BR112019012106A2 - inibidores de azepano de interação menin-mill - Google Patents

inibidores de azepano de interação menin-mill

Info

Publication number
BR112019012106A2
BR112019012106A2 BR112019012106-4A BR112019012106A BR112019012106A2 BR 112019012106 A2 BR112019012106 A2 BR 112019012106A2 BR 112019012106 A BR112019012106 A BR 112019012106A BR 112019012106 A2 BR112019012106 A2 BR 112019012106A2
Authority
BR
Brazil
Prior art keywords
azepane
inhibitors
menin
mill
interaction
Prior art date
Application number
BR112019012106-4A
Other languages
English (en)
Inventor
Nathaniel Patrick Aaron
Herkert Barbara
Jason Krosky Daniel
Noëlle Constance Pilatte Isabelle
Alexis Georges Querolle Olivier
René Angibaud Patrick
Pande Vineet
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority claimed from PCT/EP2017/082826 external-priority patent/WO2018109088A1/en
Publication of BR112019012106A2 publication Critical patent/BR112019012106A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

a presente invenção refere-se a agentes farmacêuticos úteis para terapia e/ou profilaxia em um mamífero e, em particular, a compostos de azepano, a composição farmacêutica que compreende tais compostos, e ao seu uso como inibidores de interação proteína/proteína menin/mll, úteis para tratar doenças, tais como câncer, síndrome mieolodisplásica (mds) e diabetes.'
BR112019012106-4A 2016-12-15 2017-12-14 inibidores de azepano de interação menin-mill BR112019012106A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662434549P 2016-12-15 2016-12-15
EP17150502 2017-01-06
PCT/EP2017/082826 WO2018109088A1 (en) 2016-12-15 2017-12-14 Azepane inhibitors of menin-mll interaction

Publications (1)

Publication Number Publication Date
BR112019012106A2 true BR112019012106A2 (pt) 2019-10-29

Family

ID=60935807

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112019012106-4A BR112019012106A2 (pt) 2016-12-15 2017-12-14 inibidores de azepano de interação menin-mill

Country Status (11)

Country Link
US (2) US10745409B2 (pt)
EP (1) EP3555103B1 (pt)
JP (1) JP7142010B2 (pt)
KR (1) KR102513564B1 (pt)
CN (1) CN110248946B (pt)
AU (1) AU2017376599B2 (pt)
BR (1) BR112019012106A2 (pt)
CA (1) CA3044739A1 (pt)
ES (1) ES2901227T3 (pt)
IL (1) IL267277B (pt)
MX (1) MX2019007067A (pt)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116903609A (zh) * 2021-11-05 2023-10-20 上海优理惠生医药有限公司 一种化合物、包含其的药物组合物及其应用

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GB0713602D0 (en) 2007-07-12 2007-08-22 Syngenta Participations Ag Chemical compounds
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JP2011026305A (ja) 2009-06-24 2011-02-10 Daiichi Sankyo Co Ltd イミダゾールカルボニル化合物を含有する医薬組成物
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WO2012075500A2 (en) 2010-12-03 2012-06-07 Epizyme, Inc. 7-deazapurine modulators of histone methyltransferase, and methods of use thereof
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US20170198006A1 (en) 2014-06-25 2017-07-13 Epizyme, Inc. Prmt5 inhibitors and uses thereof
WO2016040330A1 (en) 2014-09-09 2016-03-17 The Regents Of The University Of Michigan Thienopyrimidine and thienopyridine compounds and methods of use thereof
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CN105732636B (zh) 2014-12-30 2020-04-21 广东东阳光药业有限公司 杂芳化合物及其在药物中的应用
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TWI791251B (zh) 2015-08-26 2023-02-01 比利時商健生藥品公司 使用作為ｐｒｍｔ５抑制劑之新穎經６-６雙環芳香環取代之核苷類似物
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EP3512857B1 (en) 2016-09-14 2021-02-24 Janssen Pharmaceutica NV Spiro bicyclic inhibitors of menin-mll interaction
US10611778B2 (en) 2016-09-14 2020-04-07 Janssen Pharmaceutica Nv Fused bicyclic inhibitors of menin-MLL interaction
CA3033239A1 (en) 2016-09-14 2018-03-22 Janssen Pharmaceutica Nv Spiro bicyclic inhibitors of menin-mll interaction
IL265028B (en) 2016-09-16 2022-09-01 Vitae Pharmaceuticals Llc Inhibitors of the menin-mil interaction
WO2018109088A1 (en) 2016-12-15 2018-06-21 Janssen Pharmaceutica Nv Azepane inhibitors of menin-mll interaction
EP3601249A4 (en) 2017-03-24 2020-12-16 Kura Oncology, Inc. METHODS OF TREATMENT OF MALIGNANT HEMOPATHIES AND EWING'S SARCOMA

Also Published As

Publication number Publication date
ES2901227T3 (es) 2022-03-21
JP7142010B2 (ja) 2022-09-26
US11530226B2 (en) 2022-12-20
KR102513564B1 (ko) 2023-03-22
US10745409B2 (en) 2020-08-18
EP3555103B1 (en) 2021-09-22
CA3044739A1 (en) 2018-06-21
KR20190092518A (ko) 2019-08-07
IL267277A (en) 2019-08-29
MX2019007067A (es) 2019-10-15
JP2020512290A (ja) 2020-04-23
AU2017376599A1 (en) 2019-08-01
EP3555103A1 (en) 2019-10-23
AU2017376599B2 (en) 2021-10-07
IL267277B (en) 2022-04-01
CN110248946B (zh) 2023-05-23
US20200339594A1 (en) 2020-10-29
CN110248946A (zh) 2019-09-17
US20190322685A1 (en) 2019-10-24

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06W Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]