KR102424219B1 - 분석물의 검출을 위한 방법 및 시스템 - Google Patents
분석물의 검출을 위한 방법 및 시스템 Download PDFInfo
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- KR102424219B1 KR102424219B1 KR1020177011722A KR20177011722A KR102424219B1 KR 102424219 B1 KR102424219 B1 KR 102424219B1 KR 1020177011722 A KR1020177011722 A KR 1020177011722A KR 20177011722 A KR20177011722 A KR 20177011722A KR 102424219 B1 KR102424219 B1 KR 102424219B1
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- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
- G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- G—PHYSICS
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- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
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- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
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- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (11)
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| US14/507,820 US10352899B2 (en) | 2014-10-06 | 2014-10-06 | System and method for detection of silver |
| US14/507,820 | 2014-10-06 | ||
| US14/507,818 | 2014-10-06 | ||
| US14/507,825 | 2014-10-06 | ||
| US14/507,828 | 2014-10-06 | ||
| US14/507,818 US9921182B2 (en) | 2014-10-06 | 2014-10-06 | System and method for detection of mercury |
| US14/507,828 US10627358B2 (en) | 2014-10-06 | 2014-10-06 | Method for detection of analytes |
| US14/507,825 US9506908B2 (en) | 2014-10-06 | 2014-10-06 | System for detection of analytes |
| US14/535,378 | 2014-11-07 | ||
| US14/535,378 US10196678B2 (en) | 2014-10-06 | 2014-11-07 | System and method for detection of nucleic acids |
| PCT/US2015/054074 WO2016057422A2 (en) | 2014-10-06 | 2015-10-05 | Methods and systems for detection of analytes |
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Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10196678B2 (en) | 2014-10-06 | 2019-02-05 | ALVEO Technologies Inc. | System and method for detection of nucleic acids |
| US10627358B2 (en) | 2014-10-06 | 2020-04-21 | Alveo Technologies, Inc. | Method for detection of analytes |
| US10352899B2 (en) | 2014-10-06 | 2019-07-16 | ALVEO Technologies Inc. | System and method for detection of silver |
| US9506908B2 (en) | 2014-10-06 | 2016-11-29 | Alveo Technologies, Inc. | System for detection of analytes |
| US9921182B2 (en) | 2014-10-06 | 2018-03-20 | ALVEO Technologies Inc. | System and method for detection of mercury |
| KR102461735B1 (ko) * | 2016-09-23 | 2022-11-01 | 알베오 테크놀로지스 인크. | 분석물을 검출하기 위한 방법 및 조성물 |
| CN107643228B (zh) * | 2017-08-31 | 2021-04-27 | 中国船舶重工集团公司第七一九研究所 | 一种测量汞蒸气的芯片的制备方法及其传感器的使用方法 |
| US12390812B2 (en) | 2018-12-19 | 2025-08-19 | Nuclein, Llc | Apparatus and methods for molecular diagnostics |
| AU2019401601A1 (en) | 2018-12-20 | 2021-07-15 | Alveo Technologies, Inc. | Handheld impedance-based diagnostic test system for detecting analytes |
| CN110523447B (zh) * | 2019-08-29 | 2021-05-11 | 苏州大学 | 一种对细胞多角度力学测量的微流控芯片及其制作方法 |
| US12472492B2 (en) | 2020-08-14 | 2025-11-18 | Alveo Technologies, Inc. | Systems and methods of sample depositing and testing |
| KR102618172B1 (ko) * | 2020-12-24 | 2023-12-29 | 경북대학교 산학협력단 | 액체의 전기적 특성 측정 시스템 및 액체의 전기적 특성 측정 방법 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008532005A (ja) | 2005-02-25 | 2008-08-14 | インバーネス・メデイカル・スウイツツアーランド・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | 流体ゲート装置 |
| US20100200400A1 (en) | 2009-02-06 | 2010-08-12 | Commissariat A L'energie Atomique | Embedded bodily fluid analysis device |
| JP2012501627A (ja) | 2008-09-03 | 2012-01-26 | ナブシス， インコーポレイテッド | 流体チャネル内の生体分子および他の分析物の電圧感知のための、長手方向に変位されるナノスケールの電極の使用 |
| JP2012177599A (ja) | 2011-02-25 | 2012-09-13 | Arkray Inc | 再生可能なマイクロチップ、それを用いる測定装置、およびマイクロチップの再生方法 |
Family Cites Families (142)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5234795A (en) * | 1975-06-19 | 1977-03-16 | Nippon Miniature Bearing Co | Detecting apparatus for fluid concentration |
| JPS5914054U (ja) * | 1982-07-19 | 1984-01-27 | 東ソー株式会社 | 液体クロマトグラフ用フロ−セル |
| JPS59139624A (ja) | 1983-01-31 | 1984-08-10 | Fujitsu Ltd | 試料の加熱方法 |
| GB9318677D0 (en) * | 1993-09-09 | 1993-10-27 | Kodak Ltd | Method and apparatus for measuring silver ion activity |
| US6403367B1 (en) | 1994-07-07 | 2002-06-11 | Nanogen, Inc. | Integrated portable biological detection system |
| US5589136A (en) | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
| US6524532B1 (en) | 1995-06-20 | 2003-02-25 | The Regents Of The University Of California | Microfabricated sleeve devices for chemical reactions |
| EP1179585B1 (en) | 1997-12-24 | 2008-07-09 | Cepheid | Device and method for lysis |
| JPH11241977A (ja) * | 1998-02-25 | 1999-09-07 | Shimadzu Corp | 流体濃度測定装置 |
| US6699713B2 (en) | 2000-01-04 | 2004-03-02 | The Regents Of The University Of California | Polymerase chain reaction system |
| US6489785B2 (en) | 2000-12-05 | 2002-12-03 | Agilent Technologies, Inc. | Comparative contactless conductivity detector |
| US6576459B2 (en) | 2001-03-23 | 2003-06-10 | The Regents Of The University Of California | Sample preparation and detection device for infectious agents |
| GB0116384D0 (en) | 2001-07-04 | 2001-08-29 | Diagnoswiss Sa | Microfluidic chemical assay apparatus and method |
| TWI245895B (en) * | 2001-11-29 | 2005-12-21 | Sun-Wing Tong | Molecular detection and assay by electrobiochip micro-array |
| US20030203504A1 (en) | 2002-04-26 | 2003-10-30 | John Hefti | Diffusion-based system and method for detecting and monitoring activity of biologic and chemical species |
| JP4092990B2 (ja) | 2002-09-06 | 2008-05-28 | 株式会社日立製作所 | 生体および化学試料検査装置 |
| ITTO20020808A1 (it) | 2002-09-17 | 2004-03-18 | St Microelectronics Srl | Dispositivo integrato di analisi del dna. |
| AU2003270832A1 (en) | 2002-09-24 | 2004-04-19 | U.S. Government As Represented By The Secretary Of The Army | Portable thermocycler |
| KR100858080B1 (ko) | 2002-11-12 | 2008-09-10 | 삼성전자주식회사 | 전기적 신호를 측정하는 ｐｃｒ 증폭 산물을 검출하는 방법 |
| US7062385B2 (en) | 2002-11-25 | 2006-06-13 | Tufts University | Intelligent electro-optical nucleic acid-based sensor array and method for detecting volatile compounds in ambient air |
| KR101214179B1 (ko) | 2003-08-06 | 2013-01-10 | 더 프록터 앤드 갬블 컴퍼니 | 표적 물질 검출용 가교 부재 |
| US8346482B2 (en) | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
| CN1860366A (zh) * | 2003-09-29 | 2006-11-08 | 皇家飞利浦电子股份有限公司 | 免标记检测生物分子 |
| US6990849B2 (en) * | 2004-03-26 | 2006-01-31 | Lifescan, Inc. | Microfluidic analytical system with position electrodes |
| JP3952042B2 (ja) | 2004-06-07 | 2007-08-01 | ソニー株式会社 | 凹状部位を有する電極を備えるハイブリダイゼーション検出部と該検出部を備えるｄｎａチップ |
| EP1794581A2 (en) | 2004-09-15 | 2007-06-13 | Microchip Biotechnologies, Inc. | Microfluidic devices |
| ES2380775T3 (es) | 2004-10-18 | 2012-05-18 | Brandeis University | Reactivos y procedimientos para mejorar la reproducibilidad y reducir el cebado defectuoso en la amplificación por PCR |
| CA2592204C (en) | 2004-12-23 | 2013-03-12 | I-Stat Corporation | Nucleic acid diagnostics system and methods |
| US20060176179A1 (en) | 2005-01-26 | 2006-08-10 | Battelle Memorial Institute | Bendable, active radio-frequency sensor tags and a system of same |
| US8841076B2 (en) | 2005-05-09 | 2014-09-23 | Theranos, Inc. | Systems and methods for conducting animal studies |
| US20150141264A1 (en) | 2005-05-20 | 2015-05-21 | Apdn (B.V.I.) Inc. | In-field dna extraction, detection and authentication methods and systems therefor |
| CN101258397B (zh) | 2005-07-14 | 2012-07-04 | 毫微创新科技公司 | 微流装置和制备及使用方法 |
| CN101300352B (zh) | 2005-09-01 | 2013-03-20 | 佳能美国生命科学公司 | 检测、分析和鉴定基因组dna的方法和分子诊断装置 |
| WO2007061943A2 (en) | 2005-11-21 | 2007-05-31 | Applera Corporation | Portable preparation, analysis, and detection apparatus for nucleic acid processing |
| US8173077B2 (en) | 2005-12-16 | 2012-05-08 | The Curators Of The University Of Missouri | Reusable PCR amplification system and method |
| WO2007092552A2 (en) | 2006-02-07 | 2007-08-16 | Antara Biosciences Inc. | Device and methods for detecting and quantifying one or more target agents |
| US20090061450A1 (en) | 2006-03-14 | 2009-03-05 | Micronics, Inc. | System and method for diagnosis of infectious diseases |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| US7708944B1 (en) | 2006-06-13 | 2010-05-04 | Research Foundation Of State University Of New York | Ultra-sensitive, portable capillary sensor |
| US20070298487A1 (en) | 2006-06-23 | 2007-12-27 | Becton, Dickinson And Company | Radio Frequency Transponder Assay |
| US20120058547A1 (en) | 2006-08-11 | 2012-03-08 | The Hong Kong University Of Science And Technology | Method and system for nucleic acid detection using electroconductive or electrochemically active labels |
| GB0618966D0 (en) | 2006-09-26 | 2006-11-08 | Iti Scotland Ltd | Cartridge system |
| EP2069070B1 (en) | 2006-09-28 | 2013-11-27 | Stokes Bio Limited | A qpcr analysis apparatus |
| WO2008066747A2 (en) | 2006-11-22 | 2008-06-05 | The Board Of Trustees Of Michigan State University | Electroluminescent-based fluorescence detection device |
| JP5185948B2 (ja) * | 2006-12-06 | 2013-04-17 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | メッキ及びエッチング浴組成をスクリーニングするマイクロ流体システム及び方法 |
| US7483805B2 (en) | 2006-12-26 | 2009-01-27 | Integrated Sensing Systems, Inc. | Sensing and analysis system, network, and method |
| ES2307430B1 (es) | 2007-05-09 | 2009-10-20 | Consejo Superior De Investigaciones Cientificas | Biosensor y sus aplicaciones. |
| US8198658B2 (en) * | 2007-06-13 | 2012-06-12 | Samsung Electronics Co., Ltd. | Device and method for detecting biomolecules using adsorptive medium and field effect transistor |
| US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| BRPI0703025B1 (pt) | 2007-08-08 | 2018-07-17 | Universidade De São Paulo - Usp | microdispositivo multicamada, processo de preparação de microdispositivo multicamada |
| EP3756767B1 (en) | 2007-10-02 | 2024-05-01 | Labrador Diagnostics LLC | Modular point-of-care devices and uses thereof |
| CL2008003007A1 (es) | 2007-10-12 | 2009-10-02 | Bigtec Private Ltd | Un micro chip con capas de ceramicas de coccion conjunta a baja temperatura (ltcc) formando una camara de reaccion, anillos conductores que rodean a la camara de reaccion y un calentador que suministra calor a los anillos, el metodo de fabricacion del micro chip y un micro dispositivo de reaccion en cadena de polimerasa (pcr). |
| WO2009075513A2 (en) | 2007-12-10 | 2009-06-18 | Jae Chern Yoo | A thin film bio valve device and its controlling apparatus |
| US8865401B2 (en) | 2007-12-14 | 2014-10-21 | The Johns Hopkins University | Purification and concentration of proteins and DNA from a complex sample using isotachophoresis and a device to perform the purification |
| US8614059B2 (en) | 2007-12-14 | 2013-12-24 | The Johns Hopkins University | Purification and concentration of proteins and DNA from a complex sample using isotachophoresis and a device to perform the purification |
| DE102007062441A1 (de) | 2007-12-20 | 2009-06-25 | Aj Innuscreen Gmbh | Mobiles Schnelltestsystem für die Nukleinsäureanalytik |
| KR101608749B1 (ko) | 2008-01-21 | 2016-04-06 | 삼성전자주식회사 | 박막 원심분리 분석 장치 및 이를 이용한 분석 방법 |
| DE102008009920A1 (de) | 2008-02-15 | 2009-08-20 | Aj Innuscreen Gmbh | Mobiles Gerät für die Nukleinsäureisolierung |
| KR100969667B1 (ko) | 2008-03-24 | 2010-07-14 | 디지탈 지노믹스(주) | 생리활성물질을 전기적으로 검출하는 방법 및 이를 위한바이오칩 |
| EP2324128A4 (en) | 2008-08-14 | 2012-09-12 | Zygem Corp Ltd | TEMPERATURE CONTROLLED NUCLEIC ACID DETECTION METHOD FOR CLOSED SYSTEM |
| EP2321429B1 (en) | 2008-09-03 | 2016-08-17 | Quantumdx Group Limited | Methods and kits for nucleic acid sequencing |
| WO2010033604A2 (en) | 2008-09-18 | 2010-03-25 | X-Bar Diagnostic System, Inc. | Fully automated portable dna detection system |
| GB0818609D0 (en) | 2008-10-10 | 2008-11-19 | Univ Hull | apparatus and method |
| US20100122904A1 (en) | 2008-11-17 | 2010-05-20 | Board Of Regents, The University Of Texas System | Incorporating cmos integrated circuits in the design of affinity-based biosensor systems |
| US8551767B2 (en) * | 2008-11-20 | 2013-10-08 | Agency Of Science, Technology And Research | Sensor for detection of nucleic acid |
| WO2010078420A2 (en) | 2008-12-30 | 2010-07-08 | Redhorse Fluidics | Systems, devices, methods and kits for fluid handling |
| JP5715068B2 (ja) | 2009-01-30 | 2015-05-07 | マイクロニクス， インコーポレイテッド | 携帯型高利得蛍光検出システム |
| US20100216225A1 (en) | 2009-02-25 | 2010-08-26 | Ag-Defense Systems, Inc. | Portable microorganism detection unit |
| US8106428B2 (en) | 2009-03-03 | 2012-01-31 | Board Of Regents, The University Of Texas System | Nano-scale bridge biosensors |
| EP2411536B1 (en) | 2009-03-27 | 2014-09-17 | Nabsys, Inc. | Methods for analyzing biomolecules and probes bound thereto |
| WO2010114842A1 (en) | 2009-03-30 | 2010-10-07 | Ibis Biosciences, Inc. | Bioagent detection systems, devices, and methods |
| US20120183965A1 (en) | 2009-06-15 | 2012-07-19 | David Ward | Nucleic acid detection |
| KR101217576B1 (ko) | 2009-09-22 | 2013-01-03 | 한국전자통신연구원 | 바이오 센서 및 그의 구동 방법 |
| US20110136104A1 (en) | 2009-12-04 | 2011-06-09 | Massachusetts Institute Of Technology | Multiplexed quantitative pcr end point analysis of nucleic acid targets |
| KR20110080067A (ko) | 2010-01-04 | 2011-07-12 | 엘지전자 주식회사 | 샘플분석 카트리지 및 샘플분석 카트리지 리더 |
| WO2011086497A2 (en) | 2010-01-12 | 2011-07-21 | Ahram Biosystems, Inc. | Three-stage thermal convection apparatus and uses thereof |
| BR112012017152A2 (pt) | 2010-01-12 | 2020-10-06 | Ahram Biosystems, Inc. | aparelho de convecção térmica de dois estágios e usos do mesmo. |
| US10295472B2 (en) | 2010-05-05 | 2019-05-21 | Alverix, Inc. | Assay reader operable to scan a test strip |
| CN102004126A (zh) * | 2010-05-11 | 2011-04-06 | 中国科学院上海应用物理研究所 | 电化学生物传感器及其检测方法 |
| US20110312759A1 (en) | 2010-06-17 | 2011-12-22 | Geneasys Pty Ltd | Genetic analysis loc with reagent reservoir |
| US9029168B2 (en) | 2010-06-28 | 2015-05-12 | The Trustees Of Princeton University | Use and making of biosensors utilizing antimicrobial peptides for highly sensitive biological monitoring |
| US8951472B2 (en) | 2010-07-19 | 2015-02-10 | Andalyze, Inc. | Portable fluorimetric apparatus, method and system |
| EP2754496A3 (en) | 2010-07-23 | 2017-08-02 | Beckman Coulter, Inc. | System Or Method Of Including Analytical Units |
| US20130240376A1 (en) * | 2010-09-02 | 2013-09-19 | Heed Diagnostics Aps | Electrochemical detection of analyte |
| US8865075B2 (en) | 2010-11-01 | 2014-10-21 | Princeton Biochemicals, Inc. | Multi-task immunoaffinity device secured to a peripheral box and integrated to a capillary electrophoresis apparatus |
| US9696299B2 (en) | 2010-11-01 | 2017-07-04 | Norberto Guzman | Integrated modular unit including an analyte concentrator microreactor device connected to a cartridge-cassette |
| EP2646154A2 (en) | 2010-11-30 | 2013-10-09 | Quantumdx Group Limited | The design, fabrication and use of a microfluidics multitemperature flexible reaction device |
| US9877673B2 (en) | 2010-12-10 | 2018-01-30 | Clinitech, Llc | Transdermal sampling and analysis device |
| EP2683822B1 (en) | 2011-03-10 | 2020-04-22 | General Atomics | Diagnostic and sample preparation devices and methods |
| WO2012142192A2 (en) | 2011-04-11 | 2012-10-18 | Gray Mark A | Apparatus and method for making uniform emulsions |
| US9988668B2 (en) | 2011-06-23 | 2018-06-05 | Anitoa Systems, Llc | Apparatus for amplification of nucleic acids |
| US20140349298A1 (en) | 2011-07-14 | 2014-11-27 | William Eugene Stanchina | Portable, low power instrument for the optoelectronic detection of pathogens using isothermal nucleic acid amplification protocols |
| US9051605B2 (en) | 2011-07-29 | 2015-06-09 | Auburn University | Magnetic bead quantum dot nanoparticle assay |
| US8435738B2 (en) * | 2011-09-25 | 2013-05-07 | Theranos, Inc. | Systems and methods for multi-analysis |
| SG10201602141QA (en) | 2011-09-25 | 2016-04-28 | Theranos Inc | Systems And Methods For Multi-Analysis |
| US9417210B2 (en) | 2011-09-30 | 2016-08-16 | Pandora Genomics, LLC | System, apparatus and method for evaluating samples or analytes using a point-of-care device |
| US9030215B2 (en) | 2011-10-04 | 2015-05-12 | The Regents Of The University Of California Corporation | Real-time, label-free detection of nucleic acid amplification in droplets using impedance spectroscopy and solid-phase substrate |
| US9335292B2 (en) | 2011-10-13 | 2016-05-10 | Auburn University | Electrochemical proximity assay |
| EP2825865B1 (en) | 2012-03-09 | 2020-07-22 | Ubiquitome Limited | Portable device for detecting molecule(s) |
| US10180421B2 (en) | 2012-03-30 | 2019-01-15 | Boston Microfluidics | Methods and systems to collect a biological sample |
| WO2013155213A1 (en) | 2012-04-10 | 2013-10-17 | Keck Graduate Institute Of Applied Life Sciences | System and cartridge for efficient nucleic acid testing |
| US10132802B2 (en) | 2012-04-17 | 2018-11-20 | i-calQ, LLC | Device for performing a diagnostic test and methods for use thereof |
| WO2013159116A1 (en) | 2012-04-20 | 2013-10-24 | University Of Chicago | Fluidic devices for biospecimen preservation |
| WO2013159117A1 (en) | 2012-04-20 | 2013-10-24 | SlipChip, LLC | Fluidic devices and systems for sample preparation or autonomous analysis |
| US20130309676A1 (en) | 2012-05-18 | 2013-11-21 | Alfred E. Mann Foundation For Scientific Research | Biased n-mers identification methods, probes and systems for target amplification and detection |
| CN104937109A (zh) | 2012-09-12 | 2015-09-23 | 艾克泽基因公司 | 使用内部对照,在生物宿主中鉴定疾病状态的系统、装置和方法 |
| US20140099636A1 (en) | 2012-10-10 | 2014-04-10 | Baker Hughes Incorporated | FIELD-BASED qPCR MICROBIAL MONITORING |
| JP1628116S (enExample) | 2012-10-24 | 2019-04-01 | ||
| US8956858B2 (en) | 2013-03-14 | 2015-02-17 | Src, Inc. | Tactical and portable PCR/HRM genome identification system |
| US10933417B2 (en) | 2013-03-15 | 2021-03-02 | Nanobiosym, Inc. | Systems and methods for mobile device analysis of nucleic acids and proteins |
| KR20140115210A (ko) | 2013-03-20 | 2014-09-30 | 한국전자통신연구원 | 모바일 장비의 앱을 이용한 dna 분석 방법 및 시스템 |
| GB2516666B (en) | 2013-07-29 | 2015-09-09 | Atlas Genetics Ltd | Fluidic cartridge for nucleic acid amplification and detection |
| WO2015019195A2 (en) | 2013-08-07 | 2015-02-12 | Xagenic Inc. | Systems, devices, and methods for deploying onboard reagents in a diagnostic device |
| CA2920523A1 (en) | 2013-08-07 | 2015-02-12 | Xagenic Inc. | Sensor growth controller |
| HK1225594A1 (zh) | 2013-08-07 | 2017-09-15 | Xagenic Inc. | 恒电位器参考电极接口 |
| CA2920419A1 (en) | 2013-08-07 | 2015-02-12 | Xagenic Inc. | Systems, methods and devices for electrochemical detection using helper oligonucleotides |
| EP3030624A4 (en) | 2013-08-07 | 2017-08-02 | Xagenic, Inc. | Microchip structure and treatments for electrochemical detection |
| CN105850048A (zh) | 2013-08-07 | 2016-08-10 | 艾克泽基因公司 | 精确双极电流模式数模转换器 |
| MX392471B (es) | 2013-11-17 | 2025-03-24 | Quantum Si Inc | Sistema optico y chip de ensayo para sondear, detectar y analizar moleculas |
| US20170113221A1 (en) | 2014-06-11 | 2017-04-27 | Micronics, Inc. | Microfluidic cartridges and apparatus with integrated assay controls for analysis of nucleic acids |
| US10352899B2 (en) | 2014-10-06 | 2019-07-16 | ALVEO Technologies Inc. | System and method for detection of silver |
| US9506908B2 (en) | 2014-10-06 | 2016-11-29 | Alveo Technologies, Inc. | System for detection of analytes |
| US10627358B2 (en) | 2014-10-06 | 2020-04-21 | Alveo Technologies, Inc. | Method for detection of analytes |
| US10196678B2 (en) | 2014-10-06 | 2019-02-05 | ALVEO Technologies Inc. | System and method for detection of nucleic acids |
| US9921182B2 (en) | 2014-10-06 | 2018-03-20 | ALVEO Technologies Inc. | System and method for detection of mercury |
| JP6795495B2 (ja) | 2014-10-14 | 2020-12-02 | ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ | 微生物を検出するリアクタンス及びキャパシタンス検知プラットフォーム |
| US10210410B2 (en) | 2014-10-22 | 2019-02-19 | Integenx Inc. | Systems and methods for biometric data collections |
| US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
| KR101709762B1 (ko) | 2015-02-09 | 2017-02-23 | 광운대학교 산학협력단 | 생체분자 농축 기능 일체형 센서 및 그 제조방법 |
| US10344336B2 (en) | 2015-06-09 | 2019-07-09 | Life Technologies Corporation | Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging |
| US10303843B2 (en) | 2015-08-06 | 2019-05-28 | Microsoft Technology Licensing, Llc | Computing system for identifying health risk regions |
| US11401558B2 (en) | 2015-12-18 | 2022-08-02 | Clear Gene, Inc. | Methods, compositions, kits and devices for rapid analysis of biological markers |
| EP4556571A3 (en) | 2016-02-26 | 2025-09-03 | Abbott Diagnostics Scarborough, Inc. | Redox labeled oligonucleotide probes and their use |
| CN109790575A (zh) | 2016-07-20 | 2019-05-21 | 吉纳普赛斯股份有限公司 | 用于核酸测序的系统和方法 |
| KR102461735B1 (ko) | 2016-09-23 | 2022-11-01 | 알베오 테크놀로지스 인크. | 분석물을 검출하기 위한 방법 및 조성물 |
| TW201832726A (zh) | 2016-11-01 | 2018-09-16 | 美商海科生醫有限責任公司 | 可基於輸入數據建議檢測之免疫檢測系統 |
| US10427162B2 (en) | 2016-12-21 | 2019-10-01 | Quandx Inc. | Systems and methods for molecular diagnostics |
| JP2022516441A (ja) | 2018-12-20 | 2022-02-28 | アルヴェオ テクノロジーズ インコーポレイテッド | 電気的検出を伴う等温増幅 |
| AU2019401601A1 (en) | 2018-12-20 | 2021-07-15 | Alveo Technologies, Inc. | Handheld impedance-based diagnostic test system for detecting analytes |
| EP3899025A4 (en) | 2018-12-20 | 2023-02-22 | Alveo Technologies Inc. | AMPLIFICATION PRODUCT DETECTION METHODS AND COMPOSITIONS |
| CN113454236A (zh) | 2018-12-20 | 2021-09-28 | 阿尔韦奥科技公司 | 减少等温扩增反应中非特异性扩增的方法和组合物 |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008532005A (ja) | 2005-02-25 | 2008-08-14 | インバーネス・メデイカル・スウイツツアーランド・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | 流体ゲート装置 |
| JP2012501627A (ja) | 2008-09-03 | 2012-01-26 | ナブシス， インコーポレイテッド | 流体チャネル内の生体分子および他の分析物の電圧感知のための、長手方向に変位されるナノスケールの電極の使用 |
| US20100200400A1 (en) | 2009-02-06 | 2010-08-12 | Commissariat A L'energie Atomique | Embedded bodily fluid analysis device |
| JP2012177599A (ja) | 2011-02-25 | 2012-09-13 | Arkray Inc | 再生可能なマイクロチップ、それを用いる測定装置、およびマイクロチップの再生方法 |
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