CY1120340T1 - Gpr40 ρυθμιστες πυρρολιδινης για τη θεραπεια ασθενειων οπως διαβητη - Google Patents

Gpr40 ρυθμιστες πυρρολιδινης για τη θεραπεια ασθενειων οπως διαβητη

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Publication number
CY1120340T1
CY1120340T1 CY20181100547T CY181100547T CY1120340T1 CY 1120340 T1 CY1120340 T1 CY 1120340T1 CY 20181100547 T CY20181100547 T CY 20181100547T CY 181100547 T CY181100547 T CY 181100547T CY 1120340 T1 CY1120340 T1 CY 1120340T1
Authority
CY
Cyprus
Prior art keywords
gpr40
pyrrolidine
regulators
diabetes
treatment
Prior art date
Application number
CY20181100547T
Other languages
English (en)
Inventor
Elizabeth A. Jurica
Zhenqiu Hong
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of CY1120340T1 publication Critical patent/CY1120340T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
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  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει ενώσεις του Τύπου (I): ή στερεοϊσομερές, ταυτομερές, φαρμακευτικώς αποδεκτό άλας, πολύμορφο ή διαλύτωμα αυτών, όπου όλες οι μεταβλητές είναι όπως ορίζεται στο παρόν. Αυτές οι ενώσεις είναι ρυθμιστές υποδοχέα GPR40 συζευγμένου με πρωτεΐνη G που μπορεί να χρησιμοποιηθούν ως φάρμακα.
CY20181100547T 2014-05-07 2018-05-23 Gpr40 ρυθμιστες πυρρολιδινης για τη θεραπεια ασθενειων οπως διαβητη CY1120340T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461989651P 2014-05-07 2014-05-07
PCT/US2015/029409 WO2015171722A1 (en) 2014-05-07 2015-05-06 Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes

Publications (1)

Publication Number Publication Date
CY1120340T1 true CY1120340T1 (el) 2019-07-10

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CY20181100547T CY1120340T1 (el) 2014-05-07 2018-05-23 Gpr40 ρυθμιστες πυρρολιδινης για τη θεραπεια ασθενειων οπως διαβητη

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US (4) US9873679B2 (el)
EP (1) EP3140296B1 (el)
JP (1) JP6483156B2 (el)
KR (1) KR102336370B1 (el)
CN (1) CN106458976B (el)
AR (1) AR100328A1 (el)
AU (1) AU2015256120B2 (el)
BR (1) BR112016024936A2 (el)
CA (1) CA2948161C (el)
CL (1) CL2016002809A1 (el)
CY (1) CY1120340T1 (el)
DK (1) DK3140296T3 (el)
EA (1) EA033250B1 (el)
ES (1) ES2674531T3 (el)
HR (1) HRP20180641T1 (el)
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IL (1) IL248668B (el)
MA (1) MA39427B1 (el)
MX (1) MX2016013801A (el)
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SI (1) SI3140296T1 (el)
TN (1) TN2016000444A1 (el)
TR (1) TR201809633T4 (el)
TW (1) TWI659951B (el)
WO (1) WO2015171722A1 (el)

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JP7086942B2 (ja) * 2016-09-12 2022-06-20 インテグラル ヘルス， インコーポレイテッド Ｇｐｒ１２０モジュレーターとして有用な単環式化合物
US11186565B2 (en) 2017-03-31 2021-11-30 Takeda Pharmaceutical Company Limited Aromatic compound
CN110772636B (zh) * 2017-08-21 2021-03-16 武汉大学 Gpr31抑制剂在制备治疗心脏缺血再灌注损伤及相关疾病药物中的应用
KR102586510B1 (ko) 2018-02-13 2023-10-12 길리애드 사이언시즈, 인코포레이티드 Pd-1/pd-l1 억제제
WO2019204609A1 (en) 2018-04-19 2019-10-24 Gilead Sciences, Inc. Pd-1/pd-l1 inhibitors
PT3820572T (pt) 2018-07-13 2023-11-10 Gilead Sciences Inc Inibidores pd-1/pd-l1
JP7158577B2 (ja) 2018-10-24 2022-10-21 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤
US11034669B2 (en) 2018-11-30 2021-06-15 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof
AR126159A1 (es) 2021-06-16 2023-09-27 Celgene Corp Ácido carboxílico que contiene compuestos de azetidinilo para el tratamiento de enfermedades neurodegenerativas

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WO2015171757A1 (en) 2014-05-07 2015-11-12 Bristol-Myers Squibb Company Pyrrolidine gpr40 modulators
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CN106458976A (zh) 2017-02-22
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MA39427A1 (fr) 2017-11-30
PT3140296T (pt) 2018-06-27
AU2015256120A1 (en) 2016-12-22
BR112016024936A2 (pt) 2017-08-15
PH12016502034A1 (en) 2017-01-09
WO2015171722A1 (en) 2015-11-12
EP3140296A1 (en) 2017-03-15
US20180099949A1 (en) 2018-04-12
US20200299267A1 (en) 2020-09-24
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PH12016502034B1 (en) 2017-01-09
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MY181959A (en) 2021-01-15
TW201625585A (zh) 2016-07-16
ES2674531T3 (es) 2018-07-02
EA033250B1 (ru) 2019-09-30
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IL248668B (en) 2019-09-26
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RS57170B1 (sr) 2018-07-31
AR100328A1 (es) 2016-09-28
IL248668A0 (en) 2017-01-31
US20190112293A1 (en) 2019-04-18
PE20161363A1 (es) 2016-12-17
PL3140296T3 (pl) 2018-08-31
EP3140296B1 (en) 2018-04-11
US10717725B2 (en) 2020-07-21
HUE039288T2 (hu) 2018-12-28
KR20160147049A (ko) 2016-12-21
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US9873679B2 (en) 2018-01-23
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CN106458976B (zh) 2020-05-22
JP2017514856A (ja) 2017-06-08
AU2015256120B2 (en) 2019-03-28
EA201692037A1 (ru) 2017-06-30
US20150322044A1 (en) 2015-11-12
MA39427B1 (fr) 2018-09-28

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