CN105102425B - 制备胆汁酸衍生物的方法 - Google Patents

制备胆汁酸衍生物的方法 Download PDF

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Publication number
CN105102425B
CN105102425B CN201380068062.XA CN201380068062A CN105102425B CN 105102425 B CN105102425 B CN 105102425B CN 201380068062 A CN201380068062 A CN 201380068062A CN 105102425 B CN105102425 B CN 105102425B
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China
Prior art keywords
compound
formula
pharmaceutically acceptable
acceptable salt
idd
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Expired - Fee Related
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CN201380068062.XA
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English (en)
Chinese (zh)
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CN105102425A (zh
Inventor
R.佩利恰里
A.焦伊洛
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Intercept Pharmaceuticals Inc
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Intercept Pharmaceuticals Inc
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Priority to CN201810282054.XA priority Critical patent/CN108250264A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201380068062.XA 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法 Expired - Fee Related CN105102425B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810282054.XA CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718966P 2012-10-26 2012-10-26
US61/718966 2012-10-26
PCT/US2013/066917 WO2014066819A1 (en) 2012-10-26 2013-10-25 Process for preparing bile acid derivatives

Related Child Applications (1)

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CN201810282054.XA Division CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Publications (2)

Publication Number Publication Date
CN105102425A CN105102425A (zh) 2015-11-25
CN105102425B true CN105102425B (zh) 2018-04-10

Family

ID=50545344

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380068062.XA Expired - Fee Related CN105102425B (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法
CN201810282054.XA Pending CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201810282054.XA Pending CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Country Status (22)

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US (2) US9777038B2 (enExample)
EP (1) EP2912013B1 (enExample)
JP (1) JP6272888B2 (enExample)
KR (1) KR102068381B1 (enExample)
CN (2) CN105102425B (enExample)
AU (1) AU2013334122B2 (enExample)
BR (1) BR112015009395A2 (enExample)
CA (1) CA2889592A1 (enExample)
CY (1) CY1119731T1 (enExample)
DK (1) DK2912013T3 (enExample)
ES (1) ES2655034T3 (enExample)
HK (1) HK1253301A1 (enExample)
HU (1) HUE036887T2 (enExample)
IL (1) IL238454B (enExample)
MX (1) MX361653B (enExample)
NO (1) NO2968302T3 (enExample)
NZ (2) NZ707389A (enExample)
PL (1) PL2912013T3 (enExample)
PT (1) PT2912013T (enExample)
SG (1) SG11201503247UA (enExample)
SM (1) SMT201700602T1 (enExample)
WO (1) WO2014066819A1 (enExample)

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NZ707389A (en) 2012-10-26 2018-08-31 Intercept Pharmaceuticals Inc Process for preparing bile acid derivatives
SI3626725T1 (sl) 2014-05-29 2023-04-28 Bar Pharmaceuticals S.R.L. Derivati holana za uporabo pri zdravljenju in/ali preprečevanju bolezni, posredovanih s FXR in TGR5/GPBAR1
KR102526632B1 (ko) 2014-11-19 2023-04-27 엔제트피 유케이 리미티드 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 5β-6-알킬-7-하이드록시-3-온 스테로이드
EA033427B1 (ru) 2014-11-19 2019-10-31 Nzp Uk Ltd 6-алкил-7-гидрокси-4-ен-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
ES2748692T3 (es) 2014-11-19 2020-03-17 Nzp Uk Ltd Esteroides 6.alfa.-alquil-3,7-diona como intermedios para la producción de moduladores FXR de esteroides
JP6698085B2 (ja) 2014-11-19 2020-05-27 エヌゼットピー ユーケー リミテッド ステロイドＦＸＲモジュレーター製造のための中間体としての６α−アルキル−６，７−ジオン−ステロイド
CN104672290B (zh) * 2015-01-05 2017-06-06 北京普禄德医药科技有限公司 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途
ES2905872T3 (es) 2015-02-06 2022-04-12 Intercept Pharmaceuticals Inc Composiciones farmacéuticas para terapia combinada
KR20180052756A (ko) 2015-09-24 2018-05-18 인터셉트 파마슈티컬즈, 인크. 담즙산 유도체 제조를 위한 방법 및 중간체
CN108348533A (zh) * 2015-11-06 2018-07-31 英特塞普特医药品公司 制备奥贝胆酸及其衍生物的方法
US20200262865A1 (en) * 2016-02-15 2020-08-20 Alexander Khoruts Compositions and methods for treating clostridium associated diseases
CA3020698A1 (en) 2016-04-13 2017-10-19 Intercept Pharmaceuticals, Inc. Methods of treating or preventing hepatocellular carcinoma
TW201738254A (zh) * 2016-04-19 2017-11-01 英特賽普醫藥品公司 奧貝膽酸及其衍生物之製備方法
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
CN109963567A (zh) * 2016-09-30 2019-07-02 英特塞普特医药品公司 胆汁酸衍生物的结晶形式
CA3070837A1 (en) 2017-07-24 2019-01-31 Intercept Pharmaceuticals, Inc. Isotopically labeled bile acid derivatives
US11059854B2 (en) * 2017-07-26 2021-07-13 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Method for preparing steroid derivative FXR agonist
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
US20220226350A1 (en) 2019-05-30 2022-07-21 Intercept Pharmaceuticals, Inc. Pharmaceutical compositions comprising a fxr agonist and a fibrate for use in the treatment of cholestatic liver disease
JP2022552655A (ja) 2019-10-07 2022-12-19 キャリーオペ，インク． Ｇｐｒ１１９アゴニスト
MX2022010548A (es) 2020-02-28 2022-09-23 Kallyope Inc Agonistas de gpr40.
MX2022014505A (es) 2020-05-19 2022-12-13 Kallyope Inc Activadores de la ampk.
CA3183575A1 (en) 2020-06-26 2021-12-30 Iyassu Sebhat Ampk activators
CN116249536B (zh) 2020-09-18 2026-05-19 沙裴隆有限公司 牛磺脱氧胆酸钠的批量生产方法

Citations (1)

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CN102164940A (zh) * 2008-07-30 2011-08-24 英特塞普特医药品公司 Tgr5调节剂及其使用方法

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US5216015A (en) * 1991-02-05 1993-06-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having hypocholesterolemic properties
DK1392714T3 (da) * 2001-03-12 2006-01-09 Intercept Pharmaceuticals Inc Steroider som agonister for FXR
EP1568706A1 (en) * 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
DK2040713T3 (da) * 2006-06-27 2014-09-29 Intercept Pharmaceuticals Inc Galdesyrederivater som fxr-ligander til forebyggelsen eller behandlingen af fxr-medierede sygdomme eller tilstande
WO2010036427A1 (en) 2008-06-17 2010-04-01 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
AU2009316484B2 (en) * 2008-11-19 2015-04-16 Intercept Pharmaceuticals, Inc. TGR5 modulators and methods of use thereof
NZ707389A (en) 2012-10-26 2018-08-31 Intercept Pharmaceuticals Inc Process for preparing bile acid derivatives

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
CN102164940A (zh) * 2008-07-30 2011-08-24 英特塞普特医药品公司 Tgr5调节剂及其使用方法

Non-Patent Citations (3)

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Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist;Giovanni Rizzo等;《The American Society for Pharmacology and Experimental Therapeutics》;20100714;第78卷(第4期);第617-630页 *
Preparation and degradation of 3α-hydroxycholanic acid;Sarel, Shalom等;《Journal of Organic Chemistry》;19591231;第24卷;第2018-2019页 *

Also Published As

Publication number Publication date
US10202414B2 (en) 2019-02-12
NZ707389A (en) 2018-08-31
PL2912013T3 (pl) 2018-05-30
EP2912013B1 (en) 2017-10-11
IL238454A0 (en) 2015-06-30
DK2912013T3 (en) 2018-01-15
NO2968302T3 (enExample) 2018-02-03
SMT201700602T1 (it) 2018-03-08
KR20150074062A (ko) 2015-07-01
JP6272888B2 (ja) 2018-01-31
CY1119731T1 (el) 2018-06-27
CN108250264A (zh) 2018-07-06
PT2912013T (pt) 2018-01-03
MX2015005286A (es) 2015-10-29
US20180079776A1 (en) 2018-03-22
KR102068381B1 (ko) 2020-01-20
US20150291653A1 (en) 2015-10-15
EP2912013A4 (en) 2016-06-01
SG11201503247UA (en) 2015-06-29
EP2912013A1 (en) 2015-09-02
US9777038B2 (en) 2017-10-03
AU2013334122A1 (en) 2015-05-14
WO2014066819A1 (en) 2014-05-01
HK1214239A1 (zh) 2016-07-22
HUE036887T2 (hu) 2018-08-28
ES2655034T3 (es) 2018-02-16
CN105102425A (zh) 2015-11-25
NZ745013A (en) 2019-08-30
MX361653B (es) 2018-12-13
HK1253301A1 (zh) 2019-06-14
JP2015533852A (ja) 2015-11-26
IL238454B (en) 2018-11-29
BR112015009395A2 (pt) 2017-07-04
CA2889592A1 (en) 2014-05-01
AU2013334122B2 (en) 2017-11-02

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