-13 | 1991-12-15 | Sankyo Co | Hydroxy-ml-236b-derivate, deren herstellung und anwendung. |
| US4857547A (en) * | 1988-01-07 | 1989-08-15 | Merck & Co., Inc. | Novel HMG-CoA reductase inhibitors |
| US4857522A (en) | 1988-03-21 | 1989-08-15 | E. R. Squibb & Sons, Inc. | Derivatives of pravastatin for inhibiting cholesterol biosynthesis |
| US5180589A (en) | 1988-03-31 | 1993-01-19 | E. R. Squibb & Sons, Inc. | Pravastatin pharmaceuatical compositions having good stability |
| US5099035A (en) * | 1989-02-27 | 1992-03-24 | E. R. Squibb & Sons, Inc. | Mevinic acid derivatives useful as antihypercholesterolemic agents and method for preparing same |
| US5140012A (en) | 1990-05-31 | 1992-08-18 | E. R. Squibb & Sons, Inc. | Method for preventing onset of restenosis after angioplasty employing pravastatin |
| US5202029A (en) | 1991-03-13 | 1993-04-13 | Caron Kabushiki Kaisha | Process for purification of hmg-coa reductase inhibitors |
| US5157025A (en) * | 1991-04-01 | 1992-10-20 | E. R. Squibb & Sons, Inc. | Method for lowering serum cholesterol employing a phosphorus containing ace inhibitor alone or in combination with a cholesterol lowering drug |
| US5225202A (en) * | 1991-09-30 | 1993-07-06 | E. R. Squibb & Sons, Inc. | Enteric coated pharmaceutical compositions |
| NZ250609A (en) | 1992-12-28 | 1995-07-26 | Sankyo Co | Hexahydronaphthalene esters and ring closed lactones; preparation and medicaments |
| SI9300303A (en) * | 1993-06-08 | 1994-12-31 | Krka Tovarna Zdravil | Process for isolation of hypolipemic effective substance |
| IL112639A0 (en) | 1994-03-11 | 1995-05-26 | Bristol Myers Squibb Co | A pharmaceutical composition containing pravastin |
| US5942423A (en) * | 1995-06-07 | 1999-08-24 | Massachusetts Institute Of Technology | Conversion of compactin to pravastatin by actinomadura |
| US5616595A (en) * | 1995-06-07 | 1997-04-01 | Abbott Laboratories | Process for recovering water insoluble compounds from a fermentation broth |
| US5883109A (en) * | 1996-07-24 | 1999-03-16 | Bristol-Myers Squibb Company | Method for lowering serum lipid levels employing an MTP inhibitor in combination with another cholesterol lowering drug |
| EP0975789A1 (en) | 1997-02-20 | 2000-02-02 | Dsm N.V. | Nitrogen feed in statin fermentation |
| KR100210482B1 (ko) | 1997-04-10 | 1999-07-15 | 김종인 | 스트렙토마이세스엑스포리아투스(streptomycesexfoliatus)yj-118과이를이용한프라바스타틴나트륨의제조방법 |
| AU9264598A (en) | 1997-08-22 | 1999-03-16 | Gist-Brocades B.V. | Statin production by fermentation |
| SI9800046A (sl) | 1998-02-18 | 1999-08-31 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti |
| SI20305A (sl) * | 1999-08-06 | 2001-02-28 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Kristali natrijeve soli pravastatina |
| SI20072A (sl) | 1998-09-18 | 2000-04-30 | LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. | Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze |
| WO2000033821A1 (en) * | 1998-12-07 | 2000-06-15 | Bristol-Myers Squibb Company | Enteric coated pravastatin bead formulation |
| US6682913B1 (en) * | 1999-02-03 | 2004-01-27 | Institute For Drug Research Ltd. | Microbial process for preparing pravastatin |
| CN1260344C (zh) | 1999-02-03 | 2006-06-21 | 药物研究所有限公司 | 培养物 |
| HUP9902352A1 (hu) | 1999-07-12 | 2000-09-28 | Gyógyszerkutató Intézet Kft. | Eljárás pravasztatin mikrobiológiai előállítására |
| YU39102A (sh) * | 1999-11-30 | 2006-01-16 | Biogal Gyogyszergyar Rt | Postupak dobijanja statina iz fermentacione smeše |
| IL150187A0 (en) * | 1999-12-14 | 2002-12-01 | Biogal Pharmaceutical Co Ltd | Novel forms of pravastatin sodium |
| CN1468098A (zh) | 2000-10-05 | 2004-01-14 | �ݰ¸Ƕ�ҩ������˾ | 基本上无普伐他汀内酯和表普伐他汀的普伐他汀钠和包含普伐他汀钠的组合物 |
| DE10209305A1 (de) | 2001-04-30 | 2002-10-31 | Basf Ag | Thermische Spaltung von Allophanaten |
-
2000
- 2000-12-14 IL IL15018700A patent/IL150187A0/xx unknown
- 2000-12-14 PL PL00364929A patent/PL364929A1/xx unknown
- 2000-12-14 CZ CZ20021998A patent/CZ20021998A3/cs unknown
- 2000-12-14 SK SK831-2002A patent/SK8312002A3/sk unknown
- 2000-12-14 WO PCT/US2000/033867 patent/WO2001043723A1/en not_active Ceased
- 2000-12-14 US US09/736,796 patent/US7001919B2/en not_active Expired - Fee Related
- 2000-12-14 KR KR1020027007610A patent/KR20020062340A/ko not_active Abandoned
- 2000-12-14 JP JP2001544662A patent/JP2003516959A/ja active Pending
- 2000-12-14 CA CA002394200A patent/CA2394200C/en not_active Expired - Fee Related
- 2000-12-14 HU HU0204005A patent/HUP0204005A3/hu unknown
- 2000-12-14 YU YU45202A patent/YU45202A/sh unknown
- 2000-12-14 AU AU20987/01A patent/AU779306B2/en not_active Ceased
- 2000-12-14 EP EP00984355A patent/EP1242051A4/en not_active Withdrawn
- 2000-12-14 HK HK03101565.0A patent/HK1049441A1/zh unknown
- 2000-12-14 CN CN00818961A patent/CN1434702A/zh active Pending
-
2004
- 2004-12-01 JP JP2004349020A patent/JP2005120105A/ja active Pending
-
2005
- 2005-08-09 US US11/200,794 patent/US7262218B2/en not_active Expired - Fee Related
-
2007
- 2007-04-03 US US11/730,639 patent/US20070197633A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20010041809A1 (en) | 2001-11-15 |
| WO2001043723A1 (en) | 2001-06-21 |
| CA2394200A1 (en) | 2001-06-21 |
| PL364929A1 (en) | 2004-12-27 |
| EP1242051A4 (en) | 2004-05-12 |
| YU45202A (sh) | 2005-11-28 |
| US20050288370A1 (en) | 2005-12-29 |
| HUP0204005A3 (en) | 2003-05-28 |
| AU2098701A (en) | 2001-06-25 |
| SK8312002A3 (en) | 2003-05-02 |
| HUP0204005A2 (hu) | 2003-03-28 |
| US7262218B2 (en) | 2007-08-28 |
| EP1242051A1 (en) | 2002-09-25 |
| AU779306B2 (en) | 2005-01-13 |
| CZ20021998A3 (cs) | 2003-02-12 |
| HK1049441A1 (zh) | 2003-05-16 |
| JP2005120105A (ja) | 2005-05-12 |
| US7001919B2 (en) | 2006-02-21 |
| US20070197633A1 (en) | 2007-08-23 |
| IL150187A0 (en) | 2002-12-01 |
| JP2003516959A (ja) | 2003-05-20 |
| CN1434702A (zh) | 2003-08-06 |
| CA2394200C (en) | 2006-10-03 |
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