KR102277188B1 - 프로스타글란딘 아미드의 신규한 제조 방법 - Google Patents

프로스타글란딘 아미드의 신규한 제조 방법 Download PDF

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KR102277188B1
KR102277188B1 KR1020207019850A KR20207019850A KR102277188B1 KR 102277188 B1 KR102277188 B1 KR 102277188B1 KR 1020207019850 A KR1020207019850 A KR 1020207019850A KR 20207019850 A KR20207019850 A KR 20207019850A KR 102277188 B1 KR102277188 B1 KR 102277188B1
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bimatoprost
formula
group
mixture
preparation
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KR20200087871A (ko
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가보르 허버시
티보르 키시
이렌 호르토바지이
주전너 커르도시
이슈트반 라슬로피
졸탄 비슈츠호프
아담 보디시
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키노인 제트알티.
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Priority claimed from HU1100292A external-priority patent/HU231134B1/hu
Priority claimed from HU1100291A external-priority patent/HU230703B1/hu
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0041—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/50—Iso-indoles; Hydrogenated iso-indoles with oxygen and nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
KR1020207019850A 2011-06-02 2012-05-25 프로스타글란딘 아미드의 신규한 제조 방법 Active KR102277188B1 (ko)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
HU1100292A HU231134B1 (hu) 2011-06-02 2011-06-02 Eljárás a bimatoprost kémiailag stabil új kristályformájának előállítására
HUP1100292 2011-06-02
HU1100291A HU230703B1 (hu) 2011-06-02 2011-06-02 Új eljárás prosztaglandin amidok előállítására
HUP1100291 2011-06-02
PCT/HU2012/000045 WO2012164324A1 (en) 2011-06-02 2012-05-25 Novel processes for the preparation of prostaglandin amides
KR1020197031340A KR102135550B1 (ko) 2011-06-02 2012-05-25 프로스타글란딘 아미드의 신규한 제조 방법

Related Parent Applications (1)

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KR1020197031340A Division KR102135550B1 (ko) 2011-06-02 2012-05-25 프로스타글란딘 아미드의 신규한 제조 방법

Publications (2)

Publication Number Publication Date
KR20200087871A KR20200087871A (ko) 2020-07-21
KR102277188B1 true KR102277188B1 (ko) 2021-07-15

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KR1020207019850A Active KR102277188B1 (ko) 2011-06-02 2012-05-25 프로스타글란딘 아미드의 신규한 제조 방법
KR1020147000085A Active KR102038048B1 (ko) 2011-06-02 2012-05-25 프로스타글란딘 아미드의 신규한 제조 방법
KR1020197031340A Active KR102135550B1 (ko) 2011-06-02 2012-05-25 프로스타글란딘 아미드의 신규한 제조 방법

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KR1020197031340A Active KR102135550B1 (ko) 2011-06-02 2012-05-25 프로스타글란딘 아미드의 신규한 제조 방법

Country Status (17)

Country Link
US (3) US9238621B2 (enExample)
EP (1) EP2723714B1 (enExample)
JP (3) JP6212485B2 (enExample)
KR (3) KR102277188B1 (enExample)
CN (4) CN106278982B (enExample)
BR (3) BR122021008918B1 (enExample)
CA (3) CA2837261C (enExample)
ES (1) ES2636756T3 (enExample)
HU (1) HUE033642T2 (enExample)
IL (1) IL229647A (enExample)
MX (1) MX341839B (enExample)
PL (1) PL2723714T3 (enExample)
PT (1) PT2723714T (enExample)
RU (1) RU2618223C2 (enExample)
TW (3) TWI653222B (enExample)
WO (1) WO2012164324A1 (enExample)
ZA (1) ZA201309357B (enExample)

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HU231203B1 (hu) 2011-12-21 2021-10-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás travoprost előállítására
PT2911623T (pt) 2012-10-26 2019-11-21 Forsight Vision5 Inc Sistema oftálmico para libertação prolongada de fármaco no olho
US9447014B2 (en) * 2012-12-28 2016-09-20 Allergan, Inc. Tromethamine salt of bimatoprost acid in crystalline form, methods for preparation, and methods for use thereof
US9120738B2 (en) * 2012-12-28 2015-09-01 Allergan, Inc. Crystalline forms of bimatoprost acid, methods for preparation, and methods for use thereof
HU231214B1 (hu) * 2014-03-13 2021-11-29 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Új eljárás nagytisztaságú prosztaglandinok előállítására
US10273206B2 (en) 2014-06-27 2019-04-30 Allergan, Inc. Tromethamine salt of bimatoprost acid in crystalline form 1, methods for preparation, and methods for use thereof
WO2015199729A1 (en) * 2014-06-27 2015-12-30 Allergan, Inc. Tromethamine salt of bimatoprost acid in crystalline form 1, methods for preparation, and methods for use thereof
US20160296532A1 (en) 2015-04-13 2016-10-13 Forsight Vision5, Inc. Ocular Insert Composition of a Semi-Crystalline or Crystalline Pharmaceutically Active Agent
HU231185B1 (hu) * 2017-07-11 2021-07-28 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás Misoprostol előállítására és tisztítására
CN113548993B (zh) * 2021-09-01 2022-05-27 河北化工医药职业技术学院 一种卡前列素的制备方法

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CA3094762A1 (en) 2012-12-06
CA2837261C (en) 2020-12-15
KR20140053941A (ko) 2014-05-08
BR112013030973A8 (pt) 2021-03-30
CN106278982A (zh) 2017-01-04
JP6212485B2 (ja) 2017-10-11
JP2017075165A (ja) 2017-04-20
BR112013030973B1 (pt) 2021-08-10
CA3209613A1 (en) 2012-12-06
WO2012164324A1 (en) 2012-12-06
US20140135503A1 (en) 2014-05-15
PL2723714T3 (pl) 2018-02-28
IL229647A (en) 2017-09-28
CA3094762C (en) 2023-09-26
KR20190124804A (ko) 2019-11-05
BR112013030973A2 (pt) 2016-08-16
US9856213B2 (en) 2018-01-02
KR20200087871A (ko) 2020-07-21
EP2723714A1 (en) 2014-04-30
IL229647A0 (en) 2014-01-30
TWI653223B (zh) 2019-03-11
TWI653222B (zh) 2019-03-11
ES2636756T3 (es) 2017-10-09
ZA201309357B (en) 2014-08-27
US9573892B2 (en) 2017-02-21
BR122021008918B1 (pt) 2021-08-10
US9238621B2 (en) 2016-01-19
EP2723714B1 (en) 2017-06-21
MX2013014034A (es) 2015-06-17
CA2837261A1 (en) 2012-12-06
TW201311629A (zh) 2013-03-16
JP6487410B2 (ja) 2019-03-20
US20160137602A1 (en) 2016-05-19
CN103649047B (zh) 2017-01-11
CN103649047A (zh) 2014-03-19
HUE033642T2 (en) 2017-12-28
CN106278982B (zh) 2019-06-14
RU2013158952A (ru) 2015-07-20
TW201708191A (zh) 2017-03-01
KR102135550B1 (ko) 2020-07-21
US20160145207A1 (en) 2016-05-26
PT2723714T (pt) 2017-08-18
TWI632131B (zh) 2018-08-11
CN106349138A (zh) 2017-01-25
RU2618223C2 (ru) 2017-05-03
MX341839B (es) 2016-09-05
KR102038048B1 (ko) 2019-10-30
TW201708190A (zh) 2017-03-01
BR122021008946B1 (pt) 2021-08-10
WO2012164324A9 (en) 2014-01-09
JP6693859B2 (ja) 2020-05-13
JP2014527026A (ja) 2014-10-09
CN106316910A (zh) 2017-01-11
JP2017061555A (ja) 2017-03-30

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