KR102683288B1 - Il-17a-결합 폴리펩티드 - Google Patents

Il-17a-결합 폴리펩티드 Download PDF

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KR102683288B1
KR102683288B1 KR1020177021726A KR20177021726A KR102683288B1 KR 102683288 B1 KR102683288 B1 KR 102683288B1 KR 1020177021726 A KR1020177021726 A KR 1020177021726A KR 20177021726 A KR20177021726 A KR 20177021726A KR 102683288 B1 KR102683288 B1 KR 102683288B1
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binding
sequence
fusion protein
seq
polypeptide
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KR20170116023A (ko
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프레드릭 프리지드
요아킴 펠드위쉬
수잔 클린트
린드비 구드문드스도테르
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애피바디 에이비
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    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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    • C07K14/52Cytokines; Lymphokines; Interferons
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    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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KR1020177021726A 2015-01-12 2016-01-12 Il-17a-결합 폴리펩티드 Active KR102683288B1 (ko)

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KR1020247022438A KR20240110106A (ko) 2015-01-12 2016-01-12 Il-17a-결합 폴리펩티드

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Application Number Priority Date Filing Date Title
EP15150786 2015-01-12
EP15150786.0 2015-01-12
PCT/EP2016/050456 WO2016113246A1 (en) 2015-01-12 2016-01-12 Il-17a-binding polypeptides

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KR1020247022438A Pending KR20240110106A (ko) 2015-01-12 2016-01-12 Il-17a-결합 폴리펩티드

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US (3) US10934335B2 (enExample)
EP (3) EP4643955A2 (enExample)
JP (3) JP6943764B2 (enExample)
KR (2) KR102683288B1 (enExample)
CN (1) CN108064235A (enExample)
AU (1) AU2016208161B2 (enExample)
CA (1) CA2972683A1 (enExample)
DK (1) DK3245224T3 (enExample)
ES (1) ES2822431T3 (enExample)
HU (1) HUE052121T2 (enExample)
IL (1) IL253004B (enExample)
MX (1) MX394167B (enExample)
MY (1) MY188784A (enExample)
NZ (1) NZ732978A (enExample)
PL (1) PL3245224T3 (enExample)
PT (1) PT3245224T (enExample)
RU (1) RU2749712C2 (enExample)
WO (1) WO2016113246A1 (enExample)
ZA (1) ZA201704366B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY37651A (es) 2017-03-31 2018-10-31 Swedish Orphan Biovitrum Ab Publ Polipéptido de unión al il-1r-i
CN108949789A (zh) * 2018-06-26 2018-12-07 山东兴瑞生物科技有限公司 抗gcc的核酸、其制备方法、具有该核酸的免疫细胞及其应用
JP7525499B2 (ja) * 2019-01-31 2024-07-30 ヌマブ セラピューティクス アクチェンゲゼルシャフト TNFα及びIL-17Aに対する特異性を有する多重特異性抗体、IL-17Aを標的とする抗体、及びそれらの使用方法
WO2021089695A1 (en) * 2019-11-05 2021-05-14 Affibody Ab Polypeptides
CN111856029B (zh) * 2020-06-19 2023-09-26 北华大学 Il-17a蛋白在膀胱癌中的应用
AU2023218534A1 (en) * 2022-02-08 2024-07-11 Affibody Ab Protein z variants binding thymic stromal lymphopoietin and their medical use
WO2023196913A2 (en) 2022-04-07 2023-10-12 Acelyrin, Inc. Methods of treating ankylosing spondylitis
EP4504235A4 (en) * 2022-04-07 2025-11-19 Acelyrin Inc TREATMENT METHODS FOR HIDRADENITIS SUPPURATIVE
CN121038816A (zh) * 2023-05-04 2025-11-28 阿菲博迪公司 新多肽
CN116466095B (zh) * 2023-06-15 2023-09-01 朗肽生物制药股份有限公司 一种多肽及其应用
WO2025054498A1 (en) * 2023-09-08 2025-03-13 Acelyrin, Inc. Methods of treating hidradenitis suppurativa

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010102251A2 (en) 2009-03-05 2010-09-10 Abbott Laboratories Il-17 binding proteins
JP2013502910A (ja) 2009-08-27 2013-01-31 コヴァジェン アクチェン ゲゼルシャフト 新規なil−17結合化合物およびその医薬用途
WO2014044758A1 (en) 2012-09-21 2014-03-27 Covagen Ag Novel il-17a binding molecules and medical uses thereof

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0417487D0 (en) 2004-08-05 2004-09-08 Novartis Ag Organic compound
GB0524788D0 (en) 2005-12-05 2006-01-11 Affibody Ab Polypeptides
CN101326195B9 (zh) 2005-12-13 2022-11-11 伊莱利利公司 抗il-17抗体
EP2102339A2 (en) 2007-01-12 2009-09-23 Sea Lane Biotechnologies,llc. Combinatorial libraries of conformationally constrained polypeptide sequences
EP2190863B1 (en) 2007-07-31 2015-09-02 Affibody AB New albumin binding compositions, methods and uses
ES2373832T3 (es) * 2007-12-19 2012-02-09 Affibody Ab Polipéptido derivado de proteína a y capaz de unirse a pdgf.
US9175067B2 (en) * 2010-03-08 2015-11-03 Ge Healthcare Bio-Sciences Ab Immunoglobulin G Fc region binding polypeptide
JP5827994B2 (ja) 2010-07-09 2015-12-02 アフィボディ・アーベー ポリペプチド
WO2012125680A1 (en) 2011-03-16 2012-09-20 Novartis Ag Methods of treating vasculitis using an il-17 binding molecule
EP2597102A1 (en) * 2011-11-25 2013-05-29 Covagen AG A novel fusion protein comprising an antibody light chain and a polypeptide binding to IL-17
JP6276202B2 (ja) * 2012-02-20 2018-02-07 スウェディッシュ・オーファン・バイオヴィトラム・アーベー(ペーウーベーエル) ヒト補体c5に結合するポリペプチド
CN104662035A (zh) 2012-09-25 2015-05-27 阿菲博迪公司 白蛋白结合多肽
EP2912054B1 (en) 2012-10-25 2017-06-21 Affibody AB Albumin binding polypeptide
CN105190314A (zh) * 2013-01-21 2015-12-23 阿布维公司 用于炎性疾病的抗-tnf和抗-il17联合疗法生物标志物
MX366425B (es) * 2013-03-15 2019-07-04 Affibody Ab Nuevos polipeptidos.
EP3083675B1 (en) 2013-12-20 2018-03-07 Affibody AB Engineered albumin binding polypeptide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010102251A2 (en) 2009-03-05 2010-09-10 Abbott Laboratories Il-17 binding proteins
JP2013502910A (ja) 2009-08-27 2013-01-31 コヴァジェン アクチェン ゲゼルシャフト 新規なil−17結合化合物およびその医薬用途
WO2014044758A1 (en) 2012-09-21 2014-03-27 Covagen Ag Novel il-17a binding molecules and medical uses thereof

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AU2016208161A1 (en) 2017-07-13
BR112017014559A2 (pt) 2018-05-15
PT3245224T (pt) 2020-10-08
CN108064235A (zh) 2018-05-22
IL253004A0 (en) 2017-08-31
JP6943764B2 (ja) 2021-10-06
ES2822431T3 (es) 2021-05-04
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