KR20010102082A - 항바이러스제로서의 포스포르아미데이트, 및 (1ｒ, 시스)-4-(6-아미노-9ｈ-푸린-9-일)-2-시클로펜텐-1-메탄올의 모노-, 디-, 및 트리-포스페이트 에스테르 - Google Patents

항바이러스제로서의 포스포르아미데이트, 및 (1ｒ, 시스)-4-(6-아미노-9ｈ-푸린-9-일)-2-시클로펜텐-1-메탄올의 모노-, 디-, 및 트리-포스페이트 에스테르 Download PDF

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Publication number
KR20010102082A
KR20010102082A KR1020017010198A KR20017010198A KR20010102082A KR 20010102082 A KR20010102082 A KR 20010102082A KR 1020017010198 A KR1020017010198 A KR 1020017010198A KR 20017010198 A KR20017010198 A KR 20017010198A KR 20010102082 A KR20010102082 A KR 20010102082A
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KR
South Korea
Prior art keywords
amino
methanol
purin
cis
phosphoramidate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020017010198A
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English (en)
Korean (ko)
Inventor
수잔 메리 달루지
크리스토퍼 맥구이간
Original Assignee
그레이엄 브레레톤, 레슬리 에드워즈
글락소 그룹 리미티드
추후보정
유니버시티 칼리지 카디프 컨설턴츠 리미티드
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Publication date
Priority claimed from GBGB9903090.0A external-priority patent/GB9903090D0/en
Application filed by 그레이엄 브레레톤, 레슬리 에드워즈, 글락소 그룹 리미티드, 추후보정, 유니버시티 칼리지 카디프 컨설턴츠 리미티드 filed Critical 그레이엄 브레레톤, 레슬리 에드워즈
Publication of KR20010102082A publication Critical patent/KR20010102082A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/22—Amides of acids of phosphorus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1020017010198A 1999-02-12 2000-02-10 항바이러스제로서의 포스포르아미데이트, 및 (1ｒ, 시스)-4-(6-아미노-9ｈ-푸린-9-일)-2-시클로펜텐-1-메탄올의 모노-, 디-, 및 트리-포스페이트 에스테르 Withdrawn KR20010102082A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9903090.0 1999-02-12
GBGB9903090.0A GB9903090D0 (en) 1999-02-12 1999-02-12 Therapeutic compounds
US17020599P 1999-12-10 1999-12-10
US60/170,205 1999-12-10
PCT/EP2000/001045 WO2000047591A1 (en) 1999-02-12 2000-02-10 Phosphoramidate, and mono-, di-, and tri-phosphate esters of (1r, cis)-4-(6-amino-9h-purin-9-yl)-2-cyclopentene-1-methanol as antiviral agents

Publications (1)

Publication Number Publication Date
KR20010102082A true KR20010102082A (ko) 2001-11-15

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Family Applications (1)

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KR1020017010198A Withdrawn KR20010102082A (ko) 1999-02-12 2000-02-10 항바이러스제로서의 포스포르아미데이트, 및 (1ｒ, 시스)-4-(6-아미노-9ｈ-푸린-9-일)-2-시클로펜텐-1-메탄올의 모노-, 디-, 및 트리-포스페이트 에스테르

Country Status (24)

Country Link
US (1) US7115590B1 (enExample)
EP (1) EP1150988B1 (enExample)
JP (1) JP2002536452A (enExample)
KR (1) KR20010102082A (enExample)
CN (1) CN1346360A (enExample)
AR (1) AR031975A1 (enExample)
AT (1) ATE241633T1 (enExample)
AU (1) AU772478B2 (enExample)
BR (1) BR0008135A (enExample)
CA (1) CA2362662A1 (enExample)
CZ (1) CZ20012908A3 (enExample)
DE (1) DE60002986T2 (enExample)
DK (1) DK1150988T3 (enExample)
DZ (1) DZ3007A1 (enExample)
ES (1) ES2200820T3 (enExample)
HK (1) HK1039337B (enExample)
HU (1) HUP0105476A3 (enExample)
IL (1) IL144647A0 (enExample)
NO (1) NO20013910L (enExample)
NZ (1) NZ513450A (enExample)
PL (1) PL204458B1 (enExample)
PT (1) PT1150988E (enExample)
TR (1) TR200102313T2 (enExample)
WO (1) WO2000047591A1 (enExample)

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PE20010915A1 (es) * 1999-12-10 2001-09-29 Glaxo Group Ltd Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales
JP2003516408A (ja) * 1999-12-10 2003-05-13 グラクソ グループ リミテッド 抗ウィルス薬としての（１Ｒ，シス）−４−［４−アミノ−７Ｈ−ピロロ（２，３−ｄ）ピリミジン−７−イル］−２−シクロペンテン−１−メタノール類縁物
PL359169A1 (en) 2000-05-26 2004-08-23 Idenix (Cayman) Limited Methods and compositions for treating flaviviruses and pestiviruses
HRP20030047B1 (hr) † 2000-07-21 2016-02-26 Gilead Sciences, Inc. Prolijekovi koji su fosfonatni analozi nukleotida i metode njihovog odabira te njihova priprava
GB0129945D0 (en) * 2001-12-13 2002-02-06 Mrc Technology Ltd Chemical compounds
GB0401088D0 (en) 2004-01-19 2004-02-18 Univ Cardiff Phosphoramidate derivatives
US9243025B2 (en) 2011-03-31 2016-01-26 Idenix Pharmaceuticals, Llc Compounds and pharmaceutical compositions for the treatment of viral infections
US9403863B2 (en) 2011-09-12 2016-08-02 Idenix Pharmaceuticals Llc Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections
AR089650A1 (es) 2011-10-14 2014-09-10 Idenix Pharmaceuticals Inc Fosfatos 3,5-ciclicos sustituidos de compuestos de nucleotido de purina y composiciones farmaceuticas para el tratamiento de infecciones virales
WO2013177195A1 (en) 2012-05-22 2013-11-28 Idenix Pharmaceuticals, Inc. 3',5'-cyclic phosphate prodrugs for hcv infection
EP2852604B1 (en) 2012-05-22 2017-04-12 Idenix Pharmaceuticals LLC 3',5'-cyclic phosphoramidate prodrugs for hcv infection
MD20140134A2 (ro) 2012-05-22 2015-04-30 Idenix Pharmaceuticals, Inc. Compuşi ai D-aminoacizilor pentru tratamentul bolilor hepatice
PT2861611T (pt) 2012-05-25 2016-10-11 Janssen Sciences Ireland Uc Nucleósidos de espirooxetano de uracilo
WO2014052638A1 (en) 2012-09-27 2014-04-03 Idenix Pharmaceuticals, Inc. Esters and malonates of sate prodrugs
ES2674980T3 (es) 2012-10-08 2018-07-05 Idenix Pharmaceuticals Llc Análogos de 2'-cloro nucleósidos para infección por VHC
WO2014066239A1 (en) 2012-10-22 2014-05-01 Idenix Pharmaceuticals, Inc. 2',4'-bridged nucleosides for hcv infection
US9211300B2 (en) 2012-12-19 2015-12-15 Idenix Pharmaceuticals Llc 4′-fluoro nucleosides for the treatment of HCV
WO2014137926A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. 3'-deoxy nucleosides for the treatment of hcv
WO2014137930A1 (en) 2013-03-04 2014-09-12 Idenix Pharmaceuticals, Inc. Thiophosphate nucleosides for the treatment of hcv
EP2970357B1 (en) 2013-03-13 2025-01-01 Idenix Pharmaceuticals LLC Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
EP2981542B1 (en) 2013-04-01 2021-09-15 Idenix Pharmaceuticals LLC 2',4'-fluoro nucleosides for the treatment of hcv
EP3004130B1 (en) 2013-06-05 2019-08-07 Idenix Pharmaceuticals LLC. 1',4'-thio nucleosides for the treatment of hcv
US20150037282A1 (en) 2013-08-01 2015-02-05 Idenix Pharmaceuticals, Inc. D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease
EP3131914B1 (en) 2014-04-16 2023-05-10 Idenix Pharmaceuticals LLC 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv
FI3265102T3 (fi) 2015-03-06 2025-10-31 Atea Pharmaceuticals Inc Beta-d-2'-deoksi-2'-alfa-fluori-2'-beta-c-substituoituja-2-modifioituja-n6-substituoituja puriininukleotideja hcv-hoitoa varten
WO2018013937A1 (en) 2016-07-14 2018-01-18 Atea Pharmaceuticals, Inc. Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection
PT3512863T (pt) 2016-09-07 2022-03-09 Atea Pharmaceuticals Inc Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna
WO2021173713A1 (en) 2020-02-27 2021-09-02 Atea Pharmaceuticals, Inc. Highly active compounds against covid-19
US10874687B1 (en) 2020-02-27 2020-12-29 Atea Pharmaceuticals, Inc. Highly active compounds against COVID-19
WO2024107859A1 (en) * 2022-11-15 2024-05-23 Rome Therapeutics, Inc. Cyclopentene-oxymethylene phosphonamidates and related compounds and their use in treating medical conditions
WO2026151964A1 (en) 2025-01-10 2026-07-16 Atea Pharmaceuticals, Inc. Compositions and use thereof in treating hepatitis e infections with beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides

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US5244896A (en) * 1990-09-14 1993-09-14 Marion Merrell Dow Inc. Carbocyclic adenosine analogs useful as immunosuppressants
GB9505025D0 (en) * 1995-03-13 1995-05-03 Medical Res Council Chemical compounds
US6887707B2 (en) * 1996-10-28 2005-05-03 University Of Washington Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA
GB9821058D0 (en) * 1998-09-28 1998-11-18 Univ Cardiff Chemical compound
JP2003516408A (ja) * 1999-12-10 2003-05-13 グラクソ グループ リミテッド 抗ウィルス薬としての（１Ｒ，シス）−４−［４−アミノ−７Ｈ−ピロロ（２，３−ｄ）ピリミジン−７−イル］−２−シクロペンテン−１−メタノール類縁物
US20030096833A1 (en) * 2001-08-31 2003-05-22 Jagtap Prakash G. Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof

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Publication number Publication date
US7115590B1 (en) 2006-10-03
PL204458B1 (pl) 2010-01-29
NZ513450A (en) 2004-03-26
DK1150988T3 (da) 2003-09-29
NO20013910L (no) 2001-10-10
DE60002986D1 (en) 2003-07-03
ATE241633T1 (de) 2003-06-15
WO2000047591A1 (en) 2000-08-17
BR0008135A (pt) 2002-02-19
IL144647A0 (en) 2002-05-23
NO20013910D0 (no) 2001-08-10
PT1150988E (pt) 2003-10-31
HUP0105476A2 (en) 2002-06-29
TR200102313T2 (tr) 2002-03-21
EP1150988B1 (en) 2003-05-28
CZ20012908A3 (cs) 2002-10-16
EP1150988A1 (en) 2001-11-07
HUP0105476A3 (en) 2002-08-28
DZ3007A1 (fr) 2003-03-27
ES2200820T3 (es) 2004-03-16
AU772478B2 (en) 2004-04-29
AU2671300A (en) 2000-08-29
HK1039337B (en) 2003-11-21
CA2362662A1 (en) 2000-08-17
JP2002536452A (ja) 2002-10-29
PL350023A1 (en) 2002-10-21
AR031975A1 (es) 2003-10-22
HK1039337A1 (en) 2002-04-19
DE60002986T2 (de) 2004-05-19
CN1346360A (zh) 2002-04-24

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