BR9807640A - Aglomerado de acb de acarbose a partir de actinoplanes sp. se 50 / 110 - Google Patents
Aglomerado de acb de acarbose a partir de actinoplanes sp. se 50 / 110Info
- Publication number
- BR9807640A BR9807640A BR9807640A BR9807640A BR9807640A BR 9807640 A BR9807640 A BR 9807640A BR 9807640 A BR9807640 A BR 9807640A BR 9807640 A BR9807640 A BR 9807640A BR 9807640 A BR9807640 A BR 9807640A
- Authority
- BR
- Brazil
- Prior art keywords
- actinoplanes
- acarbose
- cluster
- genes
- acb
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/365—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinoplanes (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
- C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
Landscapes
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
invenção refere-se a genes para a biossíntese a partir do aglomerado de genes de acarbose a partir de Actinoplanes sp. SE 50/110, ao seu isolamento a partir de Actinoplanes sp. ou a partir de produtoolamento desses genes para a biossíntese, às proteínas codificadas pelos mencionados genes, à expres, bem como à aplicação dos genes para a biossíntese de acarbose para a otimização do processo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19708127A DE19708127A1 (de) | 1997-02-28 | 1997-02-28 | Acarbose acb-Cluster: Isolierung von weiteren Genen der Acarbose Biosynthese und des Acarbose-Stoffwechsels aus Actinoplanes sp. SE 50/110 sowie deren Verwendung |
PCT/EP1998/000862 WO1998038313A1 (de) | 1997-02-28 | 1998-02-16 | Acarbose acb-cluster aus $i(actinoplanes) sp. se 50/110 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9807640A true BR9807640A (pt) | 2000-03-21 |
Family
ID=7821816
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9807640A BR9807640A (pt) | 1997-02-28 | 1998-02-16 | Aglomerado de acb de acarbose a partir de actinoplanes sp. se 50 / 110 |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0968294A1 (pt) |
KR (1) | KR20000075777A (pt) |
CN (1) | CN1249001A (pt) |
AU (1) | AU6296898A (pt) |
BG (1) | BG103672A (pt) |
BR (1) | BR9807640A (pt) |
CA (1) | CA2282735A1 (pt) |
CZ (1) | CZ9903054A3 (pt) |
DE (1) | DE19708127A1 (pt) |
HU (1) | HUP0000889A2 (pt) |
IL (1) | IL131433A0 (pt) |
NO (1) | NO994164D0 (pt) |
PL (1) | PL335369A1 (pt) |
WO (1) | WO1998038313A1 (pt) |
ZA (1) | ZA981659B (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0796915A3 (de) * | 1996-03-22 | 1999-04-14 | Bayer Ag | Verfahren zur Herstellung sowie zur Verwendung von Acarviosyl-Transferase bei der Umwandlung von Acarbose-Homologen in Acarbose, zur Herstellung von Acarbose-Homologen |
TW201217533A (en) * | 2010-08-04 | 2012-05-01 | Bayer Pharma AG | Genomics of actinoplanes utahensis |
CN106167814B (zh) * | 2016-08-31 | 2019-08-09 | 河北华荣制药有限公司 | 一种提高阿卡波糖发酵单位的方法 |
CN106566796B (zh) * | 2016-10-28 | 2020-11-10 | 上海交通大学 | 阿卡波糖生产菌Actinoplanes spp.的遗传操作体系 |
EP4045520A1 (en) * | 2019-10-16 | 2022-08-24 | Bayer Aktiengesellschaft | Methods for the improved formation of acarbose |
CN112592878B (zh) * | 2020-12-25 | 2022-08-26 | 上海交通大学 | 增强正调控蛋白基因表达以提高阿卡波糖发酵水平的方法 |
CN113444670A (zh) * | 2021-07-28 | 2021-09-28 | 山东鲁抗医药股份有限公司 | 一种高活性阿卡波糖产生菌的筛选方法和培养方法 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19507214A1 (de) * | 1995-03-02 | 1996-10-31 | Bayer Ag | Acarbose-Biosynthesegene aus Actinoplanes sp., Verfahren zu ihrer Isolierung sowie ihre Verwendung |
DE19622783A1 (de) * | 1996-06-07 | 1997-12-11 | Hoechst Ag | Isolierung der Biosynthesegene für Pseudo-Oligosaccharide aus Streptomyces glaucescens GLA.O und ihre Verwendung |
-
1997
- 1997-02-28 DE DE19708127A patent/DE19708127A1/de not_active Withdrawn
-
1998
- 1998-02-16 BR BR9807640A patent/BR9807640A/pt not_active Application Discontinuation
- 1998-02-16 EP EP98906953A patent/EP0968294A1/de not_active Withdrawn
- 1998-02-16 CZ CZ993054A patent/CZ9903054A3/cs unknown
- 1998-02-16 CA CA002282735A patent/CA2282735A1/en not_active Abandoned
- 1998-02-16 IL IL13143398A patent/IL131433A0/xx unknown
- 1998-02-16 KR KR1019997007849A patent/KR20000075777A/ko not_active Application Discontinuation
- 1998-02-16 AU AU62968/98A patent/AU6296898A/en not_active Abandoned
- 1998-02-16 HU HU0000889A patent/HUP0000889A2/hu unknown
- 1998-02-16 WO PCT/EP1998/000862 patent/WO1998038313A1/de not_active Application Discontinuation
- 1998-02-16 PL PL98335369A patent/PL335369A1/xx unknown
- 1998-02-16 CN CN98802927A patent/CN1249001A/zh active Pending
- 1998-02-27 ZA ZA981659A patent/ZA981659B/xx unknown
-
1999
- 1999-08-20 BG BG103672A patent/BG103672A/xx unknown
- 1999-08-27 NO NO994164A patent/NO994164D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU6296898A (en) | 1998-09-18 |
EP0968294A1 (de) | 2000-01-05 |
NO994164L (no) | 1999-08-27 |
ZA981659B (en) | 1998-09-10 |
CA2282735A1 (en) | 1998-09-03 |
HUP0000889A2 (en) | 2000-07-28 |
IL131433A0 (en) | 2001-01-28 |
KR20000075777A (ko) | 2000-12-26 |
CZ9903054A3 (cs) | 1999-11-17 |
PL335369A1 (en) | 2000-04-25 |
DE19708127A1 (de) | 1998-09-03 |
NO994164D0 (no) | 1999-08-27 |
WO1998038313A1 (de) | 1998-09-03 |
BG103672A (en) | 2000-05-31 |
CN1249001A (zh) | 2000-03-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |