KR102916887B1 - 메닌-mll 상호 작용의 억제제 - Google Patents

메닌-mll 상호 작용의 억제제

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Publication number
KR102916887B1
KR102916887B1 KR1020227028964A KR20227028964A KR102916887B1 KR 102916887 B1 KR102916887 B1 KR 102916887B1 KR 1020227028964 A KR1020227028964 A KR 1020227028964A KR 20227028964 A KR20227028964 A KR 20227028964A KR 102916887 B1 KR102916887 B1 KR 102916887B1
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South Korea
Prior art keywords
pyrimidin
diazaspiro
fluoro
methyl
oxy
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KR1020227028964A
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English (en)
Korean (ko)
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KR20220123727A (ko
Inventor
살바시온 카카티안
데이비드 에이 클라레몬
로렌스 웨인 딜라드
쳉구오 동
이 판
란퀴 지아
스테판 디 로테스타
앤드류 마르쿠스
엔젤 모랄레스-라모스
수레시 비 싱
샹카 벤카트라만
징 유안
야준 쳉
링항 주앙
스테판 디 패런트
트레비스 엘 휴스턴
Original Assignee
비타이 파마슈티컬즈, 엘엘씨
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Application filed by 비타이 파마슈티컬즈, 엘엘씨 filed Critical 비타이 파마슈티컬즈, 엘엘씨
Priority to KR1020257017598A priority Critical patent/KR20250079083A/ko
Publication of KR20220123727A publication Critical patent/KR20220123727A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020227028964A 2016-06-10 2017-06-08 메닌-mll 상호 작용의 억제제 Active KR102916887B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020257017598A KR20250079083A (ko) 2016-06-10 2017-06-08 메닌-mll 상호 작용의 억제제

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662348496P 2016-06-10 2016-06-10
US62/348,496 2016-06-10
KR1020197000269A KR102436430B1 (ko) 2016-06-10 2017-06-08 메닌-mll 상호 작용의 억제제
PCT/US2017/036506 WO2017214367A1 (en) 2016-06-10 2017-06-08 Inhibitors of the menin-mll interaction

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020197000269A Division KR102436430B1 (ko) 2016-06-10 2017-06-08 메닌-mll 상호 작용의 억제제

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020257017598A Division KR20250079083A (ko) 2016-06-10 2017-06-08 메닌-mll 상호 작용의 억제제

Publications (2)

Publication Number Publication Date
KR20220123727A KR20220123727A (ko) 2022-09-08
KR102916887B1 true KR102916887B1 (ko) 2026-01-22

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Application Number Title Priority Date Filing Date
KR1020227028964A Active KR102916887B1 (ko) 2016-06-10 2017-06-08 메닌-mll 상호 작용의 억제제
KR1020257017598A Pending KR20250079083A (ko) 2016-06-10 2017-06-08 메닌-mll 상호 작용의 억제제
KR1020197000269A Active KR102436430B1 (ko) 2016-06-10 2017-06-08 메닌-mll 상호 작용의 억제제

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020257017598A Pending KR20250079083A (ko) 2016-06-10 2017-06-08 메닌-mll 상호 작용의 억제제
KR1020197000269A Active KR102436430B1 (ko) 2016-06-10 2017-06-08 메닌-mll 상호 작용의 억제제

Country Status (21)

Country Link
US (4) US10683302B2 (https=)
EP (2) EP3805215A1 (https=)
JP (4) JP7007302B2 (https=)
KR (3) KR102916887B1 (https=)
CN (1) CN109743875B (https=)
AU (3) AU2017278950B2 (https=)
BR (1) BR122024002146A2 (https=)
CA (2) CA3024180A1 (https=)
CY (1) CY1124834T1 (https=)
DK (1) DK3468966T3 (https=)
ES (1) ES2831084T3 (https=)
HR (1) HRP20201771T1 (https=)
HU (1) HUE051451T2 (https=)
IL (4) IL298381B2 (https=)
LT (1) LT3468966T (https=)
MX (3) MX381228B (https=)
PL (1) PL3468966T3 (https=)
PT (1) PT3468966T (https=)
SI (1) SI3468966T1 (https=)
WO (1) WO2017214367A1 (https=)
ZA (1) ZA201900150B (https=)

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