ZA981659B - Acarbose ACB cluster isolation of further acarbose biosynthesis and acarbose metabolism genes from actinoplanes SP.SE50/110 and their use - Google Patents

Acarbose ACB cluster isolation of further acarbose biosynthesis and acarbose metabolism genes from actinoplanes SP.SE50/110 and their use

Info

Publication number
ZA981659B
ZA981659B ZA981659A ZA981659A ZA981659B ZA 981659 B ZA981659 B ZA 981659B ZA 981659 A ZA981659 A ZA 981659A ZA 981659 A ZA981659 A ZA 981659A ZA 981659 B ZA981659 B ZA 981659B
Authority
ZA
South Africa
Prior art keywords
acarbose
actinoplanes
acb
biosynthesis
metabolism genes
Prior art date
Application number
ZA981659A
Other languages
English (en)
Inventor
Anneliese Crueger
Heiner Apeler
Werner Schroder
Hermann Pape
Klaus Goeke
Wolfgang Piepersberg
Jurgen Distler
Uribe Paz Mart Diaz-Guardamino
Martin Jarling
Ansgar Stratmann
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of ZA981659B publication Critical patent/ZA981659B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/365—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Actinoplanes (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
ZA981659A 1997-02-28 1998-02-27 Acarbose ACB cluster isolation of further acarbose biosynthesis and acarbose metabolism genes from actinoplanes SP.SE50/110 and their use ZA981659B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19708127A DE19708127A1 (de) 1997-02-28 1997-02-28 Acarbose acb-Cluster: Isolierung von weiteren Genen der Acarbose Biosynthese und des Acarbose-Stoffwechsels aus Actinoplanes sp. SE 50/110 sowie deren Verwendung

Publications (1)

Publication Number Publication Date
ZA981659B true ZA981659B (en) 1998-09-10

Family

ID=7821816

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA981659A ZA981659B (en) 1997-02-28 1998-02-27 Acarbose ACB cluster isolation of further acarbose biosynthesis and acarbose metabolism genes from actinoplanes SP.SE50/110 and their use

Country Status (15)

Country Link
EP (1) EP0968294A1 (no)
KR (1) KR20000075777A (no)
CN (1) CN1249001A (no)
AU (1) AU6296898A (no)
BG (1) BG103672A (no)
BR (1) BR9807640A (no)
CA (1) CA2282735A1 (no)
CZ (1) CZ9903054A3 (no)
DE (1) DE19708127A1 (no)
HU (1) HUP0000889A2 (no)
IL (1) IL131433A0 (no)
NO (1) NO994164L (no)
PL (1) PL335369A1 (no)
WO (1) WO1998038313A1 (no)
ZA (1) ZA981659B (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0796915A3 (de) * 1996-03-22 1999-04-14 Bayer Ag Verfahren zur Herstellung sowie zur Verwendung von Acarviosyl-Transferase bei der Umwandlung von Acarbose-Homologen in Acarbose, zur Herstellung von Acarbose-Homologen
TW201217533A (en) * 2010-08-04 2012-05-01 Bayer Pharma AG Genomics of actinoplanes utahensis
CN106167814B (zh) * 2016-08-31 2019-08-09 河北华荣制药有限公司 一种提高阿卡波糖发酵单位的方法
CN106566796B (zh) * 2016-10-28 2020-11-10 上海交通大学 阿卡波糖生产菌Actinoplanes spp.的遗传操作体系
EP4045520A1 (en) * 2019-10-16 2022-08-24 Bayer Aktiengesellschaft Methods for the improved formation of acarbose
CN112592878B (zh) * 2020-12-25 2022-08-26 上海交通大学 增强正调控蛋白基因表达以提高阿卡波糖发酵水平的方法
CN113444670A (zh) * 2021-07-28 2021-09-28 山东鲁抗医药股份有限公司 一种高活性阿卡波糖产生菌的筛选方法和培养方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19507214A1 (de) * 1995-03-02 1996-10-31 Bayer Ag Acarbose-Biosynthesegene aus Actinoplanes sp., Verfahren zu ihrer Isolierung sowie ihre Verwendung
DE19622783A1 (de) * 1996-06-07 1997-12-11 Hoechst Ag Isolierung der Biosynthesegene für Pseudo-Oligosaccharide aus Streptomyces glaucescens GLA.O und ihre Verwendung

Also Published As

Publication number Publication date
CN1249001A (zh) 2000-03-29
CZ9903054A3 (cs) 1999-11-17
PL335369A1 (en) 2000-04-25
NO994164D0 (no) 1999-08-27
CA2282735A1 (en) 1998-09-03
BR9807640A (pt) 2000-03-21
NO994164L (no) 1999-08-27
IL131433A0 (en) 2001-01-28
BG103672A (en) 2000-05-31
WO1998038313A1 (de) 1998-09-03
HUP0000889A2 (en) 2000-07-28
EP0968294A1 (de) 2000-01-05
AU6296898A (en) 1998-09-18
DE19708127A1 (de) 1998-09-03
KR20000075777A (ko) 2000-12-26

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