RU2722853C2 - Способы и системы обнаружения аналитов - Google Patents
Способы и системы обнаружения аналитов Download PDFInfo
- Publication number
- RU2722853C2 RU2722853C2 RU2017109736A RU2017109736A RU2722853C2 RU 2722853 C2 RU2722853 C2 RU 2722853C2 RU 2017109736 A RU2017109736 A RU 2017109736A RU 2017109736 A RU2017109736 A RU 2017109736A RU 2722853 C2 RU2722853 C2 RU 2722853C2
- Authority
- RU
- Russia
- Prior art keywords
- channel
- electrical property
- sample
- length
- value
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 258
- 239000012491 analyte Substances 0.000 claims abstract description 310
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 168
- 150000007523 nucleic acids Chemical class 0.000 claims abstract description 168
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 168
- 238000005259 measurement Methods 0.000 claims abstract description 85
- 239000000523 sample Substances 0.000 claims description 529
- 238000001514 detection method Methods 0.000 claims description 259
- 150000001875 compounds Chemical class 0.000 claims description 143
- 229910052709 silver Inorganic materials 0.000 claims description 138
- 239000004332 silver Substances 0.000 claims description 138
- 229910052753 mercury Inorganic materials 0.000 claims description 136
- 239000012530 fluid Substances 0.000 claims description 98
- -1 mercury ions Chemical class 0.000 claims description 90
- 108020004711 Nucleic Acid Probes Proteins 0.000 claims description 73
- 239000002853 nucleic acid probe Substances 0.000 claims description 73
- 238000003860 storage Methods 0.000 claims description 64
- 230000003993 interaction Effects 0.000 claims description 33
- 239000000758 substrate Substances 0.000 claims description 29
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- 230000000007 visual effect Effects 0.000 claims description 10
- 238000000354 decomposition reaction Methods 0.000 claims description 5
- 239000003989 dielectric material Substances 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000001953 sensory effect Effects 0.000 abstract description 61
- 239000000126 substance Substances 0.000 abstract description 25
- 230000000694 effects Effects 0.000 abstract description 7
- 238000005516 engineering process Methods 0.000 abstract description 4
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 110
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 97
- 239000002245 particle Substances 0.000 description 62
- 230000015572 biosynthetic process Effects 0.000 description 48
- 239000000243 solution Substances 0.000 description 46
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 41
- 239000007853 buffer solution Substances 0.000 description 40
- 150000002500 ions Chemical class 0.000 description 39
- 239000003792 electrolyte Substances 0.000 description 30
- 239000010410 layer Substances 0.000 description 29
- 238000012986 modification Methods 0.000 description 29
- 230000004048 modification Effects 0.000 description 29
- 238000011049 filling Methods 0.000 description 28
- 239000002904 solvent Substances 0.000 description 28
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 27
- 239000000203 mixture Substances 0.000 description 25
- 230000005684 electric field Effects 0.000 description 24
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 description 22
- 229910000077 silane Inorganic materials 0.000 description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
- 230000008859 change Effects 0.000 description 19
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 18
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 18
- 238000012360 testing method Methods 0.000 description 18
- 239000000463 material Substances 0.000 description 17
- 230000008569 process Effects 0.000 description 16
- 235000019441 ethanol Nutrition 0.000 description 15
- 239000002773 nucleotide Substances 0.000 description 15
- 125000003729 nucleotide group Chemical group 0.000 description 15
- 239000011521 glass Substances 0.000 description 14
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 13
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 12
- 238000010586 diagram Methods 0.000 description 12
- 238000005406 washing Methods 0.000 description 12
- 230000006399 behavior Effects 0.000 description 10
- 239000011248 coating agent Substances 0.000 description 9
- 238000000576 coating method Methods 0.000 description 9
- 239000000975 dye Substances 0.000 description 9
- 230000036961 partial effect Effects 0.000 description 9
- 230000035945 sensitivity Effects 0.000 description 9
- 239000011534 wash buffer Substances 0.000 description 9
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 8
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 8
- ZDHXKXAHOVTTAH-UHFFFAOYSA-N trichlorosilane Chemical compound Cl[SiH](Cl)Cl ZDHXKXAHOVTTAH-UHFFFAOYSA-N 0.000 description 8
- QQQSFSZALRVCSZ-UHFFFAOYSA-N triethoxysilane Chemical compound CCO[SiH](OCC)OCC QQQSFSZALRVCSZ-UHFFFAOYSA-N 0.000 description 8
- 229910021538 borax Inorganic materials 0.000 description 7
- 239000006185 dispersion Substances 0.000 description 7
- 230000000670 limiting effect Effects 0.000 description 7
- 239000002090 nanochannel Substances 0.000 description 7
- 238000012545 processing Methods 0.000 description 7
- 235000010339 sodium tetraborate Nutrition 0.000 description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 150000001299 aldehydes Chemical class 0.000 description 6
- 150000001343 alkyl silanes Chemical class 0.000 description 6
- 229910052799 carbon Inorganic materials 0.000 description 6
- 238000009792 diffusion process Methods 0.000 description 6
- 238000004090 dissolution Methods 0.000 description 6
- GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 229910021389 graphene Inorganic materials 0.000 description 6
- 239000012528 membrane Substances 0.000 description 6
- 230000003287 optical effect Effects 0.000 description 6
- 238000010791 quenching Methods 0.000 description 6
- 230000000171 quenching effect Effects 0.000 description 6
- 239000000377 silicon dioxide Substances 0.000 description 6
- 235000012239 silicon dioxide Nutrition 0.000 description 6
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 6
- 229910021642 ultra pure water Inorganic materials 0.000 description 6
- 239000012498 ultrapure water Substances 0.000 description 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 5
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 5
- 230000003321 amplification Effects 0.000 description 5
- 230000005540 biological transmission Effects 0.000 description 5
- UQGFMSUEHSUPRD-UHFFFAOYSA-N disodium;3,7-dioxido-2,4,6,8,9-pentaoxa-1,3,5,7-tetraborabicyclo[3.3.1]nonane Chemical compound [Na+].[Na+].O1B([O-])OB2OB([O-])OB1O2 UQGFMSUEHSUPRD-UHFFFAOYSA-N 0.000 description 5
- 238000011010 flushing procedure Methods 0.000 description 5
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 239000000543 intermediate Substances 0.000 description 5
- 238000002156 mixing Methods 0.000 description 5
- 238000003199 nucleic acid amplification method Methods 0.000 description 5
- 125000005007 perfluorooctyl group Chemical group FC(C(C(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)* 0.000 description 5
- 239000012488 sample solution Substances 0.000 description 5
- 239000004328 sodium tetraborate Substances 0.000 description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 239000000084 colloidal system Substances 0.000 description 4
- 238000004891 communication Methods 0.000 description 4
- 238000004132 cross linking Methods 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 4
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 4
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 description 4
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 4
- 238000012552 review Methods 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- ABTOQLMXBSRXSM-UHFFFAOYSA-N silicon tetrafluoride Chemical compound F[Si](F)(F)F ABTOQLMXBSRXSM-UHFFFAOYSA-N 0.000 description 4
- 239000002356 single layer Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000005052 trichlorosilane Substances 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 3
- 239000004606 Fillers/Extenders Substances 0.000 description 3
- 239000013060 biological fluid Substances 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 238000003776 cleavage reaction Methods 0.000 description 3
- 230000003247 decreasing effect Effects 0.000 description 3
- 238000007672 fourth generation sequencing Methods 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- SMQUZDBALVYZAC-UHFFFAOYSA-N salicylaldehyde Chemical compound OC1=CC=CC=C1C=O SMQUZDBALVYZAC-UHFFFAOYSA-N 0.000 description 3
- 230000007017 scission Effects 0.000 description 3
- 238000002444 silanisation Methods 0.000 description 3
- 238000001179 sorption measurement Methods 0.000 description 3
- 150000008053 sultones Chemical class 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- UMKSAURFQFUULT-UHFFFAOYSA-N 2-Amino-5-methoxybenzoic acid Chemical compound COC1=CC=C(N)C(C(O)=O)=C1 UMKSAURFQFUULT-UHFFFAOYSA-N 0.000 description 2
- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 description 2
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
- CZCSLHYZEQSUNV-UHFFFAOYSA-N [Na].OB(O)O Chemical compound [Na].OB(O)O CZCSLHYZEQSUNV-UHFFFAOYSA-N 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 238000013459 approach Methods 0.000 description 2
- 239000000872 buffer Substances 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000003197 catalytic effect Effects 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- UHZZMRAGKVHANO-UHFFFAOYSA-M chlormequat chloride Chemical compound [Cl-].C[N+](C)(C)CCCl UHZZMRAGKVHANO-UHFFFAOYSA-M 0.000 description 2
- 125000001309 chloro group Chemical group Cl* 0.000 description 2
- 239000006059 cover glass Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- ORMNPSYMZOGSSV-UHFFFAOYSA-N dinitrooxymercury Chemical compound [Hg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ORMNPSYMZOGSSV-UHFFFAOYSA-N 0.000 description 2
- RSIHJDGMBDPTIM-UHFFFAOYSA-N ethoxy(trimethyl)silane Chemical group CCO[Si](C)(C)C RSIHJDGMBDPTIM-UHFFFAOYSA-N 0.000 description 2
- 102000006602 glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 description 2
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 description 2
- 239000007943 implant Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 229910052748 manganese Inorganic materials 0.000 description 2
- 239000011572 manganese Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000010295 mobile communication Methods 0.000 description 2
- 238000000399 optical microscopy Methods 0.000 description 2
- 229910052697 platinum Inorganic materials 0.000 description 2
- 239000011148 porous material Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000035484 reaction time Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 2
- 150000003384 small molecules Chemical class 0.000 description 2
- 239000003826 tablet Substances 0.000 description 2
- YUYCVXFAYWRXLS-UHFFFAOYSA-N trimethoxysilane Chemical class CO[SiH](OC)OC YUYCVXFAYWRXLS-UHFFFAOYSA-N 0.000 description 2
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 229910052720 vanadium Inorganic materials 0.000 description 2
- 108020005202 Viral DNA Proteins 0.000 description 1
- BDKZHNJTLHOSDW-UHFFFAOYSA-N [Na].CC(O)=O Chemical compound [Na].CC(O)=O BDKZHNJTLHOSDW-UHFFFAOYSA-N 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000011067 equilibration Methods 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 238000007306 functionalization reaction Methods 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 239000012139 lysis buffer Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910001987 mercury nitrate Inorganic materials 0.000 description 1
- BQPIGGFYSBELGY-UHFFFAOYSA-N mercury(2+) Chemical compound [Hg+2] BQPIGGFYSBELGY-UHFFFAOYSA-N 0.000 description 1
- KVICROHOONHSRH-UHFFFAOYSA-N mercury(2+);dinitrate;hydrate Chemical compound O.[Hg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O KVICROHOONHSRH-UHFFFAOYSA-N 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- DRXYRSRECMWYAV-UHFFFAOYSA-N nitrooxymercury Chemical compound [Hg+].[O-][N+]([O-])=O DRXYRSRECMWYAV-UHFFFAOYSA-N 0.000 description 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000010980 sapphire Substances 0.000 description 1
- 229910052594 sapphire Inorganic materials 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 230000005236 sound signal Effects 0.000 description 1
- 230000003595 spectral effect Effects 0.000 description 1
- 238000011272 standard treatment Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
- C12Q1/6825—Nucleic acid detection involving sensors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
- G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
- G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44756—Apparatus specially adapted therefor
- G01N27/44791—Microapparatus
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/487—Physical analysis of biological material of liquid biological material
- G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
- G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Electrochemistry (AREA)
- Food Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Dispersion Chemistry (AREA)
- Nanotechnology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Clinical Laboratory Science (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14/507,825 | 2014-10-06 | ||
| US14/507,818 | 2014-10-06 | ||
| US14/507,818 US9921182B2 (en) | 2014-10-06 | 2014-10-06 | System and method for detection of mercury |
| US14/507,820 US10352899B2 (en) | 2014-10-06 | 2014-10-06 | System and method for detection of silver |
| US14/507,820 | 2014-10-06 | ||
| US14/507,828 | 2014-10-06 | ||
| US14/507,825 US9506908B2 (en) | 2014-10-06 | 2014-10-06 | System for detection of analytes |
| US14/507,828 US10627358B2 (en) | 2014-10-06 | 2014-10-06 | Method for detection of analytes |
| US14/535,378 US10196678B2 (en) | 2014-10-06 | 2014-11-07 | System and method for detection of nucleic acids |
| US14/535,378 | 2014-11-07 | ||
| PCT/US2015/054074 WO2016057422A2 (en) | 2014-10-06 | 2015-10-05 | Methods and systems for detection of analytes |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2017109736A RU2017109736A (ru) | 2018-11-12 |
| RU2017109736A3 RU2017109736A3 (enExample) | 2019-04-11 |
| RU2722853C2 true RU2722853C2 (ru) | 2020-06-04 |
Family
ID=54337888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017109736A RU2722853C2 (ru) | 2014-10-06 | 2015-10-05 | Способы и системы обнаружения аналитов |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US10196678B2 (enExample) |
| EP (2) | EP3901622B1 (enExample) |
| JP (1) | JP6951975B2 (enExample) |
| KR (1) | KR102424219B1 (enExample) |
| CN (2) | CN113834861A (enExample) |
| AU (2) | AU2015328394B2 (enExample) |
| CA (1) | CA2962127A1 (enExample) |
| ES (1) | ES2877076T3 (enExample) |
| IL (1) | IL251440B (enExample) |
| MX (2) | MX384494B (enExample) |
| RU (1) | RU2722853C2 (enExample) |
| SG (1) | SG11201702794VA (enExample) |
| WO (1) | WO2016057422A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9921182B2 (en) | 2014-10-06 | 2018-03-20 | ALVEO Technologies Inc. | System and method for detection of mercury |
| US10196678B2 (en) | 2014-10-06 | 2019-02-05 | ALVEO Technologies Inc. | System and method for detection of nucleic acids |
| US9506908B2 (en) | 2014-10-06 | 2016-11-29 | Alveo Technologies, Inc. | System for detection of analytes |
| US10352899B2 (en) | 2014-10-06 | 2019-07-16 | ALVEO Technologies Inc. | System and method for detection of silver |
| US10627358B2 (en) | 2014-10-06 | 2020-04-21 | Alveo Technologies, Inc. | Method for detection of analytes |
| KR20220151011A (ko) * | 2016-09-23 | 2022-11-11 | 알베오 테크놀로지스 인크. | 분석물을 검출하기 위한 방법 및 조성물 |
| CN107643228B (zh) * | 2017-08-31 | 2021-04-27 | 中国船舶重工集团公司第七一九研究所 | 一种测量汞蒸气的芯片的制备方法及其传感器的使用方法 |
| BR112021011851A2 (pt) | 2018-12-19 | 2021-09-08 | Nuclein, Llc | Aparelho e métodos para diagnósticos moleculares |
| CA3124120A1 (en) | 2018-12-20 | 2020-06-25 | Alveo Technologies, Inc. | Handheld impedance-based diagnostic test system for detecting analytes |
| CN110523447B (zh) * | 2019-08-29 | 2021-05-11 | 苏州大学 | 一种对细胞多角度力学测量的微流控芯片及其制作方法 |
| US12472492B2 (en) | 2020-08-14 | 2025-11-18 | Alveo Technologies, Inc. | Systems and methods of sample depositing and testing |
| KR102618172B1 (ko) * | 2020-12-24 | 2023-12-29 | 경북대학교 산학협력단 | 액체의 전기적 특성 측정 시스템 및 액체의 전기적 특성 측정 방법 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040170530A1 (en) * | 2002-04-26 | 2004-09-02 | Prometheus Biosciences, Inc. | Systems and methods for monitoring chemical and biological activities using differential measurements |
| EP2003446A1 (en) * | 2007-06-13 | 2008-12-17 | Samsung Electronics Co., Ltd. | A Device and Method for Detecting Biomolecules Using Adsorptive Medium and Field Effect Transistor |
| US20110068015A1 (en) * | 2009-09-22 | 2011-03-24 | Electronics And Telecommunications Research Institute | Biosensor and method of driving the same |
| CN102004126A (zh) * | 2010-05-11 | 2011-04-06 | 中国科学院上海应用物理研究所 | 电化学生物传感器及其检测方法 |
| US20120129709A1 (en) * | 2008-11-20 | 2012-05-24 | Agency For Science, Technology And Research | Sensor for detection of nucleic acid |
Family Cites Families (141)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5234795A (en) * | 1975-06-19 | 1977-03-16 | Nippon Miniature Bearing Co | Detecting apparatus for fluid concentration |
| JPS5914054U (ja) * | 1982-07-19 | 1984-01-27 | 東ソー株式会社 | 液体クロマトグラフ用フロ−セル |
| JPS59139624A (ja) | 1983-01-31 | 1984-08-10 | Fujitsu Ltd | 試料の加熱方法 |
| GB9318677D0 (en) * | 1993-09-09 | 1993-10-27 | Kodak Ltd | Method and apparatus for measuring silver ion activity |
| US6403367B1 (en) | 1994-07-07 | 2002-06-11 | Nanogen, Inc. | Integrated portable biological detection system |
| US6524532B1 (en) | 1995-06-20 | 2003-02-25 | The Regents Of The University Of California | Microfabricated sleeve devices for chemical reactions |
| US5589136A (en) | 1995-06-20 | 1996-12-31 | Regents Of The University Of California | Silicon-based sleeve devices for chemical reactions |
| EP1179585B1 (en) | 1997-12-24 | 2008-07-09 | Cepheid | Device and method for lysis |
| JPH11241977A (ja) * | 1998-02-25 | 1999-09-07 | Shimadzu Corp | 流体濃度測定装置 |
| US6699713B2 (en) | 2000-01-04 | 2004-03-02 | The Regents Of The University Of California | Polymerase chain reaction system |
| US6489785B2 (en) | 2000-12-05 | 2002-12-03 | Agilent Technologies, Inc. | Comparative contactless conductivity detector |
| US6576459B2 (en) | 2001-03-23 | 2003-06-10 | The Regents Of The University Of California | Sample preparation and detection device for infectious agents |
| GB0116384D0 (en) | 2001-07-04 | 2001-08-29 | Diagnoswiss Sa | Microfluidic chemical assay apparatus and method |
| TWI245895B (en) * | 2001-11-29 | 2005-12-21 | Sun-Wing Tong | Molecular detection and assay by electrobiochip micro-array |
| JP4092990B2 (ja) | 2002-09-06 | 2008-05-28 | 株式会社日立製作所 | 生体および化学試料検査装置 |
| ITTO20020808A1 (it) | 2002-09-17 | 2004-03-18 | St Microelectronics Srl | Dispositivo integrato di analisi del dna. |
| WO2004029195A2 (en) | 2002-09-24 | 2004-04-08 | U.S. Government As Represented By The Secretary Of The Army | Portable thermocycler |
| KR100858080B1 (ko) | 2002-11-12 | 2008-09-10 | 삼성전자주식회사 | 전기적 신호를 측정하는 pcr 증폭 산물을 검출하는 방법 |
| US7062385B2 (en) | 2002-11-25 | 2006-06-13 | Tufts University | Intelligent electro-optical nucleic acid-based sensor array and method for detecting volatile compounds in ambient air |
| WO2005038459A2 (en) | 2003-08-06 | 2005-04-28 | Bridger Technologies, Inc. | Bridged element for detection of a target substance |
| US8346482B2 (en) | 2003-08-22 | 2013-01-01 | Fernandez Dennis S | Integrated biosensor and simulation system for diagnosis and therapy |
| WO2005031352A1 (en) * | 2003-09-29 | 2005-04-07 | Koninklijke Philips Electronics N.V. | Label-free detection of biomolecules |
| US6990849B2 (en) * | 2004-03-26 | 2006-01-31 | Lifescan, Inc. | Microfluidic analytical system with position electrodes |
| JP3952042B2 (ja) | 2004-06-07 | 2007-08-01 | ソニー株式会社 | 凹状部位を有する電極を備えるハイブリダイゼーション検出部と該検出部を備えるdnaチップ |
| KR101214780B1 (ko) | 2004-09-15 | 2012-12-21 | 인터젠엑스 인크. | 미세유동 장치 |
| JP5165376B2 (ja) | 2004-10-18 | 2013-03-21 | ブランデイズ ユニバーシティー | Pcr増幅での再現性の改善およびミスプライミングの低減のための試薬および方法 |
| CA2592204C (en) | 2004-12-23 | 2013-03-12 | I-Stat Corporation | Nucleic acid diagnostics system and methods |
| US20060176179A1 (en) | 2005-01-26 | 2006-08-10 | Battelle Memorial Institute | Bendable, active radio-frequency sensor tags and a system of same |
| JP2008532005A (ja) * | 2005-02-25 | 2008-08-14 | インバーネス・メデイカル・スウイツツアーランド・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング | 流体ゲート装置 |
| ES2820430T3 (es) | 2005-05-09 | 2021-04-21 | Labrador Diagnostics Llc | Sistemas de fluidos para centros de atención y usos de los mismos |
| US20150141264A1 (en) | 2005-05-20 | 2015-05-21 | Apdn (B.V.I.) Inc. | In-field dna extraction, detection and authentication methods and systems therefor |
| US20100261286A1 (en) | 2005-07-14 | 2010-10-14 | Young Hoon Kim | Microfluidic devices and methods of preparing and using the same |
| EP1941035B1 (en) | 2005-09-01 | 2017-11-22 | Canon U.S. Life Sciences, Inc. | Method and molecular diagnostic device for detection, analysis and identification of genomic dna |
| US20070141605A1 (en) | 2005-11-21 | 2007-06-21 | Applera Corporation | Portable preparation, analysis, and detection apparatus for nucleic acid processing |
| US8173077B2 (en) | 2005-12-16 | 2012-05-08 | The Curators Of The University Of Missouri | Reusable PCR amplification system and method |
| TW200745551A (en) | 2006-02-07 | 2007-12-16 | Antara Biosciences Inc | Device and methods for detecting and quantifying one or more target agents |
| US20090061450A1 (en) | 2006-03-14 | 2009-03-05 | Micronics, Inc. | System and method for diagnosis of infectious diseases |
| US7998708B2 (en) | 2006-03-24 | 2011-08-16 | Handylab, Inc. | Microfluidic system for amplifying and detecting polynucleotides in parallel |
| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| US7708944B1 (en) | 2006-06-13 | 2010-05-04 | Research Foundation Of State University Of New York | Ultra-sensitive, portable capillary sensor |
| US20070298487A1 (en) | 2006-06-23 | 2007-12-27 | Becton, Dickinson And Company | Radio Frequency Transponder Assay |
| US20120058547A1 (en) | 2006-08-11 | 2012-03-08 | The Hong Kong University Of Science And Technology | Method and system for nucleic acid detection using electroconductive or electrochemically active labels |
| GB0618966D0 (en) | 2006-09-26 | 2006-11-08 | Iti Scotland Ltd | Cartridge system |
| WO2008038259A1 (en) | 2006-09-28 | 2008-04-03 | Stokes Bio Limited | A qpcr analysis apparatus |
| WO2008066747A2 (en) | 2006-11-22 | 2008-06-05 | The Board Of Trustees Of Michigan State University | Electroluminescent-based fluorescence detection device |
| JP5185948B2 (ja) * | 2006-12-06 | 2013-04-17 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | メッキ及びエッチング浴組成をスクリーニングするマイクロ流体システム及び方法 |
| US7483805B2 (en) | 2006-12-26 | 2009-01-27 | Integrated Sensing Systems, Inc. | Sensing and analysis system, network, and method |
| ES2307430B1 (es) | 2007-05-09 | 2009-10-20 | Consejo Superior De Investigaciones Cientificas | Biosensor y sus aplicaciones. |
| US8133671B2 (en) | 2007-07-13 | 2012-03-13 | Handylab, Inc. | Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples |
| BRPI0703025B1 (pt) | 2007-08-08 | 2018-07-17 | Universidade De São Paulo - Usp | microdispositivo multicamada, processo de preparação de microdispositivo multicamada |
| CN104297507B (zh) | 2007-10-02 | 2017-10-10 | 赛拉诺斯股份有限公司 | 模块化现场护理装置及其应用 |
| CL2008003008A1 (es) | 2007-10-12 | 2009-10-02 | Bigtec Private Ltd | Un micro dispositivo portatil de reaccion en cadena de polimerasa (pcr) basado en un micro chip de ceramica de coccion conjunta de baja temperatura (ltcc) que comprende camara de reaccion, calentador, control de temperatura del calentador, deteccion optica de interfaz de comunicacion, y el metodo para monitorearlo y controlarlo. |
| EP2240568A4 (en) | 2007-12-10 | 2016-04-13 | Samsung Electronics Co Ltd | THIN FILM BIOVENTILING DEVICE AND CONTROL UNIT THEREFOR |
| US8865401B2 (en) | 2007-12-14 | 2014-10-21 | The Johns Hopkins University | Purification and concentration of proteins and DNA from a complex sample using isotachophoresis and a device to perform the purification |
| WO2009079028A1 (en) | 2007-12-14 | 2009-06-25 | Johns Hopkins University | Purification and concentration of proteins and dna from a complex sample using isotachophoresis and a device to perform the purification |
| DE102007062441A1 (de) | 2007-12-20 | 2009-06-25 | Aj Innuscreen Gmbh | Mobiles Schnelltestsystem für die Nukleinsäureanalytik |
| CN101971035B (zh) | 2008-01-21 | 2013-10-16 | 三星电子株式会社 | 薄膜分层离心装置及使用其的分析方法 |
| DE102008009920A1 (de) | 2008-02-15 | 2009-08-20 | Aj Innuscreen Gmbh | Mobiles Gerät für die Nukleinsäureisolierung |
| KR100969667B1 (ko) | 2008-03-24 | 2010-07-14 | 디지탈 지노믹스(주) | 생리활성물질을 전기적으로 검출하는 방법 및 이를 위한바이오칩 |
| CN102203284A (zh) | 2008-08-14 | 2011-09-28 | 赛进有限公司 | 适于在封闭系统中实施的温度控制的核酸检测方法 |
| WO2010028140A2 (en) * | 2008-09-03 | 2010-03-11 | Nabsys, Inc. | Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels |
| WO2010026488A2 (en) | 2008-09-03 | 2010-03-11 | Quantumdx Group Limited | Methods and kits for nucleic acid sequencing |
| WO2010033604A2 (en) | 2008-09-18 | 2010-03-25 | X-Bar Diagnostic System, Inc. | Fully automated portable dna detection system |
| GB0818609D0 (en) | 2008-10-10 | 2008-11-19 | Univ Hull | apparatus and method |
| US20100122904A1 (en) | 2008-11-17 | 2010-05-20 | Board Of Regents, The University Of Texas System | Incorporating cmos integrated circuits in the design of affinity-based biosensor systems |
| US20110318728A1 (en) | 2008-12-30 | 2011-12-29 | Huan Lac Phan | Systems, devices, methods and kits for fluid handling |
| WO2010088514A1 (en) | 2009-01-30 | 2010-08-05 | Micronics, Inc. | Portable high gain fluorescence detection system |
| FR2942041B1 (fr) | 2009-02-06 | 2011-02-25 | Commissariat Energie Atomique | Dispositif embarque d'analyse d'un fluide corporel. |
| US20100216225A1 (en) | 2009-02-25 | 2010-08-26 | Ag-Defense Systems, Inc. | Portable microorganism detection unit |
| US8106428B2 (en) | 2009-03-03 | 2012-01-31 | Board Of Regents, The University Of Texas System | Nano-scale bridge biosensors |
| EP2411536B1 (en) * | 2009-03-27 | 2014-09-17 | Nabsys, Inc. | Methods for analyzing biomolecules and probes bound thereto |
| WO2010114842A1 (en) | 2009-03-30 | 2010-10-07 | Ibis Biosciences, Inc. | Bioagent detection systems, devices, and methods |
| JP2012530243A (ja) | 2009-06-15 | 2012-11-29 | ビージー リサーチ エルティーディー | 核酸検出方法 |
| US20110136104A1 (en) | 2009-12-04 | 2011-06-09 | Massachusetts Institute Of Technology | Multiplexed quantitative pcr end point analysis of nucleic acid targets |
| KR20110080067A (ko) | 2010-01-04 | 2011-07-12 | 엘지전자 주식회사 | 샘플분석 카트리지 및 샘플분석 카트리지 리더 |
| CN102803465B (zh) | 2010-01-12 | 2015-01-21 | 阿赫姆生物系统公司 | 两阶段热对流装置及其用途 |
| CN104611222B (zh) | 2010-01-12 | 2017-05-24 | 阿赫姆生物系统公司 | 三阶段热对流装置及其用途 |
| US10295472B2 (en) | 2010-05-05 | 2019-05-21 | Alverix, Inc. | Assay reader operable to scan a test strip |
| US8349277B2 (en) | 2010-06-17 | 2013-01-08 | Geneasys Pty Ltd | Test module with microfluidic device having LOC and dialysis device for separating pathogens from other constituents in a biological sample |
| US9029168B2 (en) | 2010-06-28 | 2015-05-12 | The Trustees Of Princeton University | Use and making of biosensors utilizing antimicrobial peptides for highly sensitive biological monitoring |
| US8951472B2 (en) | 2010-07-19 | 2015-02-10 | Andalyze, Inc. | Portable fluorimetric apparatus, method and system |
| WO2012012779A2 (en) | 2010-07-23 | 2012-01-26 | Beckman Coulter Inc. | System and method including analytical units |
| US20130240376A1 (en) * | 2010-09-02 | 2013-09-19 | Heed Diagnostics Aps | Electrochemical detection of analyte |
| US8865075B2 (en) | 2010-11-01 | 2014-10-21 | Princeton Biochemicals, Inc. | Multi-task immunoaffinity device secured to a peripheral box and integrated to a capillary electrophoresis apparatus |
| US9696299B2 (en) | 2010-11-01 | 2017-07-04 | Norberto Guzman | Integrated modular unit including an analyte concentrator microreactor device connected to a cartridge-cassette |
| EP2646154A2 (en) | 2010-11-30 | 2013-10-09 | Quantumdx Group Limited | The design, fabrication and use of a microfluidics multitemperature flexible reaction device |
| US9877673B2 (en) | 2010-12-10 | 2018-01-30 | Clinitech, Llc | Transdermal sampling and analysis device |
| JP2012177599A (ja) * | 2011-02-25 | 2012-09-13 | Arkray Inc | 再生可能なマイクロチップ、それを用いる測定装置、およびマイクロチップの再生方法 |
| US9580742B2 (en) | 2011-03-10 | 2017-02-28 | Shana O. Kelley | Diagnostic and sample preparation devices and methods |
| WO2012142192A2 (en) | 2011-04-11 | 2012-10-18 | Gray Mark A | Apparatus and method for making uniform emulsions |
| US9988668B2 (en) | 2011-06-23 | 2018-06-05 | Anitoa Systems, Llc | Apparatus for amplification of nucleic acids |
| US20140349298A1 (en) | 2011-07-14 | 2014-11-27 | William Eugene Stanchina | Portable, low power instrument for the optoelectronic detection of pathogens using isothermal nucleic acid amplification protocols |
| US9051605B2 (en) | 2011-07-29 | 2015-06-09 | Auburn University | Magnetic bead quantum dot nanoparticle assay |
| US8435738B2 (en) * | 2011-09-25 | 2013-05-07 | Theranos, Inc. | Systems and methods for multi-analysis |
| TWI624543B (zh) | 2011-09-25 | 2018-05-21 | 賽瑞諾斯有限公司 | 用於多重分析的系統和方法 |
| US9417210B2 (en) | 2011-09-30 | 2016-08-16 | Pandora Genomics, LLC | System, apparatus and method for evaluating samples or analytes using a point-of-care device |
| US9030215B2 (en) | 2011-10-04 | 2015-05-12 | The Regents Of The University Of California Corporation | Real-time, label-free detection of nucleic acid amplification in droplets using impedance spectroscopy and solid-phase substrate |
| US9335292B2 (en) | 2011-10-13 | 2016-05-10 | Auburn University | Electrochemical proximity assay |
| EP2825865B1 (en) | 2012-03-09 | 2020-07-22 | Ubiquitome Limited | Portable device for detecting molecule(s) |
| US10180421B2 (en) | 2012-03-30 | 2019-01-15 | Boston Microfluidics | Methods and systems to collect a biological sample |
| US9797006B2 (en) | 2012-04-10 | 2017-10-24 | Keck Graduate Institute Of Applied Life Sciences | System and cartridge for efficient nucleic acid testing |
| US10132802B2 (en) | 2012-04-17 | 2018-11-20 | i-calQ, LLC | Device for performing a diagnostic test and methods for use thereof |
| US9808798B2 (en) | 2012-04-20 | 2017-11-07 | California Institute Of Technology | Fluidic devices for biospecimen preservation |
| EP2839260B1 (en) | 2012-04-20 | 2018-07-18 | Talis Biomedical Corporation | Fluidic devices and systems for sample preparation or autonomous analysis |
| US20130309676A1 (en) | 2012-05-18 | 2013-11-21 | Alfred E. Mann Foundation For Scientific Research | Biased n-mers identification methods, probes and systems for target amplification and detection |
| WO2014042794A1 (en) | 2012-09-12 | 2014-03-20 | Xagenic Inc. | Systems, devices, and methods for identifying a disease state in a biological host using internal controls |
| US20140099636A1 (en) | 2012-10-10 | 2014-04-10 | Baker Hughes Incorporated | FIELD-BASED qPCR MICROBIAL MONITORING |
| WO2014066704A1 (en) | 2012-10-24 | 2014-05-01 | Genmark Diagnostics, Inc. | Integrated multiplex target analysis |
| US8956858B2 (en) | 2013-03-14 | 2015-02-17 | Src, Inc. | Tactical and portable PCR/HRM genome identification system |
| US10933417B2 (en) | 2013-03-15 | 2021-03-02 | Nanobiosym, Inc. | Systems and methods for mobile device analysis of nucleic acids and proteins |
| KR20140115210A (ko) | 2013-03-20 | 2014-09-30 | 한국전자통신연구원 | 모바일 장비의 앱을 이용한 dna 분석 방법 및 시스템 |
| GB2516666B (en) | 2013-07-29 | 2015-09-09 | Atlas Genetics Ltd | Fluidic cartridge for nucleic acid amplification and detection |
| HK1226104A1 (zh) | 2013-08-07 | 2017-09-22 | Xagenic, Inc. | 用辅助寡核苷酸电化学检测的系统、方法和装置 |
| WO2015019195A2 (en) | 2013-08-07 | 2015-02-12 | Xagenic Inc. | Systems, devices, and methods for deploying onboard reagents in a diagnostic device |
| EP3030699A4 (en) | 2013-08-07 | 2017-07-26 | Xagenic, Inc. | Sensor growth controller |
| WO2015021337A1 (en) | 2013-08-07 | 2015-02-12 | Xagenic Inc. | Precision bipolar current-mode-digital-to-analog converter |
| US10416109B2 (en) | 2013-08-07 | 2019-09-17 | General Atomics | Microchip structure and treatments for electrochemical detection |
| WO2015021339A1 (en) | 2013-08-07 | 2015-02-12 | Xagenic Inc. | Potentiostat reference electrode interface |
| KR102240166B1 (ko) | 2013-11-17 | 2021-04-14 | 퀀텀-에스아이 인코포레이티드 | 분자들을 프로빙 검출 및 분석하기 위한 외부 광원을 구비한 통합 디바이스 |
| US20170113221A1 (en) | 2014-06-11 | 2017-04-27 | Micronics, Inc. | Microfluidic cartridges and apparatus with integrated assay controls for analysis of nucleic acids |
| US9921182B2 (en) | 2014-10-06 | 2018-03-20 | ALVEO Technologies Inc. | System and method for detection of mercury |
| US9506908B2 (en) | 2014-10-06 | 2016-11-29 | Alveo Technologies, Inc. | System for detection of analytes |
| US10352899B2 (en) | 2014-10-06 | 2019-07-16 | ALVEO Technologies Inc. | System and method for detection of silver |
| US10196678B2 (en) | 2014-10-06 | 2019-02-05 | ALVEO Technologies Inc. | System and method for detection of nucleic acids |
| US10627358B2 (en) | 2014-10-06 | 2020-04-21 | Alveo Technologies, Inc. | Method for detection of analytes |
| EP3207362B1 (en) | 2014-10-14 | 2024-05-01 | Becton, Dickinson and Company | Reactance and capacitance sensing platform for detecting microorganisms |
| US10210410B2 (en) | 2014-10-22 | 2019-02-19 | Integenx Inc. | Systems and methods for biometric data collections |
| US10005080B2 (en) | 2014-11-11 | 2018-06-26 | Genmark Diagnostics, Inc. | Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation |
| KR101709762B1 (ko) | 2015-02-09 | 2017-02-23 | 광운대학교 산학협력단 | 생체분자 농축 기능 일체형 센서 및 그 제조방법 |
| CN107849600A (zh) | 2015-06-09 | 2018-03-27 | 生命技术公司 | 用于分子标记的方法、系统、组合物、试剂盒、装置和计算机可读媒体 |
| US10303843B2 (en) | 2015-08-06 | 2019-05-28 | Microsoft Technology Licensing, Llc | Computing system for identifying health risk regions |
| US11401558B2 (en) | 2015-12-18 | 2022-08-02 | Clear Gene, Inc. | Methods, compositions, kits and devices for rapid analysis of biological markers |
| EP4556571A3 (en) | 2016-02-26 | 2025-09-03 | Abbott Diagnostics Scarborough, Inc. | Redox labeled oligonucleotide probes and their use |
| CN109790575A (zh) | 2016-07-20 | 2019-05-21 | 吉纳普赛斯股份有限公司 | 用于核酸测序的系统和方法 |
| KR20220151011A (ko) | 2016-09-23 | 2022-11-11 | 알베오 테크놀로지스 인크. | 분석물을 검출하기 위한 방법 및 조성물 |
| TW201832726A (zh) | 2016-11-01 | 2018-09-16 | 美商海科生醫有限責任公司 | 可基於輸入數據建議檢測之免疫檢測系統 |
| US10427162B2 (en) | 2016-12-21 | 2019-10-01 | Quandx Inc. | Systems and methods for molecular diagnostics |
| CN113454236A (zh) | 2018-12-20 | 2021-09-28 | 阿尔韦奥科技公司 | 减少等温扩增反应中非特异性扩增的方法和组合物 |
| CA3124120A1 (en) | 2018-12-20 | 2020-06-25 | Alveo Technologies, Inc. | Handheld impedance-based diagnostic test system for detecting analytes |
| MX2021007302A (es) | 2018-12-20 | 2021-09-08 | Alveo Tech Inc | Metodos y composiciones para la deteccion de productos de amplificacion. |
| CA3123825A1 (en) | 2018-12-20 | 2020-06-25 | Alveo Technologies, Inc. | Isothermal amplification with electrical detection |
-
2014
- 2014-11-07 US US14/535,378 patent/US10196678B2/en active Active
-
2015
- 2015-10-05 JP JP2017538178A patent/JP6951975B2/ja not_active Expired - Fee Related
- 2015-10-05 SG SG11201702794VA patent/SG11201702794VA/en unknown
- 2015-10-05 EP EP21162617.1A patent/EP3901622B1/en active Active
- 2015-10-05 MX MX2017003593A patent/MX384494B/es unknown
- 2015-10-05 AU AU2015328394A patent/AU2015328394B2/en not_active Ceased
- 2015-10-05 RU RU2017109736A patent/RU2722853C2/ru active
- 2015-10-05 EP EP15784208.9A patent/EP3204760B1/en active Active
- 2015-10-05 CN CN202110906985.4A patent/CN113834861A/zh active Pending
- 2015-10-05 KR KR1020177011722A patent/KR102424219B1/ko active Active
- 2015-10-05 ES ES15784208T patent/ES2877076T3/es active Active
- 2015-10-05 WO PCT/US2015/054074 patent/WO2016057422A2/en not_active Ceased
- 2015-10-05 CN CN201580054366.XA patent/CN107110807B/zh not_active Expired - Fee Related
- 2015-10-05 CA CA2962127A patent/CA2962127A1/en active Pending
-
2017
- 2017-03-17 MX MX2021008520A patent/MX2021008520A/es unknown
- 2017-03-29 IL IL251440A patent/IL251440B/en unknown
-
2018
- 2018-12-18 US US16/223,587 patent/US10626448B2/en not_active Expired - Fee Related
-
2020
- 2020-03-11 US US16/815,404 patent/US11473128B2/en active Active
-
2021
- 2021-05-24 AU AU2021203343A patent/AU2021203343B2/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040170530A1 (en) * | 2002-04-26 | 2004-09-02 | Prometheus Biosciences, Inc. | Systems and methods for monitoring chemical and biological activities using differential measurements |
| EP2003446A1 (en) * | 2007-06-13 | 2008-12-17 | Samsung Electronics Co., Ltd. | A Device and Method for Detecting Biomolecules Using Adsorptive Medium and Field Effect Transistor |
| US20120129709A1 (en) * | 2008-11-20 | 2012-05-24 | Agency For Science, Technology And Research | Sensor for detection of nucleic acid |
| US20110068015A1 (en) * | 2009-09-22 | 2011-03-24 | Electronics And Telecommunications Research Institute | Biosensor and method of driving the same |
| CN102004126A (zh) * | 2010-05-11 | 2011-04-06 | 中国科学院上海应用物理研究所 | 电化学生物传感器及其检测方法 |
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2722853C2 (ru) | Способы и системы обнаружения аналитов | |
| US9506908B2 (en) | System for detection of analytes | |
| US9921182B2 (en) | System and method for detection of mercury | |
| US10627358B2 (en) | Method for detection of analytes | |
| US10352899B2 (en) | System and method for detection of silver | |
| Sun et al. | Electrochemistry of individual molecules in zeptoliter volumes | |
| WO2014027580A1 (ja) | 試料の分析方法 | |
| CN103975077A (zh) | 纳米孔功能性控制方法 | |
| Nicoliche et al. | Converging multidimensional sensor and machine learning toward high-throughput and biorecognition element-free multidetermination of extracellular vesicle biomarkers | |
| JP2017534064A5 (enExample) | ||
| US20170114398A1 (en) | Systems, methods and devices for detection of nucleic acids | |
| Vargas-Lara et al. | Dimensional reduction of duplex DNA under confinement to nanofluidic slits | |
| US20230183779A1 (en) | System and method for detection of nucleic acids | |
| Shah et al. | A universal approximation for conductance blockade in thin nanopore membranes | |
| HK40064463A (en) | Methods and systems for detection of analytes | |
| Charron et al. | Improved Conductance Blockage Modeling of Cylindrical Nanopores, from 2D to Thick Membranes | |
| Gutiérrez‐Capitán et al. | Compact electrochemical flow system for the analysis of environmental pollutants | |
| HK1243489B (zh) | 用於检测分析物的方法和系统 | |
| Moldoveanu et al. | Chitosan based diamond paste stochastic microsensors modified with gold nanoparticles detect hepatitis C virus core antigen | |
| Leong et al. | Interference of electrochemical ion diffusion in nanopore sensing | |
| Azevedo et al. | 3D printed adapter to commercial electronic micropipettes for electroanalysis directly inside disposable tips |