CN105102425B - 制备胆汁酸衍生物的方法 - Google Patents

制备胆汁酸衍生物的方法 Download PDF

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Publication number
CN105102425B
CN105102425B CN201380068062.XA CN201380068062A CN105102425B CN 105102425 B CN105102425 B CN 105102425B CN 201380068062 A CN201380068062 A CN 201380068062A CN 105102425 B CN105102425 B CN 105102425B
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China
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compound
formula
pharmaceutically acceptable
acceptable salt
idd
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Expired - Fee Related
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CN201380068062.XA
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English (en)
Chinese (zh)
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CN105102425A (zh
Inventor
R.佩利恰里
A.焦伊洛
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Intercept Pharmaceuticals Inc
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Intercept Pharmaceuticals Inc
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Priority to CN201810282054.XA priority Critical patent/CN108250264A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201380068062.XA 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法 Expired - Fee Related CN105102425B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810282054.XA CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261718966P 2012-10-26 2012-10-26
US61/718966 2012-10-26
PCT/US2013/066917 WO2014066819A1 (en) 2012-10-26 2013-10-25 Process for preparing bile acid derivatives

Related Child Applications (1)

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CN201810282054.XA Division CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Publications (2)

Publication Number Publication Date
CN105102425A CN105102425A (zh) 2015-11-25
CN105102425B true CN105102425B (zh) 2018-04-10

Family

ID=50545344

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CN201380068062.XA Expired - Fee Related CN105102425B (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法
CN201810282054.XA Pending CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

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CN201810282054.XA Pending CN108250264A (zh) 2012-10-26 2013-10-25 制备胆汁酸衍生物的方法

Country Status (22)

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US (2) US9777038B2 (enExample)
EP (1) EP2912013B1 (enExample)
JP (1) JP6272888B2 (enExample)
KR (1) KR102068381B1 (enExample)
CN (2) CN105102425B (enExample)
AU (1) AU2013334122B2 (enExample)
BR (1) BR112015009395A2 (enExample)
CA (1) CA2889592A1 (enExample)
CY (1) CY1119731T1 (enExample)
DK (1) DK2912013T3 (enExample)
ES (1) ES2655034T3 (enExample)
HK (1) HK1253301A1 (enExample)
HU (1) HUE036887T2 (enExample)
IL (1) IL238454B (enExample)
MX (1) MX361653B (enExample)
NO (1) NO2968302T3 (enExample)
NZ (2) NZ707389A (enExample)
PL (1) PL2912013T3 (enExample)
PT (1) PT2912013T (enExample)
SG (1) SG11201503247UA (enExample)
SM (1) SMT201700602T1 (enExample)
WO (1) WO2014066819A1 (enExample)

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HUE036887T2 (hu) 2012-10-26 2018-08-28 Intercept Pharmaceuticals Inc Eljárás epesav-származékok elõállítására
EP3626725B1 (en) * 2014-05-29 2022-11-30 Bar Pharmaceuticals S.r.l. Cholane derivatives for use in the treatment and/or prevention of fxr and tgr5/gpbar1 mediated diseases
EA033445B1 (ru) 2014-11-19 2019-10-31 Nzp Uk Ltd 5-бета-6-алкил-7-гидрокси-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr
EP3221333B1 (en) 2014-11-19 2019-07-24 NZP UK Limited 6.alpha.-alkyl-3,7-dione steroids as intermediates for the production of steroidal fxr modulators
EP3221331B1 (en) 2014-11-19 2019-09-18 Nzp Uk Limited 6-alkyl-7-hydroxy-4-en-3-one steroids as intermediates for the production of steroidal fxr modulators
JP6698085B2 (ja) 2014-11-19 2020-05-27 エヌゼットピー ユーケー リミテッド ステロイドＦＸＲモジュレーター製造のための中間体としての６α−アルキル−６，７−ジオン−ステロイド
CN104672290B (zh) * 2015-01-05 2017-06-06 北京普禄德医药科技有限公司 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途
TN2017000344A1 (en) 2015-02-06 2019-01-16 Intercept Pharmaceuticals Inc Pharmaceutical compositions for combination therapy
CN108350020A (zh) * 2015-09-24 2018-07-31 英特塞普特医药品公司 用于制备胆汁酸衍生物的方法和中间体
KR20180067699A (ko) 2015-11-06 2018-06-20 인터셉트 파마슈티컬즈, 인크. 오베티콜산 및 이의 유도체의 제조 방법
WO2017142895A1 (en) * 2016-02-15 2017-08-24 Regents Of The University Of Minnesota Compositions and methods for treating clostridium associated diseases
WO2017180577A1 (en) 2016-04-13 2017-10-19 Intercept Pharmaceuticals, Inc. Methods of treating cancer
TW201738254A (zh) * 2016-04-19 2017-11-01 英特賽普醫藥品公司 奧貝膽酸及其衍生物之製備方法
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
CA3038534A1 (en) * 2016-09-30 2018-04-05 Intercept Pharmaceuticals, Inc. Crystalline forms of a bile acid derivative
MX2020000873A (es) * 2017-07-24 2020-07-22 Intercept Pharmaceuticals Inc Derivados de ácidos biliares marcados isotópicamente.
WO2019020067A1 (zh) * 2017-07-26 2019-01-31 正大天晴药业集团股份有限公司 甾体类衍生物fxr激动剂的制备方法
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
EA202193334A1 (ru) 2019-05-30 2022-03-14 Интерсепт Фармасьютикалз, Инк. Фармацевтические композиции, содержащие агонист fxr и фибрат, для применения при лечении холестатического заболевания печени
BR112022006546A2 (pt) 2019-10-07 2022-08-30 Kallyope Inc Agonistas de gpr119
CA3173731A1 (en) 2020-02-28 2021-09-02 Kallyope, Inc. Gpr40 agonists
CN116323608A (zh) 2020-05-19 2023-06-23 卡尔优普公司 Ampk活化剂
EP4172162A4 (en) 2020-06-26 2024-08-07 Kallyope, Inc. AMPK ACTIVATORS
WO2022059948A1 (ko) 2020-09-18 2022-03-24 서울대학교 산학협력단 소디움 타우로디옥시콜레이트의 대량 생산 방법

Citations (1)

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CN102164940A (zh) * 2008-07-30 2011-08-24 英特塞普特医药品公司 Tgr5调节剂及其使用方法

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US5216015A (en) * 1991-02-05 1993-06-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having hypocholesterolemic properties
ATE303399T1 (de) * 2001-03-12 2005-09-15 Intercept Pharmaceuticals Inc Steroide als agonisten für fxr
EP1568706A1 (en) 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
CN101522703B (zh) * 2006-06-27 2013-04-17 英特塞普特医药品公司 胆酸派生物及其在制备预防或治疗fxr介导的疾病或状况的药物中的应用
US9943614B2 (en) * 2008-06-17 2018-04-17 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
CA2744135C (en) * 2008-11-19 2017-07-04 Intercept Pharmaceuticals, Inc. Tgr5 modulators and methods of use thereof
HUE036887T2 (hu) 2012-10-26 2018-08-28 Intercept Pharmaceuticals Inc Eljárás epesav-származékok elõállítására

Patent Citations (1)

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CN102164940A (zh) * 2008-07-30 2011-08-24 英特塞普特医药品公司 Tgr5调节剂及其使用方法

Non-Patent Citations (3)

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Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist;Giovanni Rizzo等;《The American Society for Pharmacology and Experimental Therapeutics》;20100714;第78卷(第4期);第617-630页 *
Preparation and degradation of 3α-hydroxycholanic acid;Sarel, Shalom等;《Journal of Organic Chemistry》;19591231;第24卷;第2018-2019页 *

Also Published As

Publication number Publication date
JP2015533852A (ja) 2015-11-26
ES2655034T3 (es) 2018-02-16
KR20150074062A (ko) 2015-07-01
SMT201700602T1 (it) 2018-03-08
CA2889592A1 (en) 2014-05-01
NO2968302T3 (enExample) 2018-02-03
KR102068381B1 (ko) 2020-01-20
EP2912013A1 (en) 2015-09-02
HK1253301A1 (zh) 2019-06-14
NZ707389A (en) 2018-08-31
HK1214239A1 (zh) 2016-07-22
HUE036887T2 (hu) 2018-08-28
JP6272888B2 (ja) 2018-01-31
CY1119731T1 (el) 2018-06-27
AU2013334122B2 (en) 2017-11-02
US9777038B2 (en) 2017-10-03
AU2013334122A1 (en) 2015-05-14
US20180079776A1 (en) 2018-03-22
SG11201503247UA (en) 2015-06-29
CN105102425A (zh) 2015-11-25
MX2015005286A (es) 2015-10-29
BR112015009395A2 (pt) 2017-07-04
EP2912013A4 (en) 2016-06-01
US10202414B2 (en) 2019-02-12
NZ745013A (en) 2019-08-30
CN108250264A (zh) 2018-07-06
MX361653B (es) 2018-12-13
DK2912013T3 (en) 2018-01-15
WO2014066819A1 (en) 2014-05-01
PT2912013T (pt) 2018-01-03
US20150291653A1 (en) 2015-10-15
IL238454B (en) 2018-11-29
PL2912013T3 (pl) 2018-05-30
IL238454A0 (en) 2015-06-30
EP2912013B1 (en) 2017-10-11

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