KR101974044B1 - 주어진 표적에 대한 친화성을 갖는 인간의 리포칼린 2의 뮤테인 - Google Patents

주어진 표적에 대한 친화성을 갖는 인간의 리포칼린 2의 뮤테인 Download PDF

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KR101974044B1
KR101974044B1 KR1020187007781A KR20187007781A KR101974044B1 KR 101974044 B1 KR101974044 B1 KR 101974044B1 KR 1020187007781 A KR1020187007781 A KR 1020187007781A KR 20187007781 A KR20187007781 A KR 20187007781A KR 101974044 B1 KR101974044 B1 KR 101974044B1
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mutein
muteins
sequence
seq
lcn2
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KR20180031081A (ko
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아르네 스케라
미케일라 게바우어
도미닉 힌츠
사비네 라우트
가브릴레 마취너
마르틴 후엘스마이어
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피어이스 파마슈티컬즈 게엠베하
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
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    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C12N2795/00—Bacteriophages
    • C12N2795/00011—Details
    • C12N2795/00041—Use of virus, viral particle or viral elements as a vector

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KR1020187007781A 2009-12-07 2010-12-07 주어진 표적에 대한 친화성을 갖는 인간의 리포칼린 2의 뮤테인 Active KR101974044B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26709809P 2009-12-07 2009-12-07
US61/267,098 2009-12-07
PCT/EP2010/069028 WO2011069992A2 (en) 2009-12-07 2010-12-07 Muteins of human lipocalin 2 (lcn2, hngal) with affinity for a given target

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KR1020127017730A Division KR101842076B1 (ko) 2009-12-07 2010-12-07 주어진 표적에 대한 친화성을 갖는 인간의 리포칼린 2의 뮤테인

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KR20180031081A KR20180031081A (ko) 2018-03-27
KR101974044B1 true KR101974044B1 (ko) 2019-04-30

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KR1020127017730A Active KR101842076B1 (ko) 2009-12-07 2010-12-07 주어진 표적에 대한 친화성을 갖는 인간의 리포칼린 2의 뮤테인

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US (3) US9549968B2 (enExample)
EP (3) EP2510357B1 (enExample)
JP (5) JP5913120B2 (enExample)
KR (2) KR101974044B1 (enExample)
CN (1) CN102770764B (enExample)
AU (1) AU2010329995B2 (enExample)
BR (1) BR112012013662B1 (enExample)
CA (1) CA2779562C (enExample)
DK (2) DK2990798T3 (enExample)
RU (2) RU2707126C2 (enExample)
SG (1) SG10201408073XA (enExample)
WO (1) WO2011069992A2 (enExample)

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US20200308237A1 (en) 2020-10-01
US20170114109A1 (en) 2017-04-27
JP2013512683A (ja) 2013-04-18
JP6346159B2 (ja) 2018-06-20
SG10201408073XA (en) 2015-01-29
JP2018148914A (ja) 2018-09-27
WO2011069992A2 (en) 2011-06-16
JP2022160410A (ja) 2022-10-19
RU2707126C2 (ru) 2019-11-22
EP2990798A1 (en) 2016-03-02
RU2015137158A3 (enExample) 2018-12-25
CA2779562C (en) 2019-12-31
JP2021006024A (ja) 2021-01-21
AU2010329995A1 (en) 2012-05-10
CA2779562A1 (en) 2011-06-16
EP2990798B1 (en) 2019-09-25
JP2016105709A (ja) 2016-06-16
US20130079286A1 (en) 2013-03-28
WO2011069992A3 (en) 2011-08-11
RU2012128586A (ru) 2014-01-20
CN102770764B (zh) 2016-04-20
DK2990798T3 (da) 2019-12-02
JP7482544B2 (ja) 2024-05-14
US9549968B2 (en) 2017-01-24
KR20180031081A (ko) 2018-03-27
US11827681B2 (en) 2023-11-28
JP5913120B2 (ja) 2016-05-11
RU2015137158A (ru) 2018-12-25
BR112012013662B1 (pt) 2022-08-02
EP3660510A3 (en) 2020-07-08
DK2510357T3 (en) 2016-07-18
US10618941B2 (en) 2020-04-14
KR20120117815A (ko) 2012-10-24
AU2010329995B2 (en) 2015-09-17
EP2510357B1 (en) 2016-03-30
BR112012013662A2 (pt) 2020-11-03
RU2564125C2 (ru) 2015-09-27
KR101842076B1 (ko) 2018-03-27
EP3660510A2 (en) 2020-06-03
CN102770764A (zh) 2012-11-07
EP2510357A2 (en) 2012-10-17

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