NZ745013A - Process for preparing bile acid derivatives - Google Patents

Process for preparing bile acid derivatives

Info

Publication number
NZ745013A
NZ745013A NZ745013A NZ74501313A NZ745013A NZ 745013 A NZ745013 A NZ 745013A NZ 745013 A NZ745013 A NZ 745013A NZ 74501313 A NZ74501313 A NZ 74501313A NZ 745013 A NZ745013 A NZ 745013A
Authority
NZ
New Zealand
Prior art keywords
compound
formula
acid derivatives
bile acid
preparing
Prior art date
Application number
NZ745013A
Other languages
English (en)
Inventor
Roberto Pellicciari
Antimo Gioiello
Original Assignee
Intercept Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intercept Pharmaceuticals Inc filed Critical Intercept Pharmaceuticals Inc
Publication of NZ745013A publication Critical patent/NZ745013A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NZ745013A 2012-10-26 2013-10-25 Process for preparing bile acid derivatives NZ745013A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261718966P 2012-10-26 2012-10-26
NZ707389A NZ707389A (en) 2012-10-26 2013-10-25 Process for preparing bile acid derivatives

Publications (1)

Publication Number Publication Date
NZ745013A true NZ745013A (en) 2019-08-30

Family

ID=50545344

Family Applications (2)

Application Number Title Priority Date Filing Date
NZ745013A NZ745013A (en) 2012-10-26 2013-10-25 Process for preparing bile acid derivatives
NZ707389A NZ707389A (en) 2012-10-26 2013-10-25 Process for preparing bile acid derivatives

Family Applications After (1)

Application Number Title Priority Date Filing Date
NZ707389A NZ707389A (en) 2012-10-26 2013-10-25 Process for preparing bile acid derivatives

Country Status (22)

Country Link
US (2) US9777038B2 (enExample)
EP (1) EP2912013B1 (enExample)
JP (1) JP6272888B2 (enExample)
KR (1) KR102068381B1 (enExample)
CN (2) CN105102425B (enExample)
AU (1) AU2013334122B2 (enExample)
BR (1) BR112015009395A2 (enExample)
CA (1) CA2889592A1 (enExample)
CY (1) CY1119731T1 (enExample)
DK (1) DK2912013T3 (enExample)
ES (1) ES2655034T3 (enExample)
HK (1) HK1253301A1 (enExample)
HU (1) HUE036887T2 (enExample)
IL (1) IL238454B (enExample)
MX (1) MX361653B (enExample)
NO (1) NO2968302T3 (enExample)
NZ (2) NZ745013A (enExample)
PL (1) PL2912013T3 (enExample)
PT (1) PT2912013T (enExample)
SG (1) SG11201503247UA (enExample)
SM (1) SMT201700602T1 (enExample)
WO (1) WO2014066819A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2912013B1 (en) 2012-10-26 2017-10-11 Intercept Pharmaceuticals, Inc. Process for preparing bile acid derivatives
FI3626725T3 (fi) * 2014-05-29 2023-03-16 Bar Pharmaceuticals S R L Kolaanijohdannaisia käytettäväksi FXR:n ja TGR5:n/GPBAR1:n välittämien sairauksien hoidossa ja/tai ennaltaehkäisyssä
CN107108687B (zh) 2014-11-19 2019-10-29 Nzp英国有限公司 作为制备类固醇FXR调节剂的中间体的5β-6-烷基-7-羟基-3-酮类固醇
CA2968310A1 (en) 2014-11-19 2016-05-26 NZP UK Limited 6.alpha.-alkyl-6,7-dione steroids as intermediates for the production of steroidal fxr modulators
TWI690536B (zh) 2014-11-19 2020-04-11 英商Ｎｚｐ英國有限公司 化合物（一）
KR102546748B1 (ko) 2014-11-19 2023-06-22 엔제트피 유케이 리미티드 스테로이드 FXR 조절인자를 제조하기 위한 중간체로서의 6α-알킬-3,7-다이온 스테로이드
CN104672290B (zh) * 2015-01-05 2017-06-06 北京普禄德医药科技有限公司 一种用于预防或治疗fxr‑介导的疾病的药物及其制备方法和用途
US11311557B2 (en) 2015-02-06 2022-04-26 Intercept Pharmaceuticals, Inc. Pharmaceutical compositions for combination therapy
EP3353189A4 (en) 2015-09-24 2019-06-19 Intercept Pharmaceuticals, Inc. METHOD AND INTERMEDIATE PRODUCTS FOR THE PREPARATION OF GALLENIC ACID DERIVATIVES
AU2016350690C1 (en) * 2015-11-06 2020-04-23 Intercept Pharmaceuticals, Inc. Methods for the preparation of obeticholic acid and derivatives thereof
US20200262865A1 (en) * 2016-02-15 2020-08-20 Alexander Khoruts Compositions and methods for treating clostridium associated diseases
US10369160B2 (en) 2016-04-13 2019-08-06 Intercept Pharmaceuticals, Inc. Methods of treating cancer
TW201738254A (zh) * 2016-04-19 2017-11-01 英特賽普醫藥品公司 奧貝膽酸及其衍生物之製備方法
GB201608777D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Compounds
GB201608776D0 (en) 2016-05-18 2016-06-29 Dextra Lab Ltd Methods and compounds
CA3038534A1 (en) * 2016-09-30 2018-04-05 Intercept Pharmaceuticals, Inc. Crystalline forms of a bile acid derivative
MX2020000873A (es) 2017-07-24 2020-07-22 Intercept Pharmaceuticals Inc Derivados de ácidos biliares marcados isotópicamente.
CN110869381B (zh) * 2017-07-26 2021-11-19 正大天晴药业集团股份有限公司 甾体类衍生物fxr激动剂的制备方法
GB201812382D0 (en) 2018-07-30 2018-09-12 Nzp Uk Ltd Compounds
CA3142358A1 (en) 2019-05-30 2020-12-03 Intercept Pharmaceuticals, Inc. Pharmaceutical compositions comprising a fxr agonist and a fibrate for use in the treatment of cholestatic liver disease
WO2021071837A1 (en) 2019-10-07 2021-04-15 Kallyope, Inc. Gpr119 agonists
TW202140440A (zh) 2020-02-28 2021-11-01 美商克力歐普股份有限公司 Gpr40激動劑
UY39222A (es) 2020-05-19 2021-11-30 Kallyope Inc Activadores de la ampk
AU2021297323A1 (en) 2020-06-26 2023-02-16 Kallyope, Inc. AMPK activators
JP7583398B2 (ja) 2020-09-18 2024-11-14 ソウル大学校産学協力団 タウロデオキシコール酸ナトリウムの大量生産方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5216015A (en) * 1991-02-05 1993-06-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compounds having hypocholesterolemic properties
ES2248581T3 (es) 2001-03-12 2006-03-16 Intercept Pharmaceuticals, Inc. Esteroides como agonistas de fxr.
EP1568706A1 (en) 2004-02-26 2005-08-31 Intercept Pharmaceuticals, Inc. Novel steroid agonist for FXR
CA2656320C (en) 2006-06-27 2015-04-28 Intercept Pharmaceuticals, Inc. Bile acid derivatives as fxr ligands for the prevention or treatment of fxr-mediated diseases or conditions
WO2010036427A1 (en) * 2008-06-17 2010-04-01 Brigham Young University Cationic steroid antimicrobial diagnostic, detection, screening and imaging methods
AU2009276507B2 (en) * 2008-07-30 2015-11-19 Intercept Pharmaceuticals, Inc. TGR5 modulators and methods of use thereof
CN106380502A (zh) * 2008-11-19 2017-02-08 英特塞普特医药品公司 G蛋白偶联受体5(tgr5)调节剂及其使用方法
EP2912013B1 (en) 2012-10-26 2017-10-11 Intercept Pharmaceuticals, Inc. Process for preparing bile acid derivatives

Also Published As

Publication number Publication date
AU2013334122A1 (en) 2015-05-14
US20180079776A1 (en) 2018-03-22
MX361653B (es) 2018-12-13
CY1119731T1 (el) 2018-06-27
EP2912013B1 (en) 2017-10-11
IL238454B (en) 2018-11-29
PL2912013T3 (pl) 2018-05-30
US10202414B2 (en) 2019-02-12
EP2912013A1 (en) 2015-09-02
KR102068381B1 (ko) 2020-01-20
AU2013334122B2 (en) 2017-11-02
US20150291653A1 (en) 2015-10-15
EP2912013A4 (en) 2016-06-01
KR20150074062A (ko) 2015-07-01
CN108250264A (zh) 2018-07-06
JP2015533852A (ja) 2015-11-26
IL238454A0 (en) 2015-06-30
BR112015009395A2 (pt) 2017-07-04
SMT201700602T1 (it) 2018-03-08
DK2912013T3 (en) 2018-01-15
HK1214239A1 (zh) 2016-07-22
HUE036887T2 (hu) 2018-08-28
NZ707389A (en) 2018-08-31
HK1253301A1 (zh) 2019-06-14
MX2015005286A (es) 2015-10-29
NO2968302T3 (enExample) 2018-02-03
JP6272888B2 (ja) 2018-01-31
CN105102425B (zh) 2018-04-10
US9777038B2 (en) 2017-10-03
ES2655034T3 (es) 2018-02-16
SG11201503247UA (en) 2015-06-29
PT2912013T (pt) 2018-01-03
CA2889592A1 (en) 2014-05-01
WO2014066819A1 (en) 2014-05-01
CN105102425A (zh) 2015-11-25

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Legal Events

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PSEA Patent sealed
RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 25 OCT 2021 BY COMPUTER PACKAGES INC

Effective date: 20201001

RENW Renewal (renewal fees accepted)

Free format text: PATENT RENEWED FOR 1 YEAR UNTIL 25 OCT 2022 BY COMPUTER PACKAGES INC

Effective date: 20210930

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