SG11201906525SA - Method of treating or ameliorating metabolic disorders using glp-1 receptor agonists conjugated to antagonists for gastric inhibitory peptide receptor (gipr) - Google Patents

Method of treating or ameliorating metabolic disorders using glp-1 receptor agonists conjugated to antagonists for gastric inhibitory peptide receptor (gipr)

Info

Publication number
SG11201906525SA
SG11201906525SA SG11201906525SA SG11201906525SA SG11201906525SA SG 11201906525S A SG11201906525S A SG 11201906525SA SG 11201906525S A SG11201906525S A SG 11201906525SA SG 11201906525S A SG11201906525S A SG 11201906525SA SG 11201906525S A SG11201906525S A SG 11201906525SA
Authority
SG
Singapore
Prior art keywords
california
international
thousand oaks
glp
oaks
Prior art date
Application number
SG11201906525SA
Inventor
Yuan Cheng
Chawita Netirojjanakul
Jerry Ryan Holder
Bin Wu
James R Falsey
Bradley J Herberich
Kelvin Sham
Leslie P Miranda
Shu-Chen Lu
Murielle M Veniant-Ellison
Shanaka Stanislaus
Junming Yie
Jing Xu
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG11201906525SA publication Critical patent/SG11201906525SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 26 July 2018 (26.07.2018) WIP0 I PCT o mono °nolo Ho Ho lio imio oimIE (10) International Publication Number WO 2018/136440 Al (51) International Patent Classification: A61K 39/395 (2006.01) A61P 3/10 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/US2018/013918 (22) International Filing Date: 16 January 2018 (16.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/447,332 17 January 2017 (17.01.2017) US (71) Applicant: AMGEN INC. [US/US]; One Amgen Center Drive, Thousand Oaks, California 91320 (US). (72) Inventors: CHENG, Yuan; 5329 Via Jacinto, New- bury Park, California 91320 (US). NETIROJJANAKUL, Chawita; 4631 Kester Ave., Apt. 103, Sherman Oaks, Cali- fornia 91403 (US). HOLDER, Jerry Ryan; 1102 Waltham Road, Simi Valley, California 93065 (US). WU, Bin; 3090 Hollycrest Avenue, Thousand Oaks, California 91362 (US). FALSEY, James R.; 13209 Peach Hill Road, Moor- park, California 93021 (US). HERBERICH, Bradley J.; 1746 Hays Drive, Newbury Park, California 91320 (US). SHAM, Kelvin; 3111 La Casa Court, Thousand Oaks, Cal- ifornia 91362 (US). MIRANDA, Leslie P.; 3586 Maple- knoll Place, Thousand Oaks, California 91362 (US). LU, Shu-Chen; 2356 Rutland Place, Thousand Oaks, Califor- nia 91362 (US). VENIANT-ELLISON, Murielle M.; 645 Camino Manzanas, Thousand Oaks, California 91360 (US). STANISLAUS, Shanaka; 4196 Minnecota Drive, Thou- sand Oaks, California 91360 (US). YIE, Junming; 4 Sugar- wood Way, Warren, New Jersey 07059 (US). XU, Jing; 67 Bishops Forest Drive, Waltham, Massachusetts 02452 (US). (74) Agent: DERMOTT, Jonathan M. et al.; One Amgen Cen- ter Drive, Patent Operations, MS-35-1-B, Thousand Oaks, California 91320 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to applicant's entitlement to apply for and be granted a patent (Rule 4.1700) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) W O 20 18/ 136 440 Al (54) Title: METHOD OF TREATING OR AMELIORATING METABOLIC DISORDERS USING GLP-1 RECEPTOR AGONISTS CONJUGATED TO ANTAGONISTS FOR GASTRIC INHIBITORY PEPTIDE RECEPTOR (GIPR) (57) : Methods of treating metabolic diseases and disorders using a composition comprising an antigen binding protein specific for the GIPR polypeptide conjugated to a GLP-1 receptor agonist are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the composition comprises an antibody or functional fragment thereof comprising a cysteine at one or more conjugation site(s) wherein the GLP-1 receptor agonist is conjugated to the antibody or functional fragment thereof through the side-chain of the cysteine residue.
SG11201906525SA 2017-01-17 2018-01-16 Method of treating or ameliorating metabolic disorders using glp-1 receptor agonists conjugated to antagonists for gastric inhibitory peptide receptor (gipr) SG11201906525SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762447332P 2017-01-17 2017-01-17
PCT/US2018/013918 WO2018136440A1 (en) 2017-01-17 2018-01-16 Method of treating or ameliorating metabolic disorders using glp-1 receptor agonists conjugated to antagonists for gastric inhibitory peptide receptor (gipr)

Publications (1)

Publication Number Publication Date
SG11201906525SA true SG11201906525SA (en) 2019-08-27

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SG11201906525SA SG11201906525SA (en) 2017-01-17 2018-01-16 Method of treating or ameliorating metabolic disorders using glp-1 receptor agonists conjugated to antagonists for gastric inhibitory peptide receptor (gipr)

Country Status (25)

Country Link
US (2) US10905772B2 (en)
EP (1) EP3570885A1 (en)
JP (2) JP7175899B2 (en)
KR (1) KR20190104158A (en)
CN (1) CN110662558B (en)
AR (1) AR110751A1 (en)
AU (1) AU2018210858A1 (en)
BR (1) BR112019014588A2 (en)
CA (1) CA3049023A1 (en)
CL (1) CL2019001963A1 (en)
CO (1) CO2019007685A2 (en)
CR (2) CR20190380A (en)
EA (1) EA201991721A1 (en)
IL (1) IL267660A (en)
JO (1) JOP20190177A1 (en)
MA (1) MA47314A (en)
MX (1) MX2019008462A (en)
NZ (1) NZ754937A (en)
PE (1) PE20191467A1 (en)
PH (1) PH12019501656A1 (en)
SA (1) SA519402246B1 (en)
SG (1) SG11201906525SA (en)
TW (1) TWI708613B (en)
UY (1) UY37568A (en)
WO (1) WO2018136440A1 (en)

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NZ743474A (en) 2015-12-23 2023-03-31 Amgen Inc Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists
JOP20190177A1 (en) 2017-01-17 2019-07-16 Amgen Inc Method of treating or ameliorating metabolic disorders using glp-1 receptor agonists conjugated to antagonists for gastric inhibitory peptide receptor (gipr)
AU2018288852A1 (en) * 2017-06-21 2020-01-02 Amgen Inc. Method of treating or ameliorating metabolic disorders using antagonistic binding proteins for gastric inhibitory peptide receptor (GIPR)/GLP-1 receptor agonist fusion proteins
MX2020001327A (en) * 2017-08-04 2020-03-20 Amgen Inc Method of conjugation of cys-mabs.
US20220152154A1 (en) 2019-03-08 2022-05-19 Amgen Inc. Growth differentiation factor 15 combination therapy
CN112521501A (en) * 2019-09-18 2021-03-19 鸿运华宁（杭州）生物医药有限公司 GIPR antibody and fusion protein thereof with GLP-1, and pharmaceutical composition and application thereof
WO2022056494A1 (en) * 2020-09-14 2022-03-17 Regeneron Pharmaceuticals, Inc. Antibody-drug conjugates comprising glp1 peptidomimetics and uses thereof
AU2022276998A1 (en) 2021-05-21 2023-12-07 Yuhan Corporation Composition for combination therapy comprising growth differentiation factor-15 variant and glucagon-like peptide-1 receptor agonist
CA3221655A1 (en) * 2021-06-09 2022-12-15 Swiftnovo Therapeutics Inc. Therapeutics and methods for treating or ameliorating metabolic disorders
WO2023173132A1 (en) * 2022-03-11 2023-09-14 Regeneron Pharmaceuticals, Inc. Anti-glp1r antibody-drug conjugates comprising glp1 peptidomimetics and uses thereof
CN117659189A (en) * 2022-09-08 2024-03-08 鸿运华宁（杭州）生物医药有限公司 GIPR antibody and fusion protein thereof with FGF21, and pharmaceutical composition and application thereof

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