JP6951975B2 - 分析種の検出のための方法およびシステム - Google Patents

分析種の検出のための方法およびシステム Download PDF

Info

Publication number
JP6951975B2
JP6951975B2 JP2017538178A JP2017538178A JP6951975B2 JP 6951975 B2 JP6951975 B2 JP 6951975B2 JP 2017538178 A JP2017538178 A JP 2017538178A JP 2017538178 A JP2017538178 A JP 2017538178A JP 6951975 B2 JP6951975 B2 JP 6951975B2
Authority
JP
Japan
Prior art keywords
flow path
sample
channel
electrical
electrical characteristic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2017538178A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017534064A5 (enExample
JP2017534064A (ja
Inventor
ペンナスール，スミタ
ジョセフ クリサリ，ピーター
ジョセフ クリサリ，ピーター
フィリップ チアレロ，ロナルド
フィリップ チアレロ，ロナルド
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alveo Technologies Inc
Original Assignee
Alveo Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/507,818 external-priority patent/US9921182B2/en
Priority claimed from US14/507,825 external-priority patent/US9506908B2/en
Priority claimed from US14/507,820 external-priority patent/US10352899B2/en
Priority claimed from US14/507,828 external-priority patent/US10627358B2/en
Application filed by Alveo Technologies Inc filed Critical Alveo Technologies Inc
Publication of JP2017534064A publication Critical patent/JP2017534064A/ja
Publication of JP2017534064A5 publication Critical patent/JP2017534064A5/ja
Application granted granted Critical
Publication of JP6951975B2 publication Critical patent/JP6951975B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Electrochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nanotechnology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2017538178A 2014-10-06 2015-10-05 分析種の検出のための方法およびシステム Expired - Fee Related JP6951975B2 (ja)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US14/507,820 2014-10-06
US14/507,818 US9921182B2 (en) 2014-10-06 2014-10-06 System and method for detection of mercury
US14/507,825 US9506908B2 (en) 2014-10-06 2014-10-06 System for detection of analytes
US14/507,820 US10352899B2 (en) 2014-10-06 2014-10-06 System and method for detection of silver
US14/507,828 US10627358B2 (en) 2014-10-06 2014-10-06 Method for detection of analytes
US14/507,825 2014-10-06
US14/507,828 2014-10-06
US14/507,818 2014-10-06
US14/535,378 US10196678B2 (en) 2014-10-06 2014-11-07 System and method for detection of nucleic acids
US14/535,378 2014-11-07
PCT/US2015/054074 WO2016057422A2 (en) 2014-10-06 2015-10-05 Methods and systems for detection of analytes

Publications (3)

Publication Number Publication Date
JP2017534064A JP2017534064A (ja) 2017-11-16
JP2017534064A5 JP2017534064A5 (enExample) 2018-11-15
JP6951975B2 true JP6951975B2 (ja) 2021-10-20

Family

ID=54337888

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017538178A Expired - Fee Related JP6951975B2 (ja) 2014-10-06 2015-10-05 分析種の検出のための方法およびシステム

Country Status (13)

Country Link
US (3) US10196678B2 (enExample)
EP (2) EP3901622B1 (enExample)
JP (1) JP6951975B2 (enExample)
KR (1) KR102424219B1 (enExample)
CN (2) CN113834861A (enExample)
AU (2) AU2015328394B2 (enExample)
CA (1) CA2962127A1 (enExample)
ES (1) ES2877076T3 (enExample)
IL (1) IL251440B (enExample)
MX (2) MX384494B (enExample)
RU (1) RU2722853C2 (enExample)
SG (1) SG11201702794VA (enExample)
WO (1) WO2016057422A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9921182B2 (en) 2014-10-06 2018-03-20 ALVEO Technologies Inc. System and method for detection of mercury
US10627358B2 (en) 2014-10-06 2020-04-21 Alveo Technologies, Inc. Method for detection of analytes
US10196678B2 (en) 2014-10-06 2019-02-05 ALVEO Technologies Inc. System and method for detection of nucleic acids
US9506908B2 (en) 2014-10-06 2016-11-29 Alveo Technologies, Inc. System for detection of analytes
US10352899B2 (en) 2014-10-06 2019-07-16 ALVEO Technologies Inc. System and method for detection of silver
KR20220151011A (ko) * 2016-09-23 2022-11-11 알베오 테크놀로지스 인크. 분석물을 검출하기 위한 방법 및 조성물
CN107643228B (zh) * 2017-08-31 2021-04-27 中国船舶重工集团公司第七一九研究所 一种测量汞蒸气的芯片的制备方法及其传感器的使用方法
BR112021011851A2 (pt) 2018-12-19 2021-09-08 Nuclein, Llc Aparelho e métodos para diagnósticos moleculares
EP3899022A4 (en) 2018-12-20 2023-03-01 Alveo Technologies Inc. PORTABLE IMPEDANCE-BASED DIAGNOSTIC TEST SYSTEM FOR DETECTING ANALYTES
CN110523447B (zh) * 2019-08-29 2021-05-11 苏州大学 一种对细胞多角度力学测量的微流控芯片及其制作方法
US12472492B2 (en) 2020-08-14 2025-11-18 Alveo Technologies, Inc. Systems and methods of sample depositing and testing
KR102618172B1 (ko) * 2020-12-24 2023-12-29 경북대학교 산학협력단 액체의 전기적 특성 측정 시스템 및 액체의 전기적 특성 측정 방법
WO2026006021A2 (en) 2024-06-25 2026-01-02 Alveo Technologies, Inc. Systems and methods of sample depositing and testing

Family Cites Families (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5234795A (en) * 1975-06-19 1977-03-16 Nippon Miniature Bearing Co Detecting apparatus for fluid concentration
JPS5914054U (ja) * 1982-07-19 1984-01-27 東ソー株式会社 液体クロマトグラフ用フロ−セル
JPS59139624A (ja) 1983-01-31 1984-08-10 Fujitsu Ltd 試料の加熱方法
GB9318677D0 (en) * 1993-09-09 1993-10-27 Kodak Ltd Method and apparatus for measuring silver ion activity
US6403367B1 (en) 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US6524532B1 (en) 1995-06-20 2003-02-25 The Regents Of The University Of California Microfabricated sleeve devices for chemical reactions
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
CA2312102C (en) 1997-12-24 2007-09-04 Cepheid Integrated fluid manipulation cartridge
JPH11241977A (ja) * 1998-02-25 1999-09-07 Shimadzu Corp 流体濃度測定装置
US6699713B2 (en) 2000-01-04 2004-03-02 The Regents Of The University Of California Polymerase chain reaction system
US6489785B2 (en) 2000-12-05 2002-12-03 Agilent Technologies, Inc. Comparative contactless conductivity detector
US6576459B2 (en) 2001-03-23 2003-06-10 The Regents Of The University Of California Sample preparation and detection device for infectious agents
GB0116384D0 (en) 2001-07-04 2001-08-29 Diagnoswiss Sa Microfluidic chemical assay apparatus and method
TWI245895B (en) * 2001-11-29 2005-12-21 Sun-Wing Tong Molecular detection and assay by electrobiochip micro-array
US20030203504A1 (en) 2002-04-26 2003-10-30 John Hefti Diffusion-based system and method for detecting and monitoring activity of biologic and chemical species
JP4092990B2 (ja) 2002-09-06 2008-05-28 株式会社日立製作所 生体および化学試料検査装置
ITTO20020808A1 (it) 2002-09-17 2004-03-18 St Microelectronics Srl Dispositivo integrato di analisi del dna.
WO2004029195A2 (en) 2002-09-24 2004-04-08 U.S. Government As Represented By The Secretary Of The Army Portable thermocycler
KR100858080B1 (ko) 2002-11-12 2008-09-10 삼성전자주식회사 전기적 신호를 측정하는 ｐｃｒ 증폭 산물을 검출하는 방법
US7062385B2 (en) 2002-11-25 2006-06-13 Tufts University Intelligent electro-optical nucleic acid-based sensor array and method for detecting volatile compounds in ambient air
CA2534632C (en) 2003-08-06 2017-07-11 Bridger Technologies, Inc. Bridged element for detection of a target substance
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
US20070072286A1 (en) * 2003-09-29 2007-03-29 Koninkljke Philips Electronics N.V. Label-free detection of biomolecules
US6990849B2 (en) * 2004-03-26 2006-01-31 Lifescan, Inc. Microfluidic analytical system with position electrodes
JP3952042B2 (ja) 2004-06-07 2007-08-01 ソニー株式会社 凹状部位を有する電極を備えるハイブリダイゼーション検出部と該検出部を備えるｄｎａチップ
EP1794581A2 (en) 2004-09-15 2007-06-13 Microchip Biotechnologies, Inc. Microfluidic devices
WO2006044995A1 (en) 2004-10-18 2006-04-27 Brandeis University Reagents and methods for improving reproducibility and reducing mispriming in pcr amplification
WO2006071770A2 (en) 2004-12-23 2006-07-06 I-Stat Corporation Molecular diagnostics system and methods
US20060176179A1 (en) 2005-01-26 2006-08-10 Battelle Memorial Institute Bendable, active radio-frequency sensor tags and a system of same
CA2598513A1 (en) * 2005-02-25 2006-08-31 Inverness Medical Switzerland Gmbh Fluidic gating device
CA2610294C (en) 2005-05-09 2023-10-03 Theranos, Inc. Point-of-care fluidic systems and uses thereof
US20150141264A1 (en) 2005-05-20 2015-05-21 Apdn (B.V.I.) Inc. In-field dna extraction, detection and authentication methods and systems therefor
KR20080027392A (ko) 2005-07-14 2008-03-26 나노디텍 코포레이션 미세유체장치와 미세유체장치의 제작 및 사용방법
JP5149184B2 (ja) 2005-09-01 2013-02-20 キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッド ゲノムｄｎａの検出、分析、および種名を同定のための方法と分子診断装置
WO2007061943A2 (en) 2005-11-21 2007-05-31 Applera Corporation Portable preparation, analysis, and detection apparatus for nucleic acid processing
WO2007078833A2 (en) 2005-12-16 2007-07-12 The Curators Of The University Of Missouri Reusable pcr amplification system and method
TW200745551A (en) 2006-02-07 2007-12-16 Antara Biosciences Inc Device and methods for detecting and quantifying one or more target agents
US20090061450A1 (en) 2006-03-14 2009-03-05 Micronics, Inc. System and method for diagnosis of infectious diseases
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US7708944B1 (en) 2006-06-13 2010-05-04 Research Foundation Of State University Of New York Ultra-sensitive, portable capillary sensor
US20070298487A1 (en) 2006-06-23 2007-12-27 Becton, Dickinson And Company Radio Frequency Transponder Assay
US20120058547A1 (en) 2006-08-11 2012-03-08 The Hong Kong University Of Science And Technology Method and system for nucleic acid detection using electroconductive or electrochemically active labels
GB0618966D0 (en) 2006-09-26 2006-11-08 Iti Scotland Ltd Cartridge system
US20100075312A1 (en) 2006-09-28 2010-03-25 Stokes Bio Limited Qpcr analysis apparatus
WO2008066747A2 (en) 2006-11-22 2008-06-05 The Board Of Trustees Of Michigan State University Electroluminescent-based fluorescence detection device
JP5185948B2 (ja) * 2006-12-06 2013-04-17 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク メッキ及びエッチング浴組成をスクリーニングするマイクロ流体システム及び方法
US7483805B2 (en) 2006-12-26 2009-01-27 Integrated Sensing Systems, Inc. Sensing and analysis system, network, and method
ES2307430B1 (es) 2007-05-09 2009-10-20 Consejo Superior De Investigaciones Cientificas Biosensor y sus aplicaciones.
US8198658B2 (en) 2007-06-13 2012-06-12 Samsung Electronics Co., Ltd. Device and method for detecting biomolecules using adsorptive medium and field effect transistor
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
BRPI0703025B1 (pt) 2007-08-08 2018-07-17 Universidade De São Paulo - Usp microdispositivo multicamada, processo de preparação de microdispositivo multicamada
CN108333379B (zh) 2007-10-02 2021-09-07 拉布拉多诊断有限责任公司 模块化现场护理装置及其应用
CL2008003008A1 (es) 2007-10-12 2009-10-02 Bigtec Private Ltd Un micro dispositivo portatil de reaccion en cadena de polimerasa (pcr) basado en un micro chip de ceramica de coccion conjunta de baja temperatura (ltcc) que comprende camara de reaccion, calentador, control de temperatura del calentador, deteccion optica de interfaz de comunicacion, y el metodo para monitorearlo y controlarlo.
WO2009075513A2 (en) 2007-12-10 2009-06-18 Jae Chern Yoo A thin film bio valve device and its controlling apparatus
US8865401B2 (en) 2007-12-14 2014-10-21 The Johns Hopkins University Purification and concentration of proteins and DNA from a complex sample using isotachophoresis and a device to perform the purification
US8614059B2 (en) 2007-12-14 2013-12-24 The Johns Hopkins University Purification and concentration of proteins and DNA from a complex sample using isotachophoresis and a device to perform the purification
DE102007062441A1 (de) 2007-12-20 2009-06-25 Aj Innuscreen Gmbh Mobiles Schnelltestsystem für die Nukleinsäureanalytik
ES2842969T3 (es) 2008-01-21 2021-07-15 Nexus Dx Inc Dispositivo centrifugador de capas de película delgada y método de análisis que utiliza el mismo
DE102008009920A1 (de) 2008-02-15 2009-08-20 Aj Innuscreen Gmbh Mobiles Gerät für die Nukleinsäureisolierung
KR100969667B1 (ko) 2008-03-24 2010-07-14 디지탈 지노믹스(주) 생리활성물질을 전기적으로 검출하는 방법 및 이를 위한바이오칩
CA2734131A1 (en) 2008-08-14 2010-02-18 Zygem Corporation Limited Temperature controlled nucleic-acid detection method suitable for practice in a closed-system
US8882980B2 (en) * 2008-09-03 2014-11-11 Nabsys, Inc. Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
BRPI0918795A2 (pt) 2008-09-03 2015-12-01 Quantumdx Group Ltd dispositivo e método de sequenciação de polinucleotídeo alvo
US8524490B2 (en) 2008-09-18 2013-09-03 X-Bar Diagnostic Systems, Inc. Fully automated portable DNA detection system
GB0818609D0 (en) 2008-10-10 2008-11-19 Univ Hull apparatus and method
US20100122904A1 (en) 2008-11-17 2010-05-20 Board Of Regents, The University Of Texas System Incorporating cmos integrated circuits in the design of affinity-based biosensor systems
GB2478446B8 (en) * 2008-11-20 2013-08-21 Agency Science Tech & Res Sensor for detection of nucleic acid
EP2384438A2 (en) 2008-12-30 2011-11-09 Redhorse Fluidics Systems, devices, methods and kits for fluid handling
WO2010088514A1 (en) 2009-01-30 2010-08-05 Micronics, Inc. Portable high gain fluorescence detection system
FR2942041B1 (fr) 2009-02-06 2011-02-25 Commissariat Energie Atomique Dispositif embarque d'analyse d'un fluide corporel.
US20100216225A1 (en) 2009-02-25 2010-08-26 Ag-Defense Systems, Inc. Portable microorganism detection unit
US8106428B2 (en) 2009-03-03 2012-01-31 Board Of Regents, The University Of Texas System Nano-scale bridge biosensors
US20100243449A1 (en) 2009-03-27 2010-09-30 Oliver John S Devices and methods for analyzing biomolecules and probes bound thereto
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
JP2012530243A (ja) 2009-06-15 2012-11-29 ビージー リサーチ エルティーディー 核酸検出方法
KR101217576B1 (ko) 2009-09-22 2013-01-03 한국전자통신연구원 바이오 센서 및 그의 구동 방법
US20110136104A1 (en) 2009-12-04 2011-06-09 Massachusetts Institute Of Technology Multiplexed quantitative pcr end point analysis of nucleic acid targets
KR20110080067A (ko) 2010-01-04 2011-07-12 엘지전자 주식회사 샘플분석 카트리지 및 샘플분석 카트리지 리더
BR112012017165A2 (pt) 2010-01-12 2015-09-15 Ahram Biosystems Inc aparelho de convecção térmica de três estágios e usos do mesmo.
JP5865261B2 (ja) 2010-01-12 2016-02-17 アーラム バイオシステムズ インコーポレイテッド ２段熱対流装置及びその使用法
US10295472B2 (en) 2010-05-05 2019-05-21 Alverix, Inc. Assay reader operable to scan a test strip
CN102004126A (zh) * 2010-05-11 2011-04-06 中国科学院上海应用物理研究所 电化学生物传感器及其检测方法
US20110312550A1 (en) 2010-06-17 2011-12-22 Geneasys Pty Ltd Loc device for genetic analysis which performs nucleic acid amplification after sample preparation in a dialysis section
US9029168B2 (en) 2010-06-28 2015-05-12 The Trustees Of Princeton University Use and making of biosensors utilizing antimicrobial peptides for highly sensitive biological monitoring
US8951472B2 (en) 2010-07-19 2015-02-10 Andalyze, Inc. Portable fluorimetric apparatus, method and system
CN103119451B (zh) 2010-07-23 2014-11-26 贝克曼考尔特公司 处理样本的系统和方法
WO2012028719A2 (en) * 2010-09-02 2012-03-08 Heed Diagnostics Aps Electrochemical detection of analyte
US8865075B2 (en) 2010-11-01 2014-10-21 Princeton Biochemicals, Inc. Multi-task immunoaffinity device secured to a peripheral box and integrated to a capillary electrophoresis apparatus
US9696299B2 (en) 2010-11-01 2017-07-04 Norberto Guzman Integrated modular unit including an analyte concentrator microreactor device connected to a cartridge-cassette
EP2646154A2 (en) 2010-11-30 2013-10-09 Quantumdx Group Limited The design, fabrication and use of a microfluidics multitemperature flexible reaction device
US9877673B2 (en) 2010-12-10 2018-01-30 Clinitech, Llc Transdermal sampling and analysis device
JP2012177599A (ja) 2011-02-25 2012-09-13 Arkray Inc 再生可能なマイクロチップ、それを用いる測定装置、およびマイクロチップの再生方法
US9580742B2 (en) 2011-03-10 2017-02-28 Shana O. Kelley Diagnostic and sample preparation devices and methods
WO2012142192A2 (en) 2011-04-11 2012-10-18 Gray Mark A Apparatus and method for making uniform emulsions
WO2012178210A1 (en) 2011-06-23 2012-12-27 Anitoa Systems, Llc Apparatus for amplification of nucleic acids
US20140349298A1 (en) 2011-07-14 2014-11-27 William Eugene Stanchina Portable, low power instrument for the optoelectronic detection of pathogens using isothermal nucleic acid amplification protocols
US9051605B2 (en) 2011-07-29 2015-06-09 Auburn University Magnetic bead quantum dot nanoparticle assay
WO2013052318A1 (en) 2011-09-25 2013-04-11 Theranos, Inc. Systems and methods for multi-analysis
US8435738B2 (en) * 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
WO2013049782A2 (en) 2011-09-30 2013-04-04 Pandora Genomics, LLC System, apparatus and method for evaluating samples or analytes using a point-of-care device
US9030215B2 (en) 2011-10-04 2015-05-12 The Regents Of The University Of California Corporation Real-time, label-free detection of nucleic acid amplification in droplets using impedance spectroscopy and solid-phase substrate
US9335292B2 (en) 2011-10-13 2016-05-10 Auburn University Electrochemical proximity assay
WO2013133725A1 (en) 2012-03-09 2013-09-12 Rawle Christopher Bruce Portable device for detecting molecule(s)
US10180421B2 (en) 2012-03-30 2019-01-15 Boston Microfluidics Methods and systems to collect a biological sample
US9797006B2 (en) 2012-04-10 2017-10-24 Keck Graduate Institute Of Applied Life Sciences System and cartridge for efficient nucleic acid testing
US10132802B2 (en) 2012-04-17 2018-11-20 i-calQ, LLC Device for performing a diagnostic test and methods for use thereof
WO2013159116A1 (en) 2012-04-20 2013-10-24 University Of Chicago Fluidic devices for biospecimen preservation
EP2839260B1 (en) 2012-04-20 2018-07-18 Talis Biomedical Corporation Fluidic devices and systems for sample preparation or autonomous analysis
US20130309676A1 (en) 2012-05-18 2013-11-21 Alfred E. Mann Foundation For Scientific Research Biased n-mers identification methods, probes and systems for target amplification and detection
JP2015529080A (ja) 2012-09-12 2015-10-05 ザジェニック インコーポレイテッド 内部対照を使用して生物学的宿主中の疾患状態を特定するためのシステム、デバイスおよび方法
US20140099636A1 (en) 2012-10-10 2014-04-10 Baker Hughes Incorporated FIELD-BASED qPCR MICROBIAL MONITORING
US9957553B2 (en) 2012-10-24 2018-05-01 Genmark Diagnostics, Inc. Integrated multiplex target analysis
US8956858B2 (en) 2013-03-14 2015-02-17 Src, Inc. Tactical and portable PCR/HRM genome identification system
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
KR20140115210A (ko) 2013-03-20 2014-09-30 한국전자통신연구원 모바일 장비의 앱을 이용한 dna 분석 방법 및 시스템
GB2516666B (en) 2013-07-29 2015-09-09 Atlas Genetics Ltd Fluidic cartridge for nucleic acid amplification and detection
CN105849277A (zh) 2013-08-07 2016-08-10 艾克泽基因公司 用于在诊断装置中配置机载试剂的系统、装置和方法
WO2015021337A1 (en) 2013-08-07 2015-02-12 Xagenic Inc. Precision bipolar current-mode-digital-to-analog converter
EP3030699A4 (en) 2013-08-07 2017-07-26 Xagenic, Inc. Sensor growth controller
HK1226104A1 (zh) 2013-08-07 2017-09-22 Xagenic, Inc. 用辅助寡核苷酸电化学检测的系统、方法和装置
US10416109B2 (en) 2013-08-07 2019-09-17 General Atomics Microchip structure and treatments for electrochemical detection
HK1225594A1 (zh) 2013-08-07 2017-09-15 Xagenic Inc. 恒电位器参考电极接口
CN105980580B (zh) 2013-11-17 2020-03-03 宽腾矽公司 用于探测、检测和分析分子的光学系统和测定芯片
KR20170016915A (ko) 2014-06-11 2017-02-14 마이크로닉스 인코포레이티드. 핵산의 분석을 위한 통합 검정 대조군을 갖는 마이크로 유체 공학적 카트리지 및 장치
US10196678B2 (en) 2014-10-06 2019-02-05 ALVEO Technologies Inc. System and method for detection of nucleic acids
US9506908B2 (en) 2014-10-06 2016-11-29 Alveo Technologies, Inc. System for detection of analytes
US10352899B2 (en) 2014-10-06 2019-07-16 ALVEO Technologies Inc. System and method for detection of silver
US9921182B2 (en) 2014-10-06 2018-03-20 ALVEO Technologies Inc. System and method for detection of mercury
US10627358B2 (en) 2014-10-06 2020-04-21 Alveo Technologies, Inc. Method for detection of analytes
WO2016064635A1 (en) 2014-10-14 2016-04-28 Becton, Dickinson And Company Reactance and capacitance sensing platform for detecting microorganisms
US10210410B2 (en) 2014-10-22 2019-02-19 Integenx Inc. Systems and methods for biometric data collections
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
KR101709762B1 (ko) 2015-02-09 2017-02-23 광운대학교 산학협력단 생체분자 농축 기능 일체형 센서 및 그 제조방법
WO2016201142A1 (en) 2015-06-09 2016-12-15 Life Technologies Corporation Methods, systems, compositions, kits, apparatus and computer-readable media for molecular tagging
US10303843B2 (en) 2015-08-06 2019-05-28 Microsoft Technology Licensing, Llc Computing system for identifying health risk regions
US11401558B2 (en) 2015-12-18 2022-08-02 Clear Gene, Inc. Methods, compositions, kits and devices for rapid analysis of biological markers
ES3032616T3 (en) 2016-02-26 2025-07-22 Abbott Diagnostics Scarborough Inc Redox labeled oligonucleotide probes and their use
WO2018017884A1 (en) 2016-07-20 2018-01-25 Genapsys, Inc. Systems and methods for nucleic acid sequencing
KR20220151011A (ko) 2016-09-23 2022-11-11 알베오 테크놀로지스 인크. 분석물을 검출하기 위한 방법 및 조성물
TW201832726A (zh) 2016-11-01 2018-09-16 美商海科生醫有限責任公司 可基於輸入數據建議檢測之免疫檢測系統
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
CA3123839A1 (en) 2018-12-20 2020-06-25 Alveo Technologies, Inc. Methods and compositions to reduce nonspecific amplification in isothermal amplification reactions
CA3123825A1 (en) 2018-12-20 2020-06-25 Alveo Technologies, Inc. Isothermal amplification with electrical detection
EP3899022A4 (en) 2018-12-20 2023-03-01 Alveo Technologies Inc. PORTABLE IMPEDANCE-BASED DIAGNOSTIC TEST SYSTEM FOR DETECTING ANALYTES
US20220048031A1 (en) 2018-12-20 2022-02-17 Alveo Technologies, Inc. Methods and compositions for detection of amplification products

Also Published As

Publication number Publication date
KR102424219B1 (ko) 2022-07-21
EP3204760A2 (en) 2017-08-16
MX2021008520A (es) 2021-08-19
WO2016057422A2 (en) 2016-04-14
US10626448B2 (en) 2020-04-21
IL251440B (en) 2022-02-01
IL251440A0 (en) 2017-05-29
US20200277660A1 (en) 2020-09-03
KR20170066513A (ko) 2017-06-14
CN107110807B (zh) 2021-08-13
AU2015328394A1 (en) 2017-04-06
CN113834861A (zh) 2021-12-24
US20160130639A1 (en) 2016-05-12
EP3901622A1 (en) 2021-10-27
CA2962127A1 (en) 2016-04-14
US20190144926A1 (en) 2019-05-16
MX384494B (es) 2025-03-14
US11473128B2 (en) 2022-10-18
AU2021203343A1 (en) 2021-06-24
HK1243489A1 (zh) 2018-07-13
RU2017109736A (ru) 2018-11-12
AU2015328394B2 (en) 2021-03-04
RU2017109736A3 (enExample) 2019-04-11
EP3204760B1 (en) 2021-03-17
CN107110807A (zh) 2017-08-29
US10196678B2 (en) 2019-02-05
RU2722853C2 (ru) 2020-06-04
EP3901622B1 (en) 2023-05-31
AU2021203343B2 (en) 2023-03-30
SG11201702794VA (en) 2017-05-30
MX2017003593A (es) 2018-02-01
JP2017534064A (ja) 2017-11-16
WO2016057422A3 (en) 2016-05-26
ES2877076T3 (es) 2021-11-16

Similar Documents

Publication Publication Date Title
JP6951975B2 (ja) 分析種の検出のための方法およびシステム
US9506908B2 (en) System for detection of analytes
US9921182B2 (en) System and method for detection of mercury
US10627358B2 (en) Method for detection of analytes
US10352899B2 (en) System and method for detection of silver
JP6276182B2 (ja) 試料の分析方法
Confederat et al. Next‐generation nanopore sensors based on conductive pulse sensing for enhanced detection of nanoparticles
Al Sulaiman et al. Length-dependent, single-molecule analysis of short double-stranded DNA fragments through hydrogel-filled nanopores: A potential tool for size profiling cell-free DNA
US20170114398A1 (en) Systems, methods and devices for detection of nucleic acids
US20230183779A1 (en) System and method for detection of nucleic acids
HK40064463A (en) Methods and systems for detection of analytes
HK1243489B (zh) 用於检测分析物的方法和系统

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20170613

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20181004

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20181004

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20190731

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20190827

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20191118

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20200122

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20200225

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20200825

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20201113

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210113

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210217

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20210803

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20210827

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20210927

R150 Certificate of patent or registration of utility model

Ref document number: 6951975

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees