KR20000075777A - 악티노플라네스 종 se50/110 유래의 아카보스 (acb) 클러스터 - Google Patents

악티노플라네스 종 se50/110 유래의 아카보스 (acb) 클러스터 Download PDF

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Publication number
KR20000075777A
KR20000075777A KR1019997007849A KR19997007849A KR20000075777A KR 20000075777 A KR20000075777 A KR 20000075777A KR 1019997007849 A KR1019997007849 A KR 1019997007849A KR 19997007849 A KR19997007849 A KR 19997007849A KR 20000075777 A KR20000075777 A KR 20000075777A
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KR
South Korea
Prior art keywords
pas5
dna
fragment
acarbose
plasmid
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KR1019997007849A
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English (en)
Korean (ko)
Inventor
안넬리제 크뤼거
하이너 아펠러
베르너 슈뢰더
헤르만 파페
클라우스 괴케
볼프강 피페르스베르크
위르겐 디스틀러
빠쓰마르타 디아쓰-구아르다미노우리베
마르틴 얄링
안스가르 스트라트만
Original Assignee
빌프리더 하이더
바이엘 악티엔게젤샤프트
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Application filed by 빌프리더 하이더, 바이엘 악티엔게젤샤프트 filed Critical 빌프리더 하이더
Publication of KR20000075777A publication Critical patent/KR20000075777A/ko

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52Genes encoding for enzymes or proenzymes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/365Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinoplanes (G)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces

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  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1019997007849A 1997-02-28 1998-02-16 악티노플라네스 종 se50/110 유래의 아카보스 (acb) 클러스터 KR20000075777A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19708127.4 1997-02-28
DE19708127A DE19708127A1 (de) 1997-02-28 1997-02-28 Acarbose acb-Cluster: Isolierung von weiteren Genen der Acarbose Biosynthese und des Acarbose-Stoffwechsels aus Actinoplanes sp. SE 50/110 sowie deren Verwendung

Publications (1)

Publication Number Publication Date
KR20000075777A true KR20000075777A (ko) 2000-12-26

Family

ID=7821816

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019997007849A KR20000075777A (ko) 1997-02-28 1998-02-16 악티노플라네스 종 se50/110 유래의 아카보스 (acb) 클러스터

Country Status (15)

Country Link
EP (1) EP0968294A1 (no)
KR (1) KR20000075777A (no)
CN (1) CN1249001A (no)
AU (1) AU6296898A (no)
BG (1) BG103672A (no)
BR (1) BR9807640A (no)
CA (1) CA2282735A1 (no)
CZ (1) CZ9903054A3 (no)
DE (1) DE19708127A1 (no)
HU (1) HUP0000889A2 (no)
IL (1) IL131433A0 (no)
NO (1) NO994164L (no)
PL (1) PL335369A1 (no)
WO (1) WO1998038313A1 (no)
ZA (1) ZA981659B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0796915A3 (de) * 1996-03-22 1999-04-14 Bayer Ag Verfahren zur Herstellung sowie zur Verwendung von Acarviosyl-Transferase bei der Umwandlung von Acarbose-Homologen in Acarbose, zur Herstellung von Acarbose-Homologen
TW201217533A (en) * 2010-08-04 2012-05-01 Bayer Pharma AG Genomics of actinoplanes utahensis
CN106167814B (zh) * 2016-08-31 2019-08-09 河北华荣制药有限公司 一种提高阿卡波糖发酵单位的方法
CN106566796B (zh) * 2016-10-28 2020-11-10 上海交通大学 阿卡波糖生产菌Actinoplanes spp.的遗传操作体系
EP4045520A1 (en) * 2019-10-16 2022-08-24 Bayer Aktiengesellschaft Methods for the improved formation of acarbose
CN112592878B (zh) * 2020-12-25 2022-08-26 上海交通大学 增强正调控蛋白基因表达以提高阿卡波糖发酵水平的方法
CN113444670A (zh) * 2021-07-28 2021-09-28 山东鲁抗医药股份有限公司 一种高活性阿卡波糖产生菌的筛选方法和培养方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19507214A1 (de) * 1995-03-02 1996-10-31 Bayer Ag Acarbose-Biosynthesegene aus Actinoplanes sp., Verfahren zu ihrer Isolierung sowie ihre Verwendung
DE19622783A1 (de) * 1996-06-07 1997-12-11 Hoechst Ag Isolierung der Biosynthesegene für Pseudo-Oligosaccharide aus Streptomyces glaucescens GLA.O und ihre Verwendung

Also Published As

Publication number Publication date
CN1249001A (zh) 2000-03-29
CZ9903054A3 (cs) 1999-11-17
PL335369A1 (en) 2000-04-25
NO994164D0 (no) 1999-08-27
CA2282735A1 (en) 1998-09-03
BR9807640A (pt) 2000-03-21
NO994164L (no) 1999-08-27
IL131433A0 (en) 2001-01-28
BG103672A (en) 2000-05-31
WO1998038313A1 (de) 1998-09-03
HUP0000889A2 (en) 2000-07-28
ZA981659B (en) 1998-09-10
EP0968294A1 (de) 2000-01-05
AU6296898A (en) 1998-09-18
DE19708127A1 (de) 1998-09-03

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