KR102535195B1 - 항-코로나바이러스 항체 및 사용 방법 - Google Patents

항-코로나바이러스 항체 및 사용 방법 Download PDF

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KR102535195B1
KR102535195B1 KR1020200174502A KR20200174502A KR102535195B1 KR 102535195 B1 KR102535195 B1 KR 102535195B1 KR 1020200174502 A KR1020200174502 A KR 1020200174502A KR 20200174502 A KR20200174502 A KR 20200174502A KR 102535195 B1 KR102535195 B1 KR 102535195B1
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South Korea
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seq
chain variable
variable region
cdrs
set forth
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KR20210113936A (ko
Inventor
캐서린 웨스텐도르프
스테파니 젠텔리스
크리티카 머투라만
케빈 젭슨
에스터 팔코너
존 마스콜라
바니 그레이엄
키즈메키아 코베트
줄리 레저우드
링슈 왕
올루부콜라 아비오나
웨이 시
윙-푸이 콩
이 장
브라이언 에드워드 존스
데니사 포스터
줄리안 데이비스
칭 차이
크리스토퍼 칼 프라이
가나패시 고팔라트남
외르그 헨들
존 마이클 사우더
제프리 스트리트만 보일즈
안나 퍼스틸닉
Original Assignee
앱셀레라 바이올로직스 인크.
더 유나이티드 스테이츠 오브 아메리카, 애즈 레프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬스 앤드 휴먼 서비시즈
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/08—RNA viruses
    • C07K14/165—Coronaviridae, e.g. avian infectious bronchitis virus
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
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    • C07K16/102—Coronaviridae (F)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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KR1020200174502A 2020-03-09 2020-12-14 항-코로나바이러스 항체 및 사용 방법 Active KR102535195B1 (ko)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US202062987313P 2020-03-09 2020-03-09
US62/987,313 2020-03-09
US202063010999P 2020-04-16 2020-04-16
US63/010,999 2020-04-16
US202063030530P 2020-05-27 2020-05-27
US63/030,530 2020-05-27
US202063036089P 2020-06-08 2020-06-08
US63/036,089 2020-06-08
US202063080351P 2020-09-18 2020-09-18
US63/080,351 2020-09-18
US202063085042P 2020-09-29 2020-09-29
US63/085,042 2020-09-29
US202063116483P 2020-11-20 2020-11-20
US63/116,483 2020-11-20

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KR20210113936A KR20210113936A (ko) 2021-09-17
KR102535195B1 true KR102535195B1 (ko) 2023-05-25

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KR1020227032747A Pending KR20220167273A (ko) 2020-03-09 2021-03-04 항-코로나바이러스 항체 및 사용 방법

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US (5) US20210292393A1 (https=)
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Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016187356A1 (en) * 2015-05-18 2016-11-24 Agensys, Inc. Antibodies that bind to axl proteins
WO2016187354A1 (en) * 2015-05-18 2016-11-24 Agensys, Inc. Antibodies that bind to axl proteins
US20180128545A1 (en) 2016-11-08 2018-05-10 Berry Metal Company Modular furnace cooling wall
US12384811B2 (en) 2019-04-05 2025-08-12 Academia Sinica Sialidase-resistant saccharide and method of making and using the same
TWI789711B (zh) * 2020-02-24 2023-01-11 中國科學院微生物研究所 新型冠狀病毒的人源單克隆抗體及其應用
FI4045533T3 (fi) 2020-03-26 2024-02-02 Univ Vanderbilt Ihmisen monoklonaalisia vasta-aineita vakavalle akuutille koronavirus 2 -hengityselinoireyhtymälle (sars-cov-2)
CR20220552A (es) 2020-04-02 2023-01-17 Regeneron Pharma Anticuerpos contra glicoproteína de espícula anti-sars-cov-2 y fragmentos de unión al antígeno
KR20230038416A (ko) 2020-05-08 2023-03-20 아카데미아 시니카 키메릭 인플루엔자 백신
WO2021231976A1 (en) 2020-05-14 2021-11-18 Xencor, Inc. Heterodimeric antibodies that bind prostate specific membrane antigen (psma) and cd3
AU2021275361A1 (en) * 2020-05-17 2023-01-19 Astrazeneca Uk Limited SARS-CoV-2 antibodies and methods of selecting and using the same
CA3181026A1 (en) 2020-06-03 2021-12-09 Samit GANGULY Methods for treating or preventing sars-cov-2 infections and covid-19 with anti-sars-cov-2 spike glycoprotein antibodies
US20220003779A1 (en) * 2020-07-03 2022-01-06 The Research Foundation For The State University Of New York Methods for qualitative and quantitative analysis of a plurality of biomarkers
EP4182687A4 (en) * 2020-07-20 2024-09-11 Bio-Rad Laboratories, Inc. IMMUNOASSAY FOR SARS-COV-2 NEUTRALISING ANTIBODIES AND MATERIALS THEREFOR
WO2022035918A1 (en) * 2020-08-11 2022-02-17 Eli Lilly And Company Anti-sars-cov-2 antibodies
AR123688A1 (es) * 2020-10-02 2023-01-04 Lilly Co Eli Métodos para reducir el contenido de proteínas de célula huésped en procesos de purificación de proteínas
US11440952B2 (en) 2020-10-16 2022-09-13 Invisishield Technologies Ltd. Compositions for preventing or treating viral and other microbial infections
WO2022162587A1 (en) * 2021-01-27 2022-08-04 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection
CN115141270A (zh) * 2021-03-29 2022-10-04 深圳市康麦生物技术有限公司 特异性结合新型冠状病毒的抗体
AU2022257113B2 (en) 2021-04-12 2024-07-18 Academia Sinica Improved coronavirus vaccine
CN113461810B (zh) * 2021-05-17 2021-12-28 深圳市福田区格物智康病原研究所 一种抗新型冠状病毒刺突蛋白的全人源单克隆抗体及其应用
CA3221441A1 (en) * 2021-06-08 2022-12-15 Yu Tang 2019 novel coronavirus antibody-containing pharmaceutical formulations
WO2022263638A1 (en) * 2021-06-17 2022-12-22 Centre Hospitalier Universitaire Vaudois (C.H.U.V.) Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection
WO2023285620A2 (en) * 2021-07-14 2023-01-19 Alchemab Therapeutics Ltd. Compositions and methods for targeting viral proteins
IL310012A (en) 2021-07-14 2024-03-01 Regeneron Pharma Antibodies against SARS-COV-2 spike glycoprotein and antigen-binding fragments
US12600764B2 (en) * 2021-08-27 2026-04-14 International Business Machines Corporation Antigen-binding proteins targeting coronavirus (COV) variants
CN113735969B (zh) * 2021-09-20 2023-05-12 中国人民解放军军事科学院军事医学研究院 一种全人源抗新冠病毒广谱高中和活性单克隆抗体及应用
TW202334429A (zh) * 2021-10-01 2023-09-01 中央研究院 Sars-cov-2棘蛋白特異性抗體及其用途
US20240400653A1 (en) * 2021-10-07 2024-12-05 Seqirus Pty Ltd Anti-sars-cov-2 antibodies and uses thereof i
WO2023059900A2 (en) * 2021-10-08 2023-04-13 Invivyd, Inc. Pharmaceutical formulations comprising anti-coronavirus s protein antibodies and uses thereof
WO2023070051A1 (en) * 2021-10-22 2023-04-27 Atreca, Inc. Antibodies to coronavirus sars-cov-2
WO2023076419A2 (en) * 2021-10-27 2023-05-04 Twist Bioscience Corporation Sars-cov-2 antibodies and methods of use
WO2023079137A1 (en) * 2021-11-05 2023-05-11 Katholieke Universiteit Leuven Neutralizing anti-sars-cov-2 human antibodies
US20250034234A1 (en) * 2021-11-09 2025-01-30 Rhode Island Hospital Predicting covid-19 antibodies among survivors with deep rna sequencing
EP4430070A1 (en) * 2021-11-12 2024-09-18 RQ Biotechnology Limited Compositions
MX2024005999A (es) * 2021-11-19 2024-05-30 Ap Biosciences Inc Anticuerpos bispecificos dirigidos a cd137 y usos de los mismos para la inmunoterapia anticancer.
EP4183800A1 (en) * 2021-11-19 2023-05-24 Medizinische Hochschule Hannover Novel sars-cov-2 neutralizing antibodies
CN116217711A (zh) * 2021-12-03 2023-06-06 广东菲鹏生物有限公司 一种SARS-CoV-2检测方法和试剂盒
KR102793620B1 (ko) 2021-12-09 2025-04-09 한국화학연구원 사스-코로나바이러스-2 뉴클레오캡시드 단백질에 대한 단클론 항체 및 이의 용도
WO2023133338A2 (en) * 2022-01-10 2023-07-13 University Of Pittsburgh – Of The Commonwealth System Of Higher Education Molecules that bind to neutrophil elastase polypeptides
CN119421953A (zh) 2022-01-28 2025-02-11 株式会社伊贝克 具有突变株交叉性的抗SARS－CoV－2人中和抗体及其抗原结合片段
WO2023159061A2 (en) * 2022-02-15 2023-08-24 Board Of Regents, The University Of Texas System Human monoclonal antibodies targeting the s2 subunit of the sars-cov-2 spike protein
TW202342510A (zh) 2022-02-18 2023-11-01 英商Ｒｑ生物科技有限公司 抗體
CN119110809A (zh) 2022-02-23 2024-12-10 Xencor股份有限公司 抗CD28 x抗PSMA抗体
WO2023159316A1 (en) * 2022-02-28 2023-08-31 Immune Biosolutions Inc. Formulation of anti-sars-cov-2 neutralizing antibodies and uses thereof
WO2023168195A2 (en) * 2022-03-04 2023-09-07 The Scripps Research Institute Human broadly neutralizing antibodies against betacoronaviruses
WO2023178182A1 (en) * 2022-03-16 2023-09-21 10X Genomics, Inc. Compositions and methods for detection and treatment of coronavirus infection
CN114349855B (zh) * 2022-03-18 2022-06-28 百斯医学诊断科技(北京)有限公司 新型冠状病毒Delta突变株特异性抗体及其应用
WO2023183848A2 (en) * 2022-03-25 2023-09-28 The Rockefeller University Anti-sars-cov-2 antibodies and methods of use thereof
EP4505179A2 (en) * 2022-04-01 2025-02-12 Invivyd, Inc. Sars-cov2 antibodies and uses thereof
CN114656555B (zh) * 2022-04-08 2024-03-19 广州医科大学附属第一医院（广州呼吸中心） 抗SARS-CoV-2病毒的中和抗体及其制备方法和应用
WO2023201306A1 (en) 2022-04-14 2023-10-19 Invisishield Technologies Ltd. Compositions for preventing or treating influenza infections
CA3256035A1 (en) 2022-04-14 2023-10-19 Invisishield Technologies Ltd. COMPOSITIONS FOR PREVENTING OR TREATMENT OF CORONAVIRUS INFECTIONS
TW202409073A (zh) * 2022-07-26 2024-03-01 圓祥生技股份有限公司 SARS-CoV-2抗體及雙特異性抗體
CN116143910B (zh) * 2022-10-12 2026-03-24 水木未来(北京)科技有限公司 靶向SARS-CoV-2刺突蛋白的纳米抗体及其应用
KR20250122456A (ko) * 2022-11-01 2025-08-13 프로비던스 헬스 앤드 서비시즈 - 오레곤 Fas 리간드에 특이적인 단일클론 항체 및 이의 용도
EP4638490A1 (en) 2022-12-21 2025-10-29 National University of Singapore Sars-cov-2 spike protein-binding molecules
WO2024187177A2 (en) * 2023-03-09 2024-09-12 The Johns Hopkins University Recombinant antibody for the treatment of extracellular dna overload
CN121240887A (zh) 2023-04-08 2025-12-30 磐石医药生技股份有限公司 通过聚合物囊泡进行靶向递送的方法和组合物
US12508235B2 (en) 2023-04-08 2025-12-30 Rock Biomedical, Inc. Methods and compositions for dendritic cell targeting nano-delivery
WO2024238734A2 (en) 2023-05-17 2024-11-21 Rock Biomedical Inc. Mgat1 deficient cells and uses thereof
WO2025222126A1 (en) * 2024-04-19 2025-10-23 Vanderbilt University Var2csa antibodies and methods of use thereof
US20260061066A1 (en) * 2024-06-03 2026-03-05 Uct Bioscience Co., Ltd. Anti-grp78 antibody, immunoconjugate and uses thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323840B1 (en) 1999-09-17 2001-11-27 Cts Corporation Surface-mount pointing device
US20040191260A1 (en) * 2003-03-26 2004-09-30 Technion Research & Development Foundation Ltd. Compositions capable of specifically binding particular human antigen presenting molecule/pathogen-derived antigen complexes and uses thereof
US7892563B2 (en) 2003-05-20 2011-02-22 Wyeth Holdings Corporation Methods for treatment of severe acute respiratory syndrome (SARS)
CA2531684C (en) * 2003-07-22 2014-03-11 Crucell Holland B.V. Binding molecules against sars-coronavirus and uses thereof
EP1644414B1 (en) 2003-07-22 2015-01-14 Crucell Holland B.V. Binding molecules against sars-coronavirus and uses thereof
EP1812067B1 (en) 2004-11-11 2012-03-21 Crucell Holland B.V. Compositions against sars-coronavirus and uses thereof
MX2007009512A (es) 2005-02-08 2008-02-21 New York Blood Ct Inc Neutralizacion de anticuerpos monoclonales contra coronavirus asociado con sindrome respiratorio agudo severo.
WO2015080973A1 (en) * 2013-11-26 2015-06-04 Baylor College Of Medicine A novel sars immunogenic composition
JO3701B1 (ar) * 2014-05-23 2021-01-31 Regeneron Pharma مضادات حيوية بشرية لمتلازمة الشرق الأوسط التنفسية - بروتين كورونا فيروس الشوكي
AU2016243026B2 (en) * 2015-04-03 2022-03-31 Eureka Therapeutics, Inc. Constructs targeting AFP peptide/MHC complexes and uses thereof
EP3892297A1 (en) 2020-04-09 2021-10-13 Eberhard Karls Universität Tübingen Medizinische Fakultät Peptides and combinations of peptides for use in immunotherapy against an infection by sars-cov-2 (covid-19)
CN111592595B (zh) * 2020-04-27 2021-02-19 南京医科大学 抗新型冠状病毒SARS-Cov-2的中和性抗体及其应用
CN112300375B (zh) * 2020-11-06 2022-10-25 江苏三木化工股份有限公司 一种水性光固化环氧丙烯酸树脂的制备方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
EM&I, 2020*

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