CN108250264A - 制备胆汁酸衍生物的方法 - Google Patents
制备胆汁酸衍生物的方法 Download PDFInfo
- Publication number
- CN108250264A CN108250264A CN201810282054.XA CN201810282054A CN108250264A CN 108250264 A CN108250264 A CN 108250264A CN 201810282054 A CN201810282054 A CN 201810282054A CN 108250264 A CN108250264 A CN 108250264A
- Authority
- CN
- China
- Prior art keywords
- formula
- compound
- pharmaceutically acceptable
- acceptable salt
- idd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CC[C@]1[C@@](*)C(C(CC2)[C@](C)(CC3)[C@]2[C@](C)CCO)C3[C@@](C)(CC[C@](C2)OC(C)=O)[C@]2CC1 Chemical compound CC[C@]1[C@@](*)C(C(CC2)[C@](C)(CC3)[C@]2[C@](C)CCO)C3[C@@](C)(CC[C@](C2)OC(C)=O)[C@]2CC1 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261718966P | 2012-10-26 | 2012-10-26 | |
| US61/718,966 | 2012-10-26 | ||
| CN201380068062.XA CN105102425B (zh) | 2012-10-26 | 2013-10-25 | 制备胆汁酸衍生物的方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380068062.XA Division CN105102425B (zh) | 2012-10-26 | 2013-10-25 | 制备胆汁酸衍生物的方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108250264A true CN108250264A (zh) | 2018-07-06 |
Family
ID=50545344
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380068062.XA Expired - Fee Related CN105102425B (zh) | 2012-10-26 | 2013-10-25 | 制备胆汁酸衍生物的方法 |
| CN201810282054.XA Pending CN108250264A (zh) | 2012-10-26 | 2013-10-25 | 制备胆汁酸衍生物的方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201380068062.XA Expired - Fee Related CN105102425B (zh) | 2012-10-26 | 2013-10-25 | 制备胆汁酸衍生物的方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US9777038B2 (enExample) |
| EP (1) | EP2912013B1 (enExample) |
| JP (1) | JP6272888B2 (enExample) |
| KR (1) | KR102068381B1 (enExample) |
| CN (2) | CN105102425B (enExample) |
| AU (1) | AU2013334122B2 (enExample) |
| BR (1) | BR112015009395A2 (enExample) |
| CA (1) | CA2889592A1 (enExample) |
| CY (1) | CY1119731T1 (enExample) |
| DK (1) | DK2912013T3 (enExample) |
| ES (1) | ES2655034T3 (enExample) |
| HK (1) | HK1253301A1 (enExample) |
| HU (1) | HUE036887T2 (enExample) |
| IL (1) | IL238454B (enExample) |
| MX (1) | MX361653B (enExample) |
| NO (1) | NO2968302T3 (enExample) |
| NZ (2) | NZ745013A (enExample) |
| PL (1) | PL2912013T3 (enExample) |
| PT (1) | PT2912013T (enExample) |
| SG (1) | SG11201503247UA (enExample) |
| SM (1) | SMT201700602T1 (enExample) |
| WO (1) | WO2014066819A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9777038B2 (en) | 2012-10-26 | 2017-10-03 | Intercept Pharmaceuticals, Inc. | Process for preparing bile acid derivatives |
| PT3149019T (pt) | 2014-05-29 | 2020-02-19 | Bar Pharmaceuticals S R L | Derivados de colano para utilização no tratamento e/ou na prevenção de doenças mediadas por fxr e tgr5/gp-bar1 |
| ES2748692T3 (es) | 2014-11-19 | 2020-03-17 | Nzp Uk Ltd | Esteroides 6.alfa.-alquil-3,7-diona como intermedios para la producción de moduladores FXR de esteroides |
| EA033427B1 (ru) | 2014-11-19 | 2019-10-31 | Nzp Uk Ltd | 6-алкил-7-гидрокси-4-ен-3-оновые стероиды в качестве промежуточных соединений для получения стероидных модуляторов fxr |
| PL3221332T3 (pl) | 2014-11-19 | 2019-10-31 | Nzp Uk Ltd | Steroidy, 5.beta.-6-alkilo-7-hydroksy-3-ony jako związki pośrednie do wytwarzania steroidowych modulatorów fxr |
| KR102527821B1 (ko) | 2014-11-19 | 2023-05-02 | 엔제트피 유케이 리미티드 | 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-6,7-다이온 스테로이드 |
| CN104672290B (zh) * | 2015-01-05 | 2017-06-06 | 北京普禄德医药科技有限公司 | 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途 |
| BR112017016766B1 (pt) | 2015-02-06 | 2023-11-07 | Intercept Pharmaceuticals, Inc | Composição compreendendo um agonista fxr e fibrato, bem como uso para tratar doença hepática colestática |
| CN108350020A (zh) | 2015-09-24 | 2018-07-31 | 英特塞普特医药品公司 | 用于制备胆汁酸衍生物的方法和中间体 |
| EP3370728A4 (en) * | 2015-11-06 | 2019-07-10 | Intercept Pharmaceuticals, Inc. | PROCESS FOR THE PREPARATION OF OBETICHOLIC ACID AND DERIVATIVES THEREOF |
| WO2017142895A1 (en) * | 2016-02-15 | 2017-08-24 | Regents Of The University Of Minnesota | Compositions and methods for treating clostridium associated diseases |
| KR102377338B1 (ko) | 2016-04-13 | 2022-03-21 | 인터셉트 파마슈티컬즈, 인크. | 암의 치료 방법 |
| TW201738254A (zh) | 2016-04-19 | 2017-11-01 | 英特賽普醫藥品公司 | 奧貝膽酸及其衍生物之製備方法 |
| GB201608776D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Methods and compounds |
| GB201608777D0 (en) | 2016-05-18 | 2016-06-29 | Dextra Lab Ltd | Compounds |
| MX2019003684A (es) * | 2016-09-30 | 2019-08-05 | Intercept Pharmaceuticals Inc | Formas cristalinas de un derivado de acido biliar. |
| MX2020000873A (es) * | 2017-07-24 | 2020-07-22 | Intercept Pharmaceuticals Inc | Derivados de ácidos biliares marcados isotópicamente. |
| CN110869381B (zh) * | 2017-07-26 | 2021-11-19 | 正大天晴药业集团股份有限公司 | 甾体类衍生物fxr激动剂的制备方法 |
| GB201812382D0 (en) | 2018-07-30 | 2018-09-12 | Nzp Uk Ltd | Compounds |
| JP2022536060A (ja) | 2019-05-30 | 2022-08-12 | インターセプト ファーマシューティカルズ， インコーポレイテッド | 胆汁鬱滞性肝疾患の処置で使用するためのｆｘｒアゴニストおよびフィブラートを含む医薬組成物 |
| KR20220150270A (ko) | 2019-10-07 | 2022-11-10 | 칼리오페, 인크. | Gpr119 효능제 |
| JP7745559B2 (ja) | 2020-02-28 | 2025-09-29 | キャリーオペ，インク． | Ｇｐｒ４０アゴニスト |
| BR112022023359A2 (pt) | 2020-05-19 | 2023-04-18 | Kallyope Inc | Ativadores de ampk |
| JP2023531726A (ja) | 2020-06-26 | 2023-07-25 | キャリーオペ，インク． | Ａｍｐｋアクチベーター |
| WO2022059948A1 (ko) | 2020-09-18 | 2022-03-24 | 서울대학교 산학협력단 | 소디움 타우로디옥시콜레이트의 대량 생산 방법 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101522703A (zh) * | 2006-06-27 | 2009-09-02 | 英特塞普特医药品公司 | 胆酸派生物作为fxr配基预防或治疗fxr-介导的疾病或状况 |
| CN102164940A (zh) * | 2008-07-30 | 2011-08-24 | 英特塞普特医药品公司 | Tgr5调节剂及其使用方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5216015A (en) * | 1991-02-05 | 1993-06-01 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Compounds having hypocholesterolemic properties |
| EP1392714B1 (en) | 2001-03-12 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Steroids as agonists for fxr |
| EP1568706A1 (en) * | 2004-02-26 | 2005-08-31 | Intercept Pharmaceuticals, Inc. | Novel steroid agonist for FXR |
| EP2303026B1 (en) * | 2008-06-17 | 2020-09-09 | Brigham Young University | Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods |
| EP2373673B1 (en) * | 2008-11-19 | 2016-07-27 | Intercept Pharmaceuticals, Inc. | Tgr5 modulators and methods of use thereof |
| US9777038B2 (en) | 2012-10-26 | 2017-10-03 | Intercept Pharmaceuticals, Inc. | Process for preparing bile acid derivatives |
-
2013
- 2013-10-25 US US14/438,323 patent/US9777038B2/en active Active
- 2013-10-25 WO PCT/US2013/066917 patent/WO2014066819A1/en not_active Ceased
- 2013-10-25 AU AU2013334122A patent/AU2013334122B2/en not_active Ceased
- 2013-10-25 CA CA2889592A patent/CA2889592A1/en not_active Abandoned
- 2013-10-25 NZ NZ745013A patent/NZ745013A/en not_active IP Right Cessation
- 2013-10-25 SG SG11201503247UA patent/SG11201503247UA/en unknown
- 2013-10-25 DK DK13849263.2T patent/DK2912013T3/en active
- 2013-10-25 JP JP2015539862A patent/JP6272888B2/ja not_active Expired - Fee Related
- 2013-10-25 CN CN201380068062.XA patent/CN105102425B/zh not_active Expired - Fee Related
- 2013-10-25 HU HUE13849263A patent/HUE036887T2/hu unknown
- 2013-10-25 ES ES13849263.2T patent/ES2655034T3/es active Active
- 2013-10-25 EP EP13849263.2A patent/EP2912013B1/en not_active Not-in-force
- 2013-10-25 PT PT138492632T patent/PT2912013T/pt unknown
- 2013-10-25 MX MX2015005286A patent/MX361653B/es active IP Right Grant
- 2013-10-25 BR BR112015009395A patent/BR112015009395A2/pt not_active Application Discontinuation
- 2013-10-25 PL PL13849263T patent/PL2912013T3/pl unknown
- 2013-10-25 CN CN201810282054.XA patent/CN108250264A/zh active Pending
- 2013-10-25 NZ NZ707389A patent/NZ707389A/en not_active IP Right Cessation
- 2013-10-25 SM SM20170602T patent/SMT201700602T1/it unknown
- 2013-10-25 KR KR1020157012805A patent/KR102068381B1/ko not_active Expired - Fee Related
-
2014
- 2014-03-14 NO NO14725812A patent/NO2968302T3/no unknown
-
2015
- 2015-04-26 IL IL238454A patent/IL238454B/en active IP Right Grant
-
2016
- 2016-02-24 HK HK18112593.6A patent/HK1253301A1/zh unknown
-
2017
- 2017-08-21 US US15/681,609 patent/US10202414B2/en not_active Expired - Fee Related
-
2018
- 2018-01-03 CY CY20181100003T patent/CY1119731T1/el unknown
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101522703A (zh) * | 2006-06-27 | 2009-09-02 | 英特塞普特医药品公司 | 胆酸派生物作为fxr配基预防或治疗fxr-介导的疾病或状况 |
| CN102164940A (zh) * | 2008-07-30 | 2011-08-24 | 英特塞普特医药品公司 | Tgr5调节剂及其使用方法 |
Non-Patent Citations (2)
| Title |
|---|
| GIOVANNI RIZZO等: "Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist", 《THE AMERICAN SOCIETY FOR PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS》 * |
| NORINDER, JAKOB等: "An Enantioselective Route to α-Methyl Carboxylic Acids via Metal and Enzyme Catalysis", 《ORGANIC LETTERS》 * |
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