ES2877076T3 - Métodos y sistemas para la detección de analitos - Google Patents
Métodos y sistemas para la detección de analitos Download PDFInfo
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- ES2877076T3 ES2877076T3 ES15784208T ES15784208T ES2877076T3 ES 2877076 T3 ES2877076 T3 ES 2877076T3 ES 15784208 T ES15784208 T ES 15784208T ES 15784208 T ES15784208 T ES 15784208T ES 2877076 T3 ES2877076 T3 ES 2877076T3
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- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 2
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- KVICROHOONHSRH-UHFFFAOYSA-N mercury(2+);dinitrate;hydrate Chemical compound O.[Hg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O KVICROHOONHSRH-UHFFFAOYSA-N 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
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- DRXYRSRECMWYAV-UHFFFAOYSA-N nitrooxymercury Chemical compound [Hg+].[O-][N+]([O-])=O DRXYRSRECMWYAV-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
- G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Electrochemistry (AREA)
- Food Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Dispersion Chemistry (AREA)
- Nanotechnology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/507,818 US9921182B2 (en) | 2014-10-06 | 2014-10-06 | System and method for detection of mercury |
| US14/507,828 US10627358B2 (en) | 2014-10-06 | 2014-10-06 | Method for detection of analytes |
| US14/507,820 US10352899B2 (en) | 2014-10-06 | 2014-10-06 | System and method for detection of silver |
| US14/507,825 US9506908B2 (en) | 2014-10-06 | 2014-10-06 | System for detection of analytes |
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Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9506908B2 (en) | 2014-10-06 | 2016-11-29 | Alveo Technologies, Inc. | System for detection of analytes |
| US10627358B2 (en) | 2014-10-06 | 2020-04-21 | Alveo Technologies, Inc. | Method for detection of analytes |
| US10196678B2 (en) | 2014-10-06 | 2019-02-05 | ALVEO Technologies Inc. | System and method for detection of nucleic acids |
| US9921182B2 (en) | 2014-10-06 | 2018-03-20 | ALVEO Technologies Inc. | System and method for detection of mercury |
| US10352899B2 (en) | 2014-10-06 | 2019-07-16 | ALVEO Technologies Inc. | System and method for detection of silver |
| CN109996888A (zh) | 2016-09-23 | 2019-07-09 | 阿尔韦奥科技公司 | 用于检测分析物的方法和组合物 |
| CN107643228B (zh) * | 2017-08-31 | 2021-04-27 | 中国船舶重工集团公司第七一九研究所 | 一种测量汞蒸气的芯片的制备方法及其传感器的使用方法 |
| US12390812B2 (en) | 2018-12-19 | 2025-08-19 | Nuclein, Llc | Apparatus and methods for molecular diagnostics |
| EP3899022A4 (en) | 2018-12-20 | 2023-03-01 | Alveo Technologies Inc. | PORTABLE IMPEDANCE-BASED DIAGNOSTIC TEST SYSTEM FOR DETECTING ANALYTES |
| CN110523447B (zh) * | 2019-08-29 | 2021-05-11 | 苏州大学 | 一种对细胞多角度力学测量的微流控芯片及其制作方法 |
| US12472492B2 (en) | 2020-08-14 | 2025-11-18 | Alveo Technologies, Inc. | Systems and methods of sample depositing and testing |
| KR102618172B1 (ko) * | 2020-12-24 | 2023-12-29 | 경북대학교 산학협력단 | 액체의 전기적 특성 측정 시스템 및 액체의 전기적 특성 측정 방법 |
| WO2026006021A2 (en) | 2024-06-25 | 2026-01-02 | Alveo Technologies, Inc. | Systems and methods of sample depositing and testing |
Family Cites Families (146)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5234795A (en) * | 1975-06-19 | 1977-03-16 | Nippon Miniature Bearing Co | Detecting apparatus for fluid concentration |
| JPS5914054U (ja) * | 1982-07-19 | 1984-01-27 | 東ソー株式会社 | 液体クロマトグラフ用フロ−セル |
| JPS59139624A (ja) | 1983-01-31 | 1984-08-10 | Fujitsu Ltd | 試料の加熱方法 |
| GB9318677D0 (en) * | 1993-09-09 | 1993-10-27 | Kodak Ltd | Method and apparatus for measuring silver ion activity |
| US6403367B1 (en) | 1994-07-07 | 2002-06-11 | Nanogen, Inc. | Integrated portable biological detection system |
| US6524532B1 (en) | 1995-06-20 | 2003-02-25 | The Regents Of The University Of California | Microfabricated sleeve devices for chemical reactions |
| US5589136A (en) | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
| EP1179585B1 (en) | 1997-12-24 | 2008-07-09 | Cepheid | Device and method for lysis |
| JPH11241977A (ja) * | 1998-02-25 | 1999-09-07 | Shimadzu Corp | 流体濃度測定装置 |
| US6699713B2 (en) | 2000-01-04 | 2004-03-02 | The Regents Of The University Of California | Polymerase chain reaction system |
| US6489785B2 (en) | 2000-12-05 | 2002-12-03 | Agilent Technologies, Inc. | Comparative contactless conductivity detector |
| US6576459B2 (en) | 2001-03-23 | 2003-06-10 | The Regents Of The University Of California | Sample preparation and detection device for infectious agents |
| GB0116384D0 (en) | 2001-07-04 | 2001-08-29 | Diagnoswiss Sa | Microfluidic chemical assay apparatus and method |
| TWI245895B (en) * | 2001-11-29 | 2005-12-21 | Sun-Wing Tong | Molecular detection and assay by electrobiochip micro-array |
| US20030203504A1 (en) | 2002-04-26 | 2003-10-30 | John Hefti | Diffusion-based system and method for detecting and monitoring activity of biologic and chemical species |
| JP4092990B2 (ja) | 2002-09-06 | 2008-05-28 | 株式会社日立製作所 | 生体および化学試料検査装置 |
| ITTO20020808A1 (it) | 2002-09-17 | 2004-03-18 | St Microelectronics Srl | Dispositivo integrato di analisi del dna. |
| WO2004029195A2 (en) | 2002-09-24 | 2004-04-08 | U.S. Government As Represented By The Secretary Of The Army | Portable thermocycler |
| KR100858080B1 (ko) | 2002-11-12 | 2008-09-10 | 삼성전자주식회사 | 전기적 신호를 측정하는 ｐｃｒ 증폭 산물을 검출하는 방법 |
| US7062385B2 (en) | 2002-11-25 | 2006-06-13 | Tufts University | Intelligent electro-optical nucleic acid-based sensor array and method for detecting volatile compounds in ambient air |
| CN1846130B (zh) | 2003-08-06 | 2012-01-18 | 布里杰技术有限公司 | 用于检测靶物质的桥接元件 |
| US8346482B2 (en) | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
| CN1860366A (zh) * | 2003-09-29 | 2006-11-08 | 皇家飞利浦电子股份有限公司 | 免标记检测生物分子 |
| US6990849B2 (en) * | 2004-03-26 | 2006-01-31 | Lifescan, Inc. | Microfluidic analytical system with position electrodes |
| JP3952042B2 (ja) | 2004-06-07 | 2007-08-01 | ソニー株式会社 | 凹状部位を有する電極を備えるハイブリダイゼーション検出部と該検出部を備えるｄｎａチップ |
| CN101073002B (zh) | 2004-09-15 | 2012-08-08 | 英特基因有限公司 | 微流体装置 |
| ATE541055T1 (de) | 2004-10-18 | 2012-01-15 | Univ Brandeis | Reagenzien und verfahren zur verbesserung der reproduzierbarkeit und zur reduzierung des mispriming bei der pcr-amplifikation |
| WO2006071770A2 (en) | 2004-12-23 | 2006-07-06 | I-Stat Corporation | Molecular diagnostics system and methods |
| US20060176179A1 (en) | 2005-01-26 | 2006-08-10 | Battelle Memorial Institute | Bendable, active radio-frequency sensor tags and a system of same |
| EP1853911A1 (en) * | 2005-02-25 | 2007-11-14 | Inverness Medical Switzerland GmbH | Fluidic gating device |
| KR101637140B1 (ko) | 2005-05-09 | 2016-07-06 | 테라노스, 인코포레이티드 | 현장진료 유체 시스템 및 그 용도 |
| US20150141264A1 (en) | 2005-05-20 | 2015-05-21 | Apdn (B.V.I.) Inc. | In-field dna extraction, detection and authentication methods and systems therefor |
| WO2007009125A2 (en) | 2005-07-14 | 2007-01-18 | Nano-Ditech Corporation | Microfluidic devices and methods of preparing and using the same |
| US7915030B2 (en) | 2005-09-01 | 2011-03-29 | Canon U.S. Life Sciences, Inc. | Method and molecular diagnostic device for detection, analysis and identification of genomic DNA |
| WO2007061943A2 (en) | 2005-11-21 | 2007-05-31 | Applera Corporation | Portable preparation, analysis, and detection apparatus for nucleic acid processing |
| US8173077B2 (en) | 2005-12-16 | 2012-05-08 | The Curators Of The University Of Missouri | Reusable PCR amplification system and method |
| TW200745551A (en) | 2006-02-07 | 2007-12-16 | Antara Biosciences Inc | Device and methods for detecting and quantifying one or more target agents |
| US20090061450A1 (en) | 2006-03-14 | 2009-03-05 | Micronics, Inc. | System and method for diagnosis of infectious diseases |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| US7708944B1 (en) | 2006-06-13 | 2010-05-04 | Research Foundation Of State University Of New York | Ultra-sensitive, portable capillary sensor |
| US20070298487A1 (en) | 2006-06-23 | 2007-12-27 | Becton, Dickinson And Company | Radio Frequency Transponder Assay |
| US20120058547A1 (en) | 2006-08-11 | 2012-03-08 | The Hong Kong University Of Science And Technology | Method and system for nucleic acid detection using electroconductive or electrochemically active labels |
| GB0618966D0 (en) | 2006-09-26 | 2006-11-08 | Iti Scotland Ltd | Cartridge system |
| EP2069070B1 (en) | 2006-09-28 | 2013-11-27 | Stokes Bio Limited | A qpcr analysis apparatus |
| WO2008066747A2 (en) | 2006-11-22 | 2008-06-05 | The Board Of Trustees Of Michigan State University | Electroluminescent-based fluorescence detection device |
| WO2008070786A1 (en) * | 2006-12-06 | 2008-06-12 | The Trustees Of Columbia University In The City Of New York | Microfluidic systems and methods for screening plating and etching bath compositions |
| US7483805B2 (en) | 2006-12-26 | 2009-01-27 | Integrated Sensing Systems, Inc. | Sensing and analysis system, network, and method |
| ES2307430B1 (es) | 2007-05-09 | 2009-10-20 | Consejo Superior De Investigaciones Cientificas | Biosensor y sus aplicaciones. |
| US8198658B2 (en) * | 2007-06-13 | 2012-06-12 | Samsung Electronics Co., Ltd. | Device and method for detecting biomolecules using adsorptive medium and field effect transistor |
| US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| BRPI0703025B1 (pt) | 2007-08-08 | 2018-07-17 | Universidade De São Paulo - Usp | microdispositivo multicamada, processo de preparação de microdispositivo multicamada |
| CA3138078C (en) | 2007-10-02 | 2024-02-13 | Labrador Diagnostics Llc | Modular point-of-care devices and uses thereof |
| CL2008003008A1 (es) | 2007-10-12 | 2009-10-02 | Bigtec Private Ltd | Un micro dispositivo portatil de reaccion en cadena de polimerasa (pcr) basado en un micro chip de ceramica de coccion conjunta de baja temperatura (ltcc) que comprende camara de reaccion, calentador, control de temperatura del calentador, deteccion optica de interfaz de comunicacion, y el metodo para monitorearlo y controlarlo. |
| CN101918528B (zh) | 2007-12-10 | 2013-07-17 | 三星电子株式会社 | 薄膜生物阀装置和其控制设备 |
| US8865401B2 (en) | 2007-12-14 | 2014-10-21 | The Johns Hopkins University | Purification and concentration of proteins and DNA from a complex sample using isotachophoresis and a device to perform the purification |
| WO2009079028A1 (en) | 2007-12-14 | 2009-06-25 | Johns Hopkins University | Purification and concentration of proteins and dna from a complex sample using isotachophoresis and a device to perform the purification |
| DE102007062441A1 (de) | 2007-12-20 | 2009-06-25 | Aj Innuscreen Gmbh | Mobiles Schnelltestsystem für die Nukleinsäureanalytik |
| EP3869205B1 (en) | 2008-01-21 | 2023-11-22 | Nexus Dx, Inc. | Thin-film layered centrifuge device and analysis method using the same |
| DE102008009920A1 (de) | 2008-02-15 | 2009-08-20 | Aj Innuscreen Gmbh | Mobiles Gerät für die Nukleinsäureisolierung |
| KR100969667B1 (ko) | 2008-03-24 | 2010-07-14 | 디지탈 지노믹스(주) | 생리활성물질을 전기적으로 검출하는 방법 및 이를 위한바이오칩 |
| US20100041056A1 (en) | 2008-08-14 | 2010-02-18 | Zygem Corporation Limited | Temperature controlled nucleic-acid detection method suitable for practice in a closed-system |
| EP2321429B1 (en) | 2008-09-03 | 2016-08-17 | Quantumdx Group Limited | Methods and kits for nucleic acid sequencing |
| CN102186989B (zh) * | 2008-09-03 | 2021-06-29 | 纳伯塞斯2.0有限责任公司 | 用于流体通道中生物分子和其它分析物的电压感测的纵向移位纳米级电极的使用 |
| WO2010033604A2 (en) | 2008-09-18 | 2010-03-25 | X-Bar Diagnostic System, Inc. | Fully automated portable dna detection system |
| GB0818609D0 (en) | 2008-10-10 | 2008-11-19 | Univ Hull | apparatus and method |
| US20100122904A1 (en) | 2008-11-17 | 2010-05-20 | Board Of Regents, The University Of Texas System | Incorporating cmos integrated circuits in the design of affinity-based biosensor systems |
| US8551767B2 (en) * | 2008-11-20 | 2013-10-08 | Agency Of Science, Technology And Research | Sensor for detection of nucleic acid |
| EP2384438A2 (en) | 2008-12-30 | 2011-11-09 | Redhorse Fluidics | Systems, devices, methods and kits for fluid handling |
| EP2391883B1 (en) | 2009-01-30 | 2018-03-07 | Micronics, Inc. | Portable high gain fluorescence detection system |
| FR2942041B1 (fr) | 2009-02-06 | 2011-02-25 | Commissariat Energie Atomique | Dispositif embarque d'analyse d'un fluide corporel. |
| US20100216225A1 (en) | 2009-02-25 | 2010-08-26 | Ag-Defense Systems, Inc. | Portable microorganism detection unit |
| US8106428B2 (en) | 2009-03-03 | 2012-01-31 | Board Of Regents, The University Of Texas System | Nano-scale bridge biosensors |
| WO2010111605A2 (en) * | 2009-03-27 | 2010-09-30 | Nabsys, Inc. | Devices and methods for analyzing biomolecules and probes bound thereto |
| WO2010114842A1 (en) | 2009-03-30 | 2010-10-07 | Ibis Biosciences, Inc. | Bioagent detection systems, devices, and methods |
| WO2010146339A1 (en) | 2009-06-15 | 2010-12-23 | Bg Research Ltd | Nucleic acid detection |
| KR101217576B1 (ko) | 2009-09-22 | 2013-01-03 | 한국전자통신연구원 | 바이오 센서 및 그의 구동 방법 |
| US20110136104A1 (en) | 2009-12-04 | 2011-06-09 | Massachusetts Institute Of Technology | Multiplexed quantitative pcr end point analysis of nucleic acid targets |
| KR20110080067A (ko) | 2010-01-04 | 2011-07-12 | 엘지전자 주식회사 | 샘플분석 카트리지 및 샘플분석 카트리지 리더 |
| CN104630056B (zh) | 2010-01-12 | 2017-11-07 | 阿赫姆生物系统公司 | 两阶段热对流装置及其用途 |
| EP2524026A4 (en) | 2010-01-12 | 2017-10-18 | Ahram Biosystems, Inc. | Three-stage thermal convection apparatus and uses thereof |
| US10295472B2 (en) | 2010-05-05 | 2019-05-21 | Alverix, Inc. | Assay reader operable to scan a test strip |
| CN102004126A (zh) * | 2010-05-11 | 2011-04-06 | 中国科学院上海应用物理研究所 | 电化学生物传感器及其检测方法 |
| US20110312537A1 (en) | 2010-06-17 | 2011-12-22 | Geneasys Pty Ltd | Loc device for amplifying and detecting target nucleic acid sequences using electrochemiluminescent resonant energy transfer, linear probes with covalently attached primers |
| US9029168B2 (en) | 2010-06-28 | 2015-05-12 | The Trustees Of Princeton University | Use and making of biosensors utilizing antimicrobial peptides for highly sensitive biological monitoring |
| US8951472B2 (en) | 2010-07-19 | 2015-02-10 | Andalyze, Inc. | Portable fluorimetric apparatus, method and system |
| EP2752668A3 (en) | 2010-07-23 | 2014-10-15 | Beckman Coulter, Inc. | System Or Method Of Including Analytical Units |
| CN103261892A (zh) * | 2010-09-02 | 2013-08-21 | 海徳诊断学有限责任公司 | 分析物的电化学检测 |
| US8865075B2 (en) | 2010-11-01 | 2014-10-21 | Princeton Biochemicals, Inc. | Multi-task immunoaffinity device secured to a peripheral box and integrated to a capillary electrophoresis apparatus |
| US9696299B2 (en) | 2010-11-01 | 2017-07-04 | Norberto Guzman | Integrated modular unit including an analyte concentrator microreactor device connected to a cartridge-cassette |
| JP2013545475A (ja) | 2010-11-30 | 2013-12-26 | クワンタムディーエックス・グループ・リミテッド | マイクロ流体多重温度可撓性反応デバイスの設計、製造及び使用 |
| US9877673B2 (en) | 2010-12-10 | 2018-01-30 | Clinitech, Llc | Transdermal sampling and analysis device |
| JP2012177599A (ja) * | 2011-02-25 | 2012-09-13 | Arkray Inc | 再生可能なマイクロチップ、それを用いる測定装置、およびマイクロチップの再生方法 |
| US9580742B2 (en) | 2011-03-10 | 2017-02-28 | Shana O. Kelley | Diagnostic and sample preparation devices and methods |
| WO2012142192A2 (en) | 2011-04-11 | 2012-10-18 | Gray Mark A | Apparatus and method for making uniform emulsions |
| US9988668B2 (en) | 2011-06-23 | 2018-06-05 | Anitoa Systems, Llc | Apparatus for amplification of nucleic acids |
| US20140349298A1 (en) | 2011-07-14 | 2014-11-27 | William Eugene Stanchina | Portable, low power instrument for the optoelectronic detection of pathogens using isothermal nucleic acid amplification protocols |
| US9051605B2 (en) | 2011-07-29 | 2015-06-09 | Auburn University | Magnetic bead quantum dot nanoparticle assay |
| US8435738B2 (en) * | 2011-09-25 | 2013-05-07 | Theranos, Inc. | Systems and methods for multi-analysis |
| MX344792B (es) | 2011-09-25 | 2017-01-06 | Theranos Inc | Sistemas y métodos para múltiples análisis. |
| US9417210B2 (en) | 2011-09-30 | 2016-08-16 | Pandora Genomics, LLC | System, apparatus and method for evaluating samples or analytes using a point-of-care device |
| US9030215B2 (en) | 2011-10-04 | 2015-05-12 | The Regents Of The University Of California Corporation | Real-time, label-free detection of nucleic acid amplification in droplets using impedance spectroscopy and solid-phase substrate |
| US9335292B2 (en) | 2011-10-13 | 2016-05-10 | Auburn University | Electrochemical proximity assay |
| EP2825865B1 (en) | 2012-03-09 | 2020-07-22 | Ubiquitome Limited | Portable device for detecting molecule(s) |
| US10180421B2 (en) | 2012-03-30 | 2019-01-15 | Boston Microfluidics | Methods and systems to collect a biological sample |
| US9797006B2 (en) | 2012-04-10 | 2017-10-24 | Keck Graduate Institute Of Applied Life Sciences | System and cartridge for efficient nucleic acid testing |
| US10132802B2 (en) | 2012-04-17 | 2018-11-20 | i-calQ, LLC | Device for performing a diagnostic test and methods for use thereof |
| WO2013159117A1 (en) | 2012-04-20 | 2013-10-24 | SlipChip, LLC | Fluidic devices and systems for sample preparation or autonomous analysis |
| WO2013159116A1 (en) | 2012-04-20 | 2013-10-24 | University Of Chicago | Fluidic devices for biospecimen preservation |
| US20130309676A1 (en) | 2012-05-18 | 2013-11-21 | Alfred E. Mann Foundation For Scientific Research | Biased n-mers identification methods, probes and systems for target amplification and detection |
| EP2895616A1 (en) | 2012-09-12 | 2015-07-22 | Xagenic, Inc. | Systems, devices, and methods for identifying a disease state in a biological host using internal controls |
| US20140099636A1 (en) | 2012-10-10 | 2014-04-10 | Baker Hughes Incorporated | FIELD-BASED qPCR MICROBIAL MONITORING |
| AU2013334189B2 (en) | 2012-10-24 | 2018-08-02 | Genmark Diagnostics, Inc. | Integrated multiplex target analysis |
| US8956858B2 (en) | 2013-03-14 | 2015-02-17 | Src, Inc. | Tactical and portable PCR/HRM genome identification system |
| US10933417B2 (en) | 2013-03-15 | 2021-03-02 | Nanobiosym, Inc. | Systems and methods for mobile device analysis of nucleic acids and proteins |
| KR20140115210A (ko) | 2013-03-20 | 2014-09-30 | 한국전자통신연구원 | 모바일 장비의 앱을 이용한 dna 분석 방법 및 시스템 |
| GB2516666B (en) | 2013-07-29 | 2015-09-09 | Atlas Genetics Ltd | Fluidic cartridge for nucleic acid amplification and detection |
| CA2920584A1 (en) | 2013-08-07 | 2015-02-12 | Xagenic Inc. | Microchip structure and treatments for electrochemical detection |
| WO2015021338A1 (en) | 2013-08-07 | 2015-02-12 | Xagenic Inc. | Sensor growth controller |
| WO2015021337A1 (en) | 2013-08-07 | 2015-02-12 | Xagenic Inc. | Precision bipolar current-mode-digital-to-analog converter |
| EP3030678A4 (en) | 2013-08-07 | 2017-05-10 | Xagenic, Inc. | Systems, methods and devices for electrochemical detection using helper oligonucleotides |
| WO2015019195A2 (en) | 2013-08-07 | 2015-02-12 | Xagenic Inc. | Systems, devices, and methods for deploying onboard reagents in a diagnostic device |
| EP3030146A4 (en) | 2013-08-07 | 2017-04-26 | Xagenic Inc. | Potentiostat reference electrode interface |
| WO2015074001A1 (en) | 2013-11-17 | 2015-05-21 | Quantum-Si Incorporated | Optical system and assay chip for probing, detecting and analyzing molecules |
| KR20170016915A (ko) | 2014-06-11 | 2017-02-14 | 마이크로닉스 인코포레이티드. | 핵산의 분석을 위한 통합 검정 대조군을 갖는 마이크로 유체 공학적 카트리지 및 장치 |
| US9921182B2 (en) | 2014-10-06 | 2018-03-20 | ALVEO Technologies Inc. | System and method for detection of mercury |
| US9506908B2 (en) | 2014-10-06 | 2016-11-29 | Alveo Technologies, Inc. | System for detection of analytes |
| US10627358B2 (en) | 2014-10-06 | 2020-04-21 | Alveo Technologies, Inc. | Method for detection of analytes |
| US10196678B2 (en) | 2014-10-06 | 2019-02-05 | ALVEO Technologies Inc. | System and method for detection of nucleic acids |
| US10352899B2 (en) | 2014-10-06 | 2019-07-16 | ALVEO Technologies Inc. | System and method for detection of silver |
| ES2982089T3 (es) | 2014-10-14 | 2024-10-14 | Becton Dickinson Co | Plataforma de detección de reactancia y capacitancia para detectar microorganismos |
| US10210410B2 (en) | 2014-10-22 | 2019-02-19 | Integenx Inc. | Systems and methods for biometric data collections |
| US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
| KR101709762B1 (ko) | 2015-02-09 | 2017-02-23 | 광운대학교 산학협력단 | 생체분자 농축 기능 일체형 센서 및 그 제조방법 |
| EP3307908B1 (en) | 2015-06-09 | 2019-09-11 | Life Technologies Corporation | Methods for molecular tagging |
| US10303843B2 (en) | 2015-08-06 | 2019-05-28 | Microsoft Technology Licensing, Llc | Computing system for identifying health risk regions |
| CA3008273A1 (en) | 2015-12-18 | 2017-06-22 | Clear Gene, Inc. | Methods, compositions, kits and devices for rapid analysis of biological markers |
| WO2017147486A1 (en) | 2016-02-26 | 2017-08-31 | Alere San Diego Inc. | Redox labeled oligonucleotide probes and their use |
| US10544456B2 (en) | 2016-07-20 | 2020-01-28 | Genapsys, Inc. | Systems and methods for nucleic acid sequencing |
| CN109996888A (zh) | 2016-09-23 | 2019-07-09 | 阿尔韦奥科技公司 | 用于检测分析物的方法和组合物 |
| TW201832726A (zh) | 2016-11-01 | 2018-09-16 | 美商海科生醫有限責任公司 | 可基於輸入數據建議檢測之免疫檢測系統 |
| US10427162B2 (en) | 2016-12-21 | 2019-10-01 | Quandx Inc. | Systems and methods for molecular diagnostics |
| CA3123832A1 (en) | 2018-12-20 | 2020-06-25 | Alveo Technologies, Inc. | Methods and compositions for detection of amplification products |
| CA3123825A1 (en) | 2018-12-20 | 2020-06-25 | Alveo Technologies, Inc. | Isothermal amplification with electrical detection |
| MX2021007311A (es) | 2018-12-20 | 2021-09-21 | Alveo Tech Inc | Metodos y composiciones para reducir la amplificacion no especifica en reacciones de amplificacion isotermica. |
| EP3899022A4 (en) | 2018-12-20 | 2023-03-01 | Alveo Technologies Inc. | PORTABLE IMPEDANCE-BASED DIAGNOSTIC TEST SYSTEM FOR DETECTING ANALYTES |
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