KR102438965B1 - 치환된 5,6,7,8-테트라히드로[1,2,4]트리아졸로[4,3-a]피리딘-3(2H)-온 및 2,5,6,7-테트라히드로-3H-피롤로[2,1-c][1,2,4]트리아졸-3-온, 및 그의 용도 - Google Patents

치환된 5,6,7,8-테트라히드로[1,2,4]트리아졸로[4,3-a]피리딘-3(2H)-온 및 2,5,6,7-테트라히드로-3H-피롤로[2,1-c][1,2,4]트리아졸-3-온, 및 그의 용도 Download PDF

Info

Publication number
KR102438965B1
KR102438965B1 KR1020187032180A KR20187032180A KR102438965B1 KR 102438965 B1 KR102438965 B1 KR 102438965B1 KR 1020187032180 A KR1020187032180 A KR 1020187032180A KR 20187032180 A KR20187032180 A KR 20187032180A KR 102438965 B1 KR102438965 B1 KR 102438965B1
Authority
KR
South Korea
Prior art keywords
fluorine
hydrogen
methyl
optionally
carbon atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020187032180A
Other languages
English (en)
Korean (ko)
Other versions
KR20190003954A (ko
Inventor
니콜 비버
다미안 브록슈니더
케어스텐 마티아스 게리케
플로리안 쾰링
클레멘스 루스티크
외어크 메딩
하인리히 마이어
토마스 노이바우어
마르티나 섀퍼
안드레아스 팀머만
드미트리 추보프
카르스텐 테어융
니엘스 린트너
폴커 바도크
디터 무스마이어
히데키 미야타케 온도자발
스티븐 무어
알렉산더 슐츠
Original Assignee
바이엘 악티엔게젤샤프트
바이엘 파마 악티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 바이엘 악티엔게젤샤프트, 바이엘 파마 악티엔게젤샤프트 filed Critical 바이엘 악티엔게젤샤프트
Publication of KR20190003954A publication Critical patent/KR20190003954A/ko
Application granted granted Critical
Publication of KR102438965B1 publication Critical patent/KR102438965B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020187032180A 2016-05-09 2017-05-08 치환된 5,6,7,8-테트라히드로[1,2,4]트리아졸로[4,3-a]피리딘-3(2H)-온 및 2,5,6,7-테트라히드로-3H-피롤로[2,1-c][1,2,4]트리아졸-3-온, 및 그의 용도 Active KR102438965B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP16168809 2016-05-09
EP16168809.8 2016-05-09
PCT/EP2017/060900 WO2017194459A1 (de) 2016-05-09 2017-05-08 Substituierte 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2h)-one und 2,5,6,7-tetrahydro-3h-pyrrolo[2,1-c][1,2,4]triazol-3-one und ihre verwendung

Publications (2)

Publication Number Publication Date
KR20190003954A KR20190003954A (ko) 2019-01-10
KR102438965B1 true KR102438965B1 (ko) 2022-09-02

Family

ID=55919764

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187032180A Active KR102438965B1 (ko) 2016-05-09 2017-05-08 치환된 5,6,7,8-테트라히드로[1,2,4]트리아졸로[4,3-a]피리딘-3(2H)-온 및 2,5,6,7-테트라히드로-3H-피롤로[2,1-c][1,2,4]트리아졸-3-온, 및 그의 용도

Country Status (29)

Country Link
US (1) US10722501B2 (OSRAM)
JP (1) JP6987784B2 (OSRAM)
KR (1) KR102438965B1 (OSRAM)
CN (1) CN109476658B (OSRAM)
AR (1) AR110600A1 (OSRAM)
AU (1) AU2017262960B2 (OSRAM)
CA (1) CA3023383A1 (OSRAM)
CL (1) CL2018003194A1 (OSRAM)
CO (1) CO2018012136A2 (OSRAM)
CR (1) CR20180540A (OSRAM)
CU (1) CU24536B1 (OSRAM)
DO (1) DOP2018000246A (OSRAM)
EA (1) EA037531B1 (OSRAM)
EC (1) ECSP18083950A (OSRAM)
GE (1) GEP20227365B (OSRAM)
IL (1) IL262548B (OSRAM)
JO (1) JOP20170113B1 (OSRAM)
MX (1) MX385467B (OSRAM)
NI (1) NI201800118A (OSRAM)
PE (1) PE20190325A1 (OSRAM)
PH (1) PH12018502359A1 (OSRAM)
SA (1) SA518400397B1 (OSRAM)
SG (1) SG11201809724PA (OSRAM)
SV (1) SV2018005783A (OSRAM)
TN (1) TN2018000376A1 (OSRAM)
TW (1) TWI758291B (OSRAM)
UA (1) UA125644C2 (OSRAM)
UY (1) UY37234A (OSRAM)
WO (1) WO2017194459A1 (OSRAM)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007009796A (es) 2007-08-14 2009-02-25 Cell Therapy And Technology S Gel conteniendo pirfenidona.
MX2011007675A (es) 2011-07-19 2012-07-11 Cell Therapy And Technology S A De C V Procedimiento para la fabricacion de una composicion farmaceutica en forma de tabletas de liberacion prolongada conteniendo pirfenidona y su aplicacion en la regresion de la insuficiencia renal cronica, contractura capsular mamaria y fibrosis hepatica humanas.
MX346763B (es) 2012-03-28 2017-03-31 Cell Therapy And Tech S A De C V Composición tópica semisólida conteniendo pirfenidona y dialil óxido de disulfuro modificado (odd-m) para eliminar o prevenir el acné.
MX356551B (es) 2012-08-23 2018-06-04 Grupo Medifarma S A De C V Star Composición antiséptica, antiseborreica y exfoliante para eliminar o prevenir el acné.
EP3707141B1 (de) 2017-11-07 2021-12-22 Bayer Aktiengesellschaft Substituierte 2,4-dihydro-3h-1,2,4-triazol-3-one und ihre verwendung
CN110950797A (zh) * 2019-12-06 2020-04-03 丽水绿氟科技有限公司 一种2-三氟甲基-3-氟-4-吡啶甲酸及其衍生物的制备方法
GB201918414D0 (en) 2019-12-13 2020-01-29 Z Factor Ltd Compounds and their use for the treatment of Alpha1-Antitrypsin deficiency
CN115466212B (zh) * 2022-10-26 2023-09-22 河南农业大学 一种2-三氟甲基喹啉类化合物及其合成方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007116A1 (en) 1995-08-17 1997-02-27 Chinoin Gyógyszer És Vegyészeti Prolylendopeptidase inhibitors
WO2006052962A2 (en) 2004-11-10 2006-05-18 Janssen Pharmaceutica, N.V. Bicyclic triazole a4 integrin inhibitors
WO2008144748A1 (en) * 2007-05-21 2008-11-27 The Uab Research Foundation Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation
KR102122779B1 (ko) 2012-11-05 2020-06-26 바이엘 파마 악티엔게젤샤프트 아미노-치환된 이미다조[1,2-a]피리딘카르복스아미드 및 그의 용도

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3966781A (en) 1970-12-17 1976-06-29 Merck Sharp & Dohme (I.A.) Corporation Deuteration of functional group-containing hydrocarbons
DE19834044A1 (de) 1998-07-29 2000-02-03 Bayer Ag Neue substituierte Pyrazolderivate
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE19943639A1 (de) 1999-09-13 2001-03-15 Bayer Ag Dicarbonsäurederivate mit neuartigen pharmazeutischen Eigenschaften
DE19943636A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943634A1 (de) 1999-09-13 2001-04-12 Bayer Ag Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE19943635A1 (de) 1999-09-13 2001-03-15 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
AR031176A1 (es) 2000-11-22 2003-09-10 Bayer Ag Nuevos derivados de pirazolpiridina sustituidos con piridina
DE10110750A1 (de) 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
DE10110749A1 (de) 2001-03-07 2002-09-12 Bayer Ag Substituierte Aminodicarbonsäurederivate
DE10220570A1 (de) 2002-05-08 2003-11-20 Bayer Ag Carbamat-substituierte Pyrazolopyridine
WO2011062864A2 (en) 2009-11-17 2011-05-26 Emory University Inhibitors of nox enzymes and methods of use thereof
DE102010021637A1 (de) 2010-05-26 2011-12-01 Bayer Schering Pharma Aktiengesellschaft Substituierte 5-Fluor-1H-Pyrazolopyridine und ihre Verwendung
EP2708539A1 (de) 2010-07-09 2014-03-19 Bayer Intellectual Property GmbH Annellierte pyrimidine und triazine und ihre verwendung zur behandlung bzw. prophylaxe von herz-kreislauf-erkrankungen
DE102010040233A1 (de) 2010-09-03 2012-03-08 Bayer Schering Pharma Aktiengesellschaft Bicyclische Aza-Heterocyclen und ihre Verwendung
DE102010043379A1 (de) 2010-11-04 2012-05-10 Bayer Schering Pharma Aktiengesellschaft Substituierte 6-Fluor-1H-Pyrazolo[4,3-b]pyridine und ihre Verwendung
US8791162B2 (en) 2011-02-14 2014-07-29 Merck Sharp & Dohme Corp. Cathepsin cysteine protease inhibitors
KR20130091464A (ko) * 2012-02-08 2013-08-19 한미약품 주식회사 타이로신 카이네이즈 억제 활성을 갖는 트리아졸로피리딘 유도체

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997007116A1 (en) 1995-08-17 1997-02-27 Chinoin Gyógyszer És Vegyészeti Prolylendopeptidase inhibitors
WO2006052962A2 (en) 2004-11-10 2006-05-18 Janssen Pharmaceutica, N.V. Bicyclic triazole a4 integrin inhibitors
WO2008144748A1 (en) * 2007-05-21 2008-11-27 The Uab Research Foundation Prolyl endopeptidase inhibitors for reducing or preventing neutrophilic inflammation
KR102122779B1 (ko) 2012-11-05 2020-06-26 바이엘 파마 악티엔게젤샤프트 아미노-치환된 이미다조[1,2-a]피리딘카르복스아미드 및 그의 용도

Also Published As

Publication number Publication date
CR20180540A (es) 2019-03-05
TN2018000376A1 (en) 2020-06-15
IL262548A (en) 2018-12-31
MX385467B (es) 2025-03-18
NI201800118A (es) 2019-10-30
SV2018005783A (es) 2019-05-06
CO2018012136A2 (es) 2018-12-14
EA201892518A1 (ru) 2019-04-30
JP2019522628A (ja) 2019-08-15
UA125644C2 (uk) 2022-05-11
ECSP18083950A (es) 2018-11-30
SA518400397B1 (ar) 2021-11-24
AU2017262960B2 (en) 2021-11-11
WO2017194459A1 (de) 2017-11-16
TWI758291B (zh) 2022-03-21
CU20180139A7 (es) 2019-06-04
EA037531B1 (ru) 2021-04-08
JP6987784B2 (ja) 2022-01-05
JOP20170113B1 (ar) 2023-03-28
IL262548B (en) 2021-12-01
CA3023383A1 (en) 2017-11-16
BR112018073061A2 (pt) 2019-04-09
US10722501B2 (en) 2020-07-28
MX2018013797A (es) 2019-03-21
NZ747579A (en) 2025-06-27
CN109476658B (zh) 2021-08-10
PH12018502359A1 (en) 2019-10-07
AR110600A1 (es) 2019-04-17
CL2018003194A1 (es) 2019-04-12
CN109476658A (zh) 2019-03-15
SG11201809724PA (en) 2018-12-28
DOP2018000246A (es) 2018-11-30
KR20190003954A (ko) 2019-01-10
CU24536B1 (es) 2021-07-02
GEP20227365B (en) 2022-03-25
US20190160048A1 (en) 2019-05-30
UY37234A (es) 2017-11-30
PE20190325A1 (es) 2019-03-05
TW201806949A (zh) 2018-03-01

Similar Documents

Publication Publication Date Title
KR102438965B1 (ko) 치환된 5,6,7,8-테트라히드로[1,2,4]트리아졸로[4,3-a]피리딘-3(2H)-온 및 2,5,6,7-테트라히드로-3H-피롤로[2,1-c][1,2,4]트리아졸-3-온, 및 그의 용도
CN107849017A (zh) 作为magl抑制剂的1,1,1‑三氟‑3‑羟基丙‑2‑基氨基甲酸酯衍生物及1,1,1‑三氟‑4‑羟基丁‑2‑基氨基甲酸酯衍生物
AU2018243691A1 (en) Heterocyclic compound
CN116829545A (zh) 取代的吡唑基哌啶羧酸
EP4288437A1 (en) Map4k1 inhibitors
TWI758325B (zh) 7-經取代之1-芳基萘啶-3-甲醯胺及其用途
US20230065629A1 (en) Substituted 6-(1h-pyrazol-1-yl)pyrimidin-4-amine derivatives and uses thereof
CN109689654A (zh) 7-取代的1-吡啶基-萘啶-3-甲酰胺类及其用途
WO2020116662A1 (ja) シクロアルカン−１，３−ジアミン誘導体
US11337973B2 (en) Substituted [1,2,4]triazolo[4,3-A]pyrazines as prolyl endopeptidase inhibitors
ES2987656T3 (es) 5,6,7,8-tetrahidro[1,2,4]triazolo[4,3-a]piridin-3(2H)-onas y 2,5,6,7-tetrahidro-3h-pirrolo[2,1-c][1,2,4]triazol-3-onas sustituidas y uso de las mismas
BR112018073061B1 (pt) 5,6,7,8- tetra-hidro[1,2,4]triazolo[4,3-a]piridin-3(2h)-onas e 2,5,6,7-tetrahidro-3h-pirrolo[2,1-c][1,2,4]triazol-3-onas, seus usos e seu processo de preparação, e medicamento
HK40000221B (zh) 取代的5,6,7,8-四氢[1,2,4]三唑并[4,3-a]吡啶-3(2h)-酮和2,5,6,7-四氢-3h-吡咯并[2,1-c][1,2,4]三唑-3-酮及其用途
HK40000221A (en) Substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridine-3(2h)-ones and 2,5,6,7-tetrahydro-3h-pyrrolo[2,1-c][1,2,4]triazol-3-ones, and use thereof
TW202409011A (zh) 人類呼吸道融合病毒及間質肺病毒抑制劑
WO2025106362A1 (en) Ripk1 inhibitors and methods of use
HK40006282A (en) 7-substituted 1-aryl-naphthyridine-3-carboxylic acid amides and use thereof

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-OTH-PR1001 (AS PROVIDED BY THE NATIONAL OFFICE)

Year of fee payment: 4