KR102068381B1 - 담즙산 유도체의 제조 방법 - Google Patents

담즙산 유도체의 제조 방법 Download PDF

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Publication number
KR102068381B1
KR102068381B1 KR1020157012805A KR20157012805A KR102068381B1 KR 102068381 B1 KR102068381 B1 KR 102068381B1 KR 1020157012805 A KR1020157012805 A KR 1020157012805A KR 20157012805 A KR20157012805 A KR 20157012805A KR 102068381 B1 KR102068381 B1 KR 102068381B1
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formula
compound
idd
pharmaceutically acceptable
ibb
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KR20150074062A (ko
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로베르토 펠리치아리
안티모 지오이엘로
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인터셉트 파마슈티컬즈, 인크.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/12—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B45/00—Formation or introduction of functional groups containing sulfur
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020157012805A 2012-10-26 2013-10-25 담즙산 유도체의 제조 방법 Expired - Fee Related KR102068381B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718966P 2012-10-26 2012-10-26
US61/718,966 2012-10-26
PCT/US2013/066917 WO2014066819A1 (en) 2012-10-26 2013-10-25 Process for preparing bile acid derivatives

Publications (2)

Publication Number Publication Date
KR20150074062A KR20150074062A (ko) 2015-07-01
KR102068381B1 true KR102068381B1 (ko) 2020-01-20

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KR1020157012805A Expired - Fee Related KR102068381B1 (ko) 2012-10-26 2013-10-25 담즙산 유도체의 제조 방법

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US (2) US9777038B2 (enExample)
EP (1) EP2912013B1 (enExample)
JP (1) JP6272888B2 (enExample)
KR (1) KR102068381B1 (enExample)
CN (2) CN105102425B (enExample)
AU (1) AU2013334122B2 (enExample)
BR (1) BR112015009395A2 (enExample)
CA (1) CA2889592A1 (enExample)
CY (1) CY1119731T1 (enExample)
DK (1) DK2912013T3 (enExample)
ES (1) ES2655034T3 (enExample)
HK (1) HK1253301A1 (enExample)
HU (1) HUE036887T2 (enExample)
IL (1) IL238454B (enExample)
MX (1) MX361653B (enExample)
NO (1) NO2968302T3 (enExample)
NZ (2) NZ745013A (enExample)
PL (1) PL2912013T3 (enExample)
PT (1) PT2912013T (enExample)
SG (1) SG11201503247UA (enExample)
SM (1) SMT201700602T1 (enExample)
WO (1) WO2014066819A1 (enExample)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
WO2022059948A1 (ko) 2020-09-18 2022-03-24 서울대학교 산학협력단 소디움 타우로디옥시콜레이트의 대량 생산 방법

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US9777038B2 (en) 2012-10-26 2017-10-03 Intercept Pharmaceuticals, Inc. Process for preparing bile acid derivatives
PT3149019T (pt) 2014-05-29 2020-02-19 Bar Pharmaceuticals S R L Derivados de colano para utilização no tratamento e/ou na prevenção de doenças mediadas por fxr e tgr5/gp-bar1
ES2748692T3 (es) 2014-11-19 2020-03-17 Nzp Uk Ltd Esteroides 6.alfa.-alquil-3,7-diona como intermedios para la producción de moduladores FXR de esteroides
EA033427B1 (ru) 2014-11-19 2019-10-31 Nzp Uk Ltd 6-алкил-7-гидрокси-4-ен-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
PL3221332T3 (pl) 2014-11-19 2019-10-31 Nzp Uk Ltd Steroidy, 5.beta.-6-alkilo-7-hydroksy-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr
KR102527821B1 (ko) 2014-11-19 2023-05-02 엔제트피 유케이 리미티드 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-6,7-다이온 스테로이드
CN104672290B (zh) * 2015-01-05 2017-06-06 北京普禄德医药科技有限公司 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途
BR112017016766B1 (pt) 2015-02-06 2023-11-07 Intercept Pharmaceuticals, Inc Composição compreendendo um agonista fxr e fibrato, bem como uso para tratar doença hepática colestática
CN108350020A (zh) 2015-09-24 2018-07-31 英特塞普特医药品公司 用于制备胆汁酸衍生物的方法和中间体
EP3370728A4 (en) * 2015-11-06 2019-07-10 Intercept Pharmaceuticals, Inc. PROCESS FOR THE PREPARATION OF OBETICHOLIC ACID AND DERIVATIVES THEREOF
WO2017142895A1 (en) * 2016-02-15 2017-08-24 Regents Of The University Of Minnesota Compositions and methods for treating clostridium associated diseases
KR102377338B1 (ko) 2016-04-13 2022-03-21 인터셉트 파마슈티컬즈, 인크. 암의 치료 방법
TW201738254A (zh) 2016-04-19 2017-11-01 英特賽普醫藥品公司 奧貝膽酸及其衍生物之製備方法
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
MX2019003684A (es) * 2016-09-30 2019-08-05 Intercept Pharmaceuticals Inc Formas cristalinas de un derivado de acido biliar.
MX2020000873A (es) * 2017-07-24 2020-07-22 Intercept Pharmaceuticals Inc Derivados de ácidos biliares marcados isotópicamente.
CN110869381B (zh) * 2017-07-26 2021-11-19 正大天晴药业集团股份有限公司 甾体类衍生物fxr激动剂的制备方法
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
JP2022536060A (ja) 2019-05-30 2022-08-12 インターセプト ファーマシューティカルズ， インコーポレイテッド 胆汁鬱滞性肝疾患の処置で使用するためのｆｘｒアゴニストおよびフィブラートを含む医薬組成物
KR20220150270A (ko) 2019-10-07 2022-11-10 칼리오페, 인크. Gpr119 효능제
JP7745559B2 (ja) 2020-02-28 2025-09-29 キャリーオペ，インク． Ｇｐｒ４０アゴニスト
BR112022023359A2 (pt) 2020-05-19 2023-04-18 Kallyope Inc Ativadores de ampk
JP2023531726A (ja) 2020-06-26 2023-07-25 キャリーオペ，インク． Ａｍｐｋアクチベーター

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US20080182832A1 (en) 2006-06-27 2008-07-31 Intercept Pharmaceuticals, Inc. Bile acid derivatives as FXR ligands for the prevention or treatment of FXR-mediated diseases or conditions
US20110172198A1 (en) 2008-07-30 2011-07-14 Intercept Pharmaceuticals, Inc. TGR5 Modulators And Methods Of Use Thereof

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US5216015A (en) * 1991-02-05 1993-06-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having hypocholesterolemic properties
EP1392714B1 (en) 2001-03-12 2005-08-31 Intercept Pharmaceuticals, Inc. Steroids as agonists for fxr
EP1568706A1 (en) * 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
EP2303026B1 (en) * 2008-06-17 2020-09-09 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
EP2373673B1 (en) * 2008-11-19 2016-07-27 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
US9777038B2 (en) 2012-10-26 2017-10-03 Intercept Pharmaceuticals, Inc. Process for preparing bile acid derivatives

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
US20080182832A1 (en) 2006-06-27 2008-07-31 Intercept Pharmaceuticals, Inc. Bile acid derivatives as FXR ligands for the prevention or treatment of FXR-mediated diseases or conditions
US20110172198A1 (en) 2008-07-30 2011-07-14 Intercept Pharmaceuticals, Inc. TGR5 Modulators And Methods Of Use Thereof

Non-Patent Citations (3)

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Title
J. Med. Chem.(2004), 47, pp.4559~4569
J. Org. Chem. 2001, 66, pp.4814~4818
Molecular Pharmacology, 2010, Vol.78, No.4, pp.617~630

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022059948A1 (ko) 2020-09-18 2022-03-24 서울대학교 산학협력단 소디움 타우로디옥시콜레이트의 대량 생산 방법

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CN105102425B (zh) 2018-04-10
WO2014066819A1 (en) 2014-05-01
AU2013334122B2 (en) 2017-11-02
KR20150074062A (ko) 2015-07-01
JP6272888B2 (ja) 2018-01-31
BR112015009395A2 (pt) 2017-07-04
CN105102425A (zh) 2015-11-25
US10202414B2 (en) 2019-02-12
JP2015533852A (ja) 2015-11-26
ES2655034T3 (es) 2018-02-16
SG11201503247UA (en) 2015-06-29
MX2015005286A (es) 2015-10-29
US20150291653A1 (en) 2015-10-15
US9777038B2 (en) 2017-10-03
HK1214239A1 (zh) 2016-07-22
HUE036887T2 (hu) 2018-08-28
IL238454A0 (en) 2015-06-30
DK2912013T3 (en) 2018-01-15
EP2912013B1 (en) 2017-10-11
EP2912013A4 (en) 2016-06-01
US20180079776A1 (en) 2018-03-22
NO2968302T3 (enExample) 2018-02-03
CY1119731T1 (el) 2018-06-27
SMT201700602T1 (it) 2018-03-08
PT2912013T (pt) 2018-01-03
AU2013334122A1 (en) 2015-05-14
NZ707389A (en) 2018-08-31
MX361653B (es) 2018-12-13
CN108250264A (zh) 2018-07-06
EP2912013A1 (en) 2015-09-02
HK1253301A1 (zh) 2019-06-14
NZ745013A (en) 2019-08-30
IL238454B (en) 2018-11-29
CA2889592A1 (en) 2014-05-01
PL2912013T3 (pl) 2018-05-30

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