CL2019001963A1 - Método para tratar o mejorar trastornos metabólicos mediante el uso de agonistas del receptor glp-1 conjugados con antagonistas del receptor del péptido inhibidor gástrico (gipr). - Google Patents
Método para tratar o mejorar trastornos metabólicos mediante el uso de agonistas del receptor glp-1 conjugados con antagonistas del receptor del péptido inhibidor gástrico (gipr).Info
- Publication number
- CL2019001963A1 CL2019001963A1 CL2019001963A CL2019001963A CL2019001963A1 CL 2019001963 A1 CL2019001963 A1 CL 2019001963A1 CL 2019001963 A CL2019001963 A CL 2019001963A CL 2019001963 A CL2019001963 A CL 2019001963A CL 2019001963 A1 CL2019001963 A1 CL 2019001963A1
- Authority
- CL
- Chile
- Prior art keywords
- gipr
- glp
- treating
- metabolic disorders
- inhibitory peptide
- Prior art date
Links
- 101150020692 Gipr gene Proteins 0.000 title 1
- 229940089838 Glucagon-like peptide 1 receptor agonist Drugs 0.000 title 1
- 230000002496 gastric effect Effects 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 208000030159 metabolic disease Diseases 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Emergency Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762447332P | 2017-01-17 | 2017-01-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2019001963A1 true CL2019001963A1 (es) | 2020-04-03 |
Family
ID=61832572
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2019001963A CL2019001963A1 (es) | 2017-01-17 | 2019-07-12 | Método para tratar o mejorar trastornos metabólicos mediante el uso de agonistas del receptor glp-1 conjugados con antagonistas del receptor del péptido inhibidor gástrico (gipr). |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US10905772B2 (es) |
| EP (1) | EP3570885A1 (es) |
| JP (2) | JP7175899B2 (es) |
| KR (1) | KR20190104158A (es) |
| CN (2) | CN110662558B (es) |
| AR (1) | AR110751A1 (es) |
| AU (1) | AU2018210858A1 (es) |
| BR (1) | BR112019014588A2 (es) |
| CA (1) | CA3049023A1 (es) |
| CL (1) | CL2019001963A1 (es) |
| CO (1) | CO2019007685A2 (es) |
| CR (2) | CR20190380A (es) |
| EA (1) | EA201991721A1 (es) |
| IL (1) | IL267660B1 (es) |
| JO (1) | JOP20190177A1 (es) |
| MA (1) | MA47314A (es) |
| MX (1) | MX2019008462A (es) |
| NZ (1) | NZ754937A (es) |
| PE (1) | PE20191467A1 (es) |
| PH (1) | PH12019501656A1 (es) |
| SA (1) | SA519402246B1 (es) |
| SG (1) | SG11201906525SA (es) |
| TW (1) | TWI708613B (es) |
| UY (1) | UY37568A (es) |
| WO (1) | WO2018136440A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2018007859A (es) | 2015-12-23 | 2018-11-09 | Amgen Inc | Metodo para tratar o mejorar trastornos metabolicos con proteinas de union para el receptor peptidico inhibidor gastrico (gipr) en combinacion con agonistas de glp-1. |
| JOP20190177A1 (ar) | 2017-01-17 | 2019-07-16 | Amgen Inc | طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr) |
| MA49459A (fr) * | 2017-06-21 | 2020-04-29 | Amgen Inc | Méthode de traitement ou d'amélioration des troubles métaboliques à l'aide de protéines de liaison antagonistes pour protéines de fusion agonistes du récepteur du peptide inhibiteur gastrique (gipr)/récepteur glp-1 |
| CA3071852A1 (en) * | 2017-08-04 | 2019-02-07 | Amgen Inc. | Method of conjugation of cys-mabs |
| AU2020233876A1 (en) | 2019-03-08 | 2021-09-23 | Amgen Inc. | Growth differentiation factor 15 combination therapy |
| CN112521501A (zh) * | 2019-09-18 | 2021-03-19 | 鸿运华宁（杭州）生物医药有限公司 | Gipr抗体及其与glp-1的融合蛋白质，以及其药物组合物和应用 |
| WO2022056494A1 (en) * | 2020-09-14 | 2022-03-17 | Regeneron Pharmaceuticals, Inc. | Antibody-drug conjugates comprising glp1 peptidomimetics and uses thereof |
| WO2022245179A1 (en) | 2021-05-21 | 2022-11-24 | Yuhan Corporation | Composition for combination therapy comprising growth differentiation factor-15 variant and glucagon-like peptide-1 receptor agonist |
| AU2022291264A1 (en) * | 2021-06-09 | 2023-12-14 | Swiftnovo Therapeutics Inc. | Therapeutics and methods for treating or ameliorating metabolic disorders |
| WO2023173132A1 (en) * | 2022-03-11 | 2023-09-14 | Regeneron Pharmaceuticals, Inc. | Anti-glp1r antibody-drug conjugates comprising glp1 peptidomimetics and uses thereof |
| WO2024051802A1 (zh) * | 2022-09-08 | 2024-03-14 | 鸿运华宁（杭州）生物医药有限公司 | Gipr抗体及其与fgf21的融合蛋白，以及其药物组合物和应用 |
| WO2024080650A1 (ko) * | 2022-10-12 | 2024-04-18 | 서울대학교병원 | Gipr 마커를 이용한 설폰요소제 의존성 예측용 조성물 및 그 예측 방법 |
| WO2024102742A1 (en) * | 2022-11-07 | 2024-05-16 | Amgen Inc. | Methods for treating obesity |
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| EP3570885A1 (en) | 2019-11-27 |
| CO2019007685A2 (es) | 2019-07-31 |
| PH12019501656A1 (en) | 2019-10-28 |
| NZ754937A (en) | 2023-04-28 |
| JP2022184880A (ja) | 2022-12-13 |
| TWI708613B (zh) | 2020-11-01 |
| PE20191467A1 (es) | 2019-10-16 |
| WO2018136440A1 (en) | 2018-07-26 |
| AU2018210858A1 (en) | 2019-07-18 |
| US20180311372A1 (en) | 2018-11-01 |
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| JP7175899B2 (ja) | 2022-11-21 |
| BR112019014588A2 (pt) | 2020-02-18 |
| EA201991721A1 (ru) | 2020-04-08 |
| TW201838648A (zh) | 2018-11-01 |
| IL267660B1 (en) | 2024-07-01 |
| JP2020506900A (ja) | 2020-03-05 |
| CR20230302A (es) | 2023-08-25 |
| CN110662558B (zh) | 2024-04-09 |
| UY37568A (es) | 2018-07-31 |
| CN110662558A (zh) | 2020-01-07 |
| SG11201906525SA (en) | 2019-08-27 |
| CR20190380A (es) | 2019-11-07 |
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| CA3049023A1 (en) | 2018-07-26 |
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| US10905772B2 (en) | 2021-02-02 |
| SA519402246B1 (ar) | 2023-02-15 |
| JOP20190177A1 (ar) | 2019-07-16 |
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