KR101730052B1 - 심근경색의 수복 재생을 유도하는 다능성 간세포 - Google Patents

심근경색의 수복 재생을 유도하는 다능성 간세포 Download PDF

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KR101730052B1
KR101730052B1 KR1020157006629A KR20157006629A KR101730052B1 KR 101730052 B1 KR101730052 B1 KR 101730052B1 KR 1020157006629 A KR1020157006629 A KR 1020157006629A KR 20157006629 A KR20157006629 A KR 20157006629A KR 101730052 B1 KR101730052 B1 KR 101730052B1
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cells
negative
muse
cell
myocardial infarction
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KR20150043482A (ko
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마사노리 요시다
신야 미나토쿠치
마리 데자와
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가부시키가이샤 클리오
고꾸리츠 다이가꾸호오징 기후다이가꾸
도호쿠 다이가쿠
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells

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  • Wood Science & Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
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  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nutrition Science (AREA)
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KR1020157006629A 2012-08-17 2013-08-15 심근경색의 수복 재생을 유도하는 다능성 간세포 Expired - Fee Related KR101730052B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JPJP-P-2012-181029 2012-08-17
JP2012181029 2012-08-17
PCT/JP2013/054049 WO2014027474A1 (ja) 2012-08-17 2013-02-19 心筋梗塞の修復再生を誘導する多能性幹細胞
JPPCT/JP2013/054049 2013-02-19
PCT/JP2013/071981 WO2014027684A1 (ja) 2012-08-17 2013-08-15 心筋梗塞の修復再生を誘導する多能性幹細胞

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KR20150043482A KR20150043482A (ko) 2015-04-22
KR101730052B1 true KR101730052B1 (ko) 2017-04-25

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US (3) US9844570B2 (cg-RX-API-DMAC7.html)
EP (2) EP2886123B1 (cg-RX-API-DMAC7.html)
JP (1) JP5968442B2 (cg-RX-API-DMAC7.html)
KR (1) KR101730052B1 (cg-RX-API-DMAC7.html)
CN (1) CN104582711B (cg-RX-API-DMAC7.html)
AU (1) AU2013303492B2 (cg-RX-API-DMAC7.html)
CA (1) CA2882239C (cg-RX-API-DMAC7.html)
DK (1) DK2886123T3 (cg-RX-API-DMAC7.html)
ES (1) ES2767182T3 (cg-RX-API-DMAC7.html)
IN (1) IN2015DN01616A (cg-RX-API-DMAC7.html)
PL (1) PL2886123T3 (cg-RX-API-DMAC7.html)
PT (1) PT2886123T (cg-RX-API-DMAC7.html)
SG (2) SG10201800829XA (cg-RX-API-DMAC7.html)
WO (2) WO2014027474A1 (cg-RX-API-DMAC7.html)

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WO2014027474A1 (ja) 2012-08-17 2014-02-20 株式会社Ｃｌｉｏ 心筋梗塞の修復再生を誘導する多能性幹細胞
JP2015160820A (ja) * 2014-02-26 2015-09-07 株式会社Ｃｌｉｏ 慢性腎障害治療のための多能性幹細胞
JP6452107B2 (ja) 2014-09-05 2019-01-16 国立大学法人 東京大学 糖尿病性皮膚潰瘍治療のための多能性幹細胞
WO2016168993A1 (en) * 2015-04-22 2016-10-27 Innolife Co., Ltd. Methods of tissue repair and regeneration
JP6770673B2 (ja) * 2016-02-26 2020-10-21 国立大学法人東海国立大学機構 急性心筋梗塞の予後マーカー及びその利用
SG11201811806TA (en) * 2016-07-01 2019-02-27 Univ Tohoku Prophylactic or therapeutic agent for organ fibrosis
CA3032358A1 (en) * 2016-07-29 2018-02-01 Tohoku University Prophylactic or therapeutic agent for vascular disorder
SG11201900989QA (en) 2016-08-03 2019-03-28 Life Science Institute Inc Method for inducing differentiation of pluripotent stem cells in vitro
WO2018025976A1 (ja) * 2016-08-03 2018-02-08 株式会社生命科学インスティテュート 多能性幹細胞による虚血再灌流肺障害の軽減及び治療
KR102503101B1 (ko) * 2016-08-03 2023-02-23 고쿠리츠 다이가쿠 호우징 도우카이 고쿠리츠 다이가쿠 기코우 다능성 간세포에 따른 만성폐질환의 개선 및 치료
CN106822899B (zh) * 2017-03-10 2020-11-27 北京大学 一种通过抑制自噬促进心肌再生的药物
KR20200070247A (ko) * 2017-10-17 2020-06-17 고쿠리츠다이가쿠호진 히로시마다이가쿠 골연골 수복을 유도하는 다능성 간세포
JP7102666B2 (ja) * 2018-01-25 2022-07-20 国立大学法人東海国立大学機構 Ｍｕｓｅ細胞動員剤及び心筋障害への利用
JP7072777B2 (ja) * 2018-07-03 2022-05-23 株式会社生命科学インスティテュート 慢性腎障害治療のための多能性幹細胞
CN110302212A (zh) * 2019-07-17 2019-10-08 陶正博 一种用于治疗急性心肌梗死的细胞制剂及其制备方法
US12460182B2 (en) 2019-08-19 2025-11-04 Cellaxia Inc. Cell-containing pharmaceutical composition
WO2021045190A1 (ja) * 2019-09-05 2021-03-11 国立大学法人東北大学 心筋炎の治療剤
WO2021085639A1 (ja) * 2019-10-31 2021-05-06 株式会社生命科学インスティテュート 多能性幹細胞による間質性膀胱炎の治療
CN115843311A (zh) 2020-04-02 2023-03-24 国立大学法人东北大学 高潜能多能干细胞
TWI825446B (zh) * 2020-08-14 2023-12-11 中國醫藥大學 醫藥組合物治療組織缺血狀況之用途
JP2021073305A (ja) * 2021-02-09 2021-05-13 株式会社生命科学インスティテュート 慢性腎障害治療のための多能性幹細胞
CN119198334A (zh) * 2024-10-31 2024-12-27 北京大学深圳研究生院 一种心肌梗死边界区组织鉴定方法

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WO2011007900A1 (ja) * 2009-07-15 2011-01-20 Dezawa Mari 生体組織から単離できる多能性幹細胞

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ATE382681T1 (de) * 1998-07-31 2008-01-15 Genzyme Corp Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen
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CA2434362A1 (en) * 2001-01-20 2002-07-25 Cardion Ag Pluripotent adult stem cells derived from regenerative tissue
KR101073411B1 (ko) 2001-07-12 2011-10-17 제론 코포레이션 인간 다분화능 줄기 세포로부터 제조된 심근 세포 계통의 세포
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SG10201800829XA (en) 2018-03-28
EP2886123B1 (en) 2019-10-23
US20190307806A1 (en) 2019-10-10
JPWO2014027684A1 (ja) 2016-07-28
KR20150043482A (ko) 2015-04-22
AU2013303492A1 (en) 2015-03-12
SG11201501185WA (en) 2015-05-28
US20150196600A1 (en) 2015-07-16
US9844570B2 (en) 2017-12-19
IN2015DN01616A (cg-RX-API-DMAC7.html) 2015-07-03
JP5968442B2 (ja) 2016-08-10
ES2767182T3 (es) 2020-06-16
WO2014027684A1 (ja) 2014-02-20
US10376544B2 (en) 2019-08-13
CA2882239C (en) 2018-05-22
CA2882239A1 (en) 2014-02-20
EP3659612B1 (en) 2023-06-07
PT2886123T (pt) 2020-01-22
EP2886123A1 (en) 2015-06-24
US10639335B2 (en) 2020-05-05
EP3659612A1 (en) 2020-06-03
US20180050067A1 (en) 2018-02-22
WO2014027474A1 (ja) 2014-02-20
CN104582711B (zh) 2019-12-06
DK2886123T3 (da) 2020-01-27
AU2013303492B2 (en) 2017-02-16
EP2886123A4 (en) 2016-06-22
CN104582711A (zh) 2015-04-29
PL2886123T3 (pl) 2020-05-18

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