CL2016002809A1 - Compuestos derivados de pirrol, piridina o piperidina sustituidos con heterociclos, moduladores del receptor acoplado a la proteína g 40 (gpr40); composición farmacéutica que los comprende; y su uso para el tratamiento de enfermedades como diabetes, retinopatía, neuropatía, aterosclerosis, obesidad e hipertensión. - Google Patents

Compuestos derivados de pirrol, piridina o piperidina sustituidos con heterociclos, moduladores del receptor acoplado a la proteína g 40 (gpr40); composición farmacéutica que los comprende; y su uso para el tratamiento de enfermedades como diabetes, retinopatía, neuropatía, aterosclerosis, obesidad e hipertensión.

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Publication number
CL2016002809A1
CL2016002809A1 CL2016002809A CL2016002809A CL2016002809A1 CL 2016002809 A1 CL2016002809 A1 CL 2016002809A1 CL 2016002809 A CL2016002809 A CL 2016002809A CL 2016002809 A CL2016002809 A CL 2016002809A CL 2016002809 A1 CL2016002809 A1 CL 2016002809A1
Authority
CL
Chile
Prior art keywords
gpr40
retinopathy
neuropathy
heterocycles
atherosclerosis
Prior art date
Application number
CL2016002809A
Other languages
English (en)
Inventor
Zhenqiu Hong
Elizabeth A Jurica
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of CL2016002809A1 publication Critical patent/CL2016002809A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compuestos derivados de pirrol, piridina o piperidina sustituidos con heterociclos, moduladores del receptor acoplado a la proteína G 40 (GPR40); composición farmacéutica que los comprende; y su uso para el tratamiento de enfermedades como diabetes, retinopatía, neuropatía, aterosclerosis, obesidad e hipertensión.
CL2016002809A 2014-05-07 2016-11-07 Compuestos derivados de pirrol, piridina o piperidina sustituidos con heterociclos, moduladores del receptor acoplado a la proteína g 40 (gpr40); composición farmacéutica que los comprende; y su uso para el tratamiento de enfermedades como diabetes, retinopatía, neuropatía, aterosclerosis, obesidad e hipertensión. CL2016002809A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201461989651P 2014-05-07 2014-05-07

Publications (1)

Publication Number Publication Date
CL2016002809A1 true CL2016002809A1 (es) 2017-03-24

Family

ID=53181359

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2016002809A CL2016002809A1 (es) 2014-05-07 2016-11-07 Compuestos derivados de pirrol, piridina o piperidina sustituidos con heterociclos, moduladores del receptor acoplado a la proteína g 40 (gpr40); composición farmacéutica que los comprende; y su uso para el tratamiento de enfermedades como diabetes, retinopatía, neuropatía, aterosclerosis, obesidad e hipertensión.

Country Status (32)

Country Link
US (4) US9873679B2 (es)
EP (1) EP3140296B1 (es)
JP (1) JP6483156B2 (es)
KR (1) KR102336370B1 (es)
CN (1) CN106458976B (es)
AR (1) AR100328A1 (es)
AU (1) AU2015256120B2 (es)
BR (1) BR112016024936A2 (es)
CA (1) CA2948161C (es)
CL (1) CL2016002809A1 (es)
CY (1) CY1120340T1 (es)
DK (1) DK3140296T3 (es)
EA (1) EA033250B1 (es)
ES (1) ES2674531T3 (es)
HR (1) HRP20180641T1 (es)
HU (1) HUE039288T2 (es)
IL (1) IL248668B (es)
MA (1) MA39427B1 (es)
MX (1) MX2016013801A (es)
MY (1) MY181959A (es)
NZ (1) NZ727146A (es)
PE (1) PE20161363A1 (es)
PH (1) PH12016502034A1 (es)
PL (1) PL3140296T3 (es)
PT (1) PT3140296T (es)
RS (1) RS57170B1 (es)
SG (1) SG11201609170UA (es)
SI (1) SI3140296T1 (es)
TN (1) TN2016000444A1 (es)
TR (1) TR201809633T4 (es)
TW (1) TWI659951B (es)
WO (1) WO2015171722A1 (es)

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CA2948175A1 (en) * 2014-05-07 2015-11-12 Bristol-Myers Squibb Company Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes
DK3140296T3 (en) * 2014-05-07 2018-07-23 Bristol Myers Squibb Co PYRROLIDIN GPR40 MODULATORS FOR TREATMENT OF DISEASES SUCH AS DIABETES
JP7086942B2 (ja) 2016-09-12 2022-06-20 インテグラル ヘルス， インコーポレイテッド Ｇｐｒ１２０モジュレーターとして有用な単環式化合物
US10865201B2 (en) 2016-09-12 2020-12-15 Valo Health, Inc. Bicyclic compounds useful as GPR120 modulators
US11186565B2 (en) 2017-03-31 2021-11-30 Takeda Pharmaceutical Company Limited Aromatic compound
CN110947003B (zh) * 2017-08-21 2021-04-02 武汉大学 Gpr31抑制剂在制备治疗肾脏缺血再灌注损伤及相关疾病药物中的应用
AU2019222644B2 (en) 2018-02-13 2021-04-01 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
US10899735B2 (en) 2018-04-19 2021-01-26 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
JP7105359B2 (ja) 2018-07-13 2022-07-22 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤
AU2019366355B2 (en) 2018-10-24 2022-10-13 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
AU2022291768A1 (en) 2021-06-16 2023-11-30 Celgene Corporation Azetidinyl compounds comprising a carboxylic acid group for the treatment of neurodegenerative diseases

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US5614492A (en) 1986-05-05 1997-03-25 The General Hospital Corporation Insulinotropic hormone GLP-1 (7-36) and uses thereof
AU2010303670A1 (en) * 2009-10-06 2012-03-29 Bristol-Myers Squibb Company Pyrrolidine GPR40 modulators
US7939569B1 (en) * 2009-12-01 2011-05-10 Hoffmann-La Roche Inc. Aniline analogs as glycogen synthase activators
GB2498976A (en) * 2012-02-01 2013-08-07 Prosidion Ltd GPR119 agonists useful in the treatment of type II diabetes
WO2014022253A1 (en) 2012-08-01 2014-02-06 Bristol-Myers Squibb Company Amino-heteroaryl 7-hydroxy-spiropiperidine indolinyl antagonists of p2y1 receptor
KR20150082617A (ko) 2012-11-16 2015-07-15 브리스톨-마이어스 스큅 컴퍼니 디히드로피라졸 gpr40 조절제
WO2014078611A1 (en) 2012-11-16 2014-05-22 Bristol-Myers Squibb Company Dihydropyrazole gpr40 modulators
BR112015010779A2 (pt) * 2012-11-16 2017-07-11 Bristol Myers Squibb Co moduladores de di-hidropirazol gpr40
CN105121426B (zh) * 2012-11-16 2017-03-29 百时美施贵宝公司 吡咯烷gpr40调节剂
DK3140296T3 (en) * 2014-05-07 2018-07-23 Bristol Myers Squibb Co PYRROLIDIN GPR40 MODULATORS FOR TREATMENT OF DISEASES SUCH AS DIABETES
US10301260B2 (en) 2014-05-07 2019-05-28 Bristol-Myers Squibb Company Pyrrolidine GPR40 modulators
WO2015169728A1 (en) 2014-05-07 2015-11-12 Croma-Pharma Gesellschaft M.B.H. Aqueous ophthalmic solution and method for treating dry eye syndrome

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AU2015256120B2 (en) 2019-03-28
JP2017514856A (ja) 2017-06-08
MA39427B1 (fr) 2018-09-28
MX2016013801A (es) 2017-03-09
TWI659951B (zh) 2019-05-21
US9873679B2 (en) 2018-01-23
EA201692037A1 (ru) 2017-06-30
WO2015171722A1 (en) 2015-11-12
EP3140296A1 (en) 2017-03-15
PH12016502034B1 (en) 2017-01-09
US20190112293A1 (en) 2019-04-18
CA2948161A1 (en) 2015-11-12
PE20161363A1 (es) 2016-12-17
PH12016502034A1 (en) 2017-01-09
US20200299267A1 (en) 2020-09-24
MY181959A (en) 2021-01-15
IL248668A0 (en) 2017-01-31
TR201809633T4 (tr) 2018-07-23
HRP20180641T1 (hr) 2018-06-01
US20180099949A1 (en) 2018-04-12
CN106458976A (zh) 2017-02-22
CY1120340T1 (el) 2019-07-10
EA033250B1 (ru) 2019-09-30
SG11201609170UA (en) 2016-12-29
NZ727146A (en) 2020-01-31
KR20160147049A (ko) 2016-12-21
IL248668B (en) 2019-09-26
MA39427A1 (fr) 2017-11-30
US20150322044A1 (en) 2015-11-12
RS57170B1 (sr) 2018-07-31
TN2016000444A1 (en) 2018-04-04
PL3140296T3 (pl) 2018-08-31
KR102336370B1 (ko) 2021-12-06
EP3140296B1 (en) 2018-04-11
JP6483156B2 (ja) 2019-03-13
SI3140296T1 (en) 2018-06-29
PT3140296T (pt) 2018-06-27
TW201625585A (zh) 2016-07-16
AU2015256120A1 (en) 2016-12-22
HUE039288T2 (hu) 2018-12-28
DK3140296T3 (en) 2018-07-23
US10717725B2 (en) 2020-07-21
BR112016024936A2 (pt) 2017-08-15
CA2948161C (en) 2020-10-27
CN106458976B (zh) 2020-05-22
AR100328A1 (es) 2016-09-28
ES2674531T3 (es) 2018-07-02

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