KR102781241B1 - 위 저해 펩타이드 수용체(gipr)에 대한 길항제에 접합된 glp-1 수용체 작용제를 사용하여 대사 장애를 치료 또는 개선하는 방법 - Google Patents
위 저해 펩타이드 수용체(gipr)에 대한 길항제에 접합된 glp-1 수용체 작용제를 사용하여 대사 장애를 치료 또는 개선하는 방법 Download PDFInfo
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- KR102781241B1 KR102781241B1 KR1020247027644A KR20247027644A KR102781241B1 KR 102781241 B1 KR102781241 B1 KR 102781241B1 KR 1020247027644 A KR1020247027644 A KR 1020247027644A KR 20247027644 A KR20247027644 A KR 20247027644A KR 102781241 B1 KR102781241 B1 KR 102781241B1
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020257007894A KR20250038835A (ko) | 2017-01-17 | 2018-01-16 | 위 저해 펩타이드 수용체(gipr)에 대한 길항제에 접합된 glp-1 수용체 작용제를 사용하여 대사 장애를 치료 또는 개선하는 방법 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762447332P | 2017-01-17 | 2017-01-17 | |
| US62/447,332 | 2017-01-17 | ||
| PCT/US2018/013918 WO2018136440A1 (en) | 2017-01-17 | 2018-01-16 | Method of treating or ameliorating metabolic disorders using glp-1 receptor agonists conjugated to antagonists for gastric inhibitory peptide receptor (gipr) |
| KR1020197020599A KR102697797B1 (ko) | 2017-01-17 | 2018-01-16 | 위 저해 펩타이드 수용체(gipr)에 대한 길항제에 접합된 glp-1 수용체 작용제를 사용하여 대사 장애를 치료 또는 개선하는 방법 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197020599A Division KR102697797B1 (ko) | 2017-01-17 | 2018-01-16 | 위 저해 펩타이드 수용체(gipr)에 대한 길항제에 접합된 glp-1 수용체 작용제를 사용하여 대사 장애를 치료 또는 개선하는 방법 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020257007894A Division KR20250038835A (ko) | 2017-01-17 | 2018-01-16 | 위 저해 펩타이드 수용체(gipr)에 대한 길항제에 접합된 glp-1 수용체 작용제를 사용하여 대사 장애를 치료 또는 개선하는 방법 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20240131457A KR20240131457A (ko) | 2024-08-30 |
| KR102781241B1 true KR102781241B1 (ko) | 2025-03-14 |
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Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020257007894A Pending KR20250038835A (ko) | 2017-01-17 | 2018-01-16 | 위 저해 펩타이드 수용체(gipr)에 대한 길항제에 접합된 glp-1 수용체 작용제를 사용하여 대사 장애를 치료 또는 개선하는 방법 |
| KR1020197020599A Active KR102697797B1 (ko) | 2017-01-17 | 2018-01-16 | 위 저해 펩타이드 수용체(gipr)에 대한 길항제에 접합된 glp-1 수용체 작용제를 사용하여 대사 장애를 치료 또는 개선하는 방법 |
| KR1020247027644A Active KR102781241B1 (ko) | 2017-01-17 | 2018-01-16 | 위 저해 펩타이드 수용체(gipr)에 대한 길항제에 접합된 glp-1 수용체 작용제를 사용하여 대사 장애를 치료 또는 개선하는 방법 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020257007894A Pending KR20250038835A (ko) | 2017-01-17 | 2018-01-16 | 위 저해 펩타이드 수용체(gipr)에 대한 길항제에 접합된 glp-1 수용체 작용제를 사용하여 대사 장애를 치료 또는 개선하는 방법 |
| KR1020197020599A Active KR102697797B1 (ko) | 2017-01-17 | 2018-01-16 | 위 저해 펩타이드 수용체(gipr)에 대한 길항제에 접합된 glp-1 수용체 작용제를 사용하여 대사 장애를 치료 또는 개선하는 방법 |
Country Status (38)
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY197023A (en) | 2015-12-23 | 2023-05-22 | Amgen Inc | Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists |
| JOP20190177A1 (ar) | 2017-01-17 | 2019-07-16 | Amgen Inc | طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr) |
| EA201992502A1 (ru) | 2017-06-20 | 2020-04-22 | Эмджен Инк. | Способ лечения или уменьшения интенсивности метаболических нарушений с применением белков, связывающих рецептор гастроингибиторного пептида (gipr), в комбинации с агонистами glp-1 |
| WO2018237095A1 (en) | 2017-06-21 | 2018-12-27 | Amgen Inc. | METHOD OF TREATING OR ENHANCING METABOLIC DISORDERS USING ANTAGONISTIC BINDING PROTEINS FOR AGONIST FUSION PROTEINS FROM THE GASTRIC INHIBITOR PEPTIDE RECEPTOR (GIPR) / GLP-1 RECEPTOR |
| EP4464719A3 (en) * | 2017-08-04 | 2025-03-05 | Amgen Inc. | Method of conjugation of cys-mabs |
| WO2020185533A1 (en) | 2019-03-08 | 2020-09-17 | Amgen Inc. | Growth differentiation factor 15 combination therapy |
| CN112521501A (zh) * | 2019-09-18 | 2021-03-19 | 鸿运华宁(杭州)生物医药有限公司 | Gipr抗体及其与glp-1的融合蛋白质,以及其药物组合物和应用 |
| US12054551B2 (en) | 2020-07-02 | 2024-08-06 | Sanofi | FGFR1/KLB targeting agonistic antigen-binding proteins and conjugates thereof with GLP-1R agonistic peptides |
| AU2021339892A1 (en) * | 2020-09-14 | 2023-04-27 | Regeneron Pharmaceuticals, Inc. | Antibody-drug conjugates comprising glp1 peptidomimetics and uses thereof |
| CA3219645A1 (en) | 2021-05-21 | 2022-11-24 | Yuhan Corporation | Composition for combination therapy comprising growth differentiation factor-15 variant and glucagon-like peptide-1 receptor agonist |
| CA3221655A1 (en) * | 2021-06-09 | 2022-12-15 | Swiftnovo Therapeutics Inc. | Therapeutics and methods for treating or ameliorating metabolic disorders |
| EP4489855A1 (en) * | 2022-03-11 | 2025-01-15 | Regeneron Pharmaceuticals, Inc. | Anti-glp1r antibody-drug conjugates comprising glp1 peptidomimetics and uses thereof |
| CN117659189A (zh) * | 2022-09-08 | 2024-03-08 | 鸿运华宁(杭州)生物医药有限公司 | Gipr抗体及其与fgf21的融合蛋白,以及其药物组合物和应用 |
| CN120019167A (zh) * | 2022-10-12 | 2025-05-16 | 首尔大学医院 | 利用gipr标记物的用于预测磺酰脲类依赖性的组合物及其预测方法 |
| KR102679905B1 (ko) * | 2022-10-12 | 2024-07-02 | 서울대학교병원 | Gipr 마커를 이용한 설폰요소제 의존성 예측용 조성물 및 그 예측 방법 |
| TW202432600A (zh) * | 2022-11-07 | 2024-08-16 | 美商安進公司 | 用於治療肥胖症之方法 |
| WO2024123812A1 (en) * | 2022-12-05 | 2024-06-13 | Shattuck Labs, Inc. | Fusion proteins for the treatment of cardiometabolic diseases |
| WO2024209050A1 (en) | 2023-04-05 | 2024-10-10 | Antag Therapeutics Aps | Gip activity modulators and orthostatic intolerance |
| WO2024259079A2 (en) * | 2023-06-14 | 2024-12-19 | Fractyl Health, Inc. | Gene therapies for metabolic disorders |
| WO2025038435A1 (en) | 2023-08-11 | 2025-02-20 | Amgen Inc. | Methods of solid phase antibody conjugation |
| TW202528348A (zh) * | 2023-10-31 | 2025-07-16 | 大陸商山東博安生物技術股份有限公司 | Gipr阻斷型抗體及其抗體偶聯物 |
| WO2025104668A1 (en) | 2023-11-17 | 2025-05-22 | Pfizer Inc. | Anti-gastric inhibitory polypeptide receptor (gipr) antibodies and antibody conjugates for the treatment of metabolic disorders |
| WO2025199030A1 (en) * | 2024-03-18 | 2025-09-25 | Amgen Inc. | Glp-1 receptor agonists and their medical use |
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