MX2020006594A - Inhibidores de exo-azaespiro de la interaccion menina-mll. - Google Patents
Inhibidores de exo-azaespiro de la interaccion menina-mll.Info
- Publication number
- MX2020006594A MX2020006594A MX2020006594A MX2020006594A MX2020006594A MX 2020006594 A MX2020006594 A MX 2020006594A MX 2020006594 A MX2020006594 A MX 2020006594A MX 2020006594 A MX2020006594 A MX 2020006594A MX 2020006594 A MX2020006594 A MX 2020006594A
- Authority
- MX
- Mexico
- Prior art keywords
- menin
- inhibitors
- exo
- aza spiro
- mll interaction
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
La presente invención se refiere a agentes farmacéuticos útiles para terapia y/o profilaxis en un mamífero, composición farmacéutica que comprende dichos compuestos, y su uso como inhibidores de la interacción proteína/proteína menina/MLL, útiles para tratar enfermedades tales como cáncer, síndrome mielodisplásico (MDS) y diabetes.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2017117536 | 2017-12-20 | ||
CN2018091521 | 2018-06-15 | ||
PCT/CN2018/121960 WO2019120209A1 (en) | 2017-12-20 | 2018-12-19 | Exo-aza spiro inhibitors of menin-mll interaction |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2020006594A true MX2020006594A (es) | 2020-09-09 |
Family
ID=66993097
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020006594A MX2020006594A (es) | 2017-12-20 | 2018-12-19 | Inhibidores de exo-azaespiro de la interaccion menina-mll. |
Country Status (12)
Country | Link |
---|---|
US (1) | US20230039917A1 (es) |
EP (1) | EP3728260A4 (es) |
JP (1) | JP7307729B2 (es) |
KR (1) | KR20200101389A (es) |
CN (1) | CN111601807B (es) |
AU (1) | AU2018389145B2 (es) |
BR (1) | BR112020012461A2 (es) |
CA (1) | CA3083624A1 (es) |
IL (1) | IL275457A (es) |
MA (1) | MA51337A (es) |
MX (1) | MX2020006594A (es) |
WO (1) | WO2019120209A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110950818B (zh) * | 2019-12-18 | 2021-12-28 | 浙江海翔药业股份有限公司 | 顺式-2,6-二甲基吗啉的纯化方法 |
CN114478568A (zh) * | 2020-10-27 | 2022-05-13 | 苏州优理生物医药科技有限公司 | 一种噻吩并嘧啶类化合物、包含其药物组合物及其应用 |
KR20230157981A (ko) * | 2021-02-19 | 2023-11-17 | 칼비스타 파마슈티컬즈 리미티드 | 인자 xiia 저해제 |
BR112023023154A2 (pt) | 2021-05-08 | 2024-01-23 | Janssen Pharmaceutica Nv | Derivados espiro substituídos |
KR20240005747A (ko) | 2021-05-08 | 2024-01-12 | 얀센 파마슈티카 엔브이 | 치환된 스피로 유도체 |
EP4337203A1 (en) * | 2021-05-14 | 2024-03-20 | Syndax Pharmaceuticals, Inc. | Inhibitors of the menin-mll interaction |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2904612A1 (en) * | 2013-03-13 | 2014-10-09 | The Regents Of The University Of Michigan | Compositions comprising thienopyrimidine and thienopyridine compounds and methods of use thereof |
AR104020A1 (es) * | 2015-06-04 | 2017-06-21 | Kura Oncology Inc | Métodos y composiciones para inhibir la interacción de menina con proteínas mill |
US20190010167A1 (en) * | 2015-12-22 | 2019-01-10 | Vitae Pharmaceuticals, Inc. | Inhibitors of the menin-mll interaction |
WO2017207387A1 (en) * | 2016-05-31 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Spiro condensed azetidine derivatives as inhibitors of the menin-mml1 interaction |
SI3468966T1 (sl) * | 2016-06-10 | 2021-03-31 | Vitae Pharmaceuticals, Llc | Zaviralci interakcije menin-MLL |
CA3033239A1 (en) * | 2016-09-14 | 2018-03-22 | Janssen Pharmaceutica Nv | Spiro bicyclic inhibitors of menin-mll interaction |
US11396517B1 (en) * | 2017-12-20 | 2022-07-26 | Janssen Pharmaceutica Nv | Exo-aza spiro inhibitors of menin-MLL interaction |
-
2018
- 2018-12-19 BR BR112020012461-3A patent/BR112020012461A2/pt unknown
- 2018-12-19 KR KR1020207020200A patent/KR20200101389A/ko not_active Application Discontinuation
- 2018-12-19 CA CA3083624A patent/CA3083624A1/en active Pending
- 2018-12-19 AU AU2018389145A patent/AU2018389145B2/en active Active
- 2018-12-19 JP JP2020534167A patent/JP7307729B2/ja active Active
- 2018-12-19 MX MX2020006594A patent/MX2020006594A/es unknown
- 2018-12-19 MA MA051337A patent/MA51337A/fr unknown
- 2018-12-19 WO PCT/CN2018/121960 patent/WO2019120209A1/en unknown
- 2018-12-19 EP EP18892193.6A patent/EP3728260A4/en active Pending
- 2018-12-19 CN CN201880082454.4A patent/CN111601807B/zh active Active
-
2020
- 2020-06-17 IL IL275457A patent/IL275457A/en unknown
-
2022
- 2022-05-02 US US17/734,413 patent/US20230039917A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
KR20200101389A (ko) | 2020-08-27 |
JP2021506882A (ja) | 2021-02-22 |
IL275457A (en) | 2020-08-31 |
CA3083624A1 (en) | 2019-06-27 |
EP3728260A4 (en) | 2021-08-11 |
MA51337A (fr) | 2020-10-28 |
AU2018389145A1 (en) | 2020-05-21 |
JP7307729B2 (ja) | 2023-07-12 |
CN111601807A (zh) | 2020-08-28 |
RU2020123548A3 (es) | 2022-02-17 |
WO2019120209A1 (en) | 2019-06-27 |
BR112020012461A2 (pt) | 2020-11-24 |
US20230039917A1 (en) | 2023-02-09 |
RU2020123548A (ru) | 2022-01-20 |
AU2018389145B2 (en) | 2023-02-02 |
EP3728260A1 (en) | 2020-10-28 |
CN111601807B (zh) | 2023-03-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2020006594A (es) | Inhibidores de exo-azaespiro de la interaccion menina-mll. | |
EA201990699A1 (ru) | Спиробициклические ингибиторы взаимодействия менин–mll | |
MX2019002959A (es) | Inhibidores biciclicos condensados de la interaccion de menina-mll. | |
PH12017500367A1 (en) | Compounds that inhibit mcl-1 protein | |
MY196909A (en) | Boronic acid derivatives and therapeutic uses thereof | |
PH12016501898A1 (en) | Quinoxaline derivatives useful as fgfr kinase modulators | |
PH12020550901A1 (en) | Macrocyclic compounds for treating disease | |
CA2999253C (en) | Heterocyclic compounds and uses thereof | |
EA033266B1 (ru) | Гидроксисложноэфирные производные, способ их получения и фармацевтические композиции, содержащие их | |
EA201791867A1 (ru) | Бициклические гетероциклы как ингибиторы fgfr4 | |
MX2019002962A (es) | Inhibidores espirobiciclicos de la interaccion de menina-mll. | |
NZ719905A (en) | Bicyclic heterocycle compounds and their uses in therapy | |
CL2015002767A1 (es) | Compuestos terapéuticos y composiciones | |
MX2016015565A (es) | Ciertos inhibidores de la proteina quinasa. | |
EA201991448A1 (ru) | Азепановые ингибиторы взаимодействия менин-mll | |
TR201908265T4 (tr) | Isı şok transkripsiyon faktörü 1 in inhibitörleri olarak kaynaşık 1,4-dihidrodioksin türevleri. | |
MX2020000135A (es) | Nuevos compuestos de quinolinona. | |
PH12021551280A1 (en) | Heteroaromatic compounds as vanin inhibitors | |
MX2017012102A (es) | Agentes citotoxicos bifuncionales que contienen el farmacoforo de cti. | |
EA202191478A1 (ru) | Гетероароматические соединения в качестве ингибиторов ванина | |
EA201790349A1 (ru) | Производные 6-алкинил-пиридина в качестве миметиков белка smac | |
PH12021550269A1 (en) | Heteroaromatic compounds as vanin inhibitors | |
PH12017501122A1 (en) | Substituted pyridyl-cycloalkyl-carboxylic acids, compositions containing them and medical uses thereof | |
MX2019007067A (es) | Inhibidores de azepano de la interacción menina-mll. | |
WO2016187620A3 (en) | Anti-cancer compounds |