IT201900008391A1 - Procedimento di preparazione del polimorfo f di sodio neridronato - Google Patents

Procedimento di preparazione del polimorfo f di sodio neridronato

Info

Publication number
IT201900008391A1
IT201900008391A1 IT102019000008391A IT201900008391A IT201900008391A1 IT 201900008391 A1 IT201900008391 A1 IT 201900008391A1 IT 102019000008391 A IT102019000008391 A IT 102019000008391A IT 201900008391 A IT201900008391 A IT 201900008391A IT 201900008391 A1 IT201900008391 A1 IT 201900008391A1
Authority
IT
Italy
Prior art keywords
nerhydronate
polymorph
sodium
preparing
procedure
Prior art date
Application number
IT102019000008391A
Other languages
English (en)
Inventor
Fabio Neggiani
Stefano Luca Giaffreda
Serena Fabbroni
Michel Chiarucci
Barbara Politi
Original Assignee
Abiogen Pharma Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abiogen Pharma Spa filed Critical Abiogen Pharma Spa
Priority to IT102019000008391A priority Critical patent/IT201900008391A1/it
Priority to SI202030345T priority patent/SI3980434T1/sl
Priority to PL20736424.1T priority patent/PL3980434T3/pl
Priority to ES20736424T priority patent/ES2967423T3/es
Priority to AU2020289084A priority patent/AU2020289084B2/en
Priority to EP20736424.1A priority patent/EP3980434B1/en
Priority to PT207364241T priority patent/PT3980434T/pt
Priority to LTEPPCT/IB2020/055304T priority patent/LT3980434T/lt
Priority to FIEP20736424.1T priority patent/FI3980434T3/fi
Priority to HRP20231668TT priority patent/HRP20231668T1/hr
Priority to MX2021015053A priority patent/MX2021015053A/es
Priority to DK20736424.1T priority patent/DK3980434T3/da
Priority to CN202080041274.9A priority patent/CN113906039A/zh
Priority to JP2021572271A priority patent/JP7162973B2/ja
Priority to CA3142232A priority patent/CA3142232C/en
Priority to US17/595,992 priority patent/US11512104B2/en
Priority to PCT/IB2020/055304 priority patent/WO2020245780A1/en
Publication of IT201900008391A1 publication Critical patent/IT201900008391A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
IT102019000008391A 2019-06-07 2019-06-07 Procedimento di preparazione del polimorfo f di sodio neridronato IT201900008391A1 (it)

Priority Applications (17)

Application Number Priority Date Filing Date Title
IT102019000008391A IT201900008391A1 (it) 2019-06-07 2019-06-07 Procedimento di preparazione del polimorfo f di sodio neridronato
SI202030345T SI3980434T1 (sl) 2019-06-07 2020-06-05 Postopek za pripravo polimorfa f natrijevega neridronata
PL20736424.1T PL3980434T3 (pl) 2019-06-07 2020-06-05 Sposób wytwarzania polimorfu f neridronianu sodu
ES20736424T ES2967423T3 (es) 2019-06-07 2020-06-05 Procedimiento para la preparación del polimorfo F de neridronato de sodio
AU2020289084A AU2020289084B2 (en) 2019-06-07 2020-06-05 Process for the preparation of the polymorph f of sodium neridronate
EP20736424.1A EP3980434B1 (en) 2019-06-07 2020-06-05 Process for the preparation of the polymorph f of sodium neridronate
PT207364241T PT3980434T (pt) 2019-06-07 2020-06-05 Processo para a preparação do polimorfo f de neridronato de sódio
LTEPPCT/IB2020/055304T LT3980434T (lt) 2019-06-07 2020-06-05 Natrio neridronato polimorfo f gavimo būdas
FIEP20736424.1T FI3980434T3 (fi) 2019-06-07 2020-06-05 Menetelmä natriumneridronaatin polymorfi f:n valmistamiseksi
HRP20231668TT HRP20231668T1 (hr) 2019-06-07 2020-06-05 Postupak za pripravu polimorfa f natrijevog neridronata
MX2021015053A MX2021015053A (es) 2019-06-07 2020-06-05 Proceso de preparacion del polimorfo f de neridronato de sodio.
DK20736424.1T DK3980434T3 (da) 2019-06-07 2020-06-05 Fremgangsmåde til fremstilling af polymorph af natriumneridronat
CN202080041274.9A CN113906039A (zh) 2019-06-07 2020-06-05 用于制备奈立膦酸钠的多晶型物f的工艺
JP2021572271A JP7162973B2 (ja) 2019-06-07 2020-06-05 ネリドロン酸ナトリウムの多形ｆの製造方法
CA3142232A CA3142232C (en) 2019-06-07 2020-06-05 Process for the preparation of the polymorph f of sodium neridronate
US17/595,992 US11512104B2 (en) 2019-06-07 2020-06-05 Process for the preparation of the polymorph F of sodium neridronate
PCT/IB2020/055304 WO2020245780A1 (en) 2019-06-07 2020-06-05 Process for the preparation of the polymorph f of sodium neridronate

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT102019000008391A IT201900008391A1 (it) 2019-06-07 2019-06-07 Procedimento di preparazione del polimorfo f di sodio neridronato

Publications (1)

Publication Number Publication Date
IT201900008391A1 true IT201900008391A1 (it) 2020-12-07

Family

ID=68234108

Family Applications (1)

Application Number Title Priority Date Filing Date
IT102019000008391A IT201900008391A1 (it) 2019-06-07 2019-06-07 Procedimento di preparazione del polimorfo f di sodio neridronato

Country Status (17)

Country Link
US (1) US11512104B2 (it)
EP (1) EP3980434B1 (it)
JP (1) JP7162973B2 (it)
CN (1) CN113906039A (it)
AU (1) AU2020289084B2 (it)
CA (1) CA3142232C (it)
DK (1) DK3980434T3 (it)
ES (1) ES2967423T3 (it)
FI (1) FI3980434T3 (it)
HR (1) HRP20231668T1 (it)
IT (1) IT201900008391A1 (it)
LT (1) LT3980434T (it)
MX (1) MX2021015053A (it)
PL (1) PL3980434T3 (it)
PT (1) PT3980434T (it)
SI (1) SI3980434T1 (it)
WO (1) WO2020245780A1 (it)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008004000A1 (en) * 2006-07-03 2008-01-10 Generics [Uk] Limited Novel process for the preparation of bisphosphonic acids
EP3553067A1 (en) * 2018-04-10 2019-10-16 Abiogen Pharma S.p.A. Polymorph of sodium neridronate and preparation process thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1246992B (it) * 1991-01-08 1994-12-12 Gentili Ist Spa Procedimento per la preparazione di acidi difosfonici e loro sali
ITMI20040218A1 (it) * 2004-02-10 2004-05-10 Abiogen Pharma Spa Uso di neridronato sodico per promuovere la neoformazione ossea
JP2007042359A (ja) * 2005-08-02 2007-02-15 Hst Kk 押釦型スイッチ
CN104628768A (zh) * 2015-03-06 2015-05-20 江苏正大清江制药有限公司 一种伊班膦酸钠的制备方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008004000A1 (en) * 2006-07-03 2008-01-10 Generics [Uk] Limited Novel process for the preparation of bisphosphonic acids
EP3553067A1 (en) * 2018-04-10 2019-10-16 Abiogen Pharma S.p.A. Polymorph of sodium neridronate and preparation process thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
KIECZYKOWSKI G R: "Preparation of (4-amino-1-hydroxybutylidene)bisphosphonic acid sodium salt, MK217 (ALENDRONATE SODIUM). AN IMPROVED PROCEDURE FOR THE PREPARATION OF 1-HYDROXY-1,1,-BISPHOSPHONIC ACIDS", JOURNAL OF ORGANIC CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 60, no. 25, 1 January 1995 (1995-01-01), pages 8310 - 8312, XP002162672, ISSN: 0022-3263, DOI: 10.1021/JO00130A036 *

Also Published As

Publication number Publication date
SI3980434T1 (sl) 2024-02-29
WO2020245780A1 (en) 2020-12-10
US20220267359A1 (en) 2022-08-25
EP3980434B1 (en) 2023-10-04
JP2022528292A (ja) 2022-06-09
FI3980434T3 (fi) 2023-12-28
US11512104B2 (en) 2022-11-29
PL3980434T3 (pl) 2024-03-25
EP3980434A1 (en) 2022-04-13
CA3142232A1 (en) 2020-12-10
PT3980434T (pt) 2023-12-28
ES2967423T3 (es) 2024-04-30
LT3980434T (lt) 2024-01-25
CA3142232C (en) 2022-12-06
AU2020289084A1 (en) 2022-01-06
AU2020289084B2 (en) 2022-04-14
MX2021015053A (es) 2022-08-23
CN113906039A (zh) 2022-01-07
HRP20231668T1 (hr) 2024-03-15
DK3980434T3 (da) 2024-01-02
JP7162973B2 (ja) 2022-10-31

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