RU2749712C2 - IL-17A-связывающие полипептиды - Google Patents

IL-17A-связывающие полипептиды Download PDF

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RU2749712C2
RU2749712C2 RU2017127012A RU2017127012A RU2749712C2 RU 2749712 C2 RU2749712 C2 RU 2749712C2 RU 2017127012 A RU2017127012 A RU 2017127012A RU 2017127012 A RU2017127012 A RU 2017127012A RU 2749712 C2 RU2749712 C2 RU 2749712C2
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binding
sequence
binding polypeptide
seq
amino acid
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RU2017127012A
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RU2017127012A (ru
RU2017127012A3 (enExample
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Фредрик ФРЕЙД
Иоахим ФЕЛЬДВИШ
Сюзанна КЛИНТ
Линдви ГУДМУНДСДОТТЕР
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Аффибоди Аб
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    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52Cytokines; Lymphokines; Interferons
    • C07K14/54Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
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    • C07K14/195Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
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    • C07K14/745Blood coagulation or fibrinolysis factors
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    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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    • C07ORGANIC CHEMISTRY
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    • C07K2318/00Antibody mimetics or scaffolds
    • C07K2318/20Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
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    • C07K2319/00Fusion polypeptide

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
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RU2017127012A 2015-01-12 2016-01-12 IL-17A-связывающие полипептиды RU2749712C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15150786 2015-01-12
EP15150786.0 2015-01-12
PCT/EP2016/050456 WO2016113246A1 (en) 2015-01-12 2016-01-12 Il-17a-binding polypeptides

Publications (3)

Publication Number Publication Date
RU2017127012A RU2017127012A (ru) 2019-02-14
RU2017127012A3 RU2017127012A3 (enExample) 2019-06-24
RU2749712C2 true RU2749712C2 (ru) 2021-06-16

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US (3) US10934335B2 (enExample)
EP (3) EP4643955A2 (enExample)
JP (3) JP6943764B2 (enExample)
KR (2) KR20240110106A (enExample)
CN (1) CN108064235A (enExample)
AU (1) AU2016208161B2 (enExample)
CA (1) CA2972683A1 (enExample)
DK (1) DK3245224T3 (enExample)
ES (1) ES2822431T3 (enExample)
HU (1) HUE052121T2 (enExample)
IL (1) IL253004B (enExample)
MX (1) MX394167B (enExample)
MY (1) MY188784A (enExample)
NZ (1) NZ732978A (enExample)
PL (1) PL3245224T3 (enExample)
PT (1) PT3245224T (enExample)
RU (1) RU2749712C2 (enExample)
WO (1) WO2016113246A1 (enExample)
ZA (1) ZA201704366B (enExample)

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UY37651A (es) * 2017-03-31 2018-10-31 Swedish Orphan Biovitrum Ab Publ Polipéptido de unión al il-1r-i
CN108949789A (zh) * 2018-06-26 2018-12-07 山东兴瑞生物科技有限公司 抗gcc的核酸、其制备方法、具有该核酸的免疫细胞及其应用
CN120025437A (zh) * 2019-01-31 2025-05-23 努玛治疗有限公司 对TNFα和IL-17A具有特异性的多特异性抗体、靶向IL-17A的抗体及其使用方法
US20220389066A1 (en) * 2019-11-05 2022-12-08 Affibody Ab Polypeptides
CN111856029B (zh) * 2020-06-19 2023-09-26 北华大学 Il-17a蛋白在膀胱癌中的应用
CN118632866A (zh) * 2022-02-08 2024-09-10 阿菲博迪公司 结合胸腺基质淋巴细胞生成素的蛋白质z变体及其医疗用途
WO2023196913A2 (en) 2022-04-07 2023-10-12 Acelyrin, Inc. Methods of treating ankylosing spondylitis
EP4504235A4 (en) * 2022-04-07 2025-11-19 Acelyrin Inc TREATMENT METHODS FOR HIDRADENITIS SUPPURATIVE
WO2024227930A1 (en) * 2023-05-04 2024-11-07 Affibody Ab New polypeptide
CN116466095B (zh) * 2023-06-15 2023-09-01 朗肽生物制药股份有限公司 一种多肽及其应用
WO2025054498A1 (en) * 2023-09-08 2025-03-13 Acelyrin, Inc. Methods of treating hidradenitis suppurativa

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TOKURIKI N. ET AL., Stability effects of mutations and protein evolvability, Curr. Opin. Struct. Biol., 2009, v.19, n.5, p.596-604. SERGEEVA A. et al., Display technologies: application for the discovery of drug and gene delivery agents, Adv Drug Deliv Rev, 2006, V. 58, p.1622-1654. ТИКУНОВА Н.В. и др., Фаговый дисплей на основе нитчатых бактериофагов: применение для отбора рекомбинантных антител, ACTA NATURAE, 2009, Т. 1, N. 3, с.22-31. ARNAU J. et al., Current strategies for the use of affinity tags and tag removal for the purification of recombinant proteins, Protein expression and purification, 2006, V. 48, N. 1, p.1-13. SHEN B. Q. et al., Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates, Nature biotechnology, 2012, V. 30, N. 2, p.184-192. *
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MY188784A (en) 2021-12-31
JP2023052258A (ja) 2023-04-11
CN108064235A (zh) 2018-05-22
JP2018508186A (ja) 2018-03-29
EP3245224A1 (en) 2017-11-22
NZ732978A (en) 2022-01-28
EP3738976C0 (en) 2025-07-23
US20170362290A1 (en) 2017-12-21
EP4643955A2 (en) 2025-11-05
ES2822431T3 (es) 2021-05-04
AU2016208161B2 (en) 2020-01-16
US20250101074A1 (en) 2025-03-27
ZA201704366B (en) 2022-09-28
PT3245224T (pt) 2020-10-08
IL253004B (en) 2021-06-30
DK3245224T3 (da) 2020-09-21
KR20240110106A (ko) 2024-07-12
JP6943764B2 (ja) 2021-10-06
EP3738976B1 (en) 2025-07-23
MX394167B (es) 2025-03-24
RU2017127012A (ru) 2019-02-14
EP3738976A1 (en) 2020-11-18
RU2017127012A3 (enExample) 2019-06-24
CA2972683A1 (en) 2016-07-21
EP3245224B1 (en) 2020-07-15
US20210253659A1 (en) 2021-08-19
US10934335B2 (en) 2021-03-02
PL3245224T3 (pl) 2021-01-25
KR102683288B1 (ko) 2024-07-11
US12221464B2 (en) 2025-02-11
IL253004A0 (en) 2017-08-31
HUE052121T2 (hu) 2021-04-28
WO2016113246A1 (en) 2016-07-21
BR112017014559A2 (pt) 2018-05-15
JP7208963B2 (ja) 2023-01-19
KR20170116023A (ko) 2017-10-18
JP2021073174A (ja) 2021-05-13
JP7456024B2 (ja) 2024-03-26
MX2017008660A (es) 2017-11-17
AU2016208161A1 (en) 2017-07-13

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