CN105102425B - 制备胆汁酸衍生物的方法 - Google Patents

制备胆汁酸衍生物的方法 Download PDF

Info

Publication number
CN105102425B
CN105102425B CN201380068062.XA CN201380068062A CN105102425B CN 105102425 B CN105102425 B CN 105102425B CN 201380068062 A CN201380068062 A CN 201380068062A CN 105102425 B CN105102425 B CN 105102425B
Authority
CN
China
Prior art keywords
compound
formula
pharmaceutically acceptable
acceptable salt
idd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380068062.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN105102425A (zh
Inventor
R.佩利恰里
A.焦伊洛
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Intercept Pharmaceuticals Inc
Original Assignee
Intercept Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intercept Pharmaceuticals Inc filed Critical Intercept Pharmaceuticals Inc
Priority to CN201810282054.XA priority Critical patent/CN108250264A/zh
Publication of CN105102425A publication Critical patent/CN105102425A/zh
Application granted granted Critical
Publication of CN105102425B publication Critical patent/CN105102425B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201380068062.XA 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法 Expired - Fee Related CN105102425B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810282054.XA CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718966P 2012-10-26 2012-10-26
US61/718966 2012-10-26
PCT/US2013/066917 WO2014066819A1 (en) 2012-10-26 2013-10-25 Process for preparing bile acid derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201810282054.XA Division CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Publications (2)

Publication Number Publication Date
CN105102425A CN105102425A (zh) 2015-11-25
CN105102425B true CN105102425B (zh) 2018-04-10

Family

ID=50545344

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201380068062.XA Expired - Fee Related CN105102425B (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法
CN201810282054.XA Pending CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201810282054.XA Pending CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Country Status (22)

Country Link
US (2) US9777038B2 (enExample)
EP (1) EP2912013B1 (enExample)
JP (1) JP6272888B2 (enExample)
KR (1) KR102068381B1 (enExample)
CN (2) CN105102425B (enExample)
AU (1) AU2013334122B2 (enExample)
BR (1) BR112015009395A2 (enExample)
CA (1) CA2889592A1 (enExample)
CY (1) CY1119731T1 (enExample)
DK (1) DK2912013T3 (enExample)
ES (1) ES2655034T3 (enExample)
HK (1) HK1253301A1 (enExample)
HU (1) HUE036887T2 (enExample)
IL (1) IL238454B (enExample)
MX (1) MX361653B (enExample)
NO (1) NO2968302T3 (enExample)
NZ (2) NZ707389A (enExample)
PL (1) PL2912013T3 (enExample)
PT (1) PT2912013T (enExample)
SG (1) SG11201503247UA (enExample)
SM (1) SMT201700602T1 (enExample)
WO (1) WO2014066819A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015009395A2 (pt) 2012-10-26 2017-07-04 Intercept Pharmaceuticals Inc processo para preparação de derivados do ácido biliar
WO2015181275A1 (en) * 2014-05-29 2015-12-03 Bar Pharmaceuticals S.R.L. Cholane derivatives for use in the treatment and/or prevention of fxr and tgr5/gpbar1 mediated diseases
WO2016079520A1 (en) 2014-11-19 2016-05-26 Dextra Laboratories Limited 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators
MX375864B (es) 2014-11-19 2025-03-07 Nzp Uk Ltd Esteroides de 5.beta-6-alquil-7-hidroxi-3-ona como intermedios para la produccion de moduladores esteroideos del receptor x farnesoide (fxr)
CN107108688B (zh) 2014-11-19 2019-10-29 Nzp英国有限公司 作为制备类固醇FXR调节剂的中间体的6α-烷基-3,7-二酮类固醇
KR102526631B1 (ko) 2014-11-19 2023-04-27 엔제트피 유케이 리미티드 스테로이드 fxr 조절인자를 제조하기 위한 중간체로서의 6-알킬-7-하이드록시-4-엔-3-온 스테로이드
CN104672290B (zh) * 2015-01-05 2017-06-06 北京普禄德医药科技有限公司 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途
AR103624A1 (es) 2015-02-06 2017-05-24 Intercept Pharmaceuticals Inc Composiciones farmacéuticas para terapia de combinación
HK1254057A1 (zh) * 2015-09-24 2019-07-12 英特塞普特医药品公司 用於制备胆汁酸衍生物的方法和中间体
EP3370728A4 (en) * 2015-11-06 2019-07-10 Intercept Pharmaceuticals, Inc. PROCESS FOR THE PREPARATION OF OBETICHOLIC ACID AND DERIVATIVES THEREOF
US20200262865A1 (en) * 2016-02-15 2020-08-20 Alexander Khoruts Compositions and methods for treating clostridium associated diseases
CN109071452A (zh) 2016-04-13 2018-12-21 英特塞普特医药品公司 治疗癌症的方法
TW201738254A (zh) * 2016-04-19 2017-11-01 英特賽普醫藥品公司 奧貝膽酸及其衍生物之製備方法
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
KR20190057108A (ko) * 2016-09-30 2019-05-27 인터셉트 파마슈티컬즈, 인크. 담즙산 유도체의 결정형
CA3070837A1 (en) 2017-07-24 2019-01-31 Intercept Pharmaceuticals, Inc. Isotopically labeled bile acid derivatives
CN110869381B (zh) * 2017-07-26 2021-11-19 正大天晴药业集团股份有限公司 甾体类衍生物fxr激动剂的制备方法
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
EA202193334A1 (ru) 2019-05-30 2022-03-14 Интерсепт Фармасьютикалз, Инк. Фармацевтические композиции, содержащие агонист fxr и фибрат, для применения при лечении холестатического заболевания печени
JP2022552655A (ja) 2019-10-07 2022-12-19 キャリーオペ，インク． Ｇｐｒ１１９アゴニスト
PH12022552277A1 (en) 2020-02-28 2024-03-04 Kallyope Inc Gpr40 agonists
JP2023526625A (ja) 2020-05-19 2023-06-22 キャリーオペ，インク． Ａｍｐｋアクチベーター
CN116390925A (zh) 2020-06-26 2023-07-04 卡尔优普公司 Ampk活化剂
WO2022059948A1 (ko) 2020-09-18 2022-03-24 서울대학교 산학협력단 소디움 타우로디옥시콜레이트의 대량 생산 방법

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102164940A (zh) * 2008-07-30 2011-08-24 英特塞普特医药品公司 Tgr5调节剂及其使用方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216015A (en) 1991-02-05 1993-06-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having hypocholesterolemic properties
EP1392714B1 (en) 2001-03-12 2005-08-31 Intercept Pharmaceuticals, Inc. Steroids as agonists for fxr
EP1568706A1 (en) 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
DK2040713T3 (da) * 2006-06-27 2014-09-29 Intercept Pharmaceuticals Inc Galdesyrederivater som fxr-ligander til forebyggelsen eller behandlingen af fxr-medierede sygdomme eller tilstande
US9943614B2 (en) 2008-06-17 2018-04-17 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
EP2373673B1 (en) * 2008-11-19 2016-07-27 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
BR112015009395A2 (pt) 2012-10-26 2017-07-04 Intercept Pharmaceuticals Inc processo para preparação de derivados do ácido biliar

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102164940A (zh) * 2008-07-30 2011-08-24 英特塞普特医药品公司 Tgr5调节剂及其使用方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
An Enantioselective Route to α-Methyl Carboxylic Acids via Metal and Enzyme Catalysis;Norinder, Jakob等;《 Organic Letters》;20071231;第9卷(第24期);第5095-5098页 *
Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist;Giovanni Rizzo等;《The American Society for Pharmacology and Experimental Therapeutics》;20100714;第78卷(第4期);第617-630页 *
Preparation and degradation of 3α-hydroxycholanic acid;Sarel, Shalom等;《Journal of Organic Chemistry》;19591231;第24卷;第2018-2019页 *

Also Published As

Publication number Publication date
JP2015533852A (ja) 2015-11-26
HK1214239A1 (zh) 2016-07-22
HUE036887T2 (hu) 2018-08-28
DK2912013T3 (en) 2018-01-15
EP2912013A4 (en) 2016-06-01
AU2013334122B2 (en) 2017-11-02
SMT201700602T1 (it) 2018-03-08
BR112015009395A2 (pt) 2017-07-04
MX361653B (es) 2018-12-13
US20150291653A1 (en) 2015-10-15
SG11201503247UA (en) 2015-06-29
US20180079776A1 (en) 2018-03-22
NZ707389A (en) 2018-08-31
PL2912013T3 (pl) 2018-05-30
US10202414B2 (en) 2019-02-12
NZ745013A (en) 2019-08-30
WO2014066819A1 (en) 2014-05-01
CA2889592A1 (en) 2014-05-01
NO2968302T3 (enExample) 2018-02-03
ES2655034T3 (es) 2018-02-16
IL238454A0 (en) 2015-06-30
CN108250264A (zh) 2018-07-06
KR20150074062A (ko) 2015-07-01
IL238454B (en) 2018-11-29
AU2013334122A1 (en) 2015-05-14
HK1253301A1 (zh) 2019-06-14
KR102068381B1 (ko) 2020-01-20
CY1119731T1 (el) 2018-06-27
US9777038B2 (en) 2017-10-03
MX2015005286A (es) 2015-10-29
PT2912013T (pt) 2018-01-03
EP2912013B1 (en) 2017-10-11
JP6272888B2 (ja) 2018-01-31
CN105102425A (zh) 2015-11-25
EP2912013A1 (en) 2015-09-02

Similar Documents

Publication Publication Date Title
CN105102425B (zh) 制备胆汁酸衍生物的方法
ES2717226T3 (es) Método de producción de beraprost
EP1806338B1 (en) Process for producing 2-amino-2-[2-[4-(3-benzyloxy-phenylthio)-2-chlorophenyl[ethyl]-1,3-propanediol hydrochloride and hydrates thereof. and intermediates the production thereof
CN101193880A (zh) 喜巴辛类似物的外型和非对映立体选择合成
ITMI990134A1 (it) Metodo di sintesi di nitrossimetilfenil esteri di derivati dell'aspirina
KR20110004528A (ko) 트리사이클릭 유도체의 제조방법
CN115448971B (zh) 一种用于制备氟维司群的中间体及其制备方法
TWI623521B (zh) 一種製備利馬前列素的中間體、其製備方法以及藉由其製備利馬前列素的方法
AU2007298920B2 (en) Fluorinated catharanthine derivatives, their preparation and their utilisation as Vinca dimeric alkaloid precursors
Bisht et al. Domino reactions of alkenyl p-benzoquinones: Access to aryl sulfide derivatives of coumarins
HK1214239B (en) Process for preparing bile acid derivatives
CN110642689B (zh) 一种3,6-二溴-2-甲基苯甲醛及其化学合成方法
PL243187B1 (pl) Sposób i związki pośrednie do otrzymywania menachinonu MK-7
US6255540B1 (en) Methods for producing two-substituted glycerols having various levels of protection
CN101210010B (zh) 新型大环多聚二硫醚化合物木榄环六硫醇的合成方法
CN118359521A (zh) 一种硫醚或硫酯类化合物的制备方法
JP2019131510A (ja) ルビプロストンの製造方法
JPH01100195A (ja) １α，２４―ジヒドロキシコレステロール類の製造法
PL197215B1 (pl) Nowy chiralny bromospirolakton karanu i sposób jego wytwarzania
PL198843B1 (pl) Sposób wytwarzania N-nonylokarbazolu
JPH09143177A (ja) スルホネート誘導体およびその製造法

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1214239

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant
CP02 Change in the address of a patent holder

Address after: New jersey, USA

Patentee after: INTERCEPT PHARMACEUTICALS, Inc.

Address before: New York, United States

Patentee before: INTERCEPT PHARMACEUTICALS, Inc.

CP02 Change in the address of a patent holder
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20180410

CF01 Termination of patent right due to non-payment of annual fee