CN105102425B - 制备胆汁酸衍生物的方法 - Google Patents

制备胆汁酸衍生物的方法 Download PDF

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Publication number
CN105102425B
CN105102425B CN201380068062.XA CN201380068062A CN105102425B CN 105102425 B CN105102425 B CN 105102425B CN 201380068062 A CN201380068062 A CN 201380068062A CN 105102425 B CN105102425 B CN 105102425B
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China
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compound
formula
pharmaceutically acceptable
acceptable salt
idd
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Expired - Fee Related
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CN201380068062.XA
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English (en)
Chinese (zh)
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CN105102425A (zh
Inventor
R.佩利恰里
A.焦伊洛
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Intercept Pharmaceuticals Inc
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Intercept Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201380068062.XA 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法 Expired - Fee Related CN105102425B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810282054.XA CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718966P 2012-10-26 2012-10-26
US61/718966 2012-10-26
PCT/US2013/066917 WO2014066819A1 (en) 2012-10-26 2013-10-25 Process for preparing bile acid derivatives

Related Child Applications (1)

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CN201810282054.XA Division CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Publications (2)

Publication Number Publication Date
CN105102425A CN105102425A (zh) 2015-11-25
CN105102425B true CN105102425B (zh) 2018-04-10

Family

ID=50545344

Family Applications (2)

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CN201810282054.XA Pending CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法
CN201380068062.XA Expired - Fee Related CN105102425B (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

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CN201810282054.XA Pending CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

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US (2) US9777038B2 (enExample)
EP (1) EP2912013B1 (enExample)
JP (1) JP6272888B2 (enExample)
KR (1) KR102068381B1 (enExample)
CN (2) CN108250264A (enExample)
AU (1) AU2013334122B2 (enExample)
BR (1) BR112015009395A2 (enExample)
CA (1) CA2889592A1 (enExample)
CY (1) CY1119731T1 (enExample)
DK (1) DK2912013T3 (enExample)
ES (1) ES2655034T3 (enExample)
HK (1) HK1253301A1 (enExample)
HU (1) HUE036887T2 (enExample)
IL (1) IL238454B (enExample)
MX (1) MX361653B (enExample)
NO (1) NO2968302T3 (enExample)
NZ (2) NZ745013A (enExample)
PL (1) PL2912013T3 (enExample)
PT (1) PT2912013T (enExample)
SG (1) SG11201503247UA (enExample)
SM (1) SMT201700602T1 (enExample)
WO (1) WO2014066819A1 (enExample)

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CN108250264A (zh) 2012-10-26 2018-07-06 英特塞普特医药品公司 制备胆汁酸衍生物的方法
LT3149019T (lt) 2014-05-29 2020-02-25 Bar Pharmaceuticals S.R.L. Cholano dariniai, skirti naudoti fxr ir tgr5/gpbar1 medijuojamų ligų gydymui ir (arba) prevencijai
EA033445B1 (ru) 2014-11-19 2019-10-31 Nzp Uk Ltd 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
WO2016079517A1 (en) 2014-11-19 2016-05-26 Dextra Laboratories Limited 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators
EA033603B1 (ru) 2014-11-19 2019-11-08 Nzp Uk Ltd 6-альфа-алкил-6,7-дионовые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
WO2016079519A1 (en) 2014-11-19 2016-05-26 Dextra Laboratories Limited 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators
CN104672290B (zh) * 2015-01-05 2017-06-06 北京普禄德医药科技有限公司 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途
EA036404B1 (ru) 2015-02-06 2020-11-06 Интерсепт Фармасьютикалз, Инк. Фармацевтические композиции для комбинированной терапии
KR20180052756A (ko) * 2015-09-24 2018-05-18 인터셉트 파마슈티컬즈, 인크. 담즙산 유도체 제조를 위한 방법 및 중간체
WO2017079062A1 (en) * 2015-11-06 2017-05-11 Intercept Pharmaceuticals, Inc. Methods for the preparation of obeticholic acid and derivatives thereof
US20200262865A1 (en) * 2016-02-15 2020-08-20 Alexander Khoruts Compositions and methods for treating clostridium associated diseases
KR102377338B1 (ko) 2016-04-13 2022-03-21 인터셉트 파마슈티컬즈, 인크. 암의 치료 방법
TW201738254A (zh) * 2016-04-19 2017-11-01 英特賽普醫藥品公司 奧貝膽酸及其衍生物之製備方法
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
BR112019006242A2 (pt) * 2016-09-30 2019-06-18 Intercept Pharmaceuticals Inc formas cristalinas de um derivado de ácido biliar
AU2018307611A1 (en) 2017-07-24 2020-02-06 Intercept Pharmaceuticals, Inc. Isotopically labeled bile acid derivatives
EP3660030A4 (en) * 2017-07-26 2021-04-21 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. METHOD OF MANUFACTURING STEROID-DERIVATIVE FXR AGONISTS
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
CA3142358A1 (en) 2019-05-30 2020-12-03 Intercept Pharmaceuticals, Inc. Pharmaceutical compositions comprising a fxr agonist and a fibrate for use in the treatment of cholestatic liver disease
WO2021071837A1 (en) 2019-10-07 2021-04-15 Kallyope, Inc. Gpr119 agonists
TW202140440A (zh) 2020-02-28 2021-11-01 美商克力歐普股份有限公司 Gpr40激動劑
EP4153589A4 (en) 2020-05-19 2024-06-12 Kallyope, Inc. AMPK ACTIVATORS
WO2021263039A1 (en) 2020-06-26 2021-12-30 Kallyope, Inc. Ampk activators
JP7583398B2 (ja) 2020-09-18 2024-11-14 ソウル大学校産学協力団 タウロデオキシコール酸ナトリウムの大量生産方法

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CN102164940A (zh) * 2008-07-30 2011-08-24 英特塞普特医药品公司 Tgr5调节剂及其使用方法

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DE60205891T2 (de) 2001-03-12 2006-06-22 Intercept Pharmaceuticals, Inc. Steroide als agonisten für fxr
EP1568706A1 (en) 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
PL2040713T3 (pl) * 2006-06-27 2014-11-28 Intercept Pharmaceuticals Inc Pochodne kwasów żółciowych jako ligandy FXR do zapobiegania lub leczenia chorób lub stanów, w których pośredniczy FXR
EP2303026B1 (en) * 2008-06-17 2020-09-09 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
ES2774368T3 (es) * 2008-11-19 2020-07-20 Intercept Pharmaceuticals Inc Moduladores de TGR5 y métodos de uso de los mismos
CN108250264A (zh) 2012-10-26 2018-07-06 英特塞普特医药品公司 制备胆汁酸衍生物的方法

Patent Citations (1)

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CN102164940A (zh) * 2008-07-30 2011-08-24 英特塞普特医药品公司 Tgr5调节剂及其使用方法

Non-Patent Citations (3)

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Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist;Giovanni Rizzo等;《The American Society for Pharmacology and Experimental Therapeutics》;20100714;第78卷(第4期);第617-630页 *
Preparation and degradation of 3α-hydroxycholanic acid;Sarel, Shalom等;《Journal of Organic Chemistry》;19591231;第24卷;第2018-2019页 *

Also Published As

Publication number Publication date
ES2655034T3 (es) 2018-02-16
HK1253301A1 (zh) 2019-06-14
BR112015009395A2 (pt) 2017-07-04
SG11201503247UA (en) 2015-06-29
NO2968302T3 (enExample) 2018-02-03
AU2013334122A1 (en) 2015-05-14
MX361653B (es) 2018-12-13
NZ707389A (en) 2018-08-31
HK1214239A1 (zh) 2016-07-22
HUE036887T2 (hu) 2018-08-28
DK2912013T3 (en) 2018-01-15
US20180079776A1 (en) 2018-03-22
CN105102425A (zh) 2015-11-25
AU2013334122B2 (en) 2017-11-02
KR20150074062A (ko) 2015-07-01
EP2912013A4 (en) 2016-06-01
PL2912013T3 (pl) 2018-05-30
US10202414B2 (en) 2019-02-12
SMT201700602T1 (it) 2018-03-08
IL238454A0 (en) 2015-06-30
KR102068381B1 (ko) 2020-01-20
WO2014066819A1 (en) 2014-05-01
US9777038B2 (en) 2017-10-03
PT2912013T (pt) 2018-01-03
CN108250264A (zh) 2018-07-06
US20150291653A1 (en) 2015-10-15
CY1119731T1 (el) 2018-06-27
JP2015533852A (ja) 2015-11-26
EP2912013A1 (en) 2015-09-02
JP6272888B2 (ja) 2018-01-31
MX2015005286A (es) 2015-10-29
EP2912013B1 (en) 2017-10-11
IL238454B (en) 2018-11-29
NZ745013A (en) 2019-08-30
CA2889592A1 (en) 2014-05-01

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