HUP0105476A3 - Phosphoramidate, and mono-, di-, and tri-phosphate esters of (1r, cis)-4-(6-amino-9h-purin-9-yl)-2-cyclopentene-1-methanol as antiviral agents, process for preparation of the compounds and pharmaceutical compositions containing the same - Google Patents
Phosphoramidate, and mono-, di-, and tri-phosphate esters of (1r, cis)-4-(6-amino-9h-purin-9-yl)-2-cyclopentene-1-methanol as antiviral agents, process for preparation of the compounds and pharmaceutical compositions containing the sameInfo
- Publication number
- HUP0105476A3 HUP0105476A3 HU0105476A HUP0105476A HUP0105476A3 HU P0105476 A3 HUP0105476 A3 HU P0105476A3 HU 0105476 A HU0105476 A HU 0105476A HU P0105476 A HUP0105476 A HU P0105476A HU P0105476 A3 HUP0105476 A3 HU P0105476A3
- Authority
- HU
- Hungary
- Prior art keywords
- purin
- phosphoramidate
- cyclopentene
- cis
- tri
- Prior art date
Links
- COZAZKCWQGBJDE-JGVFFNPUSA-N [(1r,4s)-4-(6-aminopurin-9-yl)cyclopent-2-en-1-yl]methanol Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@H]1C[C@@H](CO)C=C1 COZAZKCWQGBJDE-JGVFFNPUSA-N 0.000 title 1
- 239000003443 antiviral agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 title 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical class OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9903090.0A GB9903090D0 (en) | 1999-02-12 | 1999-02-12 | Therapeutic compounds |
| US17020599P | 1999-12-10 | 1999-12-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0105476A2 HUP0105476A2 (en) | 2002-06-29 |
| HUP0105476A3 true HUP0105476A3 (en) | 2002-08-28 |
Family
ID=26315118
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0105476A HUP0105476A3 (en) | 1999-02-12 | 2000-02-10 | Phosphoramidate, and mono-, di-, and tri-phosphate esters of (1r, cis)-4-(6-amino-9h-purin-9-yl)-2-cyclopentene-1-methanol as antiviral agents, process for preparation of the compounds and pharmaceutical compositions containing the same |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US7115590B1 (enExample) |
| EP (1) | EP1150988B1 (enExample) |
| JP (1) | JP2002536452A (enExample) |
| KR (1) | KR20010102082A (enExample) |
| CN (1) | CN1346360A (enExample) |
| AR (1) | AR031975A1 (enExample) |
| AT (1) | ATE241633T1 (enExample) |
| AU (1) | AU772478B2 (enExample) |
| BR (1) | BR0008135A (enExample) |
| CA (1) | CA2362662A1 (enExample) |
| CZ (1) | CZ20012908A3 (enExample) |
| DE (1) | DE60002986T2 (enExample) |
| DK (1) | DK1150988T3 (enExample) |
| DZ (1) | DZ3007A1 (enExample) |
| ES (1) | ES2200820T3 (enExample) |
| HK (1) | HK1039337B (enExample) |
| HU (1) | HUP0105476A3 (enExample) |
| IL (1) | IL144647A0 (enExample) |
| NO (1) | NO20013910L (enExample) |
| NZ (1) | NZ513450A (enExample) |
| PL (1) | PL204458B1 (enExample) |
| PT (1) | PT1150988E (enExample) |
| TR (1) | TR200102313T2 (enExample) |
| WO (1) | WO2000047591A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20010915A1 (es) * | 1999-12-10 | 2001-09-29 | Glaxo Group Ltd | Analogos de (1s, cis)-4-(2-amino-9h-purin-9-il)-2-ciclopenten-1-metanol para uso en el tratamiento de infecciones virales |
| JP2003516408A (ja) * | 1999-12-10 | 2003-05-13 | グラクソ グループ リミテッド | 抗ウィルス薬としての（１Ｒ，シス）−４−［４−アミノ−７Ｈ−ピロロ（２，３−ｄ）ピリミジン−７−イル］−２−シクロペンテン−１−メタノール類縁物 |
| PL359169A1 (en) | 2000-05-26 | 2004-08-23 | Idenix (Cayman) Limited | Methods and compositions for treating flaviviruses and pestiviruses |
| HRP20030047B1 (hr) † | 2000-07-21 | 2016-02-26 | Gilead Sciences, Inc. | Prolijekovi koji su fosfonatni analozi nukleotida i metode njihovog odabira te njihova priprava |
| GB0129945D0 (en) * | 2001-12-13 | 2002-02-06 | Mrc Technology Ltd | Chemical compounds |
| GB0401088D0 (en) | 2004-01-19 | 2004-02-18 | Univ Cardiff | Phosphoramidate derivatives |
| US9243025B2 (en) | 2011-03-31 | 2016-01-26 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
| US9403863B2 (en) | 2011-09-12 | 2016-08-02 | Idenix Pharmaceuticals Llc | Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections |
| AR089650A1 (es) | 2011-10-14 | 2014-09-10 | Idenix Pharmaceuticals Inc | Fosfatos 3,5-ciclicos sustituidos de compuestos de nucleotido de purina y composiciones farmaceuticas para el tratamiento de infecciones virales |
| WO2013177195A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphate prodrugs for hcv infection |
| EP2852604B1 (en) | 2012-05-22 | 2017-04-12 | Idenix Pharmaceuticals LLC | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
| MD20140134A2 (ro) | 2012-05-22 | 2015-04-30 | Idenix Pharmaceuticals, Inc. | Compuşi ai D-aminoacizilor pentru tratamentul bolilor hepatice |
| PT2861611T (pt) | 2012-05-25 | 2016-10-11 | Janssen Sciences Ireland Uc | Nucleósidos de espirooxetano de uracilo |
| WO2014052638A1 (en) | 2012-09-27 | 2014-04-03 | Idenix Pharmaceuticals, Inc. | Esters and malonates of sate prodrugs |
| ES2674980T3 (es) | 2012-10-08 | 2018-07-05 | Idenix Pharmaceuticals Llc | Análogos de 2'-cloro nucleósidos para infección por VHC |
| WO2014066239A1 (en) | 2012-10-22 | 2014-05-01 | Idenix Pharmaceuticals, Inc. | 2',4'-bridged nucleosides for hcv infection |
| US9211300B2 (en) | 2012-12-19 | 2015-12-15 | Idenix Pharmaceuticals Llc | 4′-fluoro nucleosides for the treatment of HCV |
| WO2014137926A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | 3'-deoxy nucleosides for the treatment of hcv |
| WO2014137930A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | Thiophosphate nucleosides for the treatment of hcv |
| EP2970357B1 (en) | 2013-03-13 | 2025-01-01 | Idenix Pharmaceuticals LLC | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| EP2981542B1 (en) | 2013-04-01 | 2021-09-15 | Idenix Pharmaceuticals LLC | 2',4'-fluoro nucleosides for the treatment of hcv |
| EP3004130B1 (en) | 2013-06-05 | 2019-08-07 | Idenix Pharmaceuticals LLC. | 1',4'-thio nucleosides for the treatment of hcv |
| US20150037282A1 (en) | 2013-08-01 | 2015-02-05 | Idenix Pharmaceuticals, Inc. | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| EP3131914B1 (en) | 2014-04-16 | 2023-05-10 | Idenix Pharmaceuticals LLC | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| FI3265102T3 (fi) | 2015-03-06 | 2025-10-31 | Atea Pharmaceuticals Inc | Beta-d-2'-deoksi-2'-alfa-fluori-2'-beta-c-substituoituja-2-modifioituja-n6-substituoituja puriininukleotideja hcv-hoitoa varten |
| WO2018013937A1 (en) | 2016-07-14 | 2018-01-18 | Atea Pharmaceuticals, Inc. | Beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| PT3512863T (pt) | 2016-09-07 | 2022-03-09 | Atea Pharmaceuticals Inc | Nucleótidos de purina 2'-substituídos-n6-substituídos para tratamento de vírus de rna |
| WO2021173713A1 (en) | 2020-02-27 | 2021-09-02 | Atea Pharmaceuticals, Inc. | Highly active compounds against covid-19 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| WO2024107859A1 (en) * | 2022-11-15 | 2024-05-23 | Rome Therapeutics, Inc. | Cyclopentene-oxymethylene phosphonamidates and related compounds and their use in treating medical conditions |
| WO2026151964A1 (en) | 2025-01-10 | 2026-07-16 | Atea Pharmaceuticals, Inc. | Compositions and use thereof in treating hepatitis e infections with beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-c-substituted-4'-fluoro-n6-substituted-6-amino-2-substituted purine nucleotides |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5244896A (en) * | 1990-09-14 | 1993-09-14 | Marion Merrell Dow Inc. | Carbocyclic adenosine analogs useful as immunosuppressants |
| GB9505025D0 (en) * | 1995-03-13 | 1995-05-03 | Medical Res Council | Chemical compounds |
| US6887707B2 (en) * | 1996-10-28 | 2005-05-03 | University Of Washington | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA |
| GB9821058D0 (en) * | 1998-09-28 | 1998-11-18 | Univ Cardiff | Chemical compound |
| JP2003516408A (ja) * | 1999-12-10 | 2003-05-13 | グラクソ グループ リミテッド | 抗ウィルス薬としての（１Ｒ，シス）−４−［４−アミノ−７Ｈ−ピロロ（２，３−ｄ）ピリミジン−７−イル］−２−シクロペンテン−１−メタノール類縁物 |
| US20030096833A1 (en) * | 2001-08-31 | 2003-05-22 | Jagtap Prakash G. | Substituted ideno[1,2-c]isoquinoline derivatives and methods of use thereof |
-
2000
- 2000-02-10 PT PT00905043T patent/PT1150988E/pt unknown
- 2000-02-10 AU AU26713/00A patent/AU772478B2/en not_active Ceased
- 2000-02-10 IL IL14464700A patent/IL144647A0/xx unknown
- 2000-02-10 WO PCT/EP2000/001045 patent/WO2000047591A1/en not_active Ceased
- 2000-02-10 AR ARP000100596A patent/AR031975A1/es not_active Application Discontinuation
- 2000-02-10 NZ NZ513450A patent/NZ513450A/xx unknown
- 2000-02-10 BR BR0008135-3A patent/BR0008135A/pt not_active IP Right Cessation
- 2000-02-10 EP EP00905043A patent/EP1150988B1/en not_active Expired - Lifetime
- 2000-02-10 ES ES00905043T patent/ES2200820T3/es not_active Expired - Lifetime
- 2000-02-10 DE DE60002986T patent/DE60002986T2/de not_active Expired - Fee Related
- 2000-02-10 TR TR2001/02313T patent/TR200102313T2/xx unknown
- 2000-02-10 AT AT00905043T patent/ATE241633T1/de not_active IP Right Cessation
- 2000-02-10 US US09/913,226 patent/US7115590B1/en not_active Expired - Fee Related
- 2000-02-10 CN CN00806002A patent/CN1346360A/zh active Pending
- 2000-02-10 PL PL350023A patent/PL204458B1/pl not_active IP Right Cessation
- 2000-02-10 DK DK00905043T patent/DK1150988T3/da active
- 2000-02-10 CZ CZ20012908A patent/CZ20012908A3/cs unknown
- 2000-02-10 KR KR1020017010198A patent/KR20010102082A/ko not_active Withdrawn
- 2000-02-10 JP JP2000598510A patent/JP2002536452A/ja active Pending
- 2000-02-10 HK HK02100897.2A patent/HK1039337B/en not_active IP Right Cessation
- 2000-02-10 CA CA002362662A patent/CA2362662A1/en not_active Abandoned
- 2000-02-10 HU HU0105476A patent/HUP0105476A3/hu unknown
- 2000-03-09 DZ DZ000019A patent/DZ3007A1/xx active
-
2001
- 2001-08-10 NO NO20013910A patent/NO20013910L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US7115590B1 (en) | 2006-10-03 |
| PL204458B1 (pl) | 2010-01-29 |
| NZ513450A (en) | 2004-03-26 |
| DK1150988T3 (da) | 2003-09-29 |
| NO20013910L (no) | 2001-10-10 |
| DE60002986D1 (en) | 2003-07-03 |
| ATE241633T1 (de) | 2003-06-15 |
| WO2000047591A1 (en) | 2000-08-17 |
| BR0008135A (pt) | 2002-02-19 |
| KR20010102082A (ko) | 2001-11-15 |
| IL144647A0 (en) | 2002-05-23 |
| NO20013910D0 (no) | 2001-08-10 |
| PT1150988E (pt) | 2003-10-31 |
| HUP0105476A2 (en) | 2002-06-29 |
| TR200102313T2 (tr) | 2002-03-21 |
| EP1150988B1 (en) | 2003-05-28 |
| CZ20012908A3 (cs) | 2002-10-16 |
| EP1150988A1 (en) | 2001-11-07 |
| DZ3007A1 (fr) | 2003-03-27 |
| ES2200820T3 (es) | 2004-03-16 |
| AU772478B2 (en) | 2004-04-29 |
| AU2671300A (en) | 2000-08-29 |
| HK1039337B (en) | 2003-11-21 |
| CA2362662A1 (en) | 2000-08-17 |
| JP2002536452A (ja) | 2002-10-29 |
| PL350023A1 (en) | 2002-10-21 |
| AR031975A1 (es) | 2003-10-22 |
| HK1039337A1 (en) | 2002-04-19 |
| DE60002986T2 (de) | 2004-05-19 |
| CN1346360A (zh) | 2002-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA9A | Lapse of provisional patent protection due to relinquishment or protection considered relinquished |