CA2962127A1 - Methods and systems for detection of analytes - Google Patents

Methods and systems for detection of analytes Download PDF

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Publication number
CA2962127A1
CA2962127A1 CA2962127A CA2962127A CA2962127A1 CA 2962127 A1 CA2962127 A1 CA 2962127A1 CA 2962127 A CA2962127 A CA 2962127A CA 2962127 A CA2962127 A CA 2962127A CA 2962127 A1 CA2962127 A1 CA 2962127A1
Authority
CA
Canada
Prior art keywords
channel
electrical property
length
property value
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA2962127A
Other languages
English (en)
French (fr)
Inventor
Sumita PENNATHUR
Peter Joseph Crisalli
Ronald Phillip Chiarello
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Alveo Technologies Inc
Original Assignee
University of California San Diego UCSD
Alveo Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/507,820 external-priority patent/US10352899B2/en
Priority claimed from US14/507,828 external-priority patent/US10627358B2/en
Priority claimed from US14/507,818 external-priority patent/US9921182B2/en
Priority claimed from US14/507,825 external-priority patent/US9506908B2/en
Application filed by University of California San Diego UCSD, Alveo Technologies Inc filed Critical University of California San Diego UCSD
Publication of CA2962127A1 publication Critical patent/CA2962127A1/en
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/06—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721—Investigating individual macromolecules, e.g. by translocation through nanopores
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Electrochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Nanotechnology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Clinical Laboratory Science (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CA2962127A 2014-10-06 2015-10-05 Methods and systems for detection of analytes Pending CA2962127A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US14/507,820 US10352899B2 (en) 2014-10-06 2014-10-06 System and method for detection of silver
US14/507,828 US10627358B2 (en) 2014-10-06 2014-10-06 Method for detection of analytes
US14/507,825 2014-10-06
US14/507,818 US9921182B2 (en) 2014-10-06 2014-10-06 System and method for detection of mercury
US14/507,828 2014-10-06
US14/507,818 2014-10-06
US14/507,820 2014-10-06
US14/507,825 US9506908B2 (en) 2014-10-06 2014-10-06 System for detection of analytes
US14/535,378 2014-11-07
US14/535,378 US10196678B2 (en) 2014-10-06 2014-11-07 System and method for detection of nucleic acids
PCT/US2015/054074 WO2016057422A2 (en) 2014-10-06 2015-10-05 Methods and systems for detection of analytes

Publications (1)

Publication Number Publication Date
CA2962127A1 true CA2962127A1 (en) 2016-04-14

Family

ID=54337888

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2962127A Pending CA2962127A1 (en) 2014-10-06 2015-10-05 Methods and systems for detection of analytes

Country Status (13)

Country Link
US (3) US10196678B2 (enExample)
EP (2) EP3204760B1 (enExample)
JP (1) JP6951975B2 (enExample)
KR (1) KR102424219B1 (enExample)
CN (2) CN113834861A (enExample)
AU (2) AU2015328394B2 (enExample)
CA (1) CA2962127A1 (enExample)
ES (1) ES2877076T3 (enExample)
IL (1) IL251440B (enExample)
MX (2) MX384494B (enExample)
RU (1) RU2722853C2 (enExample)
SG (1) SG11201702794VA (enExample)
WO (1) WO2016057422A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9921182B2 (en) 2014-10-06 2018-03-20 ALVEO Technologies Inc. System and method for detection of mercury
US10196678B2 (en) 2014-10-06 2019-02-05 ALVEO Technologies Inc. System and method for detection of nucleic acids
US9506908B2 (en) 2014-10-06 2016-11-29 Alveo Technologies, Inc. System for detection of analytes
US10352899B2 (en) 2014-10-06 2019-07-16 ALVEO Technologies Inc. System and method for detection of silver
US10627358B2 (en) 2014-10-06 2020-04-21 Alveo Technologies, Inc. Method for detection of analytes
CA3037494A1 (en) * 2016-09-23 2018-03-29 Alveo Technologies, Inc. Methods and compositions for detecting analytes
CN107643228B (zh) * 2017-08-31 2021-04-27 中国船舶重工集团公司第七一九研究所 一种测量汞蒸气的芯片的制备方法及其传感器的使用方法
CN113396326A (zh) 2018-12-19 2021-09-14 核酸有限责任公司 用于分子诊断的设备和方法
US12275007B2 (en) 2018-12-20 2025-04-15 Alveo Technologies, Inc. Handheld impedance-based diagnostic test system for detecting analytes
CN110523447B (zh) * 2019-08-29 2021-05-11 苏州大学 一种对细胞多角度力学测量的微流控芯片及其制作方法
EP4118230A4 (en) 2020-03-09 2024-04-24 Nuclein, LLC DEVICE AND METHOD FOR MOLECULAR DIAGNOSIS
US12472492B2 (en) 2020-08-14 2025-11-18 Alveo Technologies, Inc. Systems and methods of sample depositing and testing
KR102618172B1 (ko) * 2020-12-24 2023-12-29 경북대학교 산학협력단 액체의 전기적 특성 측정 시스템 및 액체의 전기적 특성 측정 방법
WO2026006021A2 (en) 2024-06-25 2026-01-02 Alveo Technologies, Inc. Systems and methods of sample depositing and testing

Family Cites Families (146)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5234795A (en) * 1975-06-19 1977-03-16 Nippon Miniature Bearing Co Detecting apparatus for fluid concentration
JPS5914054U (ja) * 1982-07-19 1984-01-27 東ソー株式会社 液体クロマトグラフ用フロ−セル
JPS59139624A (ja) 1983-01-31 1984-08-10 Fujitsu Ltd 試料の加熱方法
GB9318677D0 (en) * 1993-09-09 1993-10-27 Kodak Ltd Method and apparatus for measuring silver ion activity
US6403367B1 (en) 1994-07-07 2002-06-11 Nanogen, Inc. Integrated portable biological detection system
US5589136A (en) 1995-06-20 1996-12-31 Regents Of The University Of California Silicon-based sleeve devices for chemical reactions
US6524532B1 (en) 1995-06-20 2003-02-25 The Regents Of The University Of California Microfabricated sleeve devices for chemical reactions
ATE400358T1 (de) 1997-12-24 2008-07-15 Cepheid Vorrichtung und verfahren zur lyse
JPH11241977A (ja) * 1998-02-25 1999-09-07 Shimadzu Corp 流体濃度測定装置
US6699713B2 (en) 2000-01-04 2004-03-02 The Regents Of The University Of California Polymerase chain reaction system
US6489785B2 (en) 2000-12-05 2002-12-03 Agilent Technologies, Inc. Comparative contactless conductivity detector
US6576459B2 (en) 2001-03-23 2003-06-10 The Regents Of The University Of California Sample preparation and detection device for infectious agents
GB0116384D0 (en) 2001-07-04 2001-08-29 Diagnoswiss Sa Microfluidic chemical assay apparatus and method
TWI245895B (en) * 2001-11-29 2005-12-21 Sun-Wing Tong Molecular detection and assay by electrobiochip micro-array
US20030203504A1 (en) 2002-04-26 2003-10-30 John Hefti Diffusion-based system and method for detecting and monitoring activity of biologic and chemical species
JP4092990B2 (ja) 2002-09-06 2008-05-28 株式会社日立製作所 生体および化学試料検査装置
ITTO20020808A1 (it) 2002-09-17 2004-03-18 St Microelectronics Srl Dispositivo integrato di analisi del dna.
US6875602B2 (en) 2002-09-24 2005-04-05 The United States Of America As Represented By The Secretary Of The Army Portable thermocycler
KR100858080B1 (ko) 2002-11-12 2008-09-10 삼성전자주식회사 전기적 신호를 측정하는 ｐｃｒ 증폭 산물을 검출하는 방법
US7062385B2 (en) 2002-11-25 2006-06-13 Tufts University Intelligent electro-optical nucleic acid-based sensor array and method for detecting volatile compounds in ambient air
JP4638431B2 (ja) 2003-08-06 2011-02-23 ブリッジャー テクノロジーズ，インク． 目標物質検出用の架橋型要素部品
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
US20070072286A1 (en) * 2003-09-29 2007-03-29 Koninkljke Philips Electronics N.V. Label-free detection of biomolecules
US6990849B2 (en) * 2004-03-26 2006-01-31 Lifescan, Inc. Microfluidic analytical system with position electrodes
JP3952042B2 (ja) 2004-06-07 2007-08-01 ソニー株式会社 凹状部位を有する電極を備えるハイブリダイゼーション検出部と該検出部を備えるｄｎａチップ
CN102759466A (zh) 2004-09-15 2012-10-31 英特基因有限公司 微流体装置
KR20070090158A (ko) 2004-10-18 2007-09-05 브랜데이스 유니버시티 Ｐｃｒ 증폭에서 재현성을 개선시키고 미스프라이밍을감소시키기 위한 시약 및 방법
EP2418018B1 (en) 2004-12-23 2013-05-22 Abbott Point of Care Inc. Methods for the separation nucleic acids
US20060176179A1 (en) 2005-01-26 2006-08-10 Battelle Memorial Institute Bendable, active radio-frequency sensor tags and a system of same
JP2008532005A (ja) * 2005-02-25 2008-08-14 インバーネス・メデイカル・スウイツツアーランド・ゲゼルシヤフト・ミツト・ベシユレンクテル・ハフツング 流体ゲート装置
KR101381331B1 (ko) 2005-05-09 2014-04-04 테라노스, 인코포레이티드 현장진료 유체 시스템 및 그 용도
US20150141264A1 (en) 2005-05-20 2015-05-21 Apdn (B.V.I.) Inc. In-field dna extraction, detection and authentication methods and systems therefor
RU2423073C2 (ru) 2005-07-14 2011-07-10 Нано-Дайтек Корпорейшн Микрофлюидные устройства и способы их подготовки и применения
JP5149184B2 (ja) 2005-09-01 2013-02-20 キヤノン ユー．エス． ライフ サイエンシズ， インコーポレイテッド ゲノムｄｎａの検出、分析、および種名を同定のための方法と分子診断装置
EP1951860A4 (en) 2005-11-21 2012-06-06 Life Technologies Corp PORTABLE PREPARATION, ANALYSIS AND DETECTION APPARATUS FOR THE TREATMENT OF NUCLEIC ACIDS
US8173077B2 (en) 2005-12-16 2012-05-08 The Curators Of The University Of Missouri Reusable PCR amplification system and method
WO2007092552A2 (en) 2006-02-07 2007-08-16 Antara Biosciences Inc. Device and methods for detecting and quantifying one or more target agents
US20090061450A1 (en) 2006-03-14 2009-03-05 Micronics, Inc. System and method for diagnosis of infectious diseases
US7998708B2 (en) 2006-03-24 2011-08-16 Handylab, Inc. Microfluidic system for amplifying and detecting polynucleotides in parallel
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US7708944B1 (en) 2006-06-13 2010-05-04 Research Foundation Of State University Of New York Ultra-sensitive, portable capillary sensor
US20070298487A1 (en) 2006-06-23 2007-12-27 Becton, Dickinson And Company Radio Frequency Transponder Assay
US20120058547A1 (en) 2006-08-11 2012-03-08 The Hong Kong University Of Science And Technology Method and system for nucleic acid detection using electroconductive or electrochemically active labels
GB0618966D0 (en) 2006-09-26 2006-11-08 Iti Scotland Ltd Cartridge system
EP2069070B1 (en) 2006-09-28 2013-11-27 Stokes Bio Limited A qpcr analysis apparatus
US20100105035A1 (en) 2006-11-22 2010-04-29 Syed Anwar Hashsham Electroluminescent-based fluorescence detection device
WO2008070786A1 (en) * 2006-12-06 2008-06-12 The Trustees Of Columbia University In The City Of New York Microfluidic systems and methods for screening plating and etching bath compositions
US7483805B2 (en) 2006-12-26 2009-01-27 Integrated Sensing Systems, Inc. Sensing and analysis system, network, and method
ES2307430B1 (es) 2007-05-09 2009-10-20 Consejo Superior De Investigaciones Cientificas Biosensor y sus aplicaciones.
US8198658B2 (en) * 2007-06-13 2012-06-12 Samsung Electronics Co., Ltd. Device and method for detecting biomolecules using adsorptive medium and field effect transistor
US8133671B2 (en) 2007-07-13 2012-03-13 Handylab, Inc. Integrated apparatus for performing nucleic acid extraction and diagnostic testing on multiple biological samples
BRPI0703025B1 (pt) 2007-08-08 2018-07-17 Universidade De São Paulo - Usp microdispositivo multicamada, processo de preparação de microdispositivo multicamada
US8088593B2 (en) 2007-10-02 2012-01-03 Theranos, Inc. Modular point-of-care devices, systems, and uses thereof
PE20090965A1 (es) 2007-10-12 2009-07-13 Bigtec Private Ltd Micro chip
EP2240568A4 (en) 2007-12-10 2016-04-13 Samsung Electronics Co Ltd THIN FILM BIOVENTILING DEVICE AND CONTROL UNIT THEREFOR
WO2009079028A1 (en) 2007-12-14 2009-06-25 Johns Hopkins University Purification and concentration of proteins and dna from a complex sample using isotachophoresis and a device to perform the purification
US8865401B2 (en) 2007-12-14 2014-10-21 The Johns Hopkins University Purification and concentration of proteins and DNA from a complex sample using isotachophoresis and a device to perform the purification
DE102007062441A1 (de) 2007-12-20 2009-06-25 Aj Innuscreen Gmbh Mobiles Schnelltestsystem für die Nukleinsäureanalytik
EP3869205B1 (en) 2008-01-21 2023-11-22 Nexus Dx, Inc. Thin-film layered centrifuge device and analysis method using the same
DE102008009920A1 (de) 2008-02-15 2009-08-20 Aj Innuscreen Gmbh Mobiles Gerät für die Nukleinsäureisolierung
KR100969667B1 (ko) 2008-03-24 2010-07-14 디지탈 지노믹스(주) 생리활성물질을 전기적으로 검출하는 방법 및 이를 위한바이오칩
WO2010019898A1 (en) 2008-08-14 2010-02-18 Zygem Corporation Limited Temperature controlled nucleic-acid detection method suitable for practice in a closed-system
EP2321429B1 (en) 2008-09-03 2016-08-17 Quantumdx Group Limited Methods and kits for nucleic acid sequencing
US8882980B2 (en) * 2008-09-03 2014-11-11 Nabsys, Inc. Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels
WO2010033604A2 (en) 2008-09-18 2010-03-25 X-Bar Diagnostic System, Inc. Fully automated portable dna detection system
GB0818609D0 (en) 2008-10-10 2008-11-19 Univ Hull apparatus and method
US20100122904A1 (en) 2008-11-17 2010-05-20 Board Of Regents, The University Of Texas System Incorporating cmos integrated circuits in the design of affinity-based biosensor systems
US8551767B2 (en) * 2008-11-20 2013-10-08 Agency Of Science, Technology And Research Sensor for detection of nucleic acid
US20110318728A1 (en) 2008-12-30 2011-12-29 Huan Lac Phan Systems, devices, methods and kits for fluid handling
WO2010088514A1 (en) 2009-01-30 2010-08-05 Micronics, Inc. Portable high gain fluorescence detection system
FR2942041B1 (fr) 2009-02-06 2011-02-25 Commissariat Energie Atomique Dispositif embarque d'analyse d'un fluide corporel.
US20100216225A1 (en) 2009-02-25 2010-08-26 Ag-Defense Systems, Inc. Portable microorganism detection unit
US8106428B2 (en) 2009-03-03 2012-01-31 Board Of Regents, The University Of Texas System Nano-scale bridge biosensors
EP2411536B1 (en) * 2009-03-27 2014-09-17 Nabsys, Inc. Methods for analyzing biomolecules and probes bound thereto
US9393564B2 (en) 2009-03-30 2016-07-19 Ibis Biosciences, Inc. Bioagent detection systems, devices, and methods
WO2010146339A1 (en) 2009-06-15 2010-12-23 Bg Research Ltd Nucleic acid detection
KR101217576B1 (ko) 2009-09-22 2013-01-03 한국전자통신연구원 바이오 센서 및 그의 구동 방법
US20110136104A1 (en) 2009-12-04 2011-06-09 Massachusetts Institute Of Technology Multiplexed quantitative pcr end point analysis of nucleic acid targets
KR20110080067A (ko) 2010-01-04 2011-07-12 엘지전자 주식회사 샘플분석 카트리지 및 샘플분석 카트리지 리더
CN104611222B (zh) 2010-01-12 2017-05-24 阿赫姆生物系统公司 三阶段热对流装置及其用途
JP5865261B2 (ja) 2010-01-12 2016-02-17 アーラム バイオシステムズ インコーポレイテッド ２段熱対流装置及びその使用法
US10295472B2 (en) 2010-05-05 2019-05-21 Alverix, Inc. Assay reader operable to scan a test strip
CN102004126A (zh) * 2010-05-11 2011-04-06 中国科学院上海应用物理研究所 电化学生物传感器及其检测方法
US20110312781A1 (en) 2010-06-17 2011-12-22 Geneasys Pty Ltd Loc with digital memory to store genetic data updates
US9029168B2 (en) 2010-06-28 2015-05-12 The Trustees Of Princeton University Use and making of biosensors utilizing antimicrobial peptides for highly sensitive biological monitoring
US8951472B2 (en) 2010-07-19 2015-02-10 Andalyze, Inc. Portable fluorimetric apparatus, method and system
EP2752247A3 (en) 2010-07-23 2016-08-31 Beckman Coulter, Inc. System or method of including analytical units
EP2612146A2 (en) * 2010-09-02 2013-07-10 Heed Diagnostics ApS Electrochemical detection of analyte
US9696299B2 (en) 2010-11-01 2017-07-04 Norberto Guzman Integrated modular unit including an analyte concentrator microreactor device connected to a cartridge-cassette
US8865075B2 (en) 2010-11-01 2014-10-21 Princeton Biochemicals, Inc. Multi-task immunoaffinity device secured to a peripheral box and integrated to a capillary electrophoresis apparatus
WO2012073114A2 (en) 2010-11-30 2012-06-07 Quantumdx Group Limited The design, fabrication and use of a microfluidics multitemperature flexible reaction device
US9877673B2 (en) 2010-12-10 2018-01-30 Clinitech, Llc Transdermal sampling and analysis device
JP2012177599A (ja) * 2011-02-25 2012-09-13 Arkray Inc 再生可能なマイクロチップ、それを用いる測定装置、およびマイクロチップの再生方法
US9580742B2 (en) 2011-03-10 2017-02-28 Shana O. Kelley Diagnostic and sample preparation devices and methods
WO2012142192A2 (en) 2011-04-11 2012-10-18 Gray Mark A Apparatus and method for making uniform emulsions
WO2012178210A1 (en) 2011-06-23 2012-12-27 Anitoa Systems, Llc Apparatus for amplification of nucleic acids
US20140349298A1 (en) 2011-07-14 2014-11-27 William Eugene Stanchina Portable, low power instrument for the optoelectronic detection of pathogens using isothermal nucleic acid amplification protocols
US9051605B2 (en) 2011-07-29 2015-06-09 Auburn University Magnetic bead quantum dot nanoparticle assay
US8435738B2 (en) * 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
MX344792B (es) 2011-09-25 2017-01-06 Theranos Inc Sistemas y métodos para múltiples análisis.
WO2013049782A2 (en) 2011-09-30 2013-04-04 Pandora Genomics, LLC System, apparatus and method for evaluating samples or analytes using a point-of-care device
US9030215B2 (en) 2011-10-04 2015-05-12 The Regents Of The University Of California Corporation Real-time, label-free detection of nucleic acid amplification in droplets using impedance spectroscopy and solid-phase substrate
US9335292B2 (en) 2011-10-13 2016-05-10 Auburn University Electrochemical proximity assay
US10928321B2 (en) 2012-03-09 2021-02-23 Ubiquitome Limited Portable device for detecting molecule(s)
US10180421B2 (en) 2012-03-30 2019-01-15 Boston Microfluidics Methods and systems to collect a biological sample
WO2013155213A1 (en) 2012-04-10 2013-10-17 Keck Graduate Institute Of Applied Life Sciences System and cartridge for efficient nucleic acid testing
US10132802B2 (en) 2012-04-17 2018-11-20 i-calQ, LLC Device for performing a diagnostic test and methods for use thereof
US9808798B2 (en) 2012-04-20 2017-11-07 California Institute Of Technology Fluidic devices for biospecimen preservation
JP6196661B2 (ja) 2012-04-20 2017-09-13 スリップチップ， エルエルシー サンプル調製または自律分析のための流体デバイスおよびシステム
US20130309676A1 (en) 2012-05-18 2013-11-21 Alfred E. Mann Foundation For Scientific Research Biased n-mers identification methods, probes and systems for target amplification and detection
HK1212394A1 (en) 2012-09-12 2016-06-10 Xagenic, Inc. Systems, devices, and methods for identifying a disease state in a biological host using internal controls
US20140099636A1 (en) 2012-10-10 2014-04-10 Baker Hughes Incorporated FIELD-BASED qPCR MICROBIAL MONITORING
EP3427830B1 (en) 2012-10-24 2021-06-23 Genmark Diagnostics Inc. Integrated multiplex target analysis
US8956858B2 (en) 2013-03-14 2015-02-17 Src, Inc. Tactical and portable PCR/HRM genome identification system
US10933417B2 (en) 2013-03-15 2021-03-02 Nanobiosym, Inc. Systems and methods for mobile device analysis of nucleic acids and proteins
KR20140115210A (ko) 2013-03-20 2014-09-30 한국전자통신연구원 모바일 장비의 앱을 이용한 dna 분석 방법 및 시스템
GB2516666B (en) 2013-07-29 2015-09-09 Atlas Genetics Ltd Fluidic cartridge for nucleic acid amplification and detection
CA2920375A1 (en) 2013-08-07 2015-02-12 Xagenic Inc. Systems, devices, and methods for deploying onboard reagents in a diagnostic device
WO2015021338A1 (en) 2013-08-07 2015-02-12 Xagenic Inc. Sensor growth controller
CN105850048A (zh) 2013-08-07 2016-08-10 艾克泽基因公司 精确双极电流模式数模转换器
CA2920584A1 (en) 2013-08-07 2015-02-12 Xagenic Inc. Microchip structure and treatments for electrochemical detection
WO2015019194A2 (en) 2013-08-07 2015-02-12 Xagenic Inc. Systems, methods and devices for electrochemical detection using helper oligonucleotides
EP3030146A4 (en) 2013-08-07 2017-04-26 Xagenic Inc. Potentiostat reference electrode interface
JP6573899B2 (ja) 2013-11-17 2019-09-11 クアンタム−エスアイ インコーポレイテッドＱｕａｎｔｕｍ−Ｓｉ Ｉｎｃｏｒｐｏｒａｔｅｄ 分子をプローブし、検出し、及び分析するための、外部光源を備えた集積デバイス
KR20170016915A (ko) 2014-06-11 2017-02-14 마이크로닉스 인코포레이티드. 핵산의 분석을 위한 통합 검정 대조군을 갖는 마이크로 유체 공학적 카트리지 및 장치
US10196678B2 (en) 2014-10-06 2019-02-05 ALVEO Technologies Inc. System and method for detection of nucleic acids
US10627358B2 (en) 2014-10-06 2020-04-21 Alveo Technologies, Inc. Method for detection of analytes
US10352899B2 (en) 2014-10-06 2019-07-16 ALVEO Technologies Inc. System and method for detection of silver
US9921182B2 (en) 2014-10-06 2018-03-20 ALVEO Technologies Inc. System and method for detection of mercury
US9506908B2 (en) 2014-10-06 2016-11-29 Alveo Technologies, Inc. System for detection of analytes
CN115963149A (zh) 2014-10-14 2023-04-14 贝克顿·迪金森公司 用于检测微生物的电抗和电容型传感平台
US10210410B2 (en) 2014-10-22 2019-02-19 Integenx Inc. Systems and methods for biometric data collections
US10005080B2 (en) 2014-11-11 2018-06-26 Genmark Diagnostics, Inc. Instrument and cartridge for performing assays in a closed sample preparation and reaction system employing electrowetting fluid manipulation
KR101709762B1 (ko) 2015-02-09 2017-02-23 광운대학교 산학협력단 생체분자 농축 기능 일체형 센서 및 그 제조방법
JP6698708B2 (ja) 2015-06-09 2020-05-27 ライフ テクノロジーズ コーポレーション 分子タグ付けのための方法、システム、組成物、キット、装置、及びコンピュータ可読媒体
US10303843B2 (en) 2015-08-06 2019-05-28 Microsoft Technology Licensing, Llc Computing system for identifying health risk regions
CA3008273A1 (en) 2015-12-18 2017-06-22 Clear Gene, Inc. Methods, compositions, kits and devices for rapid analysis of biological markers
WO2017147486A1 (en) 2016-02-26 2017-08-31 Alere San Diego Inc. Redox labeled oligonucleotide probes and their use
US10544456B2 (en) 2016-07-20 2020-01-28 Genapsys, Inc. Systems and methods for nucleic acid sequencing
CA3037494A1 (en) 2016-09-23 2018-03-29 Alveo Technologies, Inc. Methods and compositions for detecting analytes
TW201832726A (zh) 2016-11-01 2018-09-16 美商海科生醫有限責任公司 可基於輸入數據建議檢測之免疫檢測系統
US10427162B2 (en) 2016-12-21 2019-10-01 Quandx Inc. Systems and methods for molecular diagnostics
JP2022516441A (ja) 2018-12-20 2022-02-28 アルヴェオ テクノロジーズ インコーポレイテッド 電気的検出を伴う等温増幅
AU2019403220A1 (en) 2018-12-20 2021-07-15 Alveo Technologies, Inc. Methods and compositions to reduce nonspecific amplification in isothermal amplification reactions
US12275007B2 (en) 2018-12-20 2025-04-15 Alveo Technologies, Inc. Handheld impedance-based diagnostic test system for detecting analytes
CA3123832A1 (en) 2018-12-20 2020-06-25 Alveo Technologies, Inc. Methods and compositions for detection of amplification products

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