KR102654470B1 - 용액-기반 플라스몬 특이적-결합 파트너 검정 및 금속성 나노구조체 - Google Patents
용액-기반 플라스몬 특이적-결합 파트너 검정 및 금속성 나노구조체 Download PDFInfo
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- SOBHUZYZLFQYFK-UHFFFAOYSA-K trisodium;hydroxy-[[phosphonatomethyl(phosphonomethyl)amino]methyl]phosphinate Chemical compound [Na+].[Na+].[Na+].OP(O)(=O)CN(CP(O)([O-])=O)CP([O-])([O-])=O SOBHUZYZLFQYFK-UHFFFAOYSA-K 0.000 description 1
- 238000002371 ultraviolet--visible spectrum Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000012224 working solution Substances 0.000 description 1
Classifications
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/55—Specular reflectivity
- G01N21/552—Attenuated total reflection
- G01N21/553—Attenuated total reflection and using surface plasmons
- G01N21/554—Attenuated total reflection and using surface plasmons detecting the surface plasmon resonance of nanostructured metals, e.g. localised surface plasmon resonance
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54346—Nanoparticles
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/551—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being inorganic
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- G—PHYSICS
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/558—Immunoassay; Biospecific binding assay; Materials therefor using diffusion or migration of antigen or antibody
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- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
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- Health & Medical Sciences (AREA)
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- Investigating Or Analysing Materials By Optical Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
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| DK3489685T3 (da) | 2011-11-21 | 2023-12-04 | Zoetis Services Llc | Signalforstærkning i sidestrømning og tilsvarende immunoassays |
| TWI691716B (zh) | 2014-08-13 | 2020-04-21 | 美商艾巴希斯公司 | 電漿特異性結合搭配物檢定中之信號放大 |
| JP6944438B2 (ja) | 2015-08-04 | 2021-10-06 | ゾエティス サービシズ リミテッド ライアビリティ カンパニー | 溶液ベースのプラズモン特異的結合パートナーアッセイにおけるシグナル増幅 |
| US9617587B1 (en) | 2016-04-04 | 2017-04-11 | Nat Diagnostics, Inc. | Isothermal amplification components and processes |
| US11299777B2 (en) | 2016-04-04 | 2022-04-12 | Nat Diagnostics, Inc. | Isothermal amplification components and processes |
| KR102654470B1 (ko) | 2017-01-30 | 2024-04-05 | 조에티스 서비시즈 엘엘씨 | 용액-기반 플라스몬 특이적-결합 파트너 검정 및 금속성 나노구조체 |
| CN111770955B (zh) | 2018-11-01 | 2022-12-23 | 韩国浦项科技大学校企公司 | 包含非共价连接的有机纳米结构分子的硝酸纤维素膜 |
| GB2590485B (en) * | 2019-12-19 | 2022-04-13 | Vidya Holdings Ltd | Nanoparticle conjugation |
| US11609229B2 (en) | 2020-04-30 | 2023-03-21 | Mytech Co. Ltd. | Fluorescence counting system for quantifying viruses or antibodies on an immobilized metal substrate by using an antigen-antibody reaction |
| JP7589532B2 (ja) * | 2020-12-14 | 2024-11-26 | 日油株式会社 | イムノクロマト測定法用増感剤及び測定法 |
| CA3215851A1 (en) * | 2021-04-21 | 2022-10-27 | Udayan Kanade | System and method for simulating a localized surface plasmon resonance (lspr) spectrometer |
| CN114480591B (zh) * | 2022-03-09 | 2022-11-08 | 武汉爱博泰克生物科技有限公司 | 一种用于一步法qpcr试剂的冻干保护剂及其应用 |
| EP4517323A1 (en) * | 2022-05-18 | 2025-03-05 | University Public Corporation Osaka | Kit for detecting glycoprotein |
| CN119816734A (zh) * | 2022-10-06 | 2025-04-11 | 积水医疗株式会社 | 非特异反应抑制剂、非特异反应抑制剂的使用方法、非特异反应抑制方法、生化测定用试剂、检体预处理液和生化测定用试剂盒 |
| CN116183901B (zh) * | 2023-01-04 | 2025-04-18 | 烟台大学 | 一种基于环糊精-金刚烷化铱络合物主客体组装标记的蛋白标记物荧光检测方法 |
| CN120741863A (zh) * | 2025-06-06 | 2025-10-03 | 上海太阳生物技术有限公司 | 蛋白c检测试剂 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014020293A1 (en) | 2012-07-31 | 2014-02-06 | Imperial Innovations Limited | Assay |
| JP2014228385A (ja) | 2013-05-22 | 2014-12-08 | キヤノン株式会社 | 免疫試験方法および免疫試験キット |
| JP2015007652A (ja) | 2009-10-30 | 2015-01-15 | 協和メデックス株式会社 | 検体中の測定対象成分の測定方法及び測定用キット |
| JP2016510126A (ja) | 2013-03-14 | 2016-04-04 | ホリバ・エービーエックス・エスエーエス | 関心対象のための新規のフロー分析方法 |
Family Cites Families (109)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4704366A (en) | 1984-06-22 | 1987-11-03 | Bio-Rad Laboratories, Inc. | Process for binding IgG to protein A |
| US5061381A (en) | 1990-06-04 | 1991-10-29 | Abaxis, Inc. | Apparatus and method for separating cells from biological fluids |
| US5186844A (en) | 1991-04-01 | 1993-02-16 | Abaxis, Inc. | Apparatus and method for continuous centrifugal blood cell separation |
| US5122284A (en) | 1990-06-04 | 1992-06-16 | Abaxis, Inc. | Apparatus and method for optically analyzing biological fluids |
| US5413732A (en) | 1991-08-19 | 1995-05-09 | Abaxis, Inc. | Reagent compositions for analytical testing |
| US5304348A (en) | 1992-02-11 | 1994-04-19 | Abaxis, Inc. | Reagent container for analytical rotor |
| WO1993019827A1 (en) | 1992-04-02 | 1993-10-14 | Abaxis, Inc. | Analytical rotor with dye mixing chamber |
| JP3706214B2 (ja) | 1996-10-28 | 2005-10-12 | 株式会社三菱化学ヤトロン | 免疫学的分析方法 |
| US5939021A (en) | 1997-01-23 | 1999-08-17 | Hansen; W. Peter | Homogeneous binding assay |
| US6180415B1 (en) | 1997-02-20 | 2001-01-30 | The Regents Of The University Of California | Plasmon resonant particles, methods and apparatus |
| US7144627B2 (en) | 1997-03-12 | 2006-12-05 | William Marsh Rice University | Multi-layer nanoshells comprising a metallic or conducting shell |
| US6344272B1 (en) | 1997-03-12 | 2002-02-05 | Wm. Marsh Rice University | Metal nanoshells |
| JPH10282100A (ja) * | 1997-04-11 | 1998-10-23 | Sekisui Chem Co Ltd | 測定方法及び測定キット |
| JP4427182B2 (ja) * | 1997-09-22 | 2010-03-03 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 抗原を安定化するための緩衝液 |
| US6699724B1 (en) | 1998-03-11 | 2004-03-02 | Wm. Marsh Rice University | Metal nanoshells for biosensing applications |
| JP3841559B2 (ja) | 1998-07-07 | 2006-11-01 | 日東電工株式会社 | 免疫学的検査方法および免疫学的検査キット |
| JP2000028612A (ja) | 1998-07-07 | 2000-01-28 | Nitto Denko Corp | 免疫学的検査方法および免疫学的検査キット |
| JP3298836B2 (ja) | 1998-11-12 | 2002-07-08 | アークレイ株式会社 | 検体分析用具 |
| EP1212458A4 (en) | 1999-07-30 | 2005-01-05 | Surromed Inc | INSTRUMENTS, METHODS AND REAGENTS FOR PLASMON SURFACE RESONANCE |
| JP2001074742A (ja) * | 1999-09-06 | 2001-03-23 | Jsr Corp | ラテックス免疫比濁法および測定キット |
| JP2003514224A (ja) | 1999-11-12 | 2003-04-15 | サーロメッド・インコーポレーテッド | 表面プラズモン共鳴を使用するバイオセンシング |
| AU2002246587A1 (en) | 2000-11-03 | 2002-08-06 | Wm. Marsh Rice University | Partial coverage metal nanoshells and method of making same |
| US6861263B2 (en) | 2001-01-26 | 2005-03-01 | Surromed, Inc. | Surface-enhanced spectroscopy-active sandwich nanoparticles |
| US20030170618A1 (en) | 2001-02-02 | 2003-09-11 | Chien David Y. | Buffers for stabilizing antigens |
| WO2002096262A2 (en) | 2001-05-25 | 2002-12-05 | Northwestern University | Non-alloying core shell nanoparticles |
| EP1428028A2 (de) | 2001-09-14 | 2004-06-16 | Reinhard Zeidler | Identifizierung von antigenen durch xenogene, allogene oder autologe antikörper-vermittelte präzipitation |
| US7135054B2 (en) | 2001-09-26 | 2006-11-14 | Northwestern University | Nanoprisms and method of making them |
| CN1417586A (zh) | 2001-11-05 | 2003-05-14 | 福州市迈新生物技术开发公司 | 一种免疫检测信号放大系统和它的制备方法及其应用 |
| JP3851807B2 (ja) | 2001-11-07 | 2006-11-29 | アルフレッサファーマ株式会社 | 免疫反応におけるプロゾーン現象抑制方法及び免疫反応測定用試薬 |
| US6970239B2 (en) | 2002-06-12 | 2005-11-29 | Intel Corporation | Metal coated nanocrystalline silicon as an active surface enhanced Raman spectroscopy (SERS) substrate |
| US7212692B2 (en) | 2002-11-08 | 2007-05-01 | Ming Yan | Multiple array surface plasmon resonance biosensor |
| EP1512972B1 (en) * | 2002-12-10 | 2009-03-18 | Panasonic Corporation | Immunoreaction measurement method |
| JP4787938B2 (ja) | 2003-03-28 | 2011-10-05 | ザ・プロウボウスト・フェロウズ・ファウンデーション・スカラーズ・アンド・ザ・アザー・メンバーズ・オブ・ボード・オブ・ザ・カレッジ・オブ・ザ・ホリー・アンド・アンデバイデッド・トリニティ・オブ・クイーン | 銀ナノ粒子を用いた検体検出用センサ |
| KR100531760B1 (ko) | 2003-04-28 | 2005-11-29 | 대한민국(관리부서 : 농림부 국립수의과학검역원) | 구제역 바이러스의 감염여부를 진단하는 방법 및 이를구현하기 위한 진단키트 |
| US20060240573A1 (en) | 2003-07-29 | 2006-10-26 | Lamdagen, Llc | Optical system including nanostructures for biological or chemical sensing |
| GB0321937D0 (en) | 2003-09-19 | 2003-10-22 | Univ Liverpool | Nanoparticle conjugates and method of production thereof |
| US20070298432A1 (en) | 2003-11-07 | 2007-12-27 | Hep-Genics Pty Ltd | Binding Assay Components |
| JP4109205B2 (ja) | 2004-01-07 | 2008-07-02 | 富士フイルム株式会社 | 被検体検出方法 |
| US20080227219A1 (en) * | 2004-11-17 | 2008-09-18 | Frank Gamez | Electrochemiluminescent assay |
| CN1296492C (zh) * | 2004-11-18 | 2007-01-24 | 博奥生物有限公司 | 一种基于生物芯片检测能结合特异序列的核酸结合蛋白的方法 |
| US7405054B1 (en) | 2004-12-13 | 2008-07-29 | University Of Washington Uw Tech Transfer - Invention Licensing | Signal amplification method for surface plasmon resonance-based chemical detection |
| CA2592254A1 (en) * | 2004-12-31 | 2006-07-13 | Genentech, Inc. | Detecting human antibodies in non-human serum |
| US8628727B2 (en) | 2005-04-08 | 2014-01-14 | Northwestern University | Compositions, devices and methods for SERS and LSPR |
| US20060246513A1 (en) | 2005-05-02 | 2006-11-02 | Bohannon Robert C | Method and device to detect the presence of analytes in a sample |
| WO2007053201A2 (en) | 2005-06-15 | 2007-05-10 | University Of Maryland Biotechnology Institute | Bioassays using plasmonic scattering from noble metal nanostructures |
| US20070092978A1 (en) | 2005-10-20 | 2007-04-26 | Ronald Mink | Target ligand detection |
| JP5442179B2 (ja) | 2005-10-21 | 2014-03-12 | アルフレッサファーマ株式会社 | 反応性物質が結合した微小粒子の沈降抑制方法および該微小粒子含有試薬 |
| CN103357007A (zh) | 2005-10-25 | 2013-10-23 | 人工细胞技术公司 | 免疫原性组合物及其使用方法 |
| WO2007061793A2 (en) | 2005-11-18 | 2007-05-31 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SCIENCES, CENTERS FOR DISEASE CONTROL AND PREVENTION | Modified cardiolipin and uses therefor |
| US7790066B2 (en) | 2006-03-03 | 2010-09-07 | William Marsh Rice University | Nanorice particles: hybrid plasmonic nanostructures |
| JP4810304B2 (ja) | 2006-05-12 | 2011-11-09 | キヤノン株式会社 | 化学センサ素子及びその製造方法 |
| US20090203154A1 (en) | 2006-06-06 | 2009-08-13 | Vivacta Ltd. | Method for Sensing a Chemical |
| JP2008157652A (ja) | 2006-12-21 | 2008-07-10 | Yokogawa Electric Corp | 電源装置 |
| US8426152B2 (en) | 2007-01-03 | 2013-04-23 | Lamdagen Corporation | Enzymatic assay for LSPR |
| EP2126581B1 (en) | 2007-03-20 | 2014-07-09 | Becton Dickinson and Company | Assays using surface-enhanced raman spectroscopy (sers)-active particles |
| JP2009150708A (ja) | 2007-12-19 | 2009-07-09 | Canon Inc | 標的物質の検出方法及び検査キット |
| US8808420B2 (en) | 2007-12-21 | 2014-08-19 | The Provost, Fellows And Scholars Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth, Near Dublin | Process for preparing nanoparticles |
| WO2009117510A2 (en) | 2008-03-20 | 2009-09-24 | Abaxis, Inc. | Multi-wavelength analyses of sol-particle specific binding assays |
| WO2010006201A2 (en) | 2008-07-10 | 2010-01-14 | Abaxis, Inc. | Methods of reducing non-specific interaction in metal nanoparticle assays |
| US8846319B2 (en) | 2008-12-03 | 2014-09-30 | Abaxis, Inc. | Lateral flow strip assay with immobilized conjugate |
| US8313915B2 (en) | 2009-01-21 | 2012-11-20 | Gundersen Lutheran Medical Foundation, Inc. | Early detection of canine lyme disease by specific peptides and antibodies |
| WO2010091293A1 (en) | 2009-02-06 | 2010-08-12 | The Regents Of The University Of California | Plasmonic system for detecting binding of biological molecules |
| MX2011009019A (es) * | 2009-02-27 | 2011-09-29 | Beckman Coulter Inc | Ensayos homogeneos de fase de solucion. |
| WO2010116345A1 (en) | 2009-04-08 | 2010-10-14 | National University Of Ireland, Galway | Silver nanoplates |
| JP5563789B2 (ja) | 2009-06-11 | 2014-07-30 | 富士フイルム株式会社 | 検出方法 |
| US8568989B2 (en) | 2009-11-17 | 2013-10-29 | Abaxis, Inc. | Peptides and methods for the detection of Lyme disease antibodies |
| AU2010321790B2 (en) | 2009-11-20 | 2016-08-04 | Zoetis Services Llc | Peptides, devices, and methods for the detection of Ehrlichia antibodies |
| WO2011065747A2 (ko) | 2009-11-24 | 2011-06-03 | 한국생명공학연구원 | 나노입자를 이용한 미생물의 고속 검출방법 |
| US9308582B2 (en) | 2009-12-24 | 2016-04-12 | Yi Sun | Solution stable and chemically reactive metallic nanoparticles |
| EP2354792A1 (en) | 2010-02-08 | 2011-08-10 | Biomonitor A/S | Method for detecting anti-drug antibodies |
| ES2636908T3 (es) | 2010-04-27 | 2017-10-10 | Ventana Medical Systems, Inc. | Conjugados de nanopartícula-anticuerpo y procedimientos para producir y usar dichos conjugados |
| US20130071619A1 (en) | 2010-05-28 | 2013-03-21 | Nippon Steel & Sumikin Chemical Co., Ltd. | Metal fine-particle composite and method for fabricating the same |
| CN102023151B (zh) | 2010-09-17 | 2013-01-02 | 江南大学 | 用拉曼光谱在金纳米棒端面自组装介导下检测微囊藻毒素的方法 |
| JP5822239B2 (ja) | 2010-12-08 | 2015-11-24 | 公立大学法人大阪府立大学 | 金属ナノ粒子集積構造体を利用した被検出物質の検出装置および方法 |
| JP5614278B2 (ja) | 2010-12-24 | 2014-10-29 | セイコーエプソン株式会社 | センサーチップ、センサーチップの製造方法、検出装置 |
| CN102103145B (zh) | 2011-02-24 | 2013-01-16 | 南京基蛋生物科技有限公司 | 一种双放大系统的胶体金试纸条及其制备方法 |
| US8697129B2 (en) | 2011-03-02 | 2014-04-15 | Imra America, Inc. | Stable colloidal gold nanoparticles with controllable surface modification and functionalization |
| WO2012125693A2 (en) | 2011-03-15 | 2012-09-20 | Northwestern University | Multifunctional metal nanoparticles having a polydopamine-based surface and methods of making and using the same |
| JP5703098B2 (ja) * | 2011-03-31 | 2015-04-15 | 富士フイルム株式会社 | 生体分子検出装置および生体分子検出方法 |
| CN102323422B (zh) * | 2011-05-30 | 2014-03-12 | 中国科学院上海微系统与信息技术研究所 | 半定量同时检测cTnI和Myo的免疫层析试纸条及其制备 |
| US20130230717A1 (en) | 2011-09-02 | 2013-09-05 | Washington University In St. Louis | Copper nanostructures and methods for their preparation |
| US8758772B2 (en) | 2011-11-04 | 2014-06-24 | Abaxis, Inc. | Peptides and methods for the detection of lyme disease antibodies |
| CH705758B1 (fr) | 2011-11-15 | 2016-03-31 | Metalor Technologies Int | Nanoparticules cœur-coquille métal-silice, procédé de fabrication et dispositif de test par immunochromatographie comprenant de telles nanoparticules. |
| DK3489685T3 (da) | 2011-11-21 | 2023-12-04 | Zoetis Services Llc | Signalforstærkning i sidestrømning og tilsvarende immunoassays |
| US9823246B2 (en) | 2011-12-28 | 2017-11-21 | The Board Of Trustees Of The Leland Stanford Junior University | Fluorescence enhancing plasmonic nanoscopic gold films and assays based thereon |
| US20130189793A1 (en) | 2012-01-20 | 2013-07-25 | Wei Qian | Stable Colloidal Suspensions Of Gold Nanoconjugates And The Method For Preparing The Same |
| EP2810067A4 (en) | 2012-01-31 | 2015-12-09 | American University Of Cairo Auc | DIRECT DETECTION OF ILLEGAL BIOMARKERS IN CLINICAL SAMPLES USING CATIONIC NANOPARTICLE BASED ASSAYS AND VERSATILE AND GREEN METHODS FOR SYNTHESIS FROM ANISOTROPIC SILVER NANOSTRUCTURES |
| EP2625966A1 (en) | 2012-02-13 | 2013-08-14 | Bionanoplus, S.L. | Nanoparticles comprising a vegetable hydrophobic protein and a water miscible non-volatile organic solvent and uses thereof |
| TWI435843B (zh) | 2012-04-27 | 2014-05-01 | Univ Nat Taiwan | 奈米顆粒的製造方法 |
| WO2013169640A1 (en) | 2012-05-05 | 2013-11-14 | Academia Sinica | Diaminobenzoic or ortho-phenylene diamine conjugated peptides as functional saccharide tagging reagents |
| CN105051541B (zh) | 2012-10-11 | 2017-07-04 | 爱贝斯股份有限公司 | 用于检测埃里希体属抗体的肽、装置和方法 |
| EP2906286B1 (en) | 2012-10-11 | 2017-06-14 | Nanocomposix, Inc. | Silver nanoplate compositions and methods |
| US9441301B2 (en) | 2012-12-06 | 2016-09-13 | Nanyang Technological University | Method for forming a bimetallic core-shell nanostructure |
| KR20150125920A (ko) * | 2013-03-01 | 2015-11-10 | 후지레비오 가부시키가이샤 | 미감작 라텍스 시약의 열화 방지 방법 |
| WO2014158272A1 (en) | 2013-03-14 | 2014-10-02 | Abbott Laboratories | Hcv antigen-antibody combination assay and methods and compositions for use therein |
| CN105209616A (zh) * | 2013-03-14 | 2015-12-30 | 雅培制药有限公司 | 用于改进的抗体检测的hcv ns3重组抗原及其突变体 |
| WO2014197222A1 (en) | 2013-06-05 | 2014-12-11 | Purdue Research Foundation | Titanium nitride plasmonic nanoparticles for clinical therapeutic applications |
| CN103335984B (zh) | 2013-06-09 | 2015-10-28 | 清华大学 | 一种基于lspr的无实体壁微阵列芯片及其应用 |
| EP3028043A4 (en) | 2013-07-30 | 2017-04-19 | Bio-rad Laboratories, Inc. | Multiplex blocker beads for immunoassays |
| WO2015130980A1 (en) | 2014-02-26 | 2015-09-03 | Lamdagen Corporation | Digital lspr for enhanced assay sensitivity |
| US10024800B2 (en) * | 2014-04-15 | 2018-07-17 | Rutgers, The State University Of New Jersey | Gold nanostar substrates for SERS sensing in the femtomolar regime |
| US10518331B2 (en) | 2014-07-11 | 2019-12-31 | Northwestern University | Synthesis of uniform anisotropic nanoparticles |
| US20160202251A1 (en) * | 2014-08-01 | 2016-07-14 | Beacle Inc. | Virus-like particle for use in immunoassay, blocking agent for use in the immunoassay, and kit comprising the virus-like particle and the blocking agent |
| TWI691716B (zh) | 2014-08-13 | 2020-04-21 | 美商艾巴希斯公司 | 電漿特異性結合搭配物檢定中之信號放大 |
| WO2016134214A1 (en) | 2015-02-19 | 2016-08-25 | Ionica Sciences | Reagents and methods for detecting infectious diseases |
| WO2016170183A1 (en) * | 2015-04-24 | 2016-10-27 | Pharmadiagnostics Nv | Improved method of measuring an interaction between molecules |
| JP6944438B2 (ja) | 2015-08-04 | 2021-10-06 | ゾエティス サービシズ リミテッド ライアビリティ カンパニー | 溶液ベースのプラズモン特異的結合パートナーアッセイにおけるシグナル増幅 |
| CN106290893B (zh) | 2016-07-18 | 2018-09-25 | 南昌大学 | 一种基于纳米铂探针检测牛乳β-乳球蛋白及其致敏性残基的方法 |
| KR102654470B1 (ko) | 2017-01-30 | 2024-04-05 | 조에티스 서비시즈 엘엘씨 | 용액-기반 플라스몬 특이적-결합 파트너 검정 및 금속성 나노구조체 |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015007652A (ja) | 2009-10-30 | 2015-01-15 | 協和メデックス株式会社 | 検体中の測定対象成分の測定方法及び測定用キット |
| WO2014020293A1 (en) | 2012-07-31 | 2014-02-06 | Imperial Innovations Limited | Assay |
| JP2016510126A (ja) | 2013-03-14 | 2016-04-04 | ホリバ・エービーエックス・エスエーエス | 関心対象のための新規のフロー分析方法 |
| JP2014228385A (ja) | 2013-05-22 | 2014-12-08 | キヤノン株式会社 | 免疫試験方法および免疫試験キット |
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